Metherspan

Metherspan Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Metherspan is a brand name. Its generic name is Methylergometrine.

Metherspan

Metherspan (also known as ergonovine or Ergometrine) is a medication used to decrease bleeding after childbirth (postpartum haemorrhage). It belongs to the ergot alkaloid class of medications and works by causing strong contractions of the uterus.

Uses

Metherspan is used to prevent and to treat postpartum haemorrhage (abnormal heavy bleeding) by stimulating uterine contractions after a delivery. It is also used to control severe bleeding or to induce labour.

Mechanism of Action

Metherspan works by activating serotonin and dopamine receptors that are located on the smooth muscle of the uterus. When these receptors are activated, they cause the uterus to contract strongly which reduces blood flow and helps to stop bleeding.

How Long Does It Take To Work?

Metherspan usually begins to take effect within several minutes of being taken, and the effects of the medication typically last for a few hours.

Absorption

Metherspan is rapidly absorbed in the stomach and intestine and undergoes some first pass metabolism before reaching the systemic circulation. The mean peak serum concentrations are achieved within about 1 hour of ingestion.

Route of Elimination

Metherspan is mainly metabolized in the liver and excreted in the urine as metabolites.

Dosage

The starting dose of Metherspan in postpartum haemorrhage is 0.2mg intramuscularly. This dose can be repeated up 0.2mg as often as necessary. The maximum total dose in 24 hours should not exceed 1 or 1.2mg. For induction of labour the recommended dose is 0.2mg intramuscularly or 0.5-1mg orally with caution.

Administration

Metherspan is intended for intramuscular injection and should be injected deeply into a large muscle. It can also be administered orally.

Side Effects

Common side effects of Metherspan include nausea, vomiting, confusion, headache, sweating, tremor, and difficulty breathing. Serious side effects include high blood pressure and seizures.

Toxicity

Metherspan can be toxic if too much is administered or if an existing medical condition is present. Overdose symptoms may include chest pain, dizziness, feeling of warmth, fever, rapid heart rate, nausea, vomiting, confusion, and seizures.

Precaution

Metherspan should not be used in people with certain medical conditions including uncontrolled hypertension, coronary artery disease, seizures, or stroke. It should not be used during pregnancy.

Interaction

Metherspan can interact with several other medications including nonsteroidal anti-inflammatory drugs (NSAIDs), antifungals, and antibiotics. It can also interact with certain herbs and supplements like kava and St. John’s wort.

Disease Interaction

Metherspan should not be used in people with certain medical conditions including uncontrolled hypertension, coronary artery disease, seizures, or stroke.

Drug Interaction

Metherspan can interact with several other medications including nonsteroidal anti-inflammatory drugs (NSAIDs), antifungals, and antibiotics. It can also interact with certain herbs and supplements like kava and St. John’s wort.

Food Interactions

Metherspan may interact with certain foods, such as foods high in tyramine. Grapefruit and drunken can also interact with Metherspan.

Pregnancy Use

Metherspan should not be used during pregnancy due to the risk of birth defects and miscarriage.

Lactation Use

Metherspan is excreted in breast milk and should not be used by breastfeeding women.

Acute Overdose

Overdose symptoms may include chest pain, dizziness, feeling of warmth, fever, rapid heart rate, nausea, vomiting, confusion, and seizures.

Contraindication

Metherspan is contraindicated in people with uncontrolled hypertension, coronary artery disease, seizures, or stroke.

Directions for Use

• Metherspan should not be taken by mouth if it is intended for intramuscular injection.
• Metherspan should be administered intramuscularly using a sterile needle and syringe.
• The dosage should be carefully adjusted according to the instructions of a medical professional.
• Metherspan should not be used during pregnancy.

Storage Condition

Metherspan should be stored at room temperature away from light and moisture. It should be kept in a child-proof container and out of the reach of children and pets.

Volume of Distribution

The volume of distribution of Metherspan is 1.7 L/kg.

Half Life

The elimination half-life of Metherspan is 8.2 hours.

Clearance

The clearance of Metherspan is 9.3 mL/min/kg.

Here you find in details version of Metherspan

Some Frequently Asked Questions About Metherspan

What is Metherspan?

Metherspan is a drug that is used to stop bleeding after childbirth. It is also referred to as oxytocin methobromide and ergonovine maleate.

How does Metherspan work?

Metherspan works by stimulating contractions of the uterus, which help to stop bleeding after childbirth.

What are the side effects of Metherspan?

Common side effects of Metherspan include nausea, vomiting, cramping, dizziness, headache, breast tenderness, and increased blood pressure.

How should Metherspan be taken?

Metherspan should be taken exactly as prescribed by your doctor. It is typically taken as an injection just after childbirth or when bleeding is excessive.

How long does Metherspan stay in your system?

Metherspan typically stays in your system for up to 24 hours.

What should I do if I experience side effects from Metherspan?

If you experience any side effects from Metherspan, contact your doctor or healthcare provider immediately.

Can I take Metherspan if I am pregnant?

No, Metherspan should not be taken if you are pregnant, as it can have adverse effects on the fetus.

Can Metherspan cause an allergic reaction?

