reyataz
reyataz Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? reyataz is a brand name. Its generic name is Atazanavir.
reyataz
reyataz is an anti-HIV medication in the protease inhibitor class of drugs, used in combination with other medicines to treat HIV infection in adults. It was approved by the United States Food and Drug Administration (FDA) in 2003.
Uses
reyataz is used in combination with other antiretroviral medications to treat HIV infection in adults. It works by slowing down the growth and spread of the HIV virus in the body. This helps to decrease the amount of HIV in the body, which helps the immune system to fight off certain types of infections and improve the overall quality of life of people with HIV.
Mechanism of Action
reyataz belongs to a class of medicines called protease inhibitors. Protease is an HIV enzyme essential in the replication of HIV. By blocking the action of this enzyme, atazanavir works to reduce the amount of HIV present in the body, which helps to slow down the progression of HIV infection.
How long does it take to work?
reyataz can take up to 14 days before it reaches peak effectiveness. It is important to take your medications as prescribed by your doctor to ensure maximum effectiveness.
Absorption
reyataz is readily absorbed after oral administration. Peak concentrations are reached in approximately 2.5 to 4 hours.
Route of Elimination
reyataz is primarily eliminated by the kidneys through urine. Approximately 70% of an oral dose is excreted unchanged.
Dosage and Administration
The recommended adult dosage of reyataz is 300 mg once daily taken with 100 mg of ritonavir, an antiretroviral medication. This combination regimen is known as "ritonavir-boosted atazanavir." When taken with a ritonavir-boosted regimens, reyataz is well-tolerated and is associated with fewer side effects than when taken alone. reyataz should not be taken with food or grapefruit juice.
Side Effects
Common side effects associated with the use of reyataz include: nausea, vomiting, decreased appetite, headache, dizziness, dry skin, rash, and joint pain.
Toxicity
reyataz is generally well-tolerated when taken as prescribed by a health care provider. But like most medications, there is a risk of serious toxicity if reyataz is taken in large doses or with other medications that interact with it.
Precaution
Before taking reyataz, tell your healthcare provider if you have liver disease, kidney disease, or any other condition that may affect the way the medication is absorbed and metabolized by your body.
Interaction
reyataz may interact with prescription or over-the-counter medications. It is important to tell your healthcare provider about all medications that you are taking, including vitamins, herbal supplements, and over-the-counter medications. This will help your healthcare provider determine if any medication combinations must be adjusted.
Disease Interaction
reyataz may interact with some diseases, such as severe kidney or liver disease. It is important to talk to your healthcare provider about any diseases that you have, to make sure it is safe for you to take reyataz.
Drug Interactions
reyataz can interact with some medications, including some antibiotics, antifungals, and anti-seizure medications. It is important to tell your healthcare provider about all medications that you are taking, including prescription and over-the-counter drugs. This will help your healthcare provider determine if any medication combinations must be adjusted.
Food Interaction
reyataz should not be taken with food or grapefruit juice. Taking reyataz with certain foods or drinks can decrease the amount of the medication that is absorbed by your body, resulting in reduced effectiveness.
Pregnancy Use
reyataz has not been studied in pregnant women. Women should talk to their healthcare provider before taking reyataz if they are pregnant or planning to become pregnant.
Lactation Use
reyataz is not recommended for use during lactation. Women who are breastfeeding should talk to their healthcare provider before taking reyataz.
Acute Overdose
In cases of acute overdose, symptomatic and supportive measures should be employed, such as inducing emesis or gastric lavage, and providing antidote activated charcoal, or exchange transfusion. An intensive monitoring of vital signs and close observation of clinical signs is advised.
Contraindication
reyataz is contraindicated in patients with a known hypersensitivity to any components of the formulation.
Use Direction
reyataz should be taken once daily with a light meal. It should be taken with 100 mg of ritonavir, an antiretroviral medication. reyataz should not be taken with food or grapefruit juice.
Storage Condition
reyataz should be stored at 20-25°C (68-77°F). Keep the drug away from light, moisture, and out of reach of children.
Volume of Distribution
The volume of distribution of atazanavir is approximately 16 L/kg.
Half Life
The elimination half-life of atazanavir is approximately 94 hours.
Clearance
reyataz is cleared primarily by the kidneys, with an average total body clearance of approximately 16 mL/min.
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