Nicergoline
Nicergoline Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Nicergoline is a brand name. Its generic name is Nicergoline.
Introduction
Nicergoline is a synthetic ergoline derivative that has been developed for the treatment of certain forms of dementia and is also available over-the-counter in some countries. It is an anti-hypertensive drug that has been extensively studied for its actions on the central nervous system. Due to its potential for use in cognitive improvement, memory preservation, and deep sleep induction, Nicergoline is often used as an adjunct to existing treatments for neurological and neurodegenerative diseases.Uses and Effects of Nicergoline
Nicergoline is used to treat cognitive decline, memory impairment, deep sleep induction, depression, and a variety of neurological and neurodegenerative conditions. It is believed to act on α2-adrenergic receptor and also a serotonin-2B receptor agonist, which is thought to increase cerebral blood flow and neurotransmitter concentrations. It is also used to treat mild to moderate dementia, including Alzheimer’s Disease, Parkinson’s Disease, cerebrovascular disorders, and certain forms of mental decline.Mechanism of Action
Nicergoline works mainly by binding to neurotransmitters known as serotonin and norepinephrine transporters, increasing their levels within the central nervous system. This increases the activity of the receptor sites and thus stimulates the central nervous system. Nicergoline also increases cerebral blood flow and oxygen uptake.How Long Does it Take to Work?
Nicergoline usually begins to work within an hour of taking the medication, and its effects can last up to 24-48 hours. It is important to note that its effects may vary depending on individual and should not be assumed to manifest exactly the same in all people.Absorption
Nicergoline is highly bioavailable, with peak concentrations reached in about 30 minutes after oral ingestion.Route of Elimination
Nicergoline is mainly eliminated by the kidneys and is partially metabolized by the liver. It is excreted as metabolites in the urine.Dosage Information
The recommended daily dose of Nicergoline depends on the condition being treated and the individual’s response to treatment. The usual starting dose is 0.6 mg to 1.2 mg per day, which may be increased up to 4.8 mg per day for some patients. Dose should be adjusted according to response, although some precautions should be taken when increasing the dose. Lower doses should be tried in elderly or debilitated patients.Administration
Nicergoline is available in tablet form and should be taken orally, preferably with a full glass of water. It can also be taken with or without food.Side Effects
The most common side effects of Nicergoline are nausea, headache, blurred vision, dizziness, drowsiness, restlessness, and difficulty sleeping. In rare cases, it can produce depression, anxiety, thought disturbances, and confusion. Other serious side effects may include irregular heartbeats, hypotension, shortness of breath, seizures, and serotonin syndrome.Toxicity
Nicergoline is generally well tolerated and does not cause significant toxicity. There are no known toxic levels but overdoses can be serious.Precautions
Nicergoline should be used cautiously in patients who have a history of kidney or liver disease, heart diseases, or are pregnant or breastfeeding. It should be avoided in patients who are hypersensitive to ergoline derivatives.Interaction
Nicergoline should not be taken together with other medications like tricyclic antidepressants, antipsychotics, and MAO inhibitors as there may be an increased risk of adverse effects and drug interactions. It also has the potential to interact with certain drugs used to treat hypertension and diabetes.Disease Interaction
Nicergoline has the potential to interact with some conditions, such as hypotension, hypotension with hypertension, and hypertonia. It may also interact with certain medications used to treat psychiatric conditions, including tricyclic antidepressants and antipsychotics.Drug Interaction
Nicergoline may interact with certain medications used to treat hypertension, as well as some blood thinners, anticonvulsants, and diabetes medications.Food Interactions
Nicergoline may interact with certain foods, such as alcohol and caffeine. It is recommended that patients take nicergoline with food in order to decrease the rate of absorption and minimize the potential for an interaction.Pregnancy Use
Nicergoline should not be used during pregnancy, as its safety has not been established. Breastfeeding should also be avoided while taking this medication.Lactation Use
Nicergoline should not be used while nursing or during lactation as its safety in this setting has not been established.Acute Overdose
Symptoms of an acute overdose include confusion, disorientation, muscle weakness, and irregular heartbeat. Acute overdoses should be treated immediately by seeking medical attention.Contraindication
Nicergoline should not be used in patients with a known hypersensitivity to ergot derivatives or with severe cardiovascular or cerebral risk factors. Patients with any of the following conditions should not take this medication: Ischemic heart disease, severe pulmonary hypertension, or severe kidney or liver disease.Use Direction
Nicergoline should only be taken as directed by your physician. The usual starting dose is 0.6 mg to 1.2 mg per day, which may be increased up to 4.8 mg per day for some patients. Lower doses should be tried in elderly or debilitated patients.Storage Condition
Nicergoline should be stored in a cool, dry place at room temperature away from light and moisture. It must not be exposed to extreme temperatures. It should be kept out of reach of children and pets.Volume of Distribution
The volume of distribution of Nicergoline is approximately 4.6L/kg.Half Life
The half-life of Nicergoline is approximately 6-8 hours.Clearance
The clearance of Nicergoline is approximately 5.4 L/hr.Here you find in details version of Nicergoline
Some Frequently Asked Questions About Nicergoline
. 1.What is Nicergoline?