Yes, Metherspan may cause an allergic reaction, so be sure to tell your doctor if you have a history of allergies.

Is Methylergometrane available over the counter?

No, Metherspan is not available over the counter and must be prescribed by your doctor.

What other drugs should I avoid while taking Metherspan?

You should avoid taking any other drugs that may interact with Metherspan, such as blood pressure medications, aspirin, ibuprofen, or other uterine stimulants.

Can Metherspan be used to induce labor?

Yes, Metherspan is sometimes used to induce labor in the late stages of pregnancy.

What should I do if I miss a dose of Metherspan?

If you miss a dose of Metherspan, contact your doctor or healthcare provider as soon as possible.

How often should I take Metherspan?

Metherspan should be taken as prescribed by your doctor. Do not take more or less than the recommended amount.

Is Metherspan safe to take while breastfeeding?

No, Metherspan should not be taken while breastfeeding, as it can pass into the breast milk and harm the infant.

What happens if I overdose on Metherspan?

If you overdose on Metherspan, contact your doctor or emergency medical personnel immediately. Overdosing on Metherspan can lead to serious complications such as heart attack or stroke.

Can Metherspan be used to treat postpartum bleeding?

Yes, Metherspan can be used to treat postpartum bleeding. It is typically administered as an injection just after childbirth.

Can I drink alcohol while taking Metherspan?

No, you should avoid drinking alcohol while taking Metherspan, as it can increase the risk of side effects.

What should I do if I experience unusual uterine activity while taking Metherspan?

If you experience any unusual uterine activity while taking Metherspan, contact your doctor or healthcare provider immediately.

Can I take Metherspan if I have high blood pressure?

No, Metherspan should not be taken if you have high blood pressure. Talk to your doctor about alternative treatments.

Is Metherspan a controlled substance?

No, Metherspan is not a controlled substance, but it is only available by prescription.

What other medical conditions should I inform my doctor about before taking Metherspan?

You should always inform your doctor of any other medical conditions you may have before taking Metherspan, such as heart disease, high blood pressure, asthma, or diabetes.

Can I take Metherspan if I have a history of heart problems?

No, you should not take Metherspan if you have a history of heart problems. Talk to your doctor about alternative treatments.

Can I take other medications while taking Metherspan?

You should always inform your doctor of any other medications you may be taking before taking Metherspan, as some medications may interact with it.

Is Metherspan safe for long-term use?

No, Metherspan should not be taken for longer than your doctor has prescribed. Long-term use of Metherspan may cause serious side effects.

What is the recommended dosage of Metherspan?

The recommended dosage of Metherspan will vary depending on your individual needs and should be determined by your doctor.

Can Metherspan be taken with food?

Metherspan can be taken with food, but you should always follow your doctor's instructions when taking it.

Is Metherspan safe for children?

No, Metherspan is not recommended for children. Talk to your doctor about alternative treatments.

What is the difference between Metherspan and Oxytocin?

Metherspan and Oxytocin are both drugs used to stop bleeding after childbirth. Metherspan is more commonly used, as it is more effective and has fewer side effects than Oxytocin.

Can I take Metherspan if I have a history of asthma?

No, Metherspan should not be taken if you have a history of asthma. Talk to your doctor about alternative treatments.

What are the most common side effects of Metherspan?

The most common side effects of Metherspan are nausea, vomiting, cramping, dizziness, headache, breast tenderness, and increased blood pressure.

What should I avoid while taking Metherspan?

You should avoid taking any other drugs that may interact with Metherspan while taking it, such as blood pressure medications, aspirin, ibuprofen, or other uterine stimulants. In addition, you should avoid drinking alcohol while taking Metherspan.

Can Metherspan be used to treat uterine fibroids?

No, Metherspan should not be used to treat uterine fibroids. Talk to your doctor about alternative treatments.

Can Metherspan be used to treat postpartum depression?

No, Metherspan should not be used to treat postpartum depression. Talk to your doctor about alternative treatments.

Can Metherspan cause an increase in blood pressure?

Yes, Metherspan can cause an increase in blood pressure. If you experience any increase in blood pressure, contact your doctor immediately.

Is Metherspan safe for use during labor?

Yes, Metherspan can be used during labor to speed up delivery, but it should only be used under the supervision of your doctor.

What should I do if I experience chest pain while taking Metherspan?

If you experience chest pain while taking Metherspan, contact your doctor or emergency medical personnel immediately. Chest pain could be a sign of a serious medical condition.

What should I do if I miss multiple doses of Metherspan?

If you miss multiple doses of Metherspan, contact your doctor or healthcare provider as soon as possible. Your doctor may need to adjust your dosage.

Can Metherspan be used to treat postpartum headaches?

No, Metherspan should not be used to treat postpartum headaches. Talk to your doctor about alternative treatments.

Is Metherspan safe to use in the third trimester of pregnancy?

No, Metherspan should not be used in the third trimester of pregnancy, as it can have serious effects on the fetus.

If I experience a severe allergic reaction to Metherspan, what should I do?

If you experience a severe allergic reaction to Metherspan, seek medical attention immediately. Symptoms of a severe allergic reaction include difficulty breathing, hives, and swelling of the face, lips, throat, or tongue.