Pomalyst
Pomalyst Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Pomalyst is a brand name. Its generic name is Pomalidomide.
Introduction
Pomalyst (branded Imnovid) is an immunomodulatory and antiangiogenic drug used for the treatment of certain types of cancer, such as multiple myeloma and mantle cell lymphoma. Its active component is a synthetic analog of thalidomide, a drug developed in 1957 and found to have sedative and nausea-reducing properties. Pomalyst has been approved in Europe and other countries for certain types of cancer since 2013.Uses for
Pomalyst is used to treat multiple myeloma (a cancer of the bone marrow) when one or more previous treatments have not been successful. It is also used to treat relapsed or refractory mantle cell lymphomas (a type of blood cancer).Mechanism of Action
Pomalyst works by disrupting the formation of new blood vessels, interfering with the ability of the tumor to grow and spread. It also modulates the immune system by activating T-cell receptor signaling and inhibiting tumor-associated macrophages. Finally, it has also been shown to have anti-inflammatory and antifibrotic effects.How Long Does It Take To Work?
The effects of Pomalyst begin to be seen within two weeks, however it can take longer to see the full results. In some cases, results may not be seen for several months.Absorption
Pomalyst is readily absorbed following oral administration with an absolute bioavailability of about 20%. Peak plasma concentrations are reached in 4-6 hours.Route of Elimination
Pomalyst is broken down by the liver and eliminated through the kidneys.Dosage
The recommended dose of pomalidomide for multiple myeloma or mantle cell lymphoma is 4 mg once daily taken on an empty stomach, either 1 hour before or 2 hours after a meal. The maximum recommended daily dose is 8 mg once daily.Administration
Pomalyst should be taken orally, with or without food, once daily in the evening. It is important to take it at least 1 hour before or 2 hours after eating. Do not take more than 8 mg once daily.Side Effects
Pomalyst may cause side effects such as constipation, diarrhea, dizziness, headache, nausea, vomiting, fatigue, and insomnia. It can also cause serious side effects such as low red blood cell count, low white blood cell count, and increased risk of infection. It is important to talk with your doctor about any side effects that you experience.Toxicity
Pomalyst is generally well tolerated, however high doses can cause severe toxicity. Severe skin rash, eye problems, bone marrow suppression, and nerve damage have occurred with higher doses. It is important to consult with your doctor before taking any doses higher than the recommended amount.Precaution
When taking pomalidomide, it is important to be aware of the potential risks and side effects. It is important to talk with your doctor about any concerns you have before taking the medication. It is also important to follow all directions from your doctor and healthcare provider.Interaction
Pomalyst can interact with some medications and supplements, and can also interact with some foods. It is important to check with your doctor or pharmacist before taking any other medications while taking pomalidomide.Disease Interaction
Pomalyst can have serious interactions with certain health conditions, such as kidney or liver disease, anemia, and bleeding disorders. If you have any of these diseases, it is important to talk with your doctor before taking pomalidomide.Drug Interaction
Pomalyst may interact with some medications. It can interact with anticoagulants, immunosuppressants, anti-inflammatories, and certain chemotherapy drugs. It is important to tell your doctor about all medications you are taking before starting pomalidomide.Food Interactions
Pomalyst may interact with foods that are high in tyramine, such as aged cheeses, smoked fish, and yeast products. It is important to talk to your doctor about dietary restrictions while taking pomalidomide.Pregnancy Use
Pomalyst is not recommended for use during pregnancy due to the potential risk of fetal harm. Women should use an effective method of contraception while taking pomalidomide and for at least 4 weeks after stopping it.Lactation Use
Pomalyst is excreted in human milk and not recommended for use while breastfeeding.Acute Overdose
In case of an acute overdose, seek medical attention immediately. Symptoms of an acute overdose include severe skin rash, fever, eye problems, bone marrow suppression, and nerve damage.Contraindication
Pomalyst is contraindicated in patients with known hypersensitivity to the active component or any other components of the formulation.Use Direction
Pomalyst should be taken orally once daily in the evening with or without meals. It is important to take it at least 1 hour before or 2 hours after eating. The recommended dose is 4 mg once daily, with a maximum dose of 8 mg once daily.Storage Condition
Pomalyst should be stored at room temperature, away from direct light and moisture. Keep all medication out of reach of children and pets.Volume of Distribution
The volume of distribution for pomalidomide is 8.4 L/kg.Half Life
The half life of pomalidomide is 69 hours.Clearance
The clearance of pomalidomide is 2.6 liters/hour/kg.Here you find in details version of Pomalyst
Some Frequently Asked Questions About Pomalyst
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