Trimotil

Trimotil Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Trimotil is a brand name. Its generic name is Trimebutine.

Introduction

Trimotil is a muscarinic agonist and antimuscarinic drug used in the treatment of irritable bowel syndrome. It is a synthetic derivative of thebaine, an opium alkaloid, and is available as a prescription drug in many countries.

Uses

Trimotil is used to treat irritable bowel syndrome and as an antidiarrheal. It is also used to treat digestive pain caused by spasms of the digestive system.

Mechanism of action

Trimotil works by acting as an agonist of the muscarinic receptors. It promotes relaxation of smooth muscle cells in the intestines, thus reducing symptoms of GI motility disorders such as pain, cramps, and spasms. Additionally, trimebutine has anti-diarrheal properties as it reduces the secretory activity in cells of the GI tract.

How long does it take to work?

Trimotil begins to act within 30 minutes of administration, and its full effects are usually seen within 1-2 hours.

Absorption

Trimotil is readily absorbed in the intestines and is largely metabolised in the liver. It is then distributed in the body and crosses the placental barrier.

Route of Elimination

Trimotil is eliminated mainly in the urine, in trace amounts, and in faeces.

Dosage

The usual dose of Trimotil for adults and children over 12 is 1 tablet (200mg) taken 3 times daily, after meals. For children aged 6-12 years, the dose is 1 tablet (100mg) taken 2-3 times daily, after meals. The total daily dose should not exceed 600mg.

Administration

Trimotil should be taken orally, with or without food, as prescribed by your doctor. The tablets should be swallowed whole, without crushing or chewing.

Side-Effects

The most common side effects of Trimotil are nausea, diarrhoea, dizziness, constipation, dry mouth, headache and fatigue. Rarely, more serious side effects may occur, such as jaundice, skin rash, and difficulty breathing. If you experience any of these side effects, contact your doctor immediately.

Toxicity

Trimotil is relatively safe even at higher doses. However, prolonged use of Trimotil may cause liver damage, so patients should be monitored for signs and symptoms of liver injury.

Precautions

Patients with certain medical conditions, such as liver or kidney disease, should use Trimotil with caution. Additionally, Trimotil should be used with caution in patients taking other medications, as it may interact with certain drugs.

Interactions

Trimotil may interact with certain drugs, including anticoagulants, antihypertensives, digoxin, and antiepileptic drugs. It can also interact with food, resulting in reduced absorption of the drug. Additionally, Trimotil may interact with certain herbal remedies, such as St. John's Wort.

Disease Interactions

Trimotil should be used with caution in patients with kidney or liver impairment, as it could worsen the condition. Additionally, it should not be used by patients with a history of epileptic seizures.

Drug Interactions

Trimotil may interact with certain drugs, including anticoagulants, antihypertensives, digoxin, and antiepileptic drugs. It may also interact with drugs metabolised by the cytochrome P450 enzyme system, or with drugs that affect the GI tract.

Food Interactions

Trimotil should be taken at least 30 minutes before or after meals, as food may impair its absorption. It should be avoided with foods high in calcium, as calcium may reduce the absorption of the drug.

Pregnancy Use

Trimotil should not be used by pregnant women, as it may be harmful to the unborn baby. It is classified as “Pregnancy Category B” by the US FDA, which means it is not expected to be harmful to an unborn baby.

Lactation Use

Trimotil is excreted in breast milk and should therefore be used with caution in breastfeeding women.

Acute Overdose

An overdose of Trimotil may result in symptoms such as drowsiness, confusion, seizures, shallow breathing, and coma. An acute overdose should be treated by symptomatic and supportive measures. Gastric lavage may be used to remove any unabsorbed drug.

Contraindication

Trimotil should not be used by patients with a history of glaucoma, bladder obstruction, or urinary retention. It should also be avoided in patients who are allergic to the drug or to any of its components.

Use Direction

Trimotil should be used according to the directions on the prescription label, or as prescribed by your doctor. The tablets should be swallowed whole, without crushing or chewing, and should not be taken with food.

Storage Condition

Trimotil tablets should be stored at room temperature, away from light and moisture. They should not be stored in the refrigerator or bathroom.

Volume of Distribution

The volume of distribution for Trimotil is 0.77 L/kg.

Half-Life

The elimination half-life of Trimotil is approximately 6 hours.

Clearance

The clearance rate of Trimotil is 97.4 ml/min./kg.

Here you find in details version of Trimotil

Some Frequently Asked Questions About Trimotil

What is Trimotil?

Trimotil is a medication used to treat symptoms of irritable bowel syndrome, including abdominal pain, cramps, and spasms. It is also sometimes used to treat other gastrointestinal disorders.

What are the common side effects of Trimotil?

The most common side effects of trimebutine include nausea, stomach discomfort or pain, headache, dizziness, and drowsiness. Less common side effects include dry mouth, constipation, and increased appetite.

How should Trimotil be taken?

It is usually taken twice a day, either in the morning and evening, or twelve hours apart. It should be taken with food or a snack to reduce the risk of stomach upset.

Who should not take Trimotil?

Trimotil should not be taken by pregnant or nursing women, people who have had a recent heart attack or stroke, those taking certain medications, and those with certain medical conditions, such as liver or kidney disease.

What should I do if I miss a dose of Trimotil?

If you miss a dose of trimebutine, take it as soon as possible. If it is close to your next scheduled dose, skip the missed dose and take the next dose at the regular time.

How long does it take for Trimotil to work?

It typically takes several days or weeks for Trimotil to start working. It is important to take it as directed and not stop taking it suddenly, as doing so may make your symptoms worse.

