A-Metrine

A-Metrine Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? A-Metrine is a brand name. Its generic name is Methylergometrine.

A-Metrine

A-Metrine (also known as ergonovine or Ergometrine) is a medication used to decrease bleeding after childbirth (postpartum haemorrhage). It belongs to the ergot alkaloid class of medications and works by causing strong contractions of the uterus.

Uses

A-Metrine is used to prevent and to treat postpartum haemorrhage (abnormal heavy bleeding) by stimulating uterine contractions after a delivery. It is also used to control severe bleeding or to induce labour.

Mechanism of Action

A-Metrine works by activating serotonin and dopamine receptors that are located on the smooth muscle of the uterus. When these receptors are activated, they cause the uterus to contract strongly which reduces blood flow and helps to stop bleeding.

How Long Does It Take To Work?

A-Metrine usually begins to take effect within several minutes of being taken, and the effects of the medication typically last for a few hours.

Absorption

A-Metrine is rapidly absorbed in the stomach and intestine and undergoes some first pass metabolism before reaching the systemic circulation. The mean peak serum concentrations are achieved within about 1 hour of ingestion.

Route of Elimination

A-Metrine is mainly metabolized in the liver and excreted in the urine as metabolites.

Dosage

The starting dose of A-Metrine in postpartum haemorrhage is 0.2mg intramuscularly. This dose can be repeated up 0.2mg as often as necessary. The maximum total dose in 24 hours should not exceed 1 or 1.2mg. For induction of labour the recommended dose is 0.2mg intramuscularly or 0.5-1mg orally with caution.

Administration

A-Metrine is intended for intramuscular injection and should be injected deeply into a large muscle. It can also be administered orally.

Side Effects

Common side effects of A-Metrine include nausea, vomiting, confusion, headache, sweating, tremor, and difficulty breathing. Serious side effects include high blood pressure and seizures.

Toxicity

A-Metrine can be toxic if too much is administered or if an existing medical condition is present. Overdose symptoms may include chest pain, dizziness, feeling of warmth, fever, rapid heart rate, nausea, vomiting, confusion, and seizures.

Precaution

A-Metrine should not be used in people with certain medical conditions including uncontrolled hypertension, coronary artery disease, seizures, or stroke. It should not be used during pregnancy.

Interaction

A-Metrine can interact with several other medications including nonsteroidal anti-inflammatory drugs (NSAIDs), antifungals, and antibiotics. It can also interact with certain herbs and supplements like kava and St. John’s wort.

Disease Interaction

A-Metrine should not be used in people with certain medical conditions including uncontrolled hypertension, coronary artery disease, seizures, or stroke.

Drug Interaction

A-Metrine can interact with several other medications including nonsteroidal anti-inflammatory drugs (NSAIDs), antifungals, and antibiotics. It can also interact with certain herbs and supplements like kava and St. John’s wort.

Food Interactions

A-Metrine may interact with certain foods, such as foods high in tyramine. Grapefruit and drunken can also interact with A-Metrine.

Pregnancy Use

A-Metrine should not be used during pregnancy due to the risk of birth defects and miscarriage.

Lactation Use

A-Metrine is excreted in breast milk and should not be used by breastfeeding women.

Acute Overdose

Overdose symptoms may include chest pain, dizziness, feeling of warmth, fever, rapid heart rate, nausea, vomiting, confusion, and seizures.

Contraindication

A-Metrine is contraindicated in people with uncontrolled hypertension, coronary artery disease, seizures, or stroke.

Directions for Use

• A-Metrine should not be taken by mouth if it is intended for intramuscular injection.
• A-Metrine should be administered intramuscularly using a sterile needle and syringe.
• The dosage should be carefully adjusted according to the instructions of a medical professional.
• A-Metrine should not be used during pregnancy.

Storage Condition

A-Metrine should be stored at room temperature away from light and moisture. It should be kept in a child-proof container and out of the reach of children and pets.

Volume of Distribution

The volume of distribution of A-Metrine is 1.7 L/kg.

Half Life

The elimination half-life of A-Metrine is 8.2 hours.

Clearance

The clearance of A-Metrine is 9.3 mL/min/kg.

Here you find in details version of A-Metrine

Some Frequently Asked Questions About A-Metrine

What is A-Metrine?

A-Metrine is a drug that is used to stop bleeding after childbirth. It is also referred to as oxytocin methobromide and ergonovine maleate.

How does A-Metrine work?

A-Metrine works by stimulating contractions of the uterus, which help to stop bleeding after childbirth.

What are the side effects of A-Metrine?

Common side effects of A-Metrine include nausea, vomiting, cramping, dizziness, headache, breast tenderness, and increased blood pressure.

How should A-Metrine be taken?

A-Metrine should be taken exactly as prescribed by your doctor. It is typically taken as an injection just after childbirth or when bleeding is excessive.

How long does A-Metrine stay in your system?

A-Metrine typically stays in your system for up to 24 hours.

What should I do if I experience side effects from A-Metrine?

If you experience any side effects from A-Metrine, contact your doctor or healthcare provider immediately.

Can I take A-Metrine if I am pregnant?

No, A-Metrine should not be taken if you are pregnant, as it can have adverse effects on the fetus.

Can A-Metrine cause an allergic reaction?

Yes, A-Metrine may cause an allergic reaction, so be sure to tell your doctor if you have a history of allergies.

