Ergomar
Ergomar Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Ergomar is a brand name. Its generic name is Ergotamine.
Ergomar
Ergomar is an alkaloid medication used to treat migraine headaches. It is a vascular spasmolytic drug, meaning it constricts blood vessels in the body and reduces contraction of smooth muscles. It is synthetically derived from the ergot fungus that grows on various grains, and was first discovered in the early 18th century.
Uses
Ergomar is typically used to prevent and treat migraine headaches, although it can also be used for other medical purposes, such as treatment of kidney disease, high blood pressure, and peripheral vascular disease. It can also be used to abort migraines in progress that have already started, although its efficacy is debated.
Mechanism of Action
Ergomar’s principal mechanism of action is to constrict smooth muscle cells in blood vessels and reduce spasms and inflammation. It also affects the central nervous system by blocking serotonin receptors in the brain, reducing the level of pain signals sent to the brain.
How Long Does It Take to Work?
The effects of Ergomar usually kick in within 10 to 20 minutes after it is taken. The duration of effects depends on the dose and route of administration.
Absorption
Ergomar is rapidly absorbed after oral or sublingual administration, with maximum concentrations attained within 0.5 to 3 hours. Rectal administration results in slower absorption, with maximum concentrations achieved around 2-3 hours after administration.
Route of Elimination
Ergomar is metabolized in the liver and excreted primarily through the kidneys as metabolites. Approximately 10-20% of the drug is excreted in the urine as unchanged ergotamine.
Dosage
The usual dose of Ergomar is 2 to 3 tablets (2 mg to 6 mg) taken at the onset of migraine symptoms. This dose may be repeated once after 4 hours if needed. Do not exceed the recommended dose.
Administration
Ergomar can be administered orally, sublingually, or rectally. Oral administration is the most common and most effective route. Sublingual administration has a faster onset of action with higher bioavailability, and rectal administration has the slowest onset of action but allows for more complete absorption.
Side Effects
The most common side effects of Ergomar are nausea, vomiting, dizziness, headache, drowsiness, and abdominal pain. Other, more serious side effects that have been reported with Ergomar include allergic reactions, seizures, hallucinations, increased heart rate, and high blood pressure.
Toxicity
Ergomar is generally safe when used as directed. Overdose can lead to severe hypotension, seizures, and coma, and can be fatal if left untreated.
Precautions
Ergomar should be used with caution in patients with heart disease, hypertension, kidney or liver disease, or a history of previous stroke. It should not be used by pregnant women or those breastfeeding. People taking Ergomar should not consume alcohol, as it may increase the risk of side effects. Additionally, people taking Ergomar should not take other medications that contain ergot alkaloids, as this may lead to overdose.
Interactions
Ergomar can interact with many different medications, such as antifungals, antibiotics, antidepressants, blood pressure medications, and other migraine medications. It can also interact with certain foods, such as grapefruit or grapefruit juice, which can increase the risk of side effects.
Disease Interactions
Ergomar should be used cautiously in people with kidney or liver disease, hypertension, heart disease, or a history of previous stroke. It may increase the risk of side effects or worsening of underlying conditions.
Drug Interactions
Ergomar interacts with several other medications, including antibiotics, antifungals, blood pressure medications, and other migraine medications such as triptans. Talk to your doctor or pharmacist about all medications you are taking before taking Ergomar.
Food Interactions
Grapefruit and grapefruit juice can increase the risk of side effects and should be avoided while taking Ergomar. Additionally, other foods or beverages that contain caffeine may increase the risk of side effects and should be avoided.
Pregnancy Use
Ergomar should not be used during pregnancy. It is category C drug, meaning that animal studies have shown that it can potentially cause harm to the fetus.
Lactation Use
Ergomar should not be used if you are breastfeeding. It is not known if it passes into breastmilk.
Acute Overdose
An overdose of Ergomar can be fatal. Symptoms of an overdose can include nausea, vomiting, seizures, confusion, cold sweats, rapid breathing, loss of consciousness, chest pain, and irregular heart rate. If you think you or someone you know has overdosed on Ergomar, seek emergency medical attention.
Contraindication
Ergomar is contraindicated in people with hypersensitivity to ergot alkaloids, heart disease, hypertension, kidney or liver disease, a history of stroke, pregnant or breastfeeding women, and people who are taking medications containing ergot alkaloids.
Directions for Use
Ergomar tablets should be taken as directed by your doctor or according to the package instructions. For the treatment of migraine headaches, the recommended dose is usually 2 to 3 tablets (2 mg to 6 mg) taken at the onset of symptoms. The dose may be repeated once after 4 hours if needed. Do not exceed the recommended dose.
Storage Condition
Store Ergomar tablets at room temperature, away from heat and moisture, in a tightly sealed container. Keep the tablets away from children and pets.
Volume of Distribution
The volume of distribution of Ergomar is approximately 0.3 to 0.5 L/kg. This means that the amount of Ergomar in the body increases and decreases in direct proportion to the amount of drug administered.
Half Life
The half-life of Ergomar is approximately 2 hours after oral or sublingual administration and 4 hours after rectal administration.
Clearance
The clearance of Ergomar is approximately 90 to 140 ml/min. This means that the amount of Ergomar in the body is cleared from the body in about 1.5 to 2 hours.
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