6-acridinediamine

6-acridinediamine Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? 6-acridinediamine is a brand name. Its generic name is Proflavine.

Introduction

6-acridinediamine is an antibiotic and antifungal drug that is used to treat a variety of infections. 6-acridinediamine has been used for over 70 years in hospitals, outpatient clinics, and other healthcare settings. It is a broad-spectrum antimicrobial agent that works by inhibiting certain enzymes produced by bacteria and fungi.

Uses

6-acridinediamine is used to treat a variety of bacterial and fungal infections, including skin and soft tissue infections, urinary tract infections, and some types of respiratory infections. It can also be used to prevent infection in patients with compromised immune systems and to treat ulcerated conditions in the mouth.

Mechanism of Action

6-acridinediamine works by inhibiting certain enzymes that are important for bacterial and fungal growth. This prevents the organisms from reproducing and spreading infection.

How Long Does it Take to Work?

6-acridinediamine typically takes up to two weeks to start working, with the full effects taking up to four weeks to become apparent.

Absorption

6-acridinediamine is poorly absorbed from the gut and requires a high local concentration to be effective.

Route of Elimination

6-acridinediamine is metabolized and eliminated exclusively through the kidneys.

Dosage

The recommended dosage of 6-acridinediamine is 0.5 to 1.5 mg/kg/day, divided into 4 doses and given orally. The maximum daily dose is 7.5 mg/kg/day for adults and 6 mg/kg/day for children.

Administration

6-acridinediamine is administered orally every 8 to 12 hours for up to 28 days. It can be taken with or without food.

Side Effects

Common side effects of 6-acridinediamine include nausea, vomiting, and diarrhea. In rare cases, it may cause hypersensitivity reactions or allergic dermatitis.

Toxicity

There have been no reports of toxicity from 6-acridinediamine.

Precautions

Patients with a history of kidney or liver disease should take 6-acridinediamine with caution as it may cause more serious side effects. It is also advised to avoid drinking alcohol while taking 6-acridinediamine.

Interactions

6-acridinediamine may interact with other antibiotics, antifungal drugs, and antacids. It should not be taken with any medications that contain bismuth subsalicylate.

Disease Interactions

Patients with a history of gastrointestinal disorders, such as Crohn’s disease and ulcerative colitis, should use 6-acridinediamine with caution as it may worsen these conditions.

Drug Interactions

6-acridinediamine may interact with other antibiotics, antifungal medications, antacids, and medications that contain bismuth subsalicylate.

Food Interactions

6-acridinediamine should not be taken with food or within 1 hour after a meal.

Pregnancy Use

6-acridinediamine should not be used by pregnant women unless absolutely necessary.

Lactation Use

6-acridinediamine is secreted into breast milk and should be taken with caution by nursing mothers.

Acute Overdose

Symptoms of an acute 6-acridinediamine overdose may include vomiting, nausea, abdominal pain, and diarrhea.

Contraindication

6-acridinediamine is contraindicated in patients who are allergic to any of the ingredients in the drug.

Use Direction

6-acridinediamine should be taken as directed by your doctor.

Storage Condition

6-acridinediamine should be stored at room temperature and away from light and moisture.

Volume of Distribution

The volume of distribution of 6-acridinediamine is approximately 5.9L/kg.

Half Life

The half-life of 6-acridinediamine is about 3-6 hours.

Clearance

The clearance rate of 6-acridinediamine is about 2.64mL/min/kg.

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