Is Methylergometrane available over the counter?

No, A-Metrine is not available over the counter and must be prescribed by your doctor.

What other drugs should I avoid while taking A-Metrine?

You should avoid taking any other drugs that may interact with A-Metrine, such as blood pressure medications, aspirin, ibuprofen, or other uterine stimulants.

Can A-Metrine be used to induce labor?

Yes, A-Metrine is sometimes used to induce labor in the late stages of pregnancy.

What should I do if I miss a dose of A-Metrine?

If you miss a dose of A-Metrine, contact your doctor or healthcare provider as soon as possible.

How often should I take A-Metrine?

A-Metrine should be taken as prescribed by your doctor. Do not take more or less than the recommended amount.

Is A-Metrine safe to take while breastfeeding?

No, A-Metrine should not be taken while breastfeeding, as it can pass into the breast milk and harm the infant.

What happens if I overdose on A-Metrine?

If you overdose on A-Metrine, contact your doctor or emergency medical personnel immediately. Overdosing on A-Metrine can lead to serious complications such as heart attack or stroke.

Can A-Metrine be used to treat postpartum bleeding?

Yes, A-Metrine can be used to treat postpartum bleeding. It is typically administered as an injection just after childbirth.

Can I drink alcohol while taking A-Metrine?

No, you should avoid drinking alcohol while taking A-Metrine, as it can increase the risk of side effects.

What should I do if I experience unusual uterine activity while taking A-Metrine?

If you experience any unusual uterine activity while taking A-Metrine, contact your doctor or healthcare provider immediately.

Can I take A-Metrine if I have high blood pressure?

No, A-Metrine should not be taken if you have high blood pressure. Talk to your doctor about alternative treatments.

Is A-Metrine a controlled substance?

No, A-Metrine is not a controlled substance, but it is only available by prescription.

What other medical conditions should I inform my doctor about before taking A-Metrine?

You should always inform your doctor of any other medical conditions you may have before taking A-Metrine, such as heart disease, high blood pressure, asthma, or diabetes.

Can I take A-Metrine if I have a history of heart problems?

No, you should not take A-Metrine if you have a history of heart problems. Talk to your doctor about alternative treatments.

Can I take other medications while taking A-Metrine?

You should always inform your doctor of any other medications you may be taking before taking A-Metrine, as some medications may interact with it.

Is A-Metrine safe for long-term use?

No, A-Metrine should not be taken for longer than your doctor has prescribed. Long-term use of A-Metrine may cause serious side effects.

What is the recommended dosage of A-Metrine?

The recommended dosage of A-Metrine will vary depending on your individual needs and should be determined by your doctor.

Can A-Metrine be taken with food?

A-Metrine can be taken with food, but you should always follow your doctor's instructions when taking it.

Is A-Metrine safe for children?

No, A-Metrine is not recommended for children. Talk to your doctor about alternative treatments.

What is the difference between A-Metrine and Oxytocin?

A-Metrine and Oxytocin are both drugs used to stop bleeding after childbirth. A-Metrine is more commonly used, as it is more effective and has fewer side effects than Oxytocin.

Can I take A-Metrine if I have a history of asthma?

No, A-Metrine should not be taken if you have a history of asthma. Talk to your doctor about alternative treatments.

What are the most common side effects of A-Metrine?

The most common side effects of A-Metrine are nausea, vomiting, cramping, dizziness, headache, breast tenderness, and increased blood pressure.

What should I avoid while taking A-Metrine?

You should avoid taking any other drugs that may interact with A-Metrine while taking it, such as blood pressure medications, aspirin, ibuprofen, or other uterine stimulants. In addition, you should avoid drinking alcohol while taking A-Metrine.

Can A-Metrine be used to treat uterine fibroids?

No, A-Metrine should not be used to treat uterine fibroids. Talk to your doctor about alternative treatments.

Can A-Metrine be used to treat postpartum depression?

No, A-Metrine should not be used to treat postpartum depression. Talk to your doctor about alternative treatments.

Can A-Metrine cause an increase in blood pressure?

Yes, A-Metrine can cause an increase in blood pressure. If you experience any increase in blood pressure, contact your doctor immediately.

Is A-Metrine safe for use during labor?

Yes, A-Metrine can be used during labor to speed up delivery, but it should only be used under the supervision of your doctor.

What should I do if I experience chest pain while taking A-Metrine?

If you experience chest pain while taking A-Metrine, contact your doctor or emergency medical personnel immediately. Chest pain could be a sign of a serious medical condition.

What should I do if I miss multiple doses of A-Metrine?

If you miss multiple doses of A-Metrine, contact your doctor or healthcare provider as soon as possible. Your doctor may need to adjust your dosage.

Can A-Metrine be used to treat postpartum headaches?

No, A-Metrine should not be used to treat postpartum headaches. Talk to your doctor about alternative treatments.

Is A-Metrine safe to use in the third trimester of pregnancy?

No, A-Metrine should not be used in the third trimester of pregnancy, as it can have serious effects on the fetus.

If I experience a severe allergic reaction to A-Metrine, what should I do?

If you experience a severe allergic reaction to A-Metrine, seek medical attention immediately. Symptoms of a severe allergic reaction include difficulty breathing, hives, and swelling of the face, lips, throat, or tongue.