Xtrapime

Xtrapime Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Xtrapime is a brand name. Its generic name is Cefepime.

Xtrapime

Xtrapime (INN) is a fourth-generation cephalosporin antibiotic marketed by Pfizer under the brand name Maxipime. Xtrapime is a broad-spectrum injectable antibiotic with activity against both Gram-positive and Gram-negative bacteria. Xtrapime is administered intravenously, and is available for use in both hospitalized and home health care settings.

Uses

Xtrapime is used to treat a wide range of bacterial infections, including skin, lung, urinary tract, and abdominal infections. It is also used to treat bacterial meningitis, which is an infection of the covering of the brain and spinal cord. It is sometimes used for the treatment of infections that other antibiotics are unable to effectively treat, such as certain multi-drug resistant organisms.

Mechanism of Action

Xtrapime belongs to a class of antibiotics called beta-lactam antibiotics. These antibiotics work by inhibiting the growth of bacteria by preventing the formation of cell wall during replication. The cell wall is the outer layer of protection that bacteria use to defend against environmental damage and to contain their contents. Xtrapime specifically targets penicillin-binding proteins (PBPs) in bacterial cells. When PBPs are blocked, the process of bacterial cell wall formation is disturbed, which can ultimately lead to cell death.

How Long Does it Take to Work?

The time it takes for Xtrapime to work is dependent on the type and severity of the infection being treated. Generally, improvement in symptoms can be seen in one to three days, although it may take longer for the infection to be completely eliminated.

Absorption

Xtrapime is not well absorbed when taken orally, so it is not available in a pill form. When administered intravenously, the bioavailability of Xtrapime is around 100%, meaning that all of the antibiotic is present in the bloodstream.

Route of Elimination

Xtrapime is largely eliminated unchanged in the urine, but small amounts may be excreted in the bile or feces.

Dosage and Administration

Xtrapime doses are typically determined by the patient’s weight, age, and the severity of the infection. It is available in the form of a powder or a solution that must be diluted prior to administration. The usual adult dose ranges from 2 g to 4 g daily, divided into two or three equal doses. The usual pediatric dose ranges from 30 mg/kg to 50 mg/kg daily, divided into two or three equal doses. Xtrapime should be administered intravenously over a period of 30 minutes to 2 hours, depending on the patient and the severity of the infection.

Side Effects

Some common side effects of Xtrapime include nausea, vomiting, diarrhea, and headache. It may also cause an increased risk of seizures in certain individuals. If any of these side effects become severe or persist, contact a doctor immediately.

Toxicity

Xtrapime is generally well-tolerated but it may cause renal and neurological side effects, including confusion, headache, tremor, slurred speech, and agitation in rare cases.

Precautions

Xtrapime should not be used in patients who are allergic to cefepime or other cephalosporin antibiotics. It should also not be used in patients with a history of seizures or renal impairment. Patients with liver or kidney disease should be monitored closely while taking Xtrapime.

Interactions

Xtrapime may interact with certain medications, including other antibiotics, and lead to increased side effects or decreased effectiveness. Patients should discuss all other medications they are taking with their doctor before starting Xtrapime.

Disease Interactions

Xtrapime may not be effective in treating certain diseases that are resistant to antibiotics, such as tuberculosis. Patients should tell their doctor about any existing diseases before beginning treatment with Xtrapime.

Drug Interactions

Xtrapime may interact with certain medications, including other antibiotics, and lead to increased side effects or decreased effectiveness. Patients should discuss all other medications they are taking with their doctor before starting Xtrapime.

Food Interactions

Xtrapime should be taken with food for optimal absorption. Patients should take Xtrapime with a full glass of water, and should not lie down for at least 30 minutes after taking it.

Pregnancy and Lactation Use

Xtrapime should be avoided during pregnancy and lactation, as the effects of the drug on an unborn or breastfeeding baby are unknown. Patients should discuss the risks and benefits of taking Xtrapime during pregnancy or while breastfeeding with their doctor.

Acute Overdose

If an overdose of cefepime is suspected, contact a poison control center or seek medical attention immediately. Signs and symptoms of acute overdose may include nausea, vomiting, and confusion.

Contraindication

Xtrapime is contraindicated in patients who are allergic to cephalosporins, penicillins, or other beta-lactam antibiotics. It is also contraindicated in patients who have a history of kidney or liver disease, or who have had a previous reaction to cefepime.

Use Directions

Xtrapime should be taken exactly as directed by a doctor. The dosage and frequency of administration will vary depending on the type and severity of the infection being treated. Patients should not take more or less of the prescribed dose or take it for any longer than prescribed. Patients should speak to a doctor before making any changes to the medication or discontinuing it.

Storage Condition

Xtrapime should be stored at room temperature in a tightly closed container. It should be kept away from direct light, heat, and moisture. It is important to keep the medication out of reach of children.

Volume of Distribution

Xtrapime has a volume of distribution of 0.32-0.9 L/kg, meaning that the drug is largely distributed to the tissues and fluids of the body.

Half Life

The half-life of Xtrapime is 2-5 hours, meaning that it takes approximately 2-5 hours for the body to eliminate half of the medication. This can vary depending on the patient and the condition being treated.

Clearance

Xtrapime has a clearance of 0.09-0.4 L/kg/hour, meaning that the body eliminates it quickly. Renal and hepatic function can affect the clearance of the drug, so it should be monitored and adjusted as necessary.

Here you find in details version of Xtrapime

Some Frequently Asked Questions About Xtrapime

1. What is Xtrapime used for?

Xtrapime is a type of antibiotic, used to treat a wide range of bacterial infections. It is used to treat bacterial infections in the lungs, blood, skin, abdominal cavity, bladder, and urinary tract. It is also used to treat certain types of pneumonia and meningitis.

