Plendil ER
Plendil ER Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Plendil ER is a brand name. Its generic name is Felodipine.
etcPlendil ER Introduction
Plendil ER is a calcium channel blocker (CCB) used to treat essential hypertension (high blood pressure). It is sold under the brand name Plendil by the pharmaceutical company AstraZeneca. It acts as a blood vessel relaxer, and helps to reduce the symptoms of hypertension.
Uses
The most common use of felodipine is to treat hypertension (high blood pressure). It can also be used to treat angina pectoris (chest pain) and to reduce the risk of heart attack caused by angina.
Mechanism of Action
Plendil ER works by blocking the activity of calcium channels in the cells of blood vessels, More specifically, it blocks the entry of calcium into the tissues of the arteries. This action results in the relaxation of artery walls, which can lower blood pressure by reducing peripheral resistance.
How Long Does it Take to Work?
The effects of felodipine can usually be seen within 1-2 hours of taking the medication. Peak effects occur at about 4-6 hours after taking the medication.
Absorption
Plendil ER is rapidly absorbed from the gastrointestinal tract, and its absorption is not affected by food. The peak plasma concentration is achieved in about 2 hours.
Route of Elimination
Plendil ER is eliminated primarily by the kidneys. It also has an elimination half-life of about 6 hours.
Dosage
The usual starting dose of felodipine is 5 mg once daily. The dose can be increased up to 10 mg once daily, depending on individual response. In patients with liver or kidney disease, the recommended daily dose is 2.5 mg.
Administration
Plendil ER should be taken orally once a day with a full glass of water. It may be taken with or without food.
Side Effect
The most common side effects of felodipine include headache, dizziness, flushing, nausea, tiredness, palpitations, and swelling of ankles. Rare but serious side effects include chest pain, fainting, difficulty breathing, and symptoms of low blood pressure (dizziness and lightheadedness).
Toxicity
If an overdose of felodipine is suspected, contact a medical professional right away. Symptoms of overdose can include dizziness, nausea, and low blood pressure.
Precautions
Plendil ER should be used with caution in patients with liver or kidney disease, as the elimination of felodipine may be reduced in these patients. It should also be used with caution in patients who are taking any medicines that can lower blood pressure.
Interactions
Plendil ER may interact with other calcium channel blockers, beta blockers, nitrates, or ACE inhibitors. It may also interact with certain antibiotics, anticoagulants, antifungals, and anticonvulsants. It it is important to inform your doctor or pharmacist of all the medications you are currently taking.
Disease Interaction
Plendil ER may interact with certain diseases, such as liver or kidney disease. It is important to inform your doctor if you have any existing health conditions.
Drug Interaction
Plendil ER may interact with certain drugs, such as calcium channel blockers, beta blockers, nitrates, or ACE inhibitors. It is important to inform your doctor or pharmacist of all the medications you are currently taking.
Food Interactions
Plendil ER can be taken with or without food. However, it is important to avoid grapefruit or grapefruit juice while taking felodipine, as this may interfere with the effectiveness of the medication.
Pregnancy Use
Plendil ER is not recommended during pregnancy, as it may have adverse effects on a developing fetus. Women should inform their doctor if they are pregnant or plan to become pregnant before taking felodipine.
Lactation Use
Plendil ER is not recommended during breastfeeding, as it may pass into breast milk and cause adverse effects in a nursing infant. Women should inform their doctor if they are breastfeeding before taking felodipine.
Acute Overdose
An acute overdose of felodipine can cause symptoms such as dizziness, nausea, and low blood pressure. If an overdose is suspected, contact a medical professional right away.
Contraindications
Plendil ER is contraindicated in patients who are hypersensitive to any of its components. It should also not be taken with other medications that contain felodipine or its derivatives.
Use Direction
Plendil ER should be taken orally once a day with a full glass of water, with or without food. It is important to follow all instructions provided by your doctor or pharmacist when taking this medication.
Storage Conditions
Plendil ER tablets should be stored at room temperature, away from moisture, heat, and sunlight. It should also be kept away from children and pets.
Volume of Distribution
The estimated volume of distribution of felodipine is 400-800L. This indicates that the majority of the drug is distributed throughout the body.
Half Life
The elimination half-life of felodipine is approximately 6 hours. This means that it takes about 6 hours for the drug to be eliminated from the body.
Clearance
The estimated clearance of felodipine is approximately 5L/hr/kg, indicating that it is rapidly eliminated from the body.
Here you find in details version of Plendil ER
Some Frequently Asked Questions About Plendil ER
What is Plendil ER?
Plendil ER is a type of medication used to treat high blood pressure and angina. It belongs to a class of drugs known as calcium channel blockers.
What does Plendil ER do?
Plendil ER works by relaxing the muscles of your heart and blood vessels. This helps to lower blood pressure and reduce the symptoms of angina.
How long does Plendil ER take to work?
Plendil ER usually takes 2-4 weeks to start working. However, it may take longer for its full effects to take place.
What are the side effects of Plendil ER?
Common side effects of Plendil ER include dizziness, headache, nausea, and tiredness. If you experience any severe side effects, contact your doctor immediately.
What is the usual dose of Plendil ER?
The usual dose of Plendil ER is 5-10mg once daily. Your doctor may adjust your dosage depending on your response to treatment.
