sabril
sabril Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? sabril is a brand name. Its generic name is Vigabatrin.
Introduction
sabril is an anti-seizure medication that is used to treat certain types of seizures. It is also sometimes used to treat bipolar disorder and for off-label use in other types of conditions. It is available in generic form as well as branded versions.
Uses for
sabril is typically used in the treatment of certain types of seizures, including refractory complex partial seizures and infantile spasms. It has also been used off label to treat bipolar disorder and other types of mental health conditions.
Mechanism of Action
sabril works by suppressing the release of certain neurotransmitters from nerve cells in the brain. It inhibits gamma-aminobutyric acid transaminase, an enzyme that breaks down the neurotransmitter GABA, thus causing an increase in GABA levels in the brain.
How Long Does it Take to Work?
The effects of sabril can begin within a few days of starting, but the full effects may take up to four weeks to become apparent. However, it may take longer for the drug to become effective in some cases.
Absorption
sabril is rapidly and completely absorbed from the gastrointestinal tract. It reaches peak concentrations in the body within 1-2 hours.
Route of Elimination
sabril is eliminated mainly through the kidneys, with approximately 10-20% of an administered dose excreted in urine.
Dosage
sabril is available in oral tablet, oral solution, and intravenous injection forms. The specific dose and regimen prescribed will depend on the individual and their medical condition. The usual adult dose for the treatment of seizures is 2,500 to 4,500 mg a day, divided into multiple doses.
Administration
sabril can be taken with or without food. The tablets or capsules should be taken whole, not crushed or chewed. The oral solution must be taken with food. It should never be taken intravenously.
Side Effect
The most common side effects of sabril include nausea, diarrhea, fatigue, headache, dizziness, depression, irritability, difficulty sleeping, weight gain, and changes in vision. Some of these side effects may lessen or go away with continued use of the medication.
Toxicity
High doses of sabril can cause serious or even fatal reactions. Symptoms of an overdose include confusion, unconsciousness, behavioural changes, and difficulty breathing. Seek immediate medical attention if an overdose is suspected.
Precaution
Patients should speak to their healthcare provider before taking sabril, especially if they have any allergies or medical conditions. Those who have kidney, liver, or heart disease should use caution when taking sabril. Alcohol can increase the risk of side effects from sabril, and it should therefore be avoided.
Interaction
sabril may interact with other medications, herbal supplements, or vitamins. Patients should speak to their doctor before taking any other medication while on sabril.
Disease Interaction
sabril may interact with certain diseases, such as kidney, liver, or heart disease, and those who have these conditions should be monitored closely while taking sabril. It may also interact with certain types of mental health disorders, including psychotic disorders, bipolar disorder, or depression.
Drug Interaction
sabril has the potential to interact with certain medications, especially those that act on the central nervous system. Common medications that can interact with sabril include benzodiazepines, alcohol, anti-seizure drugs, and certain antibiotics.
Food Interactions
It is recommended that patients take sabril with food, as food can help increase the absorption of the medication. It is also important to drink plenty of fluids while taking sabril to reduce the risk of dehydration.
Pregnancy Use
sabril is not recommended for use during pregnancy due to the risk of harm to the fetus. Women who are pregnant should not take sabril unless the benefits outweigh the risks. Women who are of childbearing age should use effective birth control methods while taking sabril.
Lactation Use
It is not known whether sabril is excreted in breast milk. Therefore, women who are breastfeeding should consult their doctor before taking sabril.
Acute Overdose
Signs and symptoms of an overdose include confusion, behavioural changes, difficulty breathing, and unconsciousness. If an overdose is suspected, seek immediate medical attention.
Contraindication
sabril should not be used in patients who are hypersensitive to it or any of its components, or in patients with kidney impairment due to the risk of increased toxicity. It should also be avoided in pregnant women or women of childbearing age due to the risk of harm to the fetus.
Use Direction
sabril must be taken exactly as prescribed by the healthcare provider. It should not be taken in larger or smaller amounts than prescribed, and should not be taken for a longer or shorter period of time than prescribed.
Storage Condition
sabril should be stored at room temperature in a dry place and away from direct sunlight. Keep the medication out of the reach of children and pets.
Volume of Distribution
The volume of distribution of sabril is approximately 10 liters.
Half life
The half-life of sabril is 8 hours, although it has been reported to range up to 12-68 hours.
Clearance
The clearance of sabril in adults is 11.9 mL/min/kg and in children is 8.5 mL/min/kg.
Here you find in details version of sabril