2. How do I take Xtrapime?

Xtrapime should be taken as prescribed by your doctor. The standard dosage is two grams by intravenous infusion over a period of two hours every 12 hours or four grams over a period of four hours.

3. What are the side effects of Xtrapime?

The most common side effects of Xtrapime are nausea, vomiting, and diarrhea. Other side effects include headaches, dizziness, and muscle pain. Severe side effects may include anaphylaxis, severe allergic reactions, and Clostridium difficile-associated diarrhea.

4. What is the best way to store Xtrapime?

Xtrapime should be stored at room temperature, away from direct sunlight and heat. It should be kept in a tightly closed container.

5. How long does it take for Xtrapime to work?

Xtrapime begins to work within hours of taking it. Most people experience relief from symptoms within 48 hours. However, it is important to finish the entire course of treatment to ensure the bacteria is completely cleared.

6. What should I avoid while taking Xtrapime?

You should avoid activities that may increase your risk of bleeding while taking Xtrapime. You should also avoid taking any other medications without consulting your doctor.

7. Does Xtrapime interact with any other medications?

Xtrapime may interact with certain other medications, including antacids, dairy products, and probenicid. To reduce the chance of interactions, be sure to tell your doctor about any other medications you are taking.

8. Should I avoid alcohol while taking Xtrapime?

Yes, you should avoid alcohol while taking Xtrapime. Alcohol will increase your risk of side effects such as nausea and vomiting.

9. Can Xtrapime be used to treat a UTI?

Yes, Xtrapime is sometimes used to treat a urinary tract infection (UTI). Your doctor will determine if Xtrapime is appropriate to treat your UTI.

10. Is Xtrapime safe to use during pregnancy?

Xtrapime may be used during pregnancy, but only when clearly needed. Be sure to discuss the risks and benefits of taking Xtrapime with your doctor.

11. What should I do if I miss a dose of Xtrapime?

If you miss a dose of Xtrapime, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed dose.

12. Is Xtrapime safe for children?

Yes, Xtrapime is safe for children. However, the dosage amount and frequency should be determined by your child’s doctor.

13. Can Xtrapime be used to treat bacterial infections in animals?

Yes, Xtrapime can be used to treat bacterial infections in animals. However, the dosage amount and frequency should be determined by a veterinarian.

14. Can Xtrapime be used to treat both Gram-negative and Gram-positive bacteria?

Yes, Xtrapime is effective against both Gram-negative and Gram-positive bacteria.

15. Is it safe to take Xtrapime with Tylenol?

Yes, Xtrapime and Tylenol can be taken together. There are no known interactions between the two medications. However, if you have any questions, be sure to talk to your doctor or pharmacist.

16. Does Xtrapime treat all forms of bacterial infections?

No, Xtrapime is not effective against all forms of bacterial infections. Talk to your doctor about the best treatment option for your condition.

17. Is Xtrapime safe for people with kidney disease?

Yes, Xtrapime is generally safe for people with kidney disease. However, your doctor may need to adjust your dosage if you have any existing kidney problems.

18. What happens if I take an overdose of Xtrapime?

Taking an overdose of Xtrapime can cause serious side effects. If you believe that you have taken an overdose, contact your doctor or go to the nearest emergency room immediately.

19. Can Xtrapime be used to treat an abscess?

Yes, Xtrapime can be used to treat an abscess if it is caused by a bacterial infection. However, your doctor may prescribe other antibiotics to treat an abscess as well.

20. Can Xtrapime be used to treat a sinus infection?

Yes, Xtrapime can be used to treat a sinus infection if it is caused by a bacterial infection. Your doctor may prescribe other antibiotics as well to treat your sinus infection.

21. Is it safe for pregnant women to take Xtrapime?

Yes, Xtrapime may be used during pregnancy. However, it should only be taken when clearly needed, and the risks and benefits should be discussed with your doctor.

22. Will Xtrapime treat a strep throat?

Yes, Xtrapime can be used to treat a strep throat if it is caused by a bacterial infection. However, it is important to finish the entire course of treatment to ensure the infection is completely cleared.

23. Is Xtrapime covered by my insurance?

This depends on your insurance plan. You should contact your insurance company or pharmacy to find out if Xtrapime is covered by your plan.

24. How long does Xtrapime stay in your system?

Xtrapime is usually eliminated from your system within 2-4 days. However, this may vary depending on factors such as your age, kidney function, and the dosage you take. Be sure to discuss this with your doctor.

25. Can Xtrapime be used to treat a kidney infection?

Yes, Xtrapime can be used to treat a kidney infection if it is caused by a bacterial infection. Your doctor may suggest other antibiotics as well.

26. Can Xtrapime be used to treat a urinary tract infection?

Yes, Xtrapime can be used to treat a urinary tract infection (UTI). Your doctor will determine if Xtrapime is appropriate to treat your UTI.

27. Can Xtrapime be used to treat a bacterial meningitis infection?

Yes, Xtrapime is sometimes used to treat a bacterial meningitis infection. However, if you have a meningitis infection, it is important to discuss the best treatment options with your doctor.

28. Can I take Xtrapime with ibuprofen?

Yes, Xtrapime and ibuprofen can be taken together. However, if you have any questions, be sure to talk to your doctor or pharmacist.

29. Can Xtrapime be used to treat Gonorrhea?

Yes, Xtrapime is sometimes used to treat gonorrhea. However, it is important to discuss your treatment options with your doctor.

30. Is Xtrapime an over-the-counter medication?

No, Xtrapime is not an over-the-counter medication. It is only available with a prescription from your doctor.