How should I take Plendil ER?
Plendil ER should be taken with food. Make sure you take Plendil ER exactly as prescribed by your doctor.
What if I forget to take my dose of Plendil ER?
If you forget to take a dose of Plendil ER, take it as soon as you remember. Make sure to take your next dose at the regular time. Do not take a double dose to make up for the forgotten dose.
Can I drink alcohol while taking Plendil ER?
It is not recommended that you drink alcohol while taking Plendil ER. Alcohol can cause more severe side effects when taken with Plendil ER.
Should I avoid certain foods while taking Plendil ER?
You should avoid eating grapefruit and grapefruit juice while taking Plendil ER. Eating grapefruit can increase your risk of serious side effects.
Can I take other medications with Plendil ER?
You should not take Plendil ER with any other medications without consulting your doctor first. Some medications can interact with Plendil ER and cause serious side effects.
Is Plendil ER safe during pregnancy?
It is not recommended that Plendil ER be taken during pregnancy. Talk to your doctor if you are pregnant or planning to become pregnant.
Can I drive while taking Plendil ER?
It is not recommended that you drive while taking Plendil ER, as it can cause drowsiness and dizziness. Make sure to talk to your doctor about other activities that may be unsafe.
How should I store Plendil ER?
Plendil ER should be stored at room temperature away from light and moisture. Keep Plendil ER away from children and pets.
Are there any drug interactions with Plendil ER?
Plendil ER can interact with certain medications and herbal supplements. Make sure to tell your doctor about all the medications and supplements you are taking before starting Plendil ER.
Can I take Plendil ER if I have kidney disease?
It is not recommended that you take Plendil ER if you have kidney disease. Talk to your doctor before taking Plendil ER.
What if I overdose on Plendil ER?
If you think you have overdosed on Plendil ER, contact your local poison control center, emergency room, or healthcare provider immediately.
What should I do if I experience side effects from Plendil ER?
If you experience any severe or unusual side effects from Plendil ER, contact your doctor immediately.
Does Plendil ER have any long-term effects?
It is not known if Plendil ER has any long-term effects. Talk to your doctor if you are concerned about long-term effects.
What happens if I stop taking Plendil ER suddenly?
You should not stop taking Plendil ER suddenly as it can cause severe withdrawal symptoms. Talk to your doctor before stopping Plendil ER.
Can I take Plendil ER with food?
Yes, Plendil ER can be taken with food. You should take Plendil ER with food to avoid stomach irritation.
Can I take Plendil ER with ibuprofen?
No, you should not take Plendil ER with ibuprofen. Ibuprofen can increase your risk of side effects when taken with Plendil ER.
How long can I use Plendil ER for?
You can use Plendil ER for as long as your doctor prescribed. Do not use Plendil ER for longer than recommended.
Is Plendil ER habit forming?
No, Plendil ER is not habit forming. You should not take more of Plendil ER than prescribed by your doctor.
Is there a generic version of Plendil ER?
Yes, there is a generic version of Plendil ER available. Talk to your doctor about the cost difference between Plendil ER and its generic version.
Can I take Plendil ER if I have a history of heart problems?
You should talk to your doctor before taking Plendil ER if you have a history of heart problems. Your doctor may adjust your dosage or prescribe an alternative medication.
Is there an age limit to taking Plendil ER?
Yes, Plendil ER is not recommended for children under the age of 18. Talk to your doctor about the best medication option for your child.
Is Plendil ER safe for seniors?
Yes, Plendil ER is generally safe for seniors. Talk to your doctor to determine the best dosage for you.
Can Plendil ER interact with other medications?
Yes, Plendil ER can interact with other medications. Talk to your doctor before starting or stopping any medication.
What should I do if I experience an allergic reaction to Plendil ER?
If you experience an allergic reaction to Plendil ER, stop taking the medication and contact your doctor right away.
Are there any other drugs in the same class as Plendil ER?
Yes, other drugs in the same class as Plendil ER include amlodipine, diltiazem, and nifedipine.
What are the common side effects of Plendil ER?
Common side effects of Plendil ER include dizziness, headache, nausea, and tiredness. If you experience any severe side effects, contact your doctor immediately.
Can I take Plendil ER if I have diabetes?
Yes, you can take Plendil ER if you have diabetes. Your doctor may adjust your dosage depending on your response to treatment.
Can I take Plendil ER while breastfeeding?
It is not recommended that Plendil ER be taken while breastfeeding. Talk to your doctor if you are breastfeeding or planning to start.
What should I do if I miss a dose of Plendil ER?
If you miss a dose of Plendil ER, take it as soon as you remember. Make sure to take your next dose at the regular time. Do not take a double dose to make up for the missed dose.
Can I take herbal supplements with Plendil ER?
You should not take herbal supplements with Plendil ER without consulting your doctor first. Some herbal supplements can interact with Plendil ER and cause serious side effects.
Should I avoid strenuous activity while taking Plendil ER?
Yes, you should avoid strenuous activity while taking Plendil ER, as it can cause dizziness and fatigue. Make sure to talk to your doctor about other activities that may be unsafe.
Can I take Plendil ER if I have liver disease?
It is not recommended that you take Plendil ER if you have liver disease. Talk to your doctor before taking Plendil ER.