Benazepril

Benazepril Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Benazepril is a brand name. Its generic name is Benazepril.

Benazepril Introduction

Benazepril is a prescription drug that belongs to a group of medications called angiotensin-converting enzyme (ACE) inhibitors. This medication is used to treat high blood pressure (hypertension) as well as congestive heart failure (CHF). It may also be used to treat other conditions, as advised by a healthcare professional.

Uses for Benazepril

Benazepril is used as a long-term treatment to manage hypertension and heart failure in adults. It helps to reduce the risk of stroke, heart attack, and death associated with high blood pressure or heart failure. Additionally, it is also used to treat kidney disease in people with type 2 diabetes and high blood pressure.

Mechanism of Action

Benazepril works by blocking the activity of the enzyme ACE, which blocks the action of angiotensin, a hormone that is associated with hypertension and heart failure. It relaxes the blood vessels and allows the heart to pump more effectively by reducing your heart rate and blood pressure. This helps reduce symptoms related to heart failure and hypertension, such as swelling of the body, tiredness, and shortness of breath.

How Long Does it Take to Work?

Benazepril begins to work immediately, however, it may take several weeks to notice the full effects. In clinical trials, the average time was 2 months for blood pressure to be reduced by its fullest extent.

Absorption

Benazepril is absorbed rapidly when taken orally. Peak levels are generally reached within 1 hour of administration. It is metabolized in the liver, predominantly by the cytochrome P450 3A4 enzyme.

Route of Elimination

Benazepril is mainly cleared from the body through the kidneys. Approximately 78% of an oral dose is excreted in the urine, and the rest is metabolized and excreted in the feces.

Dose and Administration

The dose and administration of Benazepril varies depending on the condition being treated. Generally, it is taken orally once a day with or without food. The initial dose for hypertension is 5mg to 40mg, and for heart failure, the starting dose is 5mg to 10mg. Patients with kidney disease may require a lower dose of Benazepril.

Side Effects

Common side effects of Benazepril include headache, dizziness, and fatigue. Uncommon side effects include diarrhea, constipation, nausea, abdominal pain, and rash. Serious side effects may include low blood pressure, increased risk of infection, reduced kidney function, increased risk of angioedema (swelling of the face, lips, and throat).

Toxicity

Benazepril overdose is not common and is generally well tolerated. Overdose may cause excessive hypotension, nausea, and vomiting. If you think you or someone else may have taken an overdose, seek immediate medical attention.

Precautions

Before taking Benazepril, patients should discuss their medical history with their healthcare provider. Patients should not take Benazepril if they are allergic to ACE inhibitors, or if they have liver disease, kidney disease, or a history of angioedema. Additionally, certain patients with diabetes may be at risk for increased blood sugar levels while taking Benazepril, and therefore should discuss any possible risks with their healthcare provider before starting therapy.

Interactions

There may be an increased risk of side effects when taking Benazepril with other medications. To help reduce this risk, it is important to provide a comprehensive list of all medications and supplements being taken to a healthcare provider prior to starting treatment with Benazepril.

Drug Interactions

There are several medications known to interact with Benazepril. Examples include diuretics, antihypertensive medications, and angiotensin-receptor blockers. Some of these medications may increase the risk of side effects, while others may reduce the effectiveness of Benazepril. Patients should talk to their healthcare provider for more information on drug interactions.

Food Interactions

Benazepril is not known to interact with food. However, if a meal is consumed shortly after taking Benazepril, the effects of the medication could be delayed.

Pregnancy Use

Benazepril is classified as a pregnancy category C drug, meaning that it may be harmful to a developing fetus, and should only be used if the benefits to the mother outweigh the potential risks to the baby. Women who are pregnant or planning to become pregnant should let their healthcare provider know before taking Benazepril.

Lactation Use

It is unknown if Benazepril passes into breast milk. It is recommended that women who are breastfeeding consult their healthcare provider before taking Benazepril.

Acute Overdose

Signs of an acute overdose of Benazepril include low blood pressure, hypotension, nausea, vomiting, and dizziness. Treatment of an overdose may include supportive care such as IV fluids and medications to raise blood pressure. Dialysis may also be used to increase clearance of Benazepril from the body.

Contraindication

Benazepril is contraindicated in patients who are allergic to ACE inhibitors. Additionally, patients with a history of angioedema associated with prior ACE use should not take Benazepril.

Use Direction

Benazepril should be taken as directed by a healthcare professional. The dosage and frequency of administration may vary depending on the condition being treated. It is generally taken once a day with or without food.

