Tizanidina

Tizanidina Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Tizanidina is a brand name. Its generic name is Tizanidine.

Tizanidina Introduction

Tizanidina is a short-acting muscle relaxant used to treat spasticity, including muscle spasms, pain, and stiffness caused by neurological disorders such as cerebral palsy, multiple sclerosis, and spinal cord injuries. It is usually taken orally, but can also be injected into a muscle.

Uses For

Tizanidina is used to treat spasticity resulting from diseases such as multiple sclerosis, spinal cord injuries, cerebral palsy, and stroke. It can also be used to relieve muscle spasms and pain.

Mechanism of Action

Tizanidina works by blocking nerve signals from reaching the brain, thereby reducing the intensity of muscle spasms. It also relaxes muscles which can reduce pain and stiffness.

How Long Does it Take to Work?

Tizanidina typically takes effect within 30 to 60 minutes after it is consumed. It is a short-acting medication, so the effects will usually last 8-9 hours.

Absorption

Tizanidina is rapidly absorbed from the gastrointestinal tract. Peak plasma concentrations are reached in 1-2 hours.

Route of Elimination

Tizanidina is mainly eliminated by the kidneys. Approximately 20% is excreted unchanged in the urine.

Dosage

The recommended adult dose of tizanidine is 2-4 mg orally every 6-8 hours, not to exceed 36 mg in a 24 hour period. Maximum benefits may not be seen for up to 2-3 weeks. The maximum recommended daily dose is 36 mg.

Administration

Tizanidina should be taken with food or immediately after eating. Do not take tizanidine with other drugs that cause drowsiness or decrease alertness. Examples of these drugs include tricyclic antidepressants, other muscle relaxants, pain relievers, sleeping pills, and tranquilizers.

Side Effects

Common side effects of tizanidine include dry mouth, drowsiness, dizziness, lightheadedness, headache, constipation, nausea, and weakness. More serious side effects may include low blood pressure, slowed breathing, and changes in mental status.

Toxicity

Tizanidina may cause significant toxicity and death in overdose. Symptoms may include confusion, hallucinations, coma, seizures, and respiratory arrest. Treatment may include gastric lavage, activated charcoal, and supportive measures to control symptoms.

Precaution

Tizanidina may cause drowsiness, dizziness, or blurred vision, and may impair physical or mental abilities required for the performance of potentially hazardous activities such as driving or operating machinery. Avoid these activities until you know how the drug affects you.

Interaction

Tizanidina may interact with other drugs, such as anticholinergics, cimetidine, fluvoxamine, fluoxetine, nefazodone, and MAO inhibitors. Tell your doctor all medications and supplements you are taking before taking tizanidine.

Disease Interaction

Tizanidina may increase the effects of other drugs that cause drowsiness, including antidepressants, alcohol, antihistamines, sedatives, pain relievers, anxiety medications, and muscle relaxants.

Drug Interaction

Tizanidina can interact with other drugs, including Nefazodone, Cimetidine, Fluoxetine, Fluvoxamine, and Monoamine Oxidase inhibitors (MAOI). Tell your doctor all medications and supplements you are taking before taking tizanidine.

Food Interactions

Tizanidina may interact with food, beverages, or alcohol, causing side effects such as drowsiness, lightheadedness, dizziness, and blurred vision. Avoid these interactions by consuming tizanidine with food or at least 8 ounces of water.

Pregnancy Use

Tizanidina should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Women who are pregnant or planning to become pregnant should inform their healthcare provider of this before taking tizanidine.

Lactation Use

Tizanidina should not be used by breastfeeding women due to the potential for serious adverse reactions in nursing babies. Talk to your healthcare provider if you are breastfeeding before taking tizanidine.

Acute Overdose

Acute overdose symptoms may include drowsiness, confusion, impaired coordination, low blood pressure, and slow heartbeat. Treatment may include gastric lavage, activated charcoal, and supportive measures. Seek emergency medical help if an overdose is suspected.

Contraindication

Tizanidina is contraindicated in patients with known hypersensitivity reactions to it, as well as those taking fluvoxamine, MAO inhibitors, or cimetidine.

Use Direction

Tizanidina should be taken orally, with food or immediately after a meal. For maximum benefit, the medication should be taken at regular intervals. Do not take more than directed or change the dose without consulting a doctor.

Storage Condition

Tizanidina should be stored at room temperature, away from direct light and moisture. Keep all medications away from children and pets.

Volume of Distribution

Tizanidina has a volume of distribution of 0.9 L/kg.

Half Life

The half-life of tizanidine is 2.5-4.6 hours.

Clearance

The clearance of tizanidine is 1.2-3.2 mL/min/kg.

Here you find in details version of Tizanidina

Some Frequently Asked Questions About Tizanidina

What is Tizanidina?

Tizanidina is a centrally acting alpha-2 agonist used to treat spasticity, a condition caused by an injury or illness that results in muscle stiffness, tightness, and spasms.

What is the most common use of Tizanidina?

The most common use of Tizanidina is to treat spasticity associated with neurological conditions such as multiple sclerosis, spinal cord injury, and cerebral palsy.

How long does it take for Tizanidina to start working?

Tizanidina usually starts to work within 30 minutes to an hour after taking it.

How should I take Tizanidina?

Take Tizanidina exactly as prescribed by your doctor. Do not take more or less than prescribed. Do not take more than 3 tablets per day.

How long does Tizanidina stay in your system?

Tizanidina has a half-life of approximately 1 to 2 hours, meaning it will typically stay in your system for up to 8 hours.

Can I take Tizanidina with other medications?

