Truzole

Truzole Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Truzole is a brand name. Its generic name is Furazolidone + Metronidazole.

Introduction

Furazolidone is an antibacterial medication used to treat a variety of infections caused by bacteria. Metronidazole is an antimicrobial medication used to treat certain types of infections such as amoebiasis, giardiasis, trichomoniasis, and anaerobic bacterial infections.

Uses

Furazolidone and metronidazole are both used to treat bacterial infections such as urinary tract infections, stomach infections, skin infections, and respiratory infections. They are also used to treat certain parasitic infections such as amoebiasis and giardiasis, as well as anaerobic bacterial infections.

Mechanism of Action

Furazolidone and metronidazole work by inhibiting bacterial growth. They do this by interfering with the way bacteria make proteins, preventing them from multiplying and eventually killing them. Metronidazole also interferes with the growth of certain parasites, preventing them from multiplying and killing them as well.

How Long Does It Take to Work?

Furazolidone and metronidazole usually take two to three days to start working. It may take up to a week for the full benefits of the medication to take effect.

Absorption

Both furazolidone and metronidazole are rapidly and almost completely absorbed from the gastrointestinal tract after oral administration.

Route of Elimination

Furazolidone and metronidazole are mainly eliminated from the body through the kidneys via urine.

Dosage

The dosage of furazolidone and metronidazole depends on the condition being treated, the age and weight of the patient, and other factors that should be discussed with a doctor. Furazolidone is usually prescribed in doses of 200-400 mg four times a day. Metronidazole is usually prescribed in doses of 250-500 mg three times a day or 500-750 mg twice a day.

Administration

Furazolidone and metronidazole are usually taken by mouth, usually with or without food. They should be taken at evenly spaced intervals as prescribed by the doctor.

Side Effects

Side effects of furazolidone and metronidazole include nausea, vomiting, loss of appetite, abdominal pain, headache, dry mouth, dizziness, and rashes. Some people may experience more severe side effects such as fever, confusion, easy bruising, or swelling of the face.

Toxicity

High doses of furazolidone and metronidazole can cause toxicity. Symptoms of toxicity include nausea, vomiting, abdominal cramps, loss of appetite, and disorientation. If left untreated, toxicity can lead to seizures, coma, and even death.

Precautions

Before taking furazolidone or metronidazole, patients should discuss their medical history with their doctor and provide information about any medications, vitamins, supplements, or herbal products they are taking. It is also important for patients to tell their doctor if they have any allergies or if they are pregnant or breastfeeding.

Interactions

Furazolidone and metronidazole may interact with certain medications, vitamins, supplements, or herbal products. Patients should discuss any adverse interactions with their doctor before taking furazolidone or metronidazole.

Disease Interactions

Furazolidone and metronidazole can interact with certain conditions and diseases. Patients with liver disease, kidney disease, or history of blood clots should inform their doctor before taking furazolidone or metronidazole.

Drug Interactions

Furazolidone and metronidazole can interact with certain other medications. Patients taking warfarin, phenytoin, phenobarbital, imipramine, cyclosporine, or tolbutamide should inform their doctor before taking furazolidone or metronidazole.

Food Interactions

Alcohol can interact with furazolidone and metronidazole, and should be avoided while taking these medications. Patients should also be aware of other food interactions, including those related to specific medications or conditions, and should inform their doctor if they are experiencing any adverse reactions related to food.

Pregnancy Use

Furazolidone and metronidazole should be used during pregnancy only when absolutely necessary. Patients should talk to their doctor about the potential risks and benefits of taking these medications during pregnancy.

Lactation Use

Furazolidone and metronidazole are not recommended for women who are breastfeeding. Patients should talk to their doctor about the potential risks and benefits of taking these medications while nursing.

Acute Overdose

An acute overdose of furazolidone and metronidazole can cause dizziness, confusion, seizures, and coma. Patients should seek immediate medical attention if they believe that they have taken an overdose of these medications.

Contraindication

Furazolidone and metronidazole should not be used in patients with a known allergy to these medications or those who are taking nitrofurantoin or metronidazole. Patients should also avoid using these medications if they have a history of hepatic encephalopathy.

Use Direction

Furazolidone and metronidazole should be taken exactly as prescribed by the doctor. Patients should not take more or less than the prescribed dose or take the medication more or less often than recommended. They should also not take the medication for longer than is recommended.

Storage Condition

Furazolidone and metronidazole should be stored at room temperature between 59-86°F (15-30°C) and away from light and moisture. Patients should always follow the storage instructions provided with the medication. They should also consult with their doctor or pharmacist if they are unsure about how to properly store any medicine.

Volume of Distribution

The volume of distribution of furazolidone and metronidazole is approximately 41-63 L/kg in humans.

Half Life

The half-life of furazolidone and metronidazole is approximately 5-6 hours in humans.

Clearance

The clearance of furazolidone and metronidazole is approximately 0.1-0.2 L/hour/kg in humans.

Here you find in details version of Truzole

Some Frequently Asked Questions About Truzole

1. What is Truzole?

Truzole is a combination antibiotic medication mainly used to treat certain types of diarrheal infections caused by bacteria, protozoa or worms.

2. How does Truzole work?

Truzole works by inhibiting the growth of certain bacterial, protozoal, and worm infections. It also affects the enzymes involved in the bacterial cell wall synthesis. In this way, Truzole kills the bacteria, protozoal or worm infection.

