Nonacog Gamma
Nonacog Gamma Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Nonacog Gamma is a brand name. Its generic name is Coagulation Factor IX (Recombinant).
Introduction
Nonacog Gamma is a recombinant form of human Factor IX, a protein used to treat clotting disorders including hemophilia B and von Willebrand disease. It is approved by the U.S. Food and Drug Administration (FDA) for the prophylactic and on-demand treatment of hemophilia B. This recombinant factor IX is produced through biotechnology.Uses For
Nonacog Gamma is used to treat or prevent bleeding episodes in individuals with hemophilia B. Hemophilia B is a rare genetic disorder in which the blood does not clot normally due to a missing or deficient form of Factor IX, also known as Christmas Disease.Mechanism of Action
Nonacog Gamma works by aiding in the formation of a blood clot. It helps to activate Factor X, which is then able to convert prothrombin into thrombin, causing the formation of a fibrin clot. This clot is what ultimately prevents or stops a bleeding episode.How Long Does it Take to Work?
The time it takes for Nonacog Gamma to start working varies depending on the specific patient and severity of their clotting disorder. However, in general it usually takes between 5-15 minutes to start working.Absorption
Nonacog Gamma is rapidly absorbed into the bloodstream upon administration.Route of Elimination
Nonacog Gamma is eliminated from the body primarily through the kidneys.Dosage
The dose of Nonacog Gamma will vary depending on the patient's body weight, health condition being treated, and desired therapeutic effect. Generally, it is available in single-use vials and recommended doses range from 25 IU/kg to 100 IU/kg, every 24-72 hours or as needed.Administration
Nonacog Gamma is administered via intravenous (IV) infusion.Side Effect
The most common side effects associated with the use of Nonacog Gamma include: fever, headache, nausea, injection site reactions, hives, and muscle pain.Toxicity
Nonacog Gamma is considered to be of low toxicity. Acute overdose of this medication can lead to thromboembolic events, and may require the administration of anticoagulants.Precaution
Patients should be made aware of the potential risks of Nonacog Gamma prior to administration. This includes the risk of thromboembolic events, anaphylaxis, and the potential for allergic reactions. Patients should also be monitored for signs and symptoms of these complications.Interaction
Nonacog Gamma has the potential to interact with other medications, such as anticoagulants, antifibrinolytics, and nonsteroidal anti-inflammatory drugs (NSAIDs). Patients should be monitored closely for signs and symptoms of any possible drug interactions.Disease Interaction
Nonacog Gamma may interact with certain underlying disease states such as hemophilia, liver disease, and certain immunodeficiency states. Patients should be monitored closely for signs and symptoms of any possible disease interaction.Drug Interaction
Nonacog Gamma has the potential to interact with other drugs. Patients should be monitored closely for signs and symptoms of any possible drug interactions.Food Interactions
Nonacog Gamma does not interact with food.Pregnancy Use
Nonacog Gamma is designated as a pregnancy category C medication, meaning it should only be used during pregnancy if the potential benefit justifies the potential risk to the fetus.Lactation Use
Nonacog Gamma is not recommended for use by nursing mothers due to the potential for adverse effects in the nursing infant.Acute Overdose
Acute overdose of Nonacog Gamma can lead to increased episodes of bleeding or thromboembolic events. Treatment for an acute overdose typically involves administration of anticoagulants and other supportive measures.Contraindication
Nonacog Gamma is contraindicated in patients who are hypersensitive to this medication or any of its components.Usage Direction
Nonacog Gamma should only be used as directed by a healthcare professional.Storage Condition
Nonacog Gamma should be stored in the refrigerator until ready for use. After administration, any unused or expired product should be discarded.Volume of distribution
The volume of distribution for Nonacog Gamma is approximately 4-8 L/kg.Half-Life
The half-life of Nonacog Gamma is approximately 3 days.Clearance
The clearance of Nonacog Gamma is approximately 0.3 mL/min/kg.Here you find in details version of Nonacog Gamma
Some Frequently Asked Questions About Nonacog Gamma
https://www.medicinesfaq.com/brand/nonacog-gamma,
http://www.uniprot.org/uniprot/P00740,
https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=K02402,
http://www.genome.jp/dbget-bin/www_bget?cpd:C03101,
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46508858,
https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=1300488,
http://bidd.nus.edu.sg/group/cjttd/ZFTTDDRUG.asp?ID=DAP000964,
http://www.pharmgkb.org/drug/PA164744952,
http://www.rxlist.com/cgi/generic2/factorix.htm,
https://www.drugs.com/cdi/coagulation-factor-ix-injection-human.html,
https://en.wikipedia.org/wiki/Factor_IX,