Recombinant Factor IX
Recombinant Factor IX Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Recombinant Factor IX is a brand name. Its generic name is Coagulation Factor IX (Recombinant).
Introduction
Recombinant Factor IX is a recombinant form of human Factor IX, a protein used to treat clotting disorders including hemophilia B and von Willebrand disease. It is approved by the U.S. Food and Drug Administration (FDA) for the prophylactic and on-demand treatment of hemophilia B. This recombinant factor IX is produced through biotechnology.Uses For
Recombinant Factor IX is used to treat or prevent bleeding episodes in individuals with hemophilia B. Hemophilia B is a rare genetic disorder in which the blood does not clot normally due to a missing or deficient form of Factor IX, also known as Christmas Disease.Mechanism of Action
Recombinant Factor IX works by aiding in the formation of a blood clot. It helps to activate Factor X, which is then able to convert prothrombin into thrombin, causing the formation of a fibrin clot. This clot is what ultimately prevents or stops a bleeding episode.How Long Does it Take to Work?
The time it takes for Recombinant Factor IX to start working varies depending on the specific patient and severity of their clotting disorder. However, in general it usually takes between 5-15 minutes to start working.Absorption
Recombinant Factor IX is rapidly absorbed into the bloodstream upon administration.Route of Elimination
Recombinant Factor IX is eliminated from the body primarily through the kidneys.Dosage
The dose of Recombinant Factor IX will vary depending on the patient's body weight, health condition being treated, and desired therapeutic effect. Generally, it is available in single-use vials and recommended doses range from 25 IU/kg to 100 IU/kg, every 24-72 hours or as needed.Administration
Recombinant Factor IX is administered via intravenous (IV) infusion.Side Effect
The most common side effects associated with the use of Recombinant Factor IX include: fever, headache, nausea, injection site reactions, hives, and muscle pain.Toxicity
Recombinant Factor IX is considered to be of low toxicity. Acute overdose of this medication can lead to thromboembolic events, and may require the administration of anticoagulants.Precaution
Patients should be made aware of the potential risks of Recombinant Factor IX prior to administration. This includes the risk of thromboembolic events, anaphylaxis, and the potential for allergic reactions. Patients should also be monitored for signs and symptoms of these complications.Interaction
Recombinant Factor IX has the potential to interact with other medications, such as anticoagulants, antifibrinolytics, and nonsteroidal anti-inflammatory drugs (NSAIDs). Patients should be monitored closely for signs and symptoms of any possible drug interactions.Disease Interaction
Recombinant Factor IX may interact with certain underlying disease states such as hemophilia, liver disease, and certain immunodeficiency states. Patients should be monitored closely for signs and symptoms of any possible disease interaction.Drug Interaction
Recombinant Factor IX has the potential to interact with other drugs. Patients should be monitored closely for signs and symptoms of any possible drug interactions.Food Interactions
Recombinant Factor IX does not interact with food.Pregnancy Use
Recombinant Factor IX is designated as a pregnancy category C medication, meaning it should only be used during pregnancy if the potential benefit justifies the potential risk to the fetus.Lactation Use
Recombinant Factor IX is not recommended for use by nursing mothers due to the potential for adverse effects in the nursing infant.Acute Overdose
Acute overdose of Recombinant Factor IX can lead to increased episodes of bleeding or thromboembolic events. Treatment for an acute overdose typically involves administration of anticoagulants and other supportive measures.Contraindication
Recombinant Factor IX is contraindicated in patients who are hypersensitive to this medication or any of its components.Usage Direction
Recombinant Factor IX should only be used as directed by a healthcare professional.Storage Condition
Recombinant Factor IX should be stored in the refrigerator until ready for use. After administration, any unused or expired product should be discarded.Volume of distribution
The volume of distribution for Recombinant Factor IX is approximately 4-8 L/kg.Half-Life
The half-life of Recombinant Factor IX is approximately 3 days.Clearance
The clearance of Recombinant Factor IX is approximately 0.3 mL/min/kg.Here you find in details version of Recombinant Factor IX
Some Frequently Asked Questions About Recombinant Factor IX
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https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=1300488,
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http://www.pharmgkb.org/drug/PA164744952,
http://www.rxlist.com/cgi/generic2/factorix.htm,
https://www.drugs.com/cdi/coagulation-factor-ix-injection-human.html,
https://en.wikipedia.org/wiki/Factor_IX,