Proflavin

Proflavin Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Proflavin is a brand name. Its generic name is Proflavine.

Introduction

Proflavin is an antibiotic and antifungal drug that is used to treat a variety of infections. Proflavin has been used for over 70 years in hospitals, outpatient clinics, and other healthcare settings. It is a broad-spectrum antimicrobial agent that works by inhibiting certain enzymes produced by bacteria and fungi.

Uses

Proflavin is used to treat a variety of bacterial and fungal infections, including skin and soft tissue infections, urinary tract infections, and some types of respiratory infections. It can also be used to prevent infection in patients with compromised immune systems and to treat ulcerated conditions in the mouth.

Mechanism of Action

Proflavin works by inhibiting certain enzymes that are important for bacterial and fungal growth. This prevents the organisms from reproducing and spreading infection.

How Long Does it Take to Work?

Proflavin typically takes up to two weeks to start working, with the full effects taking up to four weeks to become apparent.

Absorption

Proflavin is poorly absorbed from the gut and requires a high local concentration to be effective.

Route of Elimination

Proflavin is metabolized and eliminated exclusively through the kidneys.

Dosage

The recommended dosage of Proflavin is 0.5 to 1.5 mg/kg/day, divided into 4 doses and given orally. The maximum daily dose is 7.5 mg/kg/day for adults and 6 mg/kg/day for children.

Administration

Proflavin is administered orally every 8 to 12 hours for up to 28 days. It can be taken with or without food.

Side Effects

Common side effects of Proflavin include nausea, vomiting, and diarrhea. In rare cases, it may cause hypersensitivity reactions or allergic dermatitis.

Toxicity

There have been no reports of toxicity from Proflavin.

Precautions

Patients with a history of kidney or liver disease should take Proflavin with caution as it may cause more serious side effects. It is also advised to avoid drinking alcohol while taking Proflavin.

Interactions

Proflavin may interact with other antibiotics, antifungal drugs, and antacids. It should not be taken with any medications that contain bismuth subsalicylate.

Disease Interactions

Patients with a history of gastrointestinal disorders, such as Crohn’s disease and ulcerative colitis, should use Proflavin with caution as it may worsen these conditions.

Drug Interactions

Proflavin may interact with other antibiotics, antifungal medications, antacids, and medications that contain bismuth subsalicylate.

Food Interactions

Proflavin should not be taken with food or within 1 hour after a meal.

Pregnancy Use

Proflavin should not be used by pregnant women unless absolutely necessary.

Lactation Use

Proflavin is secreted into breast milk and should be taken with caution by nursing mothers.

Acute Overdose

Symptoms of an acute Proflavin overdose may include vomiting, nausea, abdominal pain, and diarrhea.

Contraindication

Proflavin is contraindicated in patients who are allergic to any of the ingredients in the drug.

Use Direction

Proflavin should be taken as directed by your doctor.

Storage Condition

Proflavin should be stored at room temperature and away from light and moisture.

Volume of Distribution

The volume of distribution of Proflavin is approximately 5.9L/kg.

Half Life

The half-life of Proflavin is about 3-6 hours.

Clearance

The clearance rate of Proflavin is about 2.64mL/min/kg.

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