Storage Condition

Benazepril should be stored in a cool, dry place, away from direct light and heat, in its original containers. It should not be stored in the bathroom or near other sources of heat or moisture.

Volume of Distribution

The volume of distribution of Benazepril is approximately 15.3 L/kg. These results indicate that it is distributed widely throughout the body.

Half Life

The half-life of Benazepril is approximately 1.6 to 2.5 hours in healthy individuals. However, this may vary depending on the patient's individual metabolism and health condition.

Clearance

The clearance of Benazepril is approximately 125 mL/min/1.73 m2. This indicates that it is excreted from the body relatively quickly.

Here you find in details version of Benazepril

Some Frequently Asked Questions About Benazepril

What is Benazepril?

Benazepril is a prescription medication used to treat high blood pressure (hypertension). It belongs to a group of medications called angiotensin converting enzyme inhibitors (ACE inhibitors). It works by relaxing and widening of blood vessels, which reduces pressure on the heart.

When should Benazepril be taken?

Benazepril is usually taken once a day with or without food. If you take it more than once a day, space your doses evenly throughout the day. Follow your doctor's instructions when taking this medication.

What are the possible side effects of Benazepril?

The most common side effects of Benazepril include lightheadedness, dizziness, diarrhea, and headache. Less common side effects may include fatigue, increased appetite, muscle pain, rash, and nausea.

What should I avoid while taking Benazepril?

You should avoid drinking alcohol and taking over-the-counter nonsteroidal anti-inflammatory drugs (NSAIDS). NSAIDS can make your blood pressure harder to control. You should also avoid becoming pregnant while taking Benazepril. If you become pregnant, you should discuss the risks and benefits of using this medication with your doctor.

Does Benazepril have any drug interactions?

Yes, Benazepril may interact with other medications such as diuretics, nonsteroidal anti-inflammatory drugs (NSAIDs), and potassium-sparing diuretics. It is important to tell your doctor about all medications you take to avoid any possible interactions.

Can Benazepril be used to treat kidney disease?

Benazepril may be used to treat some forms of kidney disease. It is important to discuss this use with your doctor as the use of Benazepril may cause serious side effects in people with kidney disease.

What forms does Benazepril come in?

Benazepril comes in tablet form and is taken by mouth. It is available in both 5 mg and 10 mg tablets.

What should I do if I miss a dose of Benazepril?

If you miss a dose of Benazepril, take the missed dose as soon as you remember. If it is close to your next dose, skip the missed dose and take the next dose at the regularly scheduled time. Do not take a double dose to make up for a missed one.

What should I tell my doctor before taking Benazepril?

You should tell your doctor about all medications you are taking as well as any medical conditions you have. You should also tell your doctor if you are pregnant or plan to become pregnant as Benazepril can harm an unborn baby.

Is Benazepril safe to take while breastfeeding?

It is not recommended that you take Benazepril while breastfeeding as it could pass through the breast milk and cause harm to the baby. Talk to your doctor if you are breastfeeding or plan to breastfeed before taking this medication.

Can Benazepril be taken with other blood pressure medications?

Yes, Benazepril can be taken with other blood pressure medications. However, you should not take Benazepril with any potassium-sparing diuretics. Talk to your doctor about the appropriate medications and dosages to use to control your blood pressure.

Can Benazepril be used to treat high cholesterol levels?

No, Benazepril is not indicated for treating high cholesterol levels. It may help people with high cholesterol levels by lowering their blood pressure, but this should not be used as a primary treatment. Talk to your doctor if you have high cholesterol levels.

What should I do if I experience any serious side effects while taking Benazepril?

If you experience any serious side effects while taking Benazepril, such as chest pain, difficulty breathing, swelling of the face, lips, or tongue, you should contact your doctor or seek emergency medical care immediately.

Does Benazepril cause weight gain?

It is not common to experience weight gain while taking Benazepril. However, if you are experiencing weight gain while taking this medication, talk to your doctor to determine the cause and to determine if there are any other treatments which may work better for you.

Should I take Benazepril in the morning or at night?

It is typically recommended that Benazepril be taken once a day in the morning, with or without food. However, you should follow your doctor's instructions when taking this medication.

Is Benazepril safe for people with diabetes?

Benazepril is generally considered safe for people with diabetes. However, it is important to talk to your doctor about your individual situation and potential risk factors.

Does Benazepril have any effect on blood sugar levels?

Benazepril can potentially affect blood sugar levels. If you have diabetes or are at risk for developing diabetes, it is important to discuss how Benazepril may affect your blood sugar levels with your doctor.

What is the usual dosage of Benazepril?

