Tofanib

Tofanib Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Tofanib is a brand name. Its generic name is Tofacitinib.

Introduction

Tofanib is an inhibitor of the Janus kinase (JAK) family of enzymes. It is used to treat rheumatoid arthritis (RA) and psoriatic arthritis. It works by inhibiting the activation of signal transduction proteins involved in the overproduction of pro-inflammatory proteins. It is classified as a "biologic" medication, meaning that it is made up of genetically engineered proteins.

Uses

Tofanib is used to treat adults with active rheumatoid arthritis (RA). It can also be used to treat psoriatic arthritis in adults. Tofanib can reduce the signs and symptoms of RA and help improve physical function.

Mechanism of Action

Tofanib works by inhibiting the Janus kinase (JAK) family of enzymes. JAKs are involved in the activation of signal transduction proteins involved in the overproduction of pro-inflammatory proteins. By inhibiting the action of the JAKs, tofacitinib decreases the production of these pro-inflammatory proteins, relieving the symptoms of RA and psoriatic arthritis.

How Long Does it Take to Work?

The time it takes for tofacitinib to show its effects varies from person to person. Most patients experience relief of RA symptoms within 2 to 3 weeks of initiation of treatment. This duration may be shorter or longer in some individuals.

Absorption

Tofanib is rapidly absorbed after oral consumption with a median of 1 hour. The drug is readily absorbed from the gastrointestinal tract, with no evidence of altered absorption due to food intake.

Route of Elimination

Tofanib is primarily eliminated via metabolism in the liver. The metabolites of tofacitinib are excreted via urine and bile.

Dosage

Tofanib is available in 5 mg, 10 mg, 15 mg, and 30 mg tablets and is taken orally, usually twice daily. Patients may start with a lower dose and increase it gradually depending on their response and tolerance. The maximum recommended daily dose is 15 mg twice daily. The dose should be reduced in patients with impaired renal function.

Administration

Tofanib should be taken orally, with or without food, usually twice daily. It should be taken at the same time each day as prescribed by the physician. It is important to take tofacitinib exactly as prescribed by the doctor.

Side Effects

The common side effects associated with tofacitinib use are gastrointestinal upset, headaches, low blood pressure, and elevated liver enzymes. Serious side effects associated with tofacitinib include increased risk of infection, worsening of the underlying disease, and increased risk of blood clots.

Toxicity

Tofanib has not been associated with any reported cases of toxicity in humans. However, due to its mechanism of action, it may lead to increased susceptibility to certain infections.

Precaution

Tofanib should be used with caution in patients with impaired renal function. It is important to monitor patients closely for signs and symptoms of infection and worsening of the underlying disease. Patients should be advised to inform their doctor if they develop any signs or symptoms of infection.

Interaction

Tofanib may interact with other medications, including warfarin, cyclosporine, antifungal medications, and methotrexate. It is important for patients to inform their doctor about any medications they may be taking prior to starting tofacitinib.

Disease Interaction

Tofanib may interact with other diseases, including certain types of cancer, making them more likely to recur or worsen. It is important to discuss any existing medical conditions with the doctor prior to starting tofacitinib.

Drug Interaction

Tofanib may interact with other drugs, affecting their effectiveness or increasing their potential side effects. It is important to inform the doctor of any medications the patient is taking prior to starting tofacitinib, and to continue to monitor for possible interactions during treatment.

Food Interactions

Tofanib is not known to interact with food.

Pregnancy Use

Tofanib has not been studied in pregnant women. It is important to discuss the risks and benefits of taking tofacitinib with the doctor prior to considering use during pregnancy.

Lactation Use

Data regarding the use of tofacitinib in lactating mothers is lacking. Therefore, it is important to discuss the risks and benefits of taking tofacitinib with the doctor prior to considering use while breastfeeding.

Acute Overdose

No cases of acute overdose of tofacitinib have been reported. However, due to its mechanism of action, it is important to contact a doctor or seek emergency medical help if too much occurs.

