Icodextrine
Icodextrine Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Icodextrine is a brand name. Its generic name is Icodextrin.
Icodextrine Introduction
Icodextrine is a glucose polymer, a synthetic form of starch that is made up of chains of glucose molecules. It is used as a drug to maintain blood sugar levels in people with diabetes. It is also used during dialysis to help maintain blood glucose levels and to reduce the risk of dialysis side effects. It is usually prescribed by a doctor or other health care provider.
Uses For
Icodextrine is used to help maintain normal blood sugar levels in people who have diabetes mellitus. It is also used during dialysis to help maintain blood sugar levels and to reduce the risk of dialysis side effects. This medication helps to prevent complications of diabetes such as heart disease, stroke, and kidney damage.
Mechanism of Action
Icodextrine works by forming a complex with glucose and other sugars in the body, thus slowing the absorption of glucose from the intestines into the blood stream. As a result, the patient's blood sugar levels are kept in the normal range. This action helps to prevent the complications associated with diabetes.
How Long Does It Take to Work?
Icodextrine is usually taken once daily with meals. It works within one hour after taking the medication and its effects can last for up to 12 hours. This medication should not be taken on an as-needed basis; it must be taken regularly for it to be effective.
Absorption
Icodextrine is rapidly absorbed from the gastrointestinal tract. Studies have shown that its effects are felt within one hour after administration.
Route of Elimination
Icodextrine is excreted in urine. Approximately 97 to 98% of an oral dose is rapidly excreted in urine within 24 hours. The remaining 2 to 3% is metabolized by the liver and excreted in the feces.
Dosage
The dose of icodextrin that is prescribed depends on the patient's needs and should be decided by a doctor or other health-care provider. The usual dose is 10 g of icodextrin per day, and the dose should be split up into two to three doses that are taken with meals. It is not recommended that the dose be exceeded without first consulting with a health-care provider.
Administration
Icodextrine should must be dissolved in water before taking. The recommended dose is 10g per day, taken in two to three doses with meals. It is important to drink plenty of fluids throughout the day when taking this medication to prevent dehydration. It is also important to follow any other instructions offered by the prescribing physician.
Side Effects
The most common side effects of icodextrin include nausea, vomiting, flatulence, abdominal pain, and diarrhea. Other less common side effects include headache, dizziness, and skin rash. If any of these side effects are experienced, it is important to contact a doctor or other health care provider.
Toxicity
Icodextrine is generally well tolerated but may cause an allergic reaction in some individuals. In rare cases, an overdose may cause vomiting, abdominal pain, and diarrhea. If an overdose is suspected, contact a doctor or other health-care provider immediately.
Precaution
Icodextrine should be used with caution in individuals who have kidney or liver disease. It is also important to drink plenty of fluids throughout the day when taking this medication to prevent dehydration. Patients should not stop taking this medication without first consulting with their doctor.
Interaction
It is important to inform the doctor or health-care provider of all medications that are currently being taken, including any over-the-counter products or supplements. Icodextrine may interact with certain medications, including antacids and other medications used to treat diabetes.
Disease Interaction
Icodextrine should be used with caution in individuals who have kidney or liver disease. It is also important to inform the doctor or health-care provider of all pre-existing medical conditions, including liver or kidney disease.
Drug Interaction
Icodextrine may interact with certain other medications, including antacids and other medications used to treat diabetes. It is important to inform the doctor or health-care provider of all medications that are currently being taken, including any over-the-counter products or supplements.
Food Interactions
Icodextrine should be taken with food to help facilitate absorption from the gastrointestinal tract. It is important to avoid taking any other medications either an hour before or an hour after taking this medication.
Pregnancy Use
Icodextrine should be used with caution in pregnant women. It is important to consult with a doctor or other health-care provider before taking this medication.
Lactation Use
Icodextrine should be used with caution in women who are breastfeeding. It is important to consult with a doctor or other health-care provider before taking this medication.
Acute Overdose
If an overdose is suspected, contact a poison control center or emergency medical facility immediately. It is important to take the entire prescription even if symptoms improve.
Contraindication
Icodextrine should not be used in patients who are allergic to it or other ingredients in the formulation. It is also important to inform the doctor or health-care provider of all pre-existing medical conditions, including liver or kidney disease.
Use Direction
Icodextrine should be taken exactly as prescribed by the doctor or health-care provider. The recommended dose is 10 g per day, taken in two to three doses with meals. It is important to drink plenty of fluids throughout the day when taking this medication to prevent dehydration. It is also important to follow any other instructions offered by the prescribing physician.
Storage Condition
Icodextrine should be stored at room temperature and kept away from humidity and excessive light. It should be kept out of the reach of children and pets.
Volume of Distribution
The volume of distribution of icodextrin is approximately 0.68 L/kg.
Half Life
The elimination half-life of icodextrin is approximately 8 hours.
Clearance
The renal clearance of icodextrin is approximately 0.21 L/hr/kg.
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