Methylergometrine

Methylergometrine Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Methylergometrine is a brand name. Its generic name is Methylergometrine.

Methylergometrine

Methylergometrine (also known as ergonovine or Ergometrine) is a medication used to decrease bleeding after childbirth (postpartum haemorrhage). It belongs to the ergot alkaloid class of medications and works by causing strong contractions of the uterus.

Uses

Methylergometrine is used to prevent and to treat postpartum haemorrhage (abnormal heavy bleeding) by stimulating uterine contractions after a delivery. It is also used to control severe bleeding or to induce labour.

Mechanism of Action

Methylergometrine works by activating serotonin and dopamine receptors that are located on the smooth muscle of the uterus. When these receptors are activated, they cause the uterus to contract strongly which reduces blood flow and helps to stop bleeding.

How Long Does It Take To Work?

Methylergometrine usually begins to take effect within several minutes of being taken, and the effects of the medication typically last for a few hours.

Absorption

Methylergometrine is rapidly absorbed in the stomach and intestine and undergoes some first pass metabolism before reaching the systemic circulation. The mean peak serum concentrations are achieved within about 1 hour of ingestion.

Route of Elimination

Methylergometrine is mainly metabolized in the liver and excreted in the urine as metabolites.

Dosage

The starting dose of Methylergometrine in postpartum haemorrhage is 0.2mg intramuscularly. This dose can be repeated up 0.2mg as often as necessary. The maximum total dose in 24 hours should not exceed 1 or 1.2mg. For induction of labour the recommended dose is 0.2mg intramuscularly or 0.5-1mg orally with caution.

Administration

Methylergometrine is intended for intramuscular injection and should be injected deeply into a large muscle. It can also be administered orally.

Side Effects

Common side effects of Methylergometrine include nausea, vomiting, confusion, headache, sweating, tremor, and difficulty breathing. Serious side effects include high blood pressure and seizures.

Toxicity

Methylergometrine can be toxic if too much is administered or if an existing medical condition is present. Overdose symptoms may include chest pain, dizziness, feeling of warmth, fever, rapid heart rate, nausea, vomiting, confusion, and seizures.

Precaution

Methylergometrine should not be used in people with certain medical conditions including uncontrolled hypertension, coronary artery disease, seizures, or stroke. It should not be used during pregnancy.

Interaction

Methylergometrine can interact with several other medications including nonsteroidal anti-inflammatory drugs (NSAIDs), antifungals, and antibiotics. It can also interact with certain herbs and supplements like kava and St. John’s wort.

Disease Interaction

Methylergometrine should not be used in people with certain medical conditions including uncontrolled hypertension, coronary artery disease, seizures, or stroke.

Drug Interaction

Methylergometrine can interact with several other medications including nonsteroidal anti-inflammatory drugs (NSAIDs), antifungals, and antibiotics. It can also interact with certain herbs and supplements like kava and St. John’s wort.

Food Interactions

Methylergometrine may interact with certain foods, such as foods high in tyramine. Grapefruit and drunken can also interact with Methylergometrine.

Pregnancy Use

Methylergometrine should not be used during pregnancy due to the risk of birth defects and miscarriage.

Lactation Use

Methylergometrine is excreted in breast milk and should not be used by breastfeeding women.

Acute Overdose

Overdose symptoms may include chest pain, dizziness, feeling of warmth, fever, rapid heart rate, nausea, vomiting, confusion, and seizures.

Contraindication

Methylergometrine is contraindicated in people with uncontrolled hypertension, coronary artery disease, seizures, or stroke.

Directions for Use

• Methylergometrine should not be taken by mouth if it is intended for intramuscular injection.
• Methylergometrine should be administered intramuscularly using a sterile needle and syringe.
• The dosage should be carefully adjusted according to the instructions of a medical professional.
• Methylergometrine should not be used during pregnancy.

Storage Condition

Methylergometrine should be stored at room temperature away from light and moisture. It should be kept in a child-proof container and out of the reach of children and pets.

Volume of Distribution

The volume of distribution of Methylergometrine is 1.7 L/kg.

Half Life

The elimination half-life of Methylergometrine is 8.2 hours.

Clearance

The clearance of Methylergometrine is 9.3 mL/min/kg.

Here you find in details version of Methylergometrine

Some Frequently Asked Questions About Methylergometrine

What is Methylergometrine?

Methylergometrine is a drug that is used to stop bleeding after childbirth. It is also referred to as oxytocin methobromide and ergonovine maleate.

How does Methylergometrine work?

Methylergometrine works by stimulating contractions of the uterus, which help to stop bleeding after childbirth.

What are the side effects of Methylergometrine?

Common side effects of Methylergometrine include nausea, vomiting, cramping, dizziness, headache, breast tenderness, and increased blood pressure.

How should Methylergometrine be taken?

Methylergometrine should be taken exactly as prescribed by your doctor. It is typically taken as an injection just after childbirth or when bleeding is excessive.

How long does Methylergometrine stay in your system?

Methylergometrine typically stays in your system for up to 24 hours.

What should I do if I experience side effects from Methylergometrine?

If you experience any side effects from Methylergometrine, contact your doctor or healthcare provider immediately.

Can I take Methylergometrine if I am pregnant?

No, Methylergometrine should not be taken if you are pregnant, as it can have adverse effects on the fetus.

Can Methylergometrine cause an allergic reaction?

Yes, Methylergometrine may cause an allergic reaction, so be sure to tell your doctor if you have a history of allergies.