Can Trimotil be used long-term?

Trimotil can be used long-term, however, it is important to discuss the risks and benefits of long-term use with your doctor.

Is Trimotil safe for use in children?

Trimotil is not recommended for use in children under the age of six years. If your child is older than six and needs to take Trimotil, it is important to discuss the possible risks and benefits of the medication with your doctor.

What other medications should not be taken with Trimotil?

Trimotil should not be used with certain medications, such as anticholinergics, anticonvulsants, oral contraceptives, and certain antibiotics. It is important to discuss all of your medications with your doctor or pharmacist.

What should I do if I experience side effects from Trimotil?

If you experience side effects from Trimotil, it is important to contact your doctor or pharmacist. They can adjust the dose or suggest alternative medications if necessary.

Should Trimotil be taken with or without food?

Trimotil should be taken with food or a snack to reduce the risk of stomach irritation or discomfort.

Can Trimotil be used for conditions other than irritable bowel syndrome?

Yes, Trimotil is sometimes used to treat other gastrointestinal disorders, such as gastroparesis. It is important to discuss this use with your doctor.

Does Trimotil cause drowsiness?

Yes, Trimotil can cause drowsiness in some people. It is important to discuss any potential side effects with your doctor before taking the medication.

Can I drink alcohol while taking Trimotil?

It is best to avoid drinking alcohol while taking Trimotil. Alcohol can increase the effects of the medication and may increase the risk of side effects.

Is Trimotil addictive?

No, Trimotil is not considered to be addictive.

What should I do if I overdose on Trimotil?

If you or someone else has overdosed on Trimotil, it is important to seek immediate medical attention. Symptoms of an overdose may include dizziness, drowsiness, nausea, and vomiting.

Is Trimotil available over-the-counter?

No, Trimotil is a prescription medication and is not available over-the-counter.

How long can I take Trimotil for?

Trimotil is usually taken for a short period of time, though it can be taken long-term. It is important to discuss the risks and benefits with your doctor.

How long does Trimotil stay in the body?

Trimotil has a half-life of approximately 8 hours, meaning it takes about 8 hours for half of the drug to be eliminated from the body.

What are the possible interactions between Trimotil and other medications?

It is important to inform your doctor of all medications and supplements you are taking, as Trimotil can interact with certain medications, such as anticholinergics, anticonvulsants, oral contraceptives, and certain antibiotics.

Can Trimotil be taken with antacids?

Yes, Trimotil can be taken with antacids. However, it is important to check with your doctor or pharmacist before taking any other medications while taking Trimotil.

What if I forget to take my dose of Trimotil?

If you forget to take your dose of Trimotil, take it as soon as possible. If it is close to your next scheduled dose, skip the missed dose and take the next dose at the regular time.

Is Trimotil available in generic form?

Yes, Trimotil is available as a generic medication.

Does Trimotil need to be taken with food?

Yes, Trimotil should be taken with food or a snack to reduce the risk of stomach upset.

Does Trimotil help with symptoms of IBS?

Yes, Trimotil is indicated for the treatment of symptoms of irritable bowel syndrome, including abdominal pain, cramps, and spasms.

When should I take Trimotil?

Trimotil is usually taken twice a day, either in the morning and evening, or twelve hours apart.

What other conditions might Trimotil be used for?

Trimotil is sometimes used to treat other gastrointestinal disorders, such as gastroparesis. It is important to discuss this use with your doctor.

What are the potential adverse effects of Trimotil?

The most common side effects of trimebutine include nausea, stomach discomfort or pain, headache, dizziness, and drowsiness. Less common side effects include dry mouth, constipation, and increased appetite.

Can Trimotil be used to treat digestive disorders?

Yes, Trimotil is sometimes used to treat other gastrointestinal disorders, such as gastroparesis. It is important to discuss this use with your doctor.

Can Trimotil be taken with other medications?

It is important to inform your doctor of all medications and supplements you are taking, as Trimotil can interact with certain medications, such as anticholinergics, anticonvulsants, oral contraceptives, and certain antibiotics.

Is Trimotil safe to take while pregnant?

No, Trimotil is not recommended for pregnant or nursing women. It is important to discuss any potential risks and benefits with your doctor.

Is there anything I should avoid while taking Trimotil?

It is best to avoid drinking alcohol while taking Trimotil. Alcohol can increase the effects of the medication and may increase the risk of side effects.

Is Trimotil also known by other names?

Yes, Trimotil is also known by its generic name, trimebutin.

Can Trimotil cause diarrhea?

Yes, Trimotil can cause diarrhea in some people. If this happens, it is important to contact your doctor.

Is Trimotil safe to take long-term?

Trimotil can be used long-term, however, it is important to discuss the risks and benefits of long-term use with your doctor.

What should I do if I experience an allergic reaction to Trimotil?

If you experience an allergic reaction to Trimotil, such as rash, itching, swelling, or difficulty breathing, it is important to seek emergency medical help immediately.

Is Trimotil habit-forming?

No, Trimotil is not considered to be habit-forming.

Can I take Trimotil if I have liver or kidney disease?

No, Trimotil should not be taken by those with liver or kidney disease. It is important to discuss any potential risks and benefits with your doctor.

Does Trimotil cause constipation?

Yes, Trimotil can cause constipation in some people. If this occurs, it is important to contact your doctor.

Is Trimotil available as a generic medication?

Yes, Trimotil is available as a generic medication.

What is the recommended dosage of Trimotil?

The recommended dosage of Trimotil will vary depending on the individual patient. It is important to take it as directed by your doctor or pharmacist.