Tocit XR
Tocit XR Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Tocit XR is a brand name. Its generic name is Tofacitinib.
Introduction
Tocit XR is an inhibitor of the Janus kinase (JAK) family of enzymes. It is used to treat rheumatoid arthritis (RA) and psoriatic arthritis. It works by inhibiting the activation of signal transduction proteins involved in the overproduction of pro-inflammatory proteins. It is classified as a "biologic" medication, meaning that it is made up of genetically engineered proteins.
Uses
Tocit XR is used to treat adults with active rheumatoid arthritis (RA). It can also be used to treat psoriatic arthritis in adults. Tocit XR can reduce the signs and symptoms of RA and help improve physical function.
Mechanism of Action
Tocit XR works by inhibiting the Janus kinase (JAK) family of enzymes. JAKs are involved in the activation of signal transduction proteins involved in the overproduction of pro-inflammatory proteins. By inhibiting the action of the JAKs, tofacitinib decreases the production of these pro-inflammatory proteins, relieving the symptoms of RA and psoriatic arthritis.
How Long Does it Take to Work?
The time it takes for tofacitinib to show its effects varies from person to person. Most patients experience relief of RA symptoms within 2 to 3 weeks of initiation of treatment. This duration may be shorter or longer in some individuals.
Absorption
Tocit XR is rapidly absorbed after oral consumption with a median of 1 hour. The drug is readily absorbed from the gastrointestinal tract, with no evidence of altered absorption due to food intake.
Route of Elimination
Tocit XR is primarily eliminated via metabolism in the liver. The metabolites of tofacitinib are excreted via urine and bile.
Dosage
Tocit XR is available in 5 mg, 10 mg, 15 mg, and 30 mg tablets and is taken orally, usually twice daily. Patients may start with a lower dose and increase it gradually depending on their response and tolerance. The maximum recommended daily dose is 15 mg twice daily. The dose should be reduced in patients with impaired renal function.
Administration
Tocit XR should be taken orally, with or without food, usually twice daily. It should be taken at the same time each day as prescribed by the physician. It is important to take tofacitinib exactly as prescribed by the doctor.
Side Effects
The common side effects associated with tofacitinib use are gastrointestinal upset, headaches, low blood pressure, and elevated liver enzymes. Serious side effects associated with tofacitinib include increased risk of infection, worsening of the underlying disease, and increased risk of blood clots.
Toxicity
Tocit XR has not been associated with any reported cases of toxicity in humans. However, due to its mechanism of action, it may lead to increased susceptibility to certain infections.
Precaution
Tocit XR should be used with caution in patients with impaired renal function. It is important to monitor patients closely for signs and symptoms of infection and worsening of the underlying disease. Patients should be advised to inform their doctor if they develop any signs or symptoms of infection.
Interaction
Tocit XR may interact with other medications, including warfarin, cyclosporine, antifungal medications, and methotrexate. It is important for patients to inform their doctor about any medications they may be taking prior to starting tofacitinib.
Disease Interaction
Tocit XR may interact with other diseases, including certain types of cancer, making them more likely to recur or worsen. It is important to discuss any existing medical conditions with the doctor prior to starting tofacitinib.
Drug Interaction
Tocit XR may interact with other drugs, affecting their effectiveness or increasing their potential side effects. It is important to inform the doctor of any medications the patient is taking prior to starting tofacitinib, and to continue to monitor for possible interactions during treatment.
Food Interactions
Tocit XR is not known to interact with food.
Pregnancy Use
Tocit XR has not been studied in pregnant women. It is important to discuss the risks and benefits of taking tofacitinib with the doctor prior to considering use during pregnancy.
Lactation Use
Data regarding the use of tofacitinib in lactating mothers is lacking. Therefore, it is important to discuss the risks and benefits of taking tofacitinib with the doctor prior to considering use while breastfeeding.
Acute Overdose
No cases of acute overdose of tofacitinib have been reported. However, due to its mechanism of action, it is important to contact a doctor or seek emergency medical help if too much occurs.
Contraindication
Tocit XR is contraindicated in patients with a known hypersensitivity to tofacitinib or any of its components. It is also contraindicated in patients with active serious infections or a history of severe infections.
