Tenafet
Tenafet Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Tenafet is a brand name. Its generic name is Cefetamet Pivoxil Hydrochloride.
Introduction
Tenafet (Chemat) is an antibiotic in the cephalosporin class indicated for the treatment of a variety of infections caused by gram-positive bacteria. It is administered orally, often in combination with other drugs.Uses for
Tenafet is used for the treatment of infections caused by susceptible strains of the following microorganisms:- Gram-positive bacteria, including streptococci and staphylococci
- Gram-negative bacteria, including Enterobacteriaceae and Haemophilus influenzae
- Anaerobes, including Bacteroides fragilis
- Respiratory tract infections including pharyngitis, tonsillitis, bronchitis, community-acquired pneumonia, and sinusitis
- Skin and skin structure infections
- Lower urinary tract infections
- Bone and joint infections
Mechanism of action
Tenafet is a bactericidal cephalosporin that works by inhibiting the synthesis of bacterial cell walls. It works mainly by stopping the growth of the bacteria allowing your body’s immune system to fight the infection.How long does it take to work?
Tenafet generally takes at least 48 hours to work and the infection should improve over 5 to 7 days of treatment. However, the exact time may vary depending on the severity of the infection and how well the patient responds to the medication.Absorption
Tenafet is absorbed rapidly when taken orally, with maximum plasma concentrations attained in 1-2 hours. Its bioavailability is approximately 70%.Route of elimination
Tenafet is eliminated primarily in the urine via glomerular filtration and tubular secretion. Its half-life is approximately 4 hours.Dosage
The dosage of Tenafet varies according to the patient's age, weight and the type and severity of the infection being treated. The usual adult dose ranges from 250mg to 500mg every 12 hours for mild to moderate infections, and up to 2g every 12 hours for more severe infections. The usual dose for children is 20 to 40mg/kg/day given in two divided doses.Administration
Tenafet is usually taken orally, one or two times a day with or without food.Side effect
Common side effects of Tenafet include, but are not limited to, nausea, vomiting, diarrhea, abdominal pain, and rash. More serious side effects may include allergic reactions such as hives, skin rash, breathing difficulties, and fever. If any of these effects persist or worsen, seek medical attention.Toxicity
Tenafet is generally well tolerated with few adverse reactions. There is no known specific antidote for an overdose. Treatment should be symptomatic and supportive and may require discontinuation of Tenafet and/or other supportive measures.Precaution
Tenafet can cause increased sensitivity to the sun, so it is important to apply sunscreen for protection and to limit sun exposure during treatment. Pregnant women and nursing mothers should consult their doctor before taking Tenafet.Interaction
The drug interaction of Tenafet with other drugs has not been fully explored; however, it is known to be incompatible with penicillins, and may increase the effects of theophylline and probenecid. Patients taking Tenafet should inform their doctor of any other medications they are taking, including over-the-counter drugs, vitamins and herbal supplements.Disease interaction
Tenafet can interact with certain diseases. Patients with kidney disease may need lower doses of the drug and patients with liver disease should avoid using it. Patients with diabetes should also be monitored closely when taking Tenafet as it may affect blood sugar levels.Drug interaction
Tenafet should not be taken at the same time as penicillins as it may reduce the effectiveness of the latter. It may also interact with anticoagulants, other antibiotics, theophylline, probenecid, and cimetidine.Food interactions
Tenafet may be taken with or without food. Patients should avoid taking it with dairy products as they may reduce its absorption.Pregnancy use
Tenafet should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.Lactation use
Tenafet is not recommended during breastfeeding as it can pass into breast milk and may cause adverse effects in infants.Acute overdose
There is no known specific antidote for an overdose of Tenafet. Treatment should be symptomatic and supportive and may require discontinuation of Tenafet and/or other supportive measures.Contraindication
Tenafet should not be taken by patients with known hypersensitivity to cephalosporin antibiotics.Use direction
Tenafet should be taken as prescribed by the healthcare provider. The usual adult dose ranges from 250mg to 500mg every 12 hours for mild to moderate infections, and up to 2g every 12 hours for more severe infections. The medication should be taken with or without food, and should not be taken with any dairy products.Storage condition
Tenafet should be stored at room temperature between 15°C and 30°C in a tightly sealed container.Volume of distribution
The volume of distribution of Tenafet is 0.6 to 0.7 L/kg.Half life
Tenafet has a half-life of approximately 4 hours.Clearance
The clearance of Tenafet is 0.2 to 0.3 mL/min/kg.Here you find in details version of Tenafet