Tranazol D.s
Tranazol D.s Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Tranazol D.s is a brand name. Its generic name is Sulphamethoxazole + Trimethoprim.
Sulphamethoxazole + Trmethoprim Introduction
Sulphamethoxazole and Trimethoprim (SMZ-TMP) is a combination of antibiotics used to treat a variety of bacterial infections such as urinary tract infections, bronchitis, otitis media, and sinusitis.Uses for Tranazol D.s
SMZ-TMP is used to treat bacterial infections of the urinary tract, respiratory system, skin, and gastrointestinal tract. It can also be used to prevent Pneumocystis jirovecii pneumonia in HIV-infected patients with a CD4+ count below 200 cells/mm3.Mechanism of Action
SMZ-TMP acts to inhibit the synthesis of bacterial DNA by interfering with the enzymes responsible for formation of folic acid. Trimethoprim prevents the reduction of dihydrofolate to tetrahydrofolate, while sulfamethoxazole inhibits the formation of dihydrofolate and acts synergistically with trimethoprim.How Long Does it Take to Work
Generally, symptoms of infection begin to improve within one to two days after treatment with SMZ-TMP begins. Patients may need to take the medication for an extended period of time, typically 5-14 days, depending on the nature of the infection.Absorption
SMZ-TMP is readily absorbed by the gastrointestinal tract. Peak plasma concentrations are achieved 1.5–3 hours after oral administration.Route of Elimination
SMZ-TMP is predominantly eliminated via the kidneys by glomerular filtration, with 80-97% of the drug being excreted unchanged.Dosage
The recommended SMZ-TMP dosage regimen varies depending on indication, age, body weight, renal function, and other medical conditions. For treatment of urinary tract infections, the recommended dose is 1-2 tablets/day for adults, and 10-20mg/kg/day for children. The recommended dosage for treatment of otitis media is 8-10mg/kg/day given in divided doses every 12 hours. For treatment of Pneumocystis jirovecii pneumonia, the recommended dosage is 20-80mg/kg/day divided every 12 hours, up to a maximum of 4 g/day.Administration
SMZ-TMP is typically given orally in tablets or suspension.Side Effect
Common side effects of SMZ-TMP include nausea, vomiting, diarrhea, and rash. Less common side effects include headache, dizziness, loss of appetite, and joint pain. Severe side effects can include anemia, kidney failure, and Stevens-Johnson Syndrome.Toxicity
SMZ-TMP is generally considered well tolerated but can cause serious adverse reactions in some individuals. While there is no specific antidote for SMZ-TMP toxicity, symptomatic and supportive measures can be taken to reduce its effects.Precautions
Patients should use caution when taking SMZ-TMP if they have kidney or liver dysfunction, as the drug may accumulate. Patients should also inform their healthcare provider if they are taking any other medications.Interactions
SMZ-TMP can interact with other medications such as warfarin, probenecid, and phenytoin. Before taking SMZ-TMP, patients should inform their healthcare provider of any other medications they are taking.Disease Interaction
Patients with liver or kidney disease, or a history of blood disorders should use caution when taking SMZ-TMP as it could potentiate the effect of certain drugs or worsen their condition.Drug Interactions
SMZ-TMP can interact with other medications, such as warfarin, probenecid, and phenytoin. Patients should inform their healthcare provider if they are taking any other medications.Food Interactions
SMZ-TMP should be taken on an empty stomach. Food may interfere with the absorption of the drug, and its effectiveness should be monitored when taken with food.Pregnancy Use
Pregnancy is a relative contraindication for the use of SMZ-TMP. The drug should not be used in pregnant women unless absolutely necessary and the potential benefits outweigh the risks.Lactation Use
SMZ-TMP is not recommended to be taken during breastfeeding because of the potential risk of harm to the nursing infant.Acute Overdose
In cases of acute overdose, intensive medical care and supportive therapy should be provided to the patient. Dialysis is not effective in removing SMZ-TMP from the bloodstream.Contraindication
SMZ-TMP should not be taken by pregnant women or individuals with a hypersensitivity to sulfonamides or trimethoprim.Use Direction
SMZ-TMP should be taken as prescribed by a healthcare provider. Tablets should be taken orally, on an empty stomach. The drug should be taken with a full glass of water.Storage Condition
SMZ-TMP should be stored in a cool, dry place away from direct sunlight.Volume of Distribution
SMZ-TMP has an apparent volume of distribution in adults of approximately 0.25 L/kg.Half-Life
The elimination half-life of SMZ-TMP is between 10-20 hours.Clearance
The total systemic clearance of SMZ-TMP is approximately 3.5 L/h/kg.Here you find in details version of Tranazol D.s
Some Frequently Asked Questions About Tranazol D.s
What does Sulfamethoxazole + Trimethoprim do?