Use Direction
Tocit XR should be taken exactly as prescribed by the doctor. The dose may be increased or decreased depending on the response and tolerance. It is important to take it at the same time each day with or without food.
Storage Condition
Tocit XR should be stored at room temperature, away from direct light and moisture. It should not be exposed to extremes of temperature.
Volume of Distribution
The volume of distribution for tofacitinib is estimated to be approximately 189 L.
Half Life
The half life of tofacitinib is approximately 5 to 10 hours.
Clearance
Tocit XR has an estimated total clearance of approximately 20.7 mL/min.
Here you find in details version of Tocit XR
Some Frequently Asked Questions About Tocit XR
What is Tocit XR?
Tocit XR is a prescription medication used to treat Rheumatoid Arthritis (RA). It belongs to a class of drugs called Janus kinase (JAK) inhibitors. Tocit XR helps to reduce inflammation and relieve joint pain associated with RA.
What does Tocit XR treat?
Tocit XR is indicated for the treatment of moderately to severely active rheumatoid arthritis (RA) in adults who have had an inadequate response to one or more disease modifying anti-rheumatic drugs (DMARDs).
How does Tocit XR work?
Tocit XR works by blocking certain enzymes in the body called JAKs (Janus kinase enzymes). These enzymes are involved in the inflammatory process in RA. By blocking these enzymes, tofacitinib helps reduce inflammation and improve symptoms of RA.
What are the side effects of Tocit XR?
The most common side effects of Tocit XR include upper respiratory infection, nasopharyngitis, headache, diarrhea, elevated cholesterol levels and increased risk of infections, especially of your upper respiratory tract, skin, and urinary system.
Is Tocit XR safe?
Tocit XR is generally considered safe when taken as prescribed. Do not take more or less than the recommended dose, as this may increase the risk of side effects or make the medication less effective. You should also avoid taking other medications or supplements at the same time without consulting your doctor.
How long does it take for Tocit XR to work?
The effects of Tocit XR may vary from person to person, but typically patients can experience relief of symptoms within a few weeks to months. It usually takes up to 3-6 months to reach the full effectiveness of the medication.
Does Tocit XR have any drug interactions?
Yes, there are certain drugs that should not be taken with Tocit XR, such as CYP3A4 inhibitors, CYP3A4 inducers, PPIs, and antifungals. Be sure to talk to your doctor before taking any new medications or supplements while taking Tocit XR.
How long can I take Tocit XR?
It is generally recommended that Tocit XR be taken for as long as it is clinically effective or until methotrexate or other DMARDs can be resumed. Be sure to speak with your doctor regularly to evaluate the effectiveness of the medication.
What should I avoid while taking Tocit XR?
You should avoid taking any prescription medications or over-the-counter supplements without consulting your doctor. You should also avoid drinking alcohol, smoking, and taking illegal drugs while taking Tocit XR.
Is Tocit XR covered by insurance?
Certain health insurance plans may cover Tocit XR. Check with your insurance provider to understand your coverage and any other out-of-pocket costs.
Are there any alternatives to Tocit XR?
Yes, there are other medications available to treat RA. Biologic DMARDs (Disease Modifying Anti-Rheumatic Drugs) such as etanercept, adalimumab, and infliximab, as well as traditional DMARDs such as methotrexate, leflunomide and hydroxychloroquine may be taken as alternatives to Tocit XR.
Is Tocit XR effective?
Clinical research has shown that Tocit XR is effective in reducing the symptoms of RA and helping to maintain remission. It is important to seek treatment as soon as possible and to follow your doctor's recommended treatment plan.
When should I take Tocit XR?
Take Tocit XR as prescribed by your doctor. For the tablets, take with food, and for the oral solution, shake well before use. Tocit XR may be taken with or without food.
Can I take Tocit XR while pregnant?
No, it is not recommended to take Tocit XR during pregnancy. Talk to your doctor about alternative treatments during pregnancy.
Is Tocit XR a steroid?
No, Tocit XR is not a steroid. It is an oral medication that belongs to a class of drugs called JAK (Janus Kinase) inhibitors.
