Pegneufil
Pegneufil Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Pegneufil is a brand name. Its generic name is Pegfilgrastim.
Introduction:
Pegneufil is a recombinant, long-acting form of granulocyte-colony stimulating factor (GCSF) that is indicated for the reduction in the duration of severe neutropenia in patients with non-myeloid malignancies receiving myelosuppressive anticancer drugs associated with a clinically significant incidence of febrile neutropenia.Uses for:
Pegneufil is used to stimulate the production of white blood cells to prevent infections during chemotherapy or radiation treatment. It is also used to manage the side effects of high-dose chemotherapy prior to blood and bone marrow transplantation.Mechanism of Action:
Pegneufil is a G-CSF receptor agonist, acting by binding to specific cell-surface receptor proteins on hematopoietic stem cells and progenitor cells in the bone marrow. This binding leads to increased production of neutrophils, which are important in protection against disease-causing bacteria and other pathogens.How Long Does It Take to Work?:
The effects of pegfilgrastim may be observed within hours of injection. The drug typically begins to increase neutrophil counts in 3-4 days, with maximal effect by 7 days.Absorption:
Pegneufil is a long-acting drug and is slowly released over time. It is absorbed slowly through the gastrointestinal mucosa.Route of Elimination:
Pegneufil is eliminated primarily through the kidneys, with a half-life of approximately 18-37 hours.Dosage:
The recommended dose of pegfilgrastim for adult patients receiving myelosuppressive chemotherapy is a 6 mg single dose, given as a subcutaneous injection no more than 24 hours after completion of chemotherapy.Administration:
Pegneufil should be administered as a single, subcutaneous injection no more than 24 hours after completion of chemotherapy.Side Effect:
The most common side effects of pegfilgrastim include bone pain, headache, joint pain, musculoskeletal pain, fatigue, and nausea. Other possible side effects may include rash, Edema, Injection site reactions, Hypertension, and increased risk of infection.Toxicity:
The reported incidence of serious adverse reactions, including severe allergic reactions, was low. The overall incidence of severe allergic reactions in clinical trials was 0.3%.Precaution:
Pegneufil should be administered with caution to patients with known hypersensitivities to granulocyte-colony stimulating factors or to any of the inactive ingredients in the formulation. Pegneufil should also be administered with caution to patients with neutropenia due to other underlying causes.Interaction:
Pegneufil is not known to interact with other drugs. However, patients receiving concomitant drugs that have a hemostatic effect should be monitored for signs of bleeding or other adverse reactions.Disease Interaction:
Pegneufil should not be used in patients with neutropenia due to an underlying disease, such as congenital neutropenia, myelodysplastic syndrome, or chronic myeloid leukemia.Drug Interaction:
Pegneufil should not be used with concomitant drugs that have a hemostatic effect.Food Interactions:
No food interactions have been reported with pegfilgrastim.Pregnancy Use:
Pegneufil should not be used in pregnant women due to potential risks to the fetus.Lactation Use:
The safety and efficacy of pegfilgrastim in lactating women has not been established, and it is not recommended for use in breastfeeding mothers.Acute Overdose:
No acute overdoses of pegfilgrastim have been reported.Contraindication:
Pegneufil is contraindicated in patients with known hypersensitivities to granulocyte-colony stimulating factors or to any of the inactive ingredients in the formulation.Use Direction:
Pegneufil should be administered as a single, subcutaneous injection no more than 24 hours after completion of chemotherapy.Storage Condition:
Pegneufil should be stored at room temperature (59-86°F). It should be protected from heat and light and should not be frozen.Volume of Distribution:
The apparent volume of distribution of pegfilgrastim following subcutaneous administration is approximately 4 liters.Half Life:
The terminal half-life of pegfilgrastim is approximately 18-37 hours.Clearance:
The clearance of pegfilgrastim is approximately 7.3 mL/min/kg.Here you find in details version of Pegneufil
Some Frequently Asked Questions About Pegneufil
What is Pegneufil?
Pegneufil is a long-acting form of the drug granulocyte-colony stimulating factor (G-CSF). It is a peptide that stimulates bone marrow to produce neutrophils, a type of white blood cell that plays a key role in fighting infection.
What is Pegneufil used for?
Pegneufil is used to reduce the risk of infection due to severe neutropenia (low levels of certain white blood cells) in people with certain types of cancer (such as non-myeloid leukemia and multiple myeloma) who are receiving chemotherapy or radiation.
How does Pegneufil work?
Pegneufil works by stimulating the bone marrow to produce granulocytes, which are a type of white blood cell. It helps to increase the number of granulocytes, which can help reduce the risk of infection due to decreased levels of neutrophils.
What are the side effects of Pegneufil?
Common side effects of Pegneufil include headache, muscle pain, bone pain, dizziness, and feeling tired. More serious side effects may include swelling of the feet, ankles, or hands, chest pain, shortness of breath, and fever.
How long does Pegneufil stay in the body?
Pegneufil is a long-acting drug that stays in the body for up to 21 days.
What should I avoid while taking Pegneufil?