Contraindication

Tofanib is contraindicated in patients with a known hypersensitivity to tofacitinib or any of its components. It is also contraindicated in patients with active serious infections or a history of severe infections.

Use Direction

Tofanib should be taken exactly as prescribed by the doctor. The dose may be increased or decreased depending on the response and tolerance. It is important to take it at the same time each day with or without food.

Storage Condition

Tofanib should be stored at room temperature, away from direct light and moisture. It should not be exposed to extremes of temperature.

Volume of Distribution

The volume of distribution for tofacitinib is estimated to be approximately 189 L.

Half Life

The half life of tofacitinib is approximately 5 to 10 hours.

Clearance

Tofanib has an estimated total clearance of approximately 20.7 mL/min.

Here you find in details version of Tofanib

Some Frequently Asked Questions About Tofanib

What is Tofanib?

Tofanib is a prescription medication used to treat Rheumatoid Arthritis (RA). It belongs to a class of drugs called Janus kinase (JAK) inhibitors. Tofanib helps to reduce inflammation and relieve joint pain associated with RA.

What does Tofanib treat?

Tofanib is indicated for the treatment of moderately to severely active rheumatoid arthritis (RA) in adults who have had an inadequate response to one or more disease modifying anti-rheumatic drugs (DMARDs).

How does Tofanib work?

Tofanib works by blocking certain enzymes in the body called JAKs (Janus kinase enzymes). These enzymes are involved in the inflammatory process in RA. By blocking these enzymes, tofacitinib helps reduce inflammation and improve symptoms of RA.

What are the side effects of Tofanib?

The most common side effects of Tofanib include upper respiratory infection, nasopharyngitis, headache, diarrhea, elevated cholesterol levels and increased risk of infections, especially of your upper respiratory tract, skin, and urinary system.

Is Tofanib safe?

Tofanib is generally considered safe when taken as prescribed. Do not take more or less than the recommended dose, as this may increase the risk of side effects or make the medication less effective. You should also avoid taking other medications or supplements at the same time without consulting your doctor.

How long does it take for Tofanib to work?

The effects of Tofanib may vary from person to person, but typically patients can experience relief of symptoms within a few weeks to months. It usually takes up to 3-6 months to reach the full effectiveness of the medication.

Does Tofanib have any drug interactions?

Yes, there are certain drugs that should not be taken with Tofanib, such as CYP3A4 inhibitors, CYP3A4 inducers, PPIs, and antifungals. Be sure to talk to your doctor before taking any new medications or supplements while taking Tofanib.

How long can I take Tofanib?

It is generally recommended that Tofanib be taken for as long as it is clinically effective or until methotrexate or other DMARDs can be resumed. Be sure to speak with your doctor regularly to evaluate the effectiveness of the medication.

What should I avoid while taking Tofanib?

You should avoid taking any prescription medications or over-the-counter supplements without consulting your doctor. You should also avoid drinking alcohol, smoking, and taking illegal drugs while taking Tofanib.

Is Tofanib covered by insurance?

Certain health insurance plans may cover Tofanib. Check with your insurance provider to understand your coverage and any other out-of-pocket costs.

Are there any alternatives to Tofanib?

Yes, there are other medications available to treat RA. Biologic DMARDs (Disease Modifying Anti-Rheumatic Drugs) such as etanercept, adalimumab, and infliximab, as well as traditional DMARDs such as methotrexate, leflunomide and hydroxychloroquine may be taken as alternatives to Tofanib.

Is Tofanib effective?

Clinical research has shown that Tofanib is effective in reducing the symptoms of RA and helping to maintain remission. It is important to seek treatment as soon as possible and to follow your doctor's recommended treatment plan.

When should I take Tofanib?

Take Tofanib as prescribed by your doctor. For the tablets, take with food, and for the oral solution, shake well before use. Tofanib may be taken with or without food.

Can I take Tofanib while pregnant?

No, it is not recommended to take Tofanib during pregnancy. Talk to your doctor about alternative treatments during pregnancy.

Is Tofanib a steroid?

No, Tofanib is not a steroid. It is an oral medication that belongs to a class of drugs called JAK (Janus Kinase) inhibitors.

