Ertugliflozin
Ertugliflozin Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Ertugliflozin is a brand name. Its generic name is Ertugliflozin.
Ertugliflozin Introduction
Ertugliflozin ( INVOKANA) is an oral medication for the treatment of type 2 diabetes (T2D). It belongs to a group of medications called sodium-glucose cotransporter-2 (SGLT2) inhibitors. SGLT2 inhibitors work by preventing the reabsorption of glucose from the kidneys, increasing the glucose excretion in the urine and reducing the levels of glucose in the blood.
Ertugliflozin Uses
Ertugliflozin is used to treat adults with type 2 diabetes. It is used along with diet and exercise to lower blood sugar levels and improve glycemic control. It can also be used with other diabetes medications, such as metformin or pioglitazone.
Ertugliflozin Mechanism of Action
Ertugliflozin works by blocking the kidney's reabsorption of glucose back into the bloodstream. When glucose is not reabsorbed, it is excreted in the urine, which results in lower glucose levels in the blood. By reducing the reabsorption of glucose, Ertugliflozin also reduces the amount of glucose that can be converted to fat, resulting in weight loss.
How Long Does It Take to Work?
Ertugliflozin can take 1-2 weeks to start working, depending on how quickly the body adjusts to the medication. It may take up to 3 months to achieve the full effect of the medication, as it needs time to adjust to the changes in glucose levels.
Ertugliflozin Absorption
Ertugliflozin is absorbed rapidly and extensively after oral administration. Peak concentrations of the drug in the plasma are reached 1 hour after administration.
Route of Elimination
Ertugliflozin is primarily eliminated by the kidneys, with only a small amount excreted in the feces. The elimination half-life is approximately 7.5 to 12 hours.
Ertugliflozin Dosage
The recommended starting dose of Ertugliflozin is 5 mg once daily, with or without food. Dosage may be increased in increments of 5 mg up to a maximum of 15 mg once daily, as tolerated.
Ertugliflozin Administration
Ertugliflozin should be taken orally with or without food once daily. It should not be crushed, chewed, or divided. patients who take the drug must also be aware of their fluid intake to prevent dehydration.
Ertugliflozin Side Effects
Common side effects of Ertugliflozin include headache, urinary tract infection, stomach pain, diarrhea, dizziness, fatigue, and increased urination. Less common side effects include hypoglycemia, elevation of liver enzymes, and skin rash.
Ertugliflozin Toxicity
No specific antidote exists for Ertugliflozin overdosage. Symptoms of an overdose may include hypoglycemic episodes, severe gastrointestinal symptoms, polyuria, and dehydration.
Ertugliflozin Precaution
Patients should not take Ertugliflozin if they have ever had an allergic reaction or if they have any history of kidney problems, bladder cancer, diabetic ketoacidosis, or severe urinary tract infections. Patients should also talk to their doctor if they have had a previous heart attack or stroke. Women who are pregnant or breastfeeding should talk to their doctor before taking Ertugliflozin.
Ertugliflozin Interaction
Ertugliflozin may interact with other medications, including insulin, metformin, glipizide, pioglitazone, and glyburide. Patients should tell their doctor about all medications they are taking, including prescription and over-the-counter medications, vitamins, and herbal supplements.
Ertugliflozin Disease Interaction
Patients with impaired kidney function and those with conditions such as congestive heart failure, severe hypo- or hyperglycemia, or diabetic ketoacidosis should talk to their doctor before taking Ertugliflozin. Patients with a history of diabetic macular edema should also talk to their doctor.
Ertugliflozin Drug Interaction
Ertugliflozin may interact with insulin, metformin, glipizide, pioglitazone, glyburide, sulfonylureas, thiazolidinediones, nonsteroidal anti-inflammatory drugs (NSAIDs), angiotensin-converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), and diuretic medications. Patients should tell their doctor about all medications they are taking before starting on Ertugliflozin.
Ertugliflozin Food Interactions
Ertugliflozin should be taken with food for better absorption. Avoid ingesting grapefruit or grapefruit juice while taking Ertugliflozin as it may increase side effects.
Ertugliflozin Pregnancy Use
Ertugliflozin should not be used by pregnant women unless it is absolutely necessary. If a woman becomes pregnant while taking this medication, she should inform her doctor immediately.
Ertugliflozin Lactation Use
Ertugliflozin is not recommended for nursing mothers. Women who are breastfeeding should talk to their doctor before starting on Ertugliflozin.
Ertugliflozin Acute Overdose
In case of an acute overdose, the patient should contact a healthcare professional or poison control center right away for advice. Symptoms of an overdose may include hypoglycemic episodes, gastrointestinal symptoms, polyuria, and dehydration.
Ertugliflozin Contraindication
Ertugliflozin is contraindicated in patients with a history of anaphylaxis or angioedema with SGLT2 inhibitors, patients with known hypersensitivity to Ertugliflozin or any of its ingredients, and patients with type 1 diabetes.
Ertugliflozin Use Direction
Ertugliflozin should be taken with food as advised by the doctor. Patients should avoid taking extra doses of the medication or taking it more frequently than what is prescribed.
Ertugliflozin Storage Condition
Ertugliflozin should be stored at room temperature in a dry place and away from children and pets. It should be kept away from light and moisture.
Ertugliflozin Volume of Distribution
The volume of distribution of Ertugliflozin is approximately 1,260 L.
Ertugliflozin Half Life
The elimination half-life of Ertugliflozin is estimated to be 7.5 to 12 hours.
Ertugliflozin Clearance
The clearance of Ertugliflozin is estimated to be 210 L/hr.
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