Texcol-e
Texcol-e Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Texcol-e is a brand name. Its generic name is Albuterol + Guaifenesin.
Introduction
Albuterol and guaifenesin are two medications sometimes combined in a prescription drug product. Albuterol is a bronchodilator that opens the airways in the lungs, while guaifenesin is an expectorant that helps thin and loosen mucus. This combination of medications helps to reduce coughing and other discomfort associated with a cold or other respiratory infection.
Uses
Albuterol and guaifenesin are often used in combination to treat coughs associated with colds, infections, allergies, and other respiratory illnesses. By relaxing airways and thinning mucus, the combination of albuterol and guaifenesin helps reduce coughing, making it easier to breathe.
Mechanism of Action
Albuterol works by relaxing the muscles in the airways, allowing them to widen so that it is easier for air to move in and out of the lungs. Guaifenesin helps thin and loosen mucus in the lungs, making it easier to cough up and clear from the respiratory tract.
How Long Does it Take to Work?
Albuterol and guaifenesin typically begin working quickly, with effects usually felt within minutes. It may take up to an hour for the full effects to be felt.
Absorption
Albuterol is quickly and completely absorbed from the gastrointestinal tract. Guaifenesin is also quickly absorbed, although it is not as easily absorbed as albuterol.
Route of Elimination
Albuterol and guaifenesin are both eliminated primarily through the kidneys. Albuterol is primarily eliminated through the urine, while guaifenesin is eliminated through both the urine and fecal matter.
Dosage
Albuterol and guaifenesin are most often combined in oral syrup form for the treatment of coughs and colds. Generally, the recommended dose is one teaspoonful (5ml) taken 3-4 times daily, or as directed by a doctor. Each teaspoonful contains 1.25mg albuterol sulfate and 120mg guaifenesin.
Administration
Albuterol and guaifenesin combination syrup should be taken orally with a full glass of water. Do not take more than the recommended dose and do not take more frequently than prescribed.
Side Effects
The most common side effects associated with albuterol and guaifenesin combination include headache, sore throat, nausea, and dizziness. If any of these side effects persist or worsen, tell your doctor or pharmacist right away.
Toxicity
Albuterol and guaifenesin combination is generally well tolerated and the side effects are usually mild. It is possible to have an allergic reaction to the medication; symptoms of an allergic reaction include rash, hives, itching, difficulty breathing, and swelling of the face, tongue, and throat. If you experience any of these symptoms, seek medical attention immediately.
Precaution
Albuterol and guaifenesin combination may cause drowsiness or dizziness. Do not drive or operate heavy machinery until you know how this medication affects you. Avoid alcohol while taking this medication as it may increase the risk of side effects. Do not use more of this medication than prescribed.
Interactions
Albuterol and guaifenesin combination may interact with other medications including MAO inhibitors, beta blockers, diuretics, asthma medications, antihistamines, and other over-the-counter and prescription cold and cough medications. Be sure your doctor knows about all medications and supplements you are taking before you start taking albuterol and guaifenesin combination.
Disease Interactions
Albuterol and guaifenesin combination should be used with caution in patients with certain medical conditions such as heart disease, high blood pressure, diabetes, and thyroid disease. Tell your doctor if you have any of these conditions before taking this medication.
Drug Interactions
Albuterol and guaifenesin combination may interact with other medications. Be sure your doctor knows about all medications and supplements you are taking before you start taking albuterol and guaifenesin combination.
Food Interactions
Albuterol and guaifenesin combination should be taken at least one hour before or two hours after meals to ensure proper absorption of the medication.
Pregnancy Use
Albuterol and guaifenesin combination is generally considered safe for use in pregnant women, however it should be taken as directed by your doctor. If you become pregnant while taking this medication, tell your doctor as soon as possible.
Lactation Use
Albuterol and guaifenesin combination should not be used by nursing mothers unless directed by a doctor. Do not breastfeed while taking this medication.
Acute Overdose
An overdose of albuterol and guaifenesin combination can cause serious symptoms. Seek medical attention immediately if you experience any of the following symptoms: difficulty breathing, chest pain, seizures, or confusion.
Contraindication
Albuterol and guaifenesin combination should not be used by someone who is allergic to either medication or any of the inactive ingredients in the product. Additionally, it should not be used by people with overactive thyroid, severe heart disease, seizures, diabetes, or kidney disease unless directed to do so by a doctor.
Direction for Use
Albuterol and guaifenesin combination should be taken as prescribed by your doctor. Read the product label for directions on how to take the medication and follow all instructions provided. Do not take more of this medication than prescribed and do not take more frequently than recommended.
Storage Conditions
Store albuterol and guaifenesin combination at room temperature, away from excess heat and moisture. Keep out of reach of children and pets.
Volume of Distribution
The volume of distribution of albuterol and guaifenesin has not been determined.
Half Life
The half-life of albuterol is approximately 4.7 hours and the half-life of guaifenesin is approximately 2.4 hours.
Clearance
The renal clearance of albuterol is approximately 2.6 liters/min and the renal clearance of guaifenesin is approximately 0.79 liters/min.
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