Tizanidina may interact with certain other medications so make sure to tell your doctor about all the other medications you are taking.

What are the possible side effects of taking Tizanidina?

Common side effects of taking Tizanidina include dry mouth, drowsiness, dizziness, weakness, and fatigue. More severe side effects including low blood pressure, slow heart rate, and liver damage may also occur.

Is Tizanidina addictive?

Tizanidina is not known to be habit-forming or addictive, but it is important to take it as directed by your doctor.

Can I drink alcohol while taking Tizanidina?

It is not recommended to drink alcohol while taking Tizanidina, as it can increase the risk of side effects.

Does Tizanidina treat muscle spasms?

Yes, Tizanidina can be used to treat muscle spasms caused by spasticity.

Can Tizanidina be used to relieve pain?

Tizanidina is mainly used to treat spasticity, but it can also be used to relieve pain associated with muscle spasms.

Who should not take Tizanidina?

Tizanidina should not be taken by pregnant women, children, or those with liver or kidney disease. Additionally, those taking certain other medications should not take Tizanidina.

Is Tizanidina safe for long-term use?

Tizanidina is generally safe for long-term use, but talk to your doctor if you have any concerns about taking this medication for an extended period of time.

Does Tizanidina cause weight gain?

In some cases, Tizanidina may cause weight gain. This is more likely to occur in elderly patients and those with kidney or liver disease.

Can I take Tizanidina while breastfeeding?

It is not recommended to take Tizanidina while breastfeeding, as it could pass into breast milk and affect the baby.

Can Tizanidina be used to treat headaches?

No, Tizanidina is not used to treat headaches. It is intended to treat spasticity caused by neurological conditions.

Does Tizanidina cause depression or anxiety?

In some cases, Tizanidina can cause depression or anxiety. If these side effects occur, speak with your doctor right away.

Is Tizanidina available in generic form?

Yes, Tizanidina is available in generic form.

How is Tizanidina metabolized in the body?

Tizanidina is metabolized in the liver by cytochrome P450 3A4.

Can Tizanidina cause stomach upset?

Yes, Tizanidina can cause stomach upset including nausea, vomiting, and diarrhea.

Can I take other medications with Tizanidina?

Certain medications should not be taken with Tizanidina, including medications used to treat epilepsy, depression and anxiety, and those containing cimetidine. Be sure to tell your doctor about all medications you are currently taking before starting Tizanidina.

Does Tizanidina interact with grapefruit juice?

Yes, Tizanidina can interact with grapefruit juice and increase the risk of side effects.

What happens if I miss a dose of Tizanidina?

If you miss a dose of Tizanidina, take it as soon as you remember. However, if it is close to the time of your next dose, skip the missed dose and continue with your regular schedule.

Can Tizanidina be used to treat fibromyalgia?

Tizanidina is not traditionally used to treat fibromyalgia, but it may be recommended by your doctor in certain cases.

Can Tizanidina cause blurred vision?

Blurred vision is a possible side effect of taking Tizanidina.

What should I do if I experience an allergic reaction to Tizanidina?

If you experience any signs of an allergic reaction to Tizanidina such as itching, swelling, or difficulty breathing, seek medical attention immediately.

What should I do if I experience drowsiness while taking Tizanidina?

If you experience drowsiness while taking Tizanidina, it is recommended to avoid activities that require alertness such as driving or operating heavy machinery.

Is Tizanidina safe for children to take?

Tizanidina is not recommended for use in children. Speak with your doctor if you are considering giving this medication to a child.

What else should I know about taking Tizanidina?

Take Tizanidina exactly as directed by your doctor. Do not take more or less than prescribed. Do not take more than 3 tablets per day. Do not stop taking Tizanidina without first talking to your doctor. Be sure to tell your doctor about all medications you are currently taking.

Does Tizanidina cause cognitive impairment?

In some cases, Tizanidina may cause cognitive impairment such as confusion, memory problems, and difficulty concentrating.

Can Tizanidina be used to treat insomnia?

Tizanidina is not typically used to treat insomnia, but it can cause drowsiness in some cases which may help in falling and staying asleep.

Can I take Tizanidina if I have high blood pressure?

It is not recommended to take Tizanidina if you have high blood pressure, as it can cause further decreases in your blood pressure.

Can I take Tizanidina while pregnant?

It is not recommended to take Tizanidina while pregnant, as it may cause harm to the fetus.

Does Tizanidina contain sulfa?

No, Tizanidina does not contain sulfa.

Does Tizanidina cause memory loss?

In some cases, Tizanidina may cause memory loss and other cognitive impairments.

Does Tizanidina interact with other medications?

Yes, Tizanidina may interact with certain medications. Be sure to tell your doctor about all medications you are taking before starting Tizanidina.

Should Tizanidina be taken with food?

Tizanidina may be taken with or without food.

What are the most common side effects of taking Tizanidina?

The most common side effects of taking Tizanidina include dry mouth, drowsiness, dizziness, weakness, and fatigue.

What should I avoid while taking Tizanidina?

Avoid activities that require alertness such as driving or operating heavy machinery while taking Tizanidina due to its drowsiness-causing side effects.

What is the recommended dosage of Tizanidina for spasticity?

The recommended dosage of Tizanidina for spasticity is 2-4 mg per day, taken either 2 or 3 times a day depending on the doctor's recommendation.

Does Tizanidina cause difficulty urinating?

In some cases, Tizanidina may cause difficulty urinating due to its effects on sphincter muscles in the bladder.

Can I take Tizanidina with other muscle relaxants?

It is not recommended to take Tizanidina with other muscle relaxants, as this may increase the risk of side effects.