Does Tofanib have any other benefits?

Tofanib may also help reduce risk of joint damage and help to improve physical function. Additionally, research has shown that it may reduce the risk of serious infections due to RA.

Can Tofanib be taken with other medications?

Tofanib can be taken with some other medications, however it is important to speak with your doctor before taking any new medications or supplements. Certain drugs should not be taken with Tofanib including antifungals, CYP3A4 inhibitors, CYP3A4 inducers, and PPIs.

Are there any long-term effects of Tofanib?

The long-term effects of Tofanib are not fully known. Speak with your doctor about your individual risks and benefits of taking Tofanib.

What is the recommended dosage of Tofanib?

The recommended dosage of Tofanib is 5mg taken twice daily. Speak with your doctor about any dose changes.

Can I just stop taking Tofanib?

No, do not stop taking Tofanib without consulting your doctor. Speak with your doctor about gradually reducing and eventually stopping your medication.

Can I take Tofanib if I have an infection?

No, you should not take Tofanib if you have an active infection. Be sure to speak with your doctor to discuss any other treatments or medications that you may need while you are infected.

Does Tofanib have any serious side effects?

Tofanib may cause serious side effects. Call your doctor right away if you have signs of infection (fever, chills, body aches, cough, sore throat, etc.), signs of an allergic reaction (rash, itching, swelling, and difficulty breathing) or signs of low white blood cell count (frequent or severe infections).

Does Tofanib cause weight gain?

Weight gain is a rare side effect of Tofanib, but it can occur. If you experience any signs of weight gain, speak with your doctor.

Do I need to have regular blood tests while taking Tofanib?

Your doctor may recommend regular blood tests while taking Tofanib. This is to monitor your white blood cell count and other clinical laboratory tests. Be sure to keep all of your appointments for blood work and doctor visits.

What if I miss a dose of Tofanib?

If you miss a dose of Tofanib, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and take the next dose at the regular time. Do not take two doses at once.

Can Tofanib make it harder to fight infections?

Yes, Tofanib can make it harder to fight infections. Be sure to take precautions to avoid infection including getting a flu shot, washing your hands often, and avoiding contact with people who are sick. Speak with your doctor if you have any signs of infection.

Is Tofanib available as a generic drug?

No, Tofanib is not available as a generic drug.

What kind of research has been done on Tofanib?

Several clinical trials have been conducted evaluating the efficacy and safety of Tofanib for the treatment of moderate to severe Rheumatoid Arthritis (RA). Results of these trials have demonstrated that patients taking Tofanib had improved symptom relief and decreased joint inflammation.

Can Tofanib be used to treat other conditions?

Tofanib is only approved for the treatment of moderate to severe Rheumatoid Arthritis (RA). It is not approved for any other conditions.

Is Tofanib used to treat juvenile arthritis?

No, Tofanib is not approved for use in children under the age of 18, and is not recommended for the treatment of juvenile arthritis. Speak with your doctor about other treatments that may be available.

Does Tofanib cause joint pain?

Tofanib is generally used to help reduce joint pain caused by Rheumatoid Arthritis. However, it is possible that some people may experience joint pain as a side effect of Tofanib. Speak with your doctor if you experience any persistent joint pain.

Can I take Tofanib with ibuprofen?

It is not recommended to take Tofanib with ibuprofen. Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) and may increase the risk of side effects. Speak with your doctor about other medications that may be appropriate to take with Tofanib.

Does Tofanib cause hair loss?

Hair loss is a rare side effect of Tofanib. If you experience any signs of hair loss, talk to your doctor.

Can I take Tofanib if I am taking other medications?

It is important to speak with your doctor before taking Tofanib with any other medications. Certain medications can interact with Tofanib and should be avoided, including antifungals, CYP3A4 inhibitors, CYP3A4 inducers, and PPIs.

Are there any clinical studies that have been conducted using Tofanib?

Yes, several clinical trials have been conducted evaluating the safety and efficacy of Tofanib for the treatment of moderate to severe Rheumatoid Arthritis (RA).