Sulfamethoxazole + Trimethoprim is an antibiotic combination that is typically used to treat bacterial infections including UTIs, bronchitis, travelers’ diarrhea, and ear infections. It is also often used to prevent Pneumocystis jirovecii pneumonia.
Who can take Sulfamethoxazole + Trimethoprim?
Sulfamethoxazole + Trimethoprim is typically prescribed to individuals over the age of 12. It is not recommended for pregnant women, breastfeeding mothers, or children under the age of 12.
What is the usual dosage of Sulfamethoxazole + Trimethoprim?
The dosage of Sulfamethoxazole + Trimethoprim depends on the condition being treated, the individual's age and weight, and how they react to the medication. It is important to follow the instructions of the prescribing doctor.
Are there any side effects associated with Sulfamethoxazole + Trimethoprim?
Common side effects associated with Sulfamethoxazole + Trimethoprim include nausea, vomiting, headache, abdominal pain, rash, and dizziness. More serious side effects, though rare, include anaphylaxis, jaundice, and Stevens-Johnson Syndrome.
What are some of the drug interactions associated with Sulfamethoxazole + Trimethoprim?
Drugs that may interact with Sulfamethoxazole + Trimethoprim include cyclosporine, diuretics, warfarin, lithium, and methotrexate. It is important to tell the doctor about all medications being taken prior to starting Sulfamethoxazole + Trimethoprim.
What should I do if I forget to take my dose of Sulfamethoxazole + Trimethoprim?
It is best to take the missed dose as soon as possible, unless it is already close to the time of the next dose. In this case, the missed dose should be skipped and the regular dosing schedule should be resumed.
Is there any food or drink I should avoid while taking Sulfamethoxazole + Trimethoprim?
It is best to avoid alcohol and foods that contain high levels of vitamin K, such as leafy green vegetables, while taking Sulfamethoxazole + Trimethoprim. Be sure to speak to the prescribing doctor for more information.
Are there any special instructions or precautions I should follow while taking Sulfamethoxazole + Trimethoprim?
It is important to finish the full course of Sulfamethoxazole + Trimethoprim prescribed by the doctor, even if the symptoms are alleviated. It is also important to drink plenty of fluids while taking this medication. It is also important to tell the doctor about any underlying conditions before taking this medication.
Is it safe to take Sulfamethoxazole + Trimethoprim while pregnant?
No, it is not recommended to take Sulfamethoxazole + Trimethoprim while pregnant. It can cause serious harm to the unborn baby and should only be taken under the direct supervision of a doctor.
Can I take ibuprofen while on Sulfamethoxazole + Trimethoprim?
Yes, ibuprofen can be taken while taking Sulfamethoxazole + Trimethoprim. However, it is important to take the lowest effective dose to reduce the risk of side effects.
Are there any long-term effects associated with taking Sulfamethoxazole + Trimethoprim?
Longer exposure to Sulfamethoxazole + Trimethoprim can increase the risk of developing a form of metabolic acidosis, which can cause serious complications such as depression, confusion, heightened risk of heart attack and stroke, and kidney failure.
Does Sulfamethoxazole + Trimethoprim cause any changes in blood sugar levels?
Yes, Sulfamethoxazole + Trimethoprim can affect blood sugar levels, especially in people with diabetes. It is important to monitor blood sugar closely while taking this medication.
Does Sulfamethoxazole + Trimethoprim have any interactions with other medications?
Yes, Sulfamethoxazole + Trimethoprim can interact with other medications, including cyclosporine, diuretics, warfarin, lithium, and methotrexate. It is important to tell the doctor about all medications being taken prior to starting Sulfamethoxazole + Trimethoprim.
Should I use Sulfamethoxazole + Trimethoprim to treat a sinus infection?
Sulfamethoxazole + Trimethoprim may be prescribed for sinus infections caused by bacteria, but it is typically only prescribed for severe or chronic cases, as it is an antibiotic. Your doctor can determine if it is appropriate for your condition.
What are the most common side effects associated with Sulfamethoxazole + Trimethoprim?
The most common side effects associated with Sulfamethoxazole + Trimethoprim include nausea, vomiting, headache, abdominal pain, rash, and dizziness. More serious side effects, though rare, include anaphylaxis, jaundice, and Stevens-Johnson Syndrome.
Does Sulfamethoxazole + Trimethoprim cause any create any changes in vision?
Sulfamethoxazole + Trimethoprim is known to cause changes in vision, including blurred vision, loss of vision, or double vision. It is important to inform the doctor if any changes in vision occur.