The usual starting dose for Benazepril is 5 mg to 10 mg taken once a day with or without food. Your doctor may increase or decrease your dosage depending on how well the medication is working and your individual circumstances.

Can Benazepril be used to treat heart failure?

Yes, Benazepril can be used to treat heart failure. It works by widening and relaxing the blood vessels which can reduce pressure on the heart and improve symptoms of heart failure. Talk to your doctor if you have heart failure for more information.

What is Benazepril hydrochloride?

Benazepril hydrochloride is the active ingredient in Benazepril. It is an angiotensin converting enzyme inhibitor (ACE inhibitor) used to treat high blood pressure.

How long does Benazepril take to start working?

It can take up to two weeks for Benazepril to reach its peak effect. In some cases, it may take even longer for the medication to take effect. You should follow your doctor's instructions and contact them if you feel the medication is not working.

Does Benazepril cause dry mouth?

In rare cases, Benazepril can cause dry mouth. You should contact your doctor if you experience this side effect or if it becomes bothersome.

Can Benazepril cause dizziness?

Yes, Benazepril can cause dizziness in some people. If you experience dizziness while taking Benazepril, contact your doctor as it may be a sign of low blood pressure.

Does Benazepril have any effect on appetite?

In some cases, Benazepril may increase appetite, although this is not a common side effect. Talk to your doctor if you experience this side effect or if it becomes bothersome.

Can Benazepril be used to treat hypertension in children?

Benazepril is not approved for use in children. There may be other treatments available for hypertension in children and your doctor can discuss these with you.

Can Benazepril cause edema (water retention)?

Yes, Benazepril can cause edema in some people. If you experience water retention while taking Benazepril, contact your doctor as it could be a sign of a dangerous side effect.

Can Benazepril cause a cough?

Yes, a cough is a common side effect of Benazepril. If your cough persists or becomes bothersome, contact your doctor as it could be a sign of a more serious side effect.

Is Benazepril safe for kidney disease?

Benazepril should be used with caution in people with kidney disease. Your doctor may recommend a different treatment if you have kidney disease.

Is Benazepril habit-forming?

No, Benazepril is not a habit-forming medication. However, you should take it exactly as prescribed by your doctor and do not stop taking the medication without checking with your doctor.

Can Benazepril be used to treat a heart attack?

No, Benazepril is not indicated to treat a heart attack. If you are having a heart attack, you should seek emergency medical help immediately.

Can Benazepril cause insomnia?

Insomnia is not a commonly reported side effect of Benazepril. However, if you experience insomnia while taking this medication, contact your doctor.

Is Benazepril safe to take during pregnancy?

No, Benazepril should not be used during pregnancy as it can cause harm to an unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant before taking this medication.

Is Benazepril safe to take with alcohol?

It is not recommended that you take Benazepril with alcohol as alcohol can increase the risk of side effects and lower your blood pressure even further. Talk to your doctor if you have any questions or concerns about taking this medication with alcohol.

Does Benazepril cause kidney damage?

Benazepril can potentially cause kidney damage in some people. If you experience any symptoms of kidney damage, such as decreased urination or dark urine, contact your doctor immediately.

Does Benazepril cause constipation?

Constipation is not a commonly reported side effect of Benazepril. However, if you experience constipation while taking this medication, contact your doctor.

Can Benazepril be used to treat hypertension in elderly patients?

Yes, Benazepril can be used to treat hypertension in elderly patients. However, it is important to discuss any potential risks and side effects with your doctor before starting the medication.

What is the maximum dosage of Benazepril?

The maximum dosage of Benazepril is usually 40 mg taken once a day. Your doctor may adjust your dosage higher or lower depending on your individual needs and circumstances.

Can Benazepril be used to treat congestive heart failure?

Yes, Benazepril can be used to treat congestive heart failure. It works by widening and relaxing the blood vessels which can reduce pressure on the heart and improve symptoms of congestive heart failure. Talk to your doctor if you have congestive heart failure for more information.

Does Benazepril cause diarrhea?

Diarrhea is a common side effect of Benazepril. If your diarrhea persists or is bothersome, contact your doctor as it could be a sign of a more serious side effect.

Is Benazepril safe for long-term use?

Yes, Benazepril is safe for long-term use if taken as prescribed by your doctor. Talk to your doctor if you have any questions or concerns about taking this medication long-term.

Can Benazepril be used to treat coronary artery disease?

Yes, Benazepril can be used to treat coronary artery disease. It works by widening and relaxing the blood vessels which can reduce pressure on the heart and improve symptoms of coronary artery disease. Talk to your doctor if you have coronary artery disease for more information.