Is Methylergometrane available over the counter?

No, Methylergometrine is not available over the counter and must be prescribed by your doctor.

What other drugs should I avoid while taking Methylergometrine?

You should avoid taking any other drugs that may interact with Methylergometrine, such as blood pressure medications, aspirin, ibuprofen, or other uterine stimulants.

Can Methylergometrine be used to induce labor?

Yes, Methylergometrine is sometimes used to induce labor in the late stages of pregnancy.

What should I do if I miss a dose of Methylergometrine?

If you miss a dose of Methylergometrine, contact your doctor or healthcare provider as soon as possible.

How often should I take Methylergometrine?

Methylergometrine should be taken as prescribed by your doctor. Do not take more or less than the recommended amount.

Is Methylergometrine safe to take while breastfeeding?

No, Methylergometrine should not be taken while breastfeeding, as it can pass into the breast milk and harm the infant.

What happens if I overdose on Methylergometrine?

If you overdose on Methylergometrine, contact your doctor or emergency medical personnel immediately. Overdosing on Methylergometrine can lead to serious complications such as heart attack or stroke.

Can Methylergometrine be used to treat postpartum bleeding?

Yes, Methylergometrine can be used to treat postpartum bleeding. It is typically administered as an injection just after childbirth.

Can I drink alcohol while taking Methylergometrine?

No, you should avoid drinking alcohol while taking Methylergometrine, as it can increase the risk of side effects.

What should I do if I experience unusual uterine activity while taking Methylergometrine?

If you experience any unusual uterine activity while taking Methylergometrine, contact your doctor or healthcare provider immediately.

Can I take Methylergometrine if I have high blood pressure?

No, Methylergometrine should not be taken if you have high blood pressure. Talk to your doctor about alternative treatments.

Is Methylergometrine a controlled substance?

No, Methylergometrine is not a controlled substance, but it is only available by prescription.

What other medical conditions should I inform my doctor about before taking Methylergometrine?

You should always inform your doctor of any other medical conditions you may have before taking Methylergometrine, such as heart disease, high blood pressure, asthma, or diabetes.

Can I take Methylergometrine if I have a history of heart problems?

No, you should not take Methylergometrine if you have a history of heart problems. Talk to your doctor about alternative treatments.

Can I take other medications while taking Methylergometrine?

You should always inform your doctor of any other medications you may be taking before taking Methylergometrine, as some medications may interact with it.

Is Methylergometrine safe for long-term use?

No, Methylergometrine should not be taken for longer than your doctor has prescribed. Long-term use of Methylergometrine may cause serious side effects.

What is the recommended dosage of Methylergometrine?

The recommended dosage of Methylergometrine will vary depending on your individual needs and should be determined by your doctor.

Can Methylergometrine be taken with food?

Methylergometrine can be taken with food, but you should always follow your doctor's instructions when taking it.

Is Methylergometrine safe for children?

No, Methylergometrine is not recommended for children. Talk to your doctor about alternative treatments.

What is the difference between Methylergometrine and Oxytocin?

Methylergometrine and Oxytocin are both drugs used to stop bleeding after childbirth. Methylergometrine is more commonly used, as it is more effective and has fewer side effects than Oxytocin.

Can I take Methylergometrine if I have a history of asthma?

No, Methylergometrine should not be taken if you have a history of asthma. Talk to your doctor about alternative treatments.

What are the most common side effects of Methylergometrine?

The most common side effects of Methylergometrine are nausea, vomiting, cramping, dizziness, headache, breast tenderness, and increased blood pressure.

What should I avoid while taking Methylergometrine?

You should avoid taking any other drugs that may interact with Methylergometrine while taking it, such as blood pressure medications, aspirin, ibuprofen, or other uterine stimulants. In addition, you should avoid drinking alcohol while taking Methylergometrine.

Can Methylergometrine be used to treat uterine fibroids?

No, Methylergometrine should not be used to treat uterine fibroids. Talk to your doctor about alternative treatments.

Can Methylergometrine be used to treat postpartum depression?

No, Methylergometrine should not be used to treat postpartum depression. Talk to your doctor about alternative treatments.

Can Methylergometrine cause an increase in blood pressure?

Yes, Methylergometrine can cause an increase in blood pressure. If you experience any increase in blood pressure, contact your doctor immediately.

Is Methylergometrine safe for use during labor?

Yes, Methylergometrine can be used during labor to speed up delivery, but it should only be used under the supervision of your doctor.

What should I do if I experience chest pain while taking Methylergometrine?

If you experience chest pain while taking Methylergometrine, contact your doctor or emergency medical personnel immediately. Chest pain could be a sign of a serious medical condition.

What should I do if I miss multiple doses of Methylergometrine?

If you miss multiple doses of Methylergometrine, contact your doctor or healthcare provider as soon as possible. Your doctor may need to adjust your dosage.

Can Methylergometrine be used to treat postpartum headaches?

No, Methylergometrine should not be used to treat postpartum headaches. Talk to your doctor about alternative treatments.

Is Methylergometrine safe to use in the third trimester of pregnancy?

No, Methylergometrine should not be used in the third trimester of pregnancy, as it can have serious effects on the fetus.

If I experience a severe allergic reaction to Methylergometrine, what should I do?

If you experience a severe allergic reaction to Methylergometrine, seek medical attention immediately. Symptoms of a severe allergic reaction include difficulty breathing, hives, and swelling of the face, lips, throat, or tongue.