Proflavine
Proflavine Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Proflavine is a brand name. Its generic name is Proflavine.
Introduction
Proflavine is an antibiotic and antifungal drug that is used to treat a variety of infections. Proflavine has been used for over 70 years in hospitals, outpatient clinics, and other healthcare settings. It is a broad-spectrum antimicrobial agent that works by inhibiting certain enzymes produced by bacteria and fungi.Uses
Proflavine is used to treat a variety of bacterial and fungal infections, including skin and soft tissue infections, urinary tract infections, and some types of respiratory infections. It can also be used to prevent infection in patients with compromised immune systems and to treat ulcerated conditions in the mouth.Mechanism of Action
Proflavine works by inhibiting certain enzymes that are important for bacterial and fungal growth. This prevents the organisms from reproducing and spreading infection.How Long Does it Take to Work?
Proflavine typically takes up to two weeks to start working, with the full effects taking up to four weeks to become apparent.Absorption
Proflavine is poorly absorbed from the gut and requires a high local concentration to be effective.Route of Elimination
Proflavine is metabolized and eliminated exclusively through the kidneys.Dosage
The recommended dosage of Proflavine is 0.5 to 1.5 mg/kg/day, divided into 4 doses and given orally. The maximum daily dose is 7.5 mg/kg/day for adults and 6 mg/kg/day for children.Administration
Proflavine is administered orally every 8 to 12 hours for up to 28 days. It can be taken with or without food.Side Effects
Common side effects of Proflavine include nausea, vomiting, and diarrhea. In rare cases, it may cause hypersensitivity reactions or allergic dermatitis.Toxicity
There have been no reports of toxicity from Proflavine.Precautions
Patients with a history of kidney or liver disease should take Proflavine with caution as it may cause more serious side effects. It is also advised to avoid drinking alcohol while taking Proflavine.Interactions
Proflavine may interact with other antibiotics, antifungal drugs, and antacids. It should not be taken with any medications that contain bismuth subsalicylate.Disease Interactions
Patients with a history of gastrointestinal disorders, such as Crohn’s disease and ulcerative colitis, should use Proflavine with caution as it may worsen these conditions.Drug Interactions
Proflavine may interact with other antibiotics, antifungal medications, antacids, and medications that contain bismuth subsalicylate.Food Interactions
Proflavine should not be taken with food or within 1 hour after a meal.Pregnancy Use
Proflavine should not be used by pregnant women unless absolutely necessary.Lactation Use
Proflavine is secreted into breast milk and should be taken with caution by nursing mothers.Acute Overdose
Symptoms of an acute Proflavine overdose may include vomiting, nausea, abdominal pain, and diarrhea.Contraindication
Proflavine is contraindicated in patients who are allergic to any of the ingredients in the drug.Use Direction
Proflavine should be taken as directed by your doctor.Storage Condition
Proflavine should be stored at room temperature and away from light and moisture.Volume of Distribution
The volume of distribution of Proflavine is approximately 5.9L/kg.Half Life
The half-life of Proflavine is about 3-6 hours.Clearance
The clearance rate of Proflavine is about 2.64mL/min/kg.Here you find in details version of Proflavine
Some Frequently Asked Questions About Proflavine
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