Is Sulfamethoxazole + Trimethoprim safe for children?
Sulfamethoxazole + Trimethoprim is typically prescribed to individuals over the age of 12. It is not recommended for pregnant women, breastfeeding mothers, or children under the age of 12.
Can I take other medications while on Sulfamethoxazole + Trimethoprim?
Yes, other medications can be taken while on Sulfamethoxazole + Trimethoprim, though care should be taken to ensure that there are no drug interactions. It is important to tell the doctor about all other medications being taken and to only take the lowest effective dose of other medications.
What can I do to reduce the risk of side effects while taking Sulfamethoxazole + Trimethoprim?
The best way to reduce the risk of side effects while taking Sulfamethoxazole + Trimethoprim is to follow the instructions of the prescribing doctor. It is also important to keep the doctor updated on any changes in health or any side effects that occur.
Is Sulfamethoxazole + Trimethoprim an over-the-counter medication?
No, Sulfamethoxazole + Trimethoprim is not an over-the-counter medication. It must be prescribed by a doctor and should only be taken under the supervision of a doctor.
Should I continue to take Sulfamethoxazole + Trimethoprim even after my symptoms are gone?
Yes, it is important to continue to take Sulfamethoxazole + Trimethoprim even after symptoms are gone as it is an antibiotic. Stopping treatment prematurely can cause the bacteria to become resistant to the medication.
What should I do if I experience an allergic reaction while taking Sulfamethoxazole + Trimethoprim?
If an allergic reaction occurs while taking Sulfamethoxazole + Trimethoprim, the medication should be discontinued and the doctor should be contacted immediately. Symptoms of an allergic reaction include hives, facial swelling, itching or rash, and difficulty breathing.
Can Sulfamethoxazole + Trimethoprim affect my ability to get pregnant?
Yes, Sulfamethoxazole + Trimethoprim can affect the ability to get pregnant. It can also cause dangerous abnormalities in the unborn baby. If pregnancy is planned while on this medication, it is important to speak with the doctor.
Can Sulfamethoxazole + Trimethoprim be used to treat other infections besides bacterial infections?
No, Sulfamethoxazole + Trimethoprim is only effective against bacterial infections and is not effective against viral infections. Other medications will be needed to treat non-bacterial infections.
Should I take Sulfamethoxazole + Trimethoprim with food or without food?
Sulfamethoxazole + Trimethoprim can be taken with or without food. It is best to take it on an empty stomach, but if it causes stomach upset it can be taken with food.
Can Sulfamethoxazole + Trimethoprim be used to prevent infection?
Yes, Sulfamethoxazole + Trimethoprim is often used to prevent Pneumocystis jirovecii pneumonia. However, it is important to speak to the doctor before using this medication for prevention purposes.
Is Sulfamethoxazole + Trimethoprim addictive?
No, Sulfamethoxazole + Trimethoprim is not considered to be an addictive medication. However, as with any medication, it is important to carefully follow the instructions of the prescribing doctor.
Can Sulfamethoxazole + Trimethoprim cause blurred vision or other vision changes?
Yes, Sulfamethoxazole + Trimethoprim is known to cause changes in vision, including blurred vision, loss of vision, or double vision. It is important to inform the doctor if any changes in vision occur.
Can I take Sulfamethoxazole + Trimethoprim if I am allergic to penicillin?
Yes, Sulfamethoxazole + Trimethoprim can be taken even if an individual is allergic to penicillin, as long as it is prescribed by a doctor. However, it is important to inform the doctor of the allergy before taking this medication.
What is the most common use for Sulfamethoxazole + Trimethoprim?
The most common use for Sulfamethoxazole + Trimethoprim is for the treatment of urinary tract infections (UTIs). It is also often used to treat bacterial infections of the lungs, ears, sinuses, and skin, as well as to prevent Pneumocystis jirovecii pneumonia.
Can Sulfamethoxazole + Trimethoprim be used for other conditions not listed on the label?
Yes, Sulfamethoxazole + Trimethoprim can be used to treat other conditions not listed on the label if prescribed by a doctor. It is important to follow the instructions of the prescribing doctor and inform them of any unusual effects.
Can Sulfamethoxazole + Trimethoprim cause permanent damage?
No, Sulfamethoxazole + Trimethoprim does not cause permanent damage when used as prescribed. However, it is important to inform the doctor of any side effects that occur and to follow the instructions of the prescribing doctor.
Does Sulfamethoxazole + Trimethoprim have any interactions with natural supplements?
Yes, natural supplements may interact with Sulfamethoxazole + Trimethoprim. It is important to tell the doctor about any supplements being taken before starting this medication.