You should avoid contact with individuals who have infectious diseases and live or atten vaccinated animals. You should also avoid taking any ibuprofen, naproxen, aspirin, or other NSAID medications while taking Pegneufil.
Is Pegneufil safe for pregnant or breastfeeding women?
Pegneufil has not been adequately studied in pregnant or breastfeeding women. Talk to your doctor if you are pregnant or breastfeeding before starting Pegneufil.
How is Pegneufil administered?
Pegneufil is typically administered as a single injection under the skin once every 21 days. Your doctor will determine the appropriate dose and administration schedule for you.
How long does it take for Pegneufil to start working?
Pegneufil usually begins to work within two days of administration, but it may take up to two weeks to reach its full effect.
What is the most common side effect of Pegneufil?
The most common side effect of Pegneufil is headache, occurring in up to 30% of patients.
What should I do if I miss a dose of Pegneufil?
If you miss a dose of Pegneufil, call your doctor right away. Your doctor may advise you to take the missed dose as soon as possible, or to wait until your next scheduled dose.
Can I take other medications while taking Pegneufil?
You may be able to take other medications while taking Pegneufil, but discuss all medications (prescription, over-the-counter, and herbal supplements) with your doctor before starting them.
Is Pegneufil covered by insurance?
Pegneufil may be covered by some insurance plans. Check with your insurance provider to find out if Pegneufil is covered and what your out-of-pocket costs may be.
Can Pegneufil help with other medical conditions?
Pegneufil is approved only to reduce the risk of infection due to severe neutropenia in people with certain types of cancer receiving chemotherapy or radiation. It is not approved to treat any other medical condition.
What should I do if I experience any severe side effects from Pegneufil?
If you experience any severe side effects, such as swelling of the feet, ankles, or hands; chest pain; shortness of breath; or fever, contact your doctor immediately.
Is Pegneufil a prescription medication?
Yes, Pegneufil is a prescription medication.
Does Pegneufil have any interactions with other medications?
Yes, Pegneufil may interact with other medications. Talk to your doctor about all medications (prescription, over-the-counter, and herbal supplements) that you are taking before starting Pegneufil.
Can Pegneufil be taken with food?
Pegneufil should be taken on an empty stomach. Avoid taking it with alcohol or a high-fat meal.
Can I take aspirin or ibuprofen while taking Pegneufil?
No, you should not take any ibuprofen, naproxen, aspirin, or other NSAID medications while taking Pegneufil.
Does Pegneufil have any generic versions?
Yes, there is a generic version of Pegneufil available. Talk to your doctor to see if generic Pegneufil is right for you.
Is Pegneufil cancerous?
No, Pegneufil is not cancerous. It is a drug that is used to reduce the risk of infection due to decreased levels of neutrophils in people with certain types of cancer receiving chemotherapy or radiation.
Is Pegneufil bad for your liver?
There is no evidence that Pegneufil is bad for your liver. However, if you notice any changes in your liver function while taking Pegneufil, call your doctor.
Can I exercise while taking Pegneufil?
Yes, you can exercise while taking Pegneufil. However, be sure to drink plenty of fluids and listen to your body. If you are feeling too tired or weak to exercise, it is best to take a rest day.
Does Pegneufil affect fertility?
There is no evidence that Pegneufil affects fertility. However, it is always advisable that women who are trying to conceive talk to their doctor before taking any medication.
How long does it take for Pegneufil to work?
Pegneufil usually begins to work within two days of administration, but it may take up to two weeks to reach its full effect.
Can Pegneufil be used with radiation therapy?
Yes, Pegneufil can be used in conjunction with radiation therapy to reduce the risk of infection due to decreased levels of neutrophils in people with certain types of cancer.
Can Pegneufil be used in children?
Pegneufil has only been approved for use in adults, so it should not be given to children.
Can Pegneufil be used in combination with other medications?
Yes, Pegneufil can be used in combination with other medications to reduce the risk of infection due to neutropenia caused by certain treatments for cancer.
How quickly does Pegneufil start working?
Pegneufil usually begins to work within two days of administration, but it may take up to two weeks to reach its full effect.
What are the long-term effects of Pegneufil?
The long-term effects of Pegneufil have not been studied, so it is important to discuss the risks and potential side effects with your doctor before starting treatment.
Can I breastfeed while taking Pegneufil?
Pegneufil has not been adequately studied in breastfeeding women. Talk to your doctor before taking Pegneufil if you are breastfeeding.
Is there an age limit for taking Pegneufil?
Pegneufil has only been approved for use in adults. It should not be given to children.
Can Pegneufil cause a fever?
Yes, Pegneufil can cause a fever, which is a rare but serious side effect. If you experience a fever while taking Pegneufil, call your doctor right away.
Are there any foods or drinks I should avoid while taking Pegneufil?
You should avoid taking Pegneufil with alcohol or a high-fat meal. You should also be sure to drink plenty of fluids while taking Pegneufil.
Can Pegneufil cause allergic reactions?
Yes, Pegneufil can cause allergic reactions in some people. Symptoms of an allergic reaction include rash, itching, swelling, difficulty breathing, or chest tightness.