Ganirelix Acetate
Ganirelix Acetate Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Ganirelix Acetate is a brand name. Its generic name is Ganirelix.
Ganirelix Acetate Introduction
Ganirelix Acetate (Ganirelix Acetate acetate) is a gonadotropin-releasing hormone (GnRH) antagonist manufactured by American pharmaceutical company Ferring, and used for controlling ovulation in women for in vitro fertilization (IVF) treatment. It works by blocking the pituitary gland from producing luteinizing hormone (LH), which is the hormone responsible for triggering ovulation.
Uses for Ganirelix Acetate
Ganirelix Acetate is primarily used for controlling ovulation in women undergoing IVF treatment. It works by blocking the pituitary gland from producing luteinizing hormone (LH), which is the hormone responsible for triggering ovulation. This allows for a more controlled and coordinated fertilization of eggs, increasing the likelihood of successful fertilization.
Mechanism of Action
Ganirelix Acetate works by binding to receptors in the pituitary gland, preventing the release of LH, which is the hormone responsible for triggering ovulation. This allows for a more controlled and coordinated ovulation and fertilization process, increasing the likelihood of successful fertilization.
How Long Does It Take to Work?
Ganirelix Acetate is typically given as a subcutaneous injection, and usually takes 1–3 days to take effect. It can also be given intravenously, in which case it takes effect within minutes.
Absorption
Ganirelix Acetate is rapidly absorbed after subcutaneous injection, with peak serum concentrations of the drug achieved within 2 hours.
Route of Elimination
Ganirelix Acetate is eliminated from the body by the kidneys, with approximately 80% of a dose being excreted within 24 hours.
Dosage
Ganirelix Acetate is typically given as a single 0.25mg or 0.5mg subcutaneous injection daily, beginning on the day of ovarian stimulation. For IVF, the dosage may be adjusted depending on the patient's fertility cycle, as well as on the other medications being used. It is also available as a 250mcg/0.5ml solution for intravenous use.
Administration
Ganirelix Acetate is administered as a single-dose, subcutaneous injection, usually into the buttocks or abdomen. Alternatively, it can also be given intravenously, typically over 2 minutes.
Side Effect
Common side effects of Ganirelix Acetate include nausea, headache, dizziness, and injection site reactions. Less common side effects include depression, anxiety, and flushing of the skin. Serious side effects are rare, but may include chest pain, difficulty breathing, and low blood pressure.
Toxicity
Ganirelix Acetate is generally well tolerated with few serious side effects. The most common side effects are mild and typically go away on their own. However, in cases of acute overdose, more serious side effects may occur.
Precaution
Ganirelix Acetate should not be used in patients with hypersensitivity to the drug. It should also be used with caution in patients with a history of depression, anxiety, or epilepsy, as Ganirelix Acetate may exacerbate these conditions. It should also be used with caution in patients with severe cardiovascular or renal disease.
Interaction
Ganirelix Acetate may interact with other drugs, including some oral contraceptives and anticoagulants. Therefore, it is important to inform your doctor of any medications being taken prior to starting treatment with Ganirelix Acetate.
Disease Interaction
Ganirelix Acetate has no known interactions with any diseases, however it should be used with caution in patients with severe cardiovascular or renal diseases.
Drug Interaction
Ganirelix Acetate may interact with other drugs, including some oral contraceptives and anticoagulants. It is important to inform your doctor of any medications being taken prior to starting treatment with Ganirelix Acetate.
Food Interactions
Ganirelix Acetate is not known to interact with any of food items but food may enhance the absorption of Ganirelix Acetate, so it is advised to take it with food.
Pregnancy Use
Ganirelix Acetate is not approved for use in pregnant women. It is important to inform your doctor if you are pregnant or planning a pregnancy prior to starting treatment with Ganirelix Acetate.
Lactation Use
Ganirelix Acetate is not approved for use in breastfeeding women. It is important to inform your doctor if you are breastfeeding or planning to breastfeed prior to starting treatment with Ganirelix Acetate.
Acute Overdose
Acute overdose of Ganirelix Acetate should be treated with supportive measures, such as monitoring of vital signs and administration of fluids, if necessary. Gastric lavage may also be used in cases of acute overdose.
Contraindication
Ganirelix Acetate is contraindicated in patients with a known hypersensitivity to the drug. It should also not be used in pregnant or breastfeeding women.
Use Directions
Ganirelix Acetate should be used exactly as directed by a doctor. It is typically given as a subcutaneous injection daily, beginning on the day of ovarian stimulation. It is also available as a 250mcg/0.5ml solution for intravenous use.
Storage Condition
Ganirelix Acetate should be stored at room temperature (68°F to 77°F), and should not be frozen or refrigerated. It should also be kept away from light and moisture.
Volume of Distribution
The volume of distribution of Ganirelix Acetate is approximately 108L.
Half Life
The elimination half-life of Ganirelix Acetate is approximately 10-12 hours.
Clearance
The clearance of Ganirelix Acetate is approximately 39L/h.
Here you find in details version of Ganirelix Acetate