3. Who should not take Truzole?

People with kidney or liver disease, an infection caused by bacteria other than those that this drug is meant to treat, or those with a history of sensitivity to the ingredients in the medication should not take Truzole.

4. What are the possible side effects of Truzole ?

Common side effects of Truzole may include nausea, vomiting, stomach upset, and diarrhea. More serious side effects include fever, confusion, seizures, and jaundice. Contact your doctor right away if you experience any of these serious side effects.

5. What drugs interact with Truzole?

Certain drugs may interact with Truzole, including certain antibiotics like penicillin, certain antifungals like ketoconazole, anti-seizure drugs like phenytoin, and certain benzodiazepines like Diazepam.

6. Can I drink alcohol while taking Truzole?

It is not advisable to drink alcohol while taking Truzole. Alcohol can interfere with the antibiotic’s effectiveness, and can increase the risk of liver damage.

7. Is Truzole used for anything other than treating diarrheal infections?

Truzole is mainly used to treat diarrheal infections, but may also be used to treat certain urinary tract infections.

8. Does Truzole need to be refrigerated?

No, in general, Truzole should be stored at room temperature away from light and moisture.

9. How long does it take for Truzole to work?

Most people begin to experience symptom relief within 24 hours of taking Truzole. It is important to take the medication for the full length of time prescribed in order to ensure complete recovery.

10. Is there anything I should avoid while taking Truzole?

It is important to avoid drinking alcohol while taking Truzole as this may interfere with the medication's effectiveness. Additionally, avoid taking other medications that may interact negatively with this medication.

11. How do I take Truzole?

Truzole should be taken as directed by your doctor. Generally, this medication is taken two or three times daily. You should take Truzole for the full length of treatment prescribed by your doctor, even if you are feeling better.

12. What is the usual dose of Truzole?

The usual dose of Truzole is 100 milligrams per tablet, taken two to three times a day. Talk to your doctor to determine the best dosage for your individual needs.

13. How long should I take Truzole?

You should take Truzole for the full length of treatment prescribed by your doctor - usually five to ten days. It is important to finish the entire course of treatment in order to ensure complete recovery.

14. Are there any alternatives to Truzole?

Yes, there are several antibiotic alternatives to Truzole, such as Bactrim or Ciprofloxacin, that may be prescribed to treat certain types of diarrheal infections.

15. Are there any over-the-counter options for treating diarrheal infections?

Yes, there are several over-the-counter medications, such as Pepto-Bismol or Imodium, that may help to relieve some of the symptoms associated with diarrheal infections.

16. Are there any long-term side effects of Truzole?

Truzole can cause long-term effects if taken for a prolonged period of time, such as peripheral neuropathy, liver damage, or Stevens-Johnson syndrome. Talk to your doctor immediately if you experience any of these side effects.

17. Does Truzole cause antibiotic resistance?

Yes, long-term use of Truzole can lead to antibiotic resistance. It is important to use this medication only when absolutely necessary to prevent the development of antibiotic-resistant bacteria.

18. Is there any danger of overdose with Truzole?

Taking too much Truzole can lead to serious side effects, so it is important not to exceed the recommended dosage. If you suspect that you have overdosed on the medication, contact your doctor immediately.

19. How long does it take for symptoms to improve after starting a course of Truzole?

Most people experience symptom relief within 24-48 hours of starting a course of Truzole. However, it is still important to take the medication for the full length of time prescribed by your doctor in order to ensure complete recovery.

20. Should I take Truzole with food?

It is generally recommended to take Truzole with food or right after a meal. Taking the medication with food can help to reduce stomach upset.

21. Is Truzole safe for children?

Truzole is not recommended for use in children as it may cause serious side effects. Talk to your doctor before giving this medication to a child.

22. What should I do if I miss a dose of Truzole?

If you miss a dose of Truzole, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue on your regular schedule. Do not take a double dose to make up for a missed dose.

23. Is it safe to take Truzole while pregnant?

Truzole should not be taken during pregnancy, as the potential risks outweigh the potential benefits. Talk to your doctor before taking this medication while pregnant.

24. What should I do if I experience a serious side effects while taking Truzole?

It is important to contact your doctor immediately if you experience any serious side effects while taking Truzole, including fever, confusion, seizures, or jaundice.

25. What should I do if I experience an allergic reaction while taking Truzole?

If you experience an allergic reaction while taking Truzole, such as difficulty breathing, hives, or swelling of the face, contact your doctor immediately. You may need to stop taking the medication and seek medical attention.

26. Can I take other medications with Truzole?

It is important to talk to your doctor before taking any other medications with Truzole, including over-the-counter medications, as some may interact negatively or reduce the effectiveness of the medication.

27. Is Truzole a broad-spectrum antibiotic?

Yes, Truzole is considered a broad-spectrum antibiotic, meaning it can treat a wide variety of infections.

28. Is Truzole safe for people with kidney disease?

Truzole is not recommended for those with kidney disease, as it may increase the risk of serious side effects. Talk to your doctor before taking this medication if you have kidney disease.

29. Is Truzole effective against fungal infections?

No, Truzole is not effective against fungal infections. Other antifungal medications need to be prescribed to treat fungal infections.

30. Does Truzole come in other forms besides tablets?

Yes, Truzole also comes in the form of an oral suspension.