Nicergoline is a vasoactive drug derived from ergot alkaloids. It is used in the treatment of cerebral and peripheral vascular diseases, including age-related cognitive decline and dementia.
2.What are the uses of Nicergoline?
Nicergoline is used for the treatment of various vascular conditions, including cerebral and peripheral vascular disease,AGE-related memory loss, dementia, headaches, migraines, and Raynaud's disease.
3.How does Nicergoline work?
Nicergoline works by increasing blood flow and oxygen to the brain and other parts of the body, thereby improving cognitive function and aiding in the treatment of vascular diseases.
4.What are the side effects of Nicergoline?
Common side effects of Nicergoline include nausea, vomiting, dizziness, headache, anxiety, rash, abdominal discomfort, and insomnia. Less common side effects include depression, itching, muscle cramping, and dry mouth.
5.What are the precautions when taking Nicergoline?
Patients taking Nicergoline should not take other drugs that are vasoconstrictors or interact with nicergoline, including alcohol, antidepressants, antihistamines, MAO inhibitors, and certain anti-anxiety drugs. Patients should also talk to their physician before taking any other medications.
6.Should I take Nicergoline with food?
Nicergoline should be taken with food to reduce gastric irritation. It is advised to take Nicergoline with a light meal or snack, and not on an empty stomach.
7.How long does Nicergoline take to work?
Nicergoline typically takes about 1 to 2 weeks to show full effects. The drug's effectiveness may be dependent upon the severity of the condition
8.How should Nicergoline be stored?
Nicergoline should be stored at room temperature, away from direct sunlight and heat. Keep the medication tightly sealed, out of the reach of children and pets.
9.Is Nicergoline safe for pregnant women?
Nicergoline is not recommended for pregnant women, as it may cause harm to a developing fetus. Women who are pregnant or planning to become pregnant should consult their doctor before taking Nicergoline.
10.Can Nicergoline treat other conditions besides vascular diseases?
Nicergoline is not approved for use in the treatment of other conditions. It is only approved for the treatment of cerebral and peripheral vascular diseases.
11.Is Nicergoline available in liquid form?
No, Nicergoline is only available in tablet form and is taken orally.
12.Can Nicergoline cause weight gain?
Nicergoline may cause weight gain as a side effect. If this is a concern, it is advised to speak to a doctor about alternative medications.
13.What strengths does Nicergoline come in?
Nicergoline is available in two strengths: 10 mg and 20 mg tablets.
14.Can Nicergoline treat dementia?
Yes, Nicergoline has been approved to treat age-related cognitive decline and dementia.
15.Can Nicergoline be taken with other medications?
It is advised to speak to a doctor before taking any additional medications or supplements with Nicergoline, as some may interact and cause adverse reactions.
16.What are the most common interactions of Nicergoline?
The most common interactions of Nicergoline are with alcohol, antidepressants, antihistamines, MAO inhibitors and certain anti-anxiety drugs.
17.What is the recommended dosage of Nicergoline?
The recommended dosage of Nicergoline is typically 10mg taken twice daily. Patients should always follow the instructions of their healthcare provider regarding dosage and usage.
18.Is Nicergoline safe for children?
Nicergoline is not approved for use in children and adolescents. Parents should consult a pediatrician before giving Nicergoline to a child.
19.Can Nicergoline improve memory?
Yes, Nicergoline has been known to improve memory in patients suffering from age-related cognitive decline or dementia.
20.Can Nicergoline be used to treat headaches?
Yes, Nicergoline can be used to treat headaches and migraine attacks.
21.Can Nicergoline be used to treat Raynaud's Disease?
Yes, Nicergoline is approved for the treatment of Raynaud's disease.
22.Can Nicergoline cause liver damage?
There have been rare cases of liver injury reported while taking Nicergoline, however it is not known to be a common side effect.
23.Does Nicergoline cause drowsiness?
Yes, Nicergoline may cause drowsiness, especially in higher doses. It is advised to speak to a pharmacist or doctor if this is a concern.
24.Are there any interactions between Nicergoline and alcohol?
It is advised to avoid alcohol while taking Nicergoline, as alcohol may increase the risk of experiencing unpleasant side effects.
25.Is Nicergoline associated with any gastrointestinal side effects?
Yes, Nicergoline may cause gastrointestinal side effects such as nausea, vomiting and abdominal discomfort.
26.Can Nicergoline cause depression?
Yes, Nicergoline has been known to cause depression in some cases. If you experience depression while taking Nicergoline, it is advised to speak to a doctor or pharmacist.
27.Can Nicergoline be used to treat hypertension?
Nicergoline has been used off-label to treat hypertension, however it has not been approved by the FDA for this purpose.
28.Can Nicergoline interact with birth control?
It is not known if Nicergoline interacts with birth control, however it is advisable to discuss this with a doctor before taking the medication.
29.Does Nicergoline increase blood pressure?
Nicergoline may increase or decrease blood pressure in some individuals. It is advised to closely monitor your blood pressure, and speak to a doctor if your blood pressure increases or decreases significantly.
30.Can Nicergoline be taken with dietary supplements?
It is advised to speak to a doctor before taking supplements or other medications with Nicergoline, as some supplements and medications may interact and cause adverse reactions.