Does Tocit XR have any other benefits?
Tocit XR may also help reduce risk of joint damage and help to improve physical function. Additionally, research has shown that it may reduce the risk of serious infections due to RA.
Can Tocit XR be taken with other medications?
Tocit XR can be taken with some other medications, however it is important to speak with your doctor before taking any new medications or supplements. Certain drugs should not be taken with Tocit XR including antifungals, CYP3A4 inhibitors, CYP3A4 inducers, and PPIs.
Are there any long-term effects of Tocit XR?
The long-term effects of Tocit XR are not fully known. Speak with your doctor about your individual risks and benefits of taking Tocit XR.
What is the recommended dosage of Tocit XR?
The recommended dosage of Tocit XR is 5mg taken twice daily. Speak with your doctor about any dose changes.
Can I just stop taking Tocit XR?
No, do not stop taking Tocit XR without consulting your doctor. Speak with your doctor about gradually reducing and eventually stopping your medication.
Can I take Tocit XR if I have an infection?
No, you should not take Tocit XR if you have an active infection. Be sure to speak with your doctor to discuss any other treatments or medications that you may need while you are infected.
Does Tocit XR have any serious side effects?
Tocit XR may cause serious side effects. Call your doctor right away if you have signs of infection (fever, chills, body aches, cough, sore throat, etc.), signs of an allergic reaction (rash, itching, swelling, and difficulty breathing) or signs of low white blood cell count (frequent or severe infections).
Does Tocit XR cause weight gain?
Weight gain is a rare side effect of Tocit XR, but it can occur. If you experience any signs of weight gain, speak with your doctor.
Do I need to have regular blood tests while taking Tocit XR?
Your doctor may recommend regular blood tests while taking Tocit XR. This is to monitor your white blood cell count and other clinical laboratory tests. Be sure to keep all of your appointments for blood work and doctor visits.
What if I miss a dose of Tocit XR?
If you miss a dose of Tocit XR, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and take the next dose at the regular time. Do not take two doses at once.
Can Tocit XR make it harder to fight infections?
Yes, Tocit XR can make it harder to fight infections. Be sure to take precautions to avoid infection including getting a flu shot, washing your hands often, and avoiding contact with people who are sick. Speak with your doctor if you have any signs of infection.
Is Tocit XR available as a generic drug?
No, Tocit XR is not available as a generic drug.
What kind of research has been done on Tocit XR?
Several clinical trials have been conducted evaluating the efficacy and safety of Tocit XR for the treatment of moderate to severe Rheumatoid Arthritis (RA). Results of these trials have demonstrated that patients taking Tocit XR had improved symptom relief and decreased joint inflammation.
Can Tocit XR be used to treat other conditions?
Tocit XR is only approved for the treatment of moderate to severe Rheumatoid Arthritis (RA). It is not approved for any other conditions.
Is Tocit XR used to treat juvenile arthritis?
No, Tocit XR is not approved for use in children under the age of 18, and is not recommended for the treatment of juvenile arthritis. Speak with your doctor about other treatments that may be available.
Does Tocit XR cause joint pain?
Tocit XR is generally used to help reduce joint pain caused by Rheumatoid Arthritis. However, it is possible that some people may experience joint pain as a side effect of Tocit XR. Speak with your doctor if you experience any persistent joint pain.
Can I take Tocit XR with ibuprofen?
It is not recommended to take Tocit XR with ibuprofen. Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) and may increase the risk of side effects. Speak with your doctor about other medications that may be appropriate to take with Tocit XR.
Does Tocit XR cause hair loss?
Hair loss is a rare side effect of Tocit XR. If you experience any signs of hair loss, talk to your doctor.
Can I take Tocit XR if I am taking other medications?
It is important to speak with your doctor before taking Tocit XR with any other medications. Certain medications can interact with Tocit XR and should be avoided, including antifungals, CYP3A4 inhibitors, CYP3A4 inducers, and PPIs.
Are there any clinical studies that have been conducted using Tocit XR?
Yes, several clinical trials have been conducted evaluating the safety and efficacy of Tocit XR for the treatment of moderate to severe Rheumatoid Arthritis (RA).