Oxifyl CR

Oxifyl CR Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Oxifyl CR is a brand name. Its generic name is Pentoxifylline.

Oxifyl CR

Oxifyl CR (also known as PTX or Trental), is a medication that belongs to a group of drugs called xanthines. It works by making the blood cells more flexible, which improves blood flow and reduces the risk of blood clots. Oxifyl CR is used to improve the symptoms of peripheral vascular disease, such as pain, numbness, and weakness in the legs. It may also be used to treat other conditions as determined by your doctor.

Uses for Oxifyl CR

Oxifyl CR is used to improve the symptoms of peripheral vascular disease. It is used to decrease symptoms such as pain, numbness, and weakness in the legs.

Mechanism of Action

Oxifyl CR works by making red blood cells more flexible, which reduces their tendency to stick together and clump. This improves blood flow, which can improve symptoms of peripheral vascular disease.

How Long Does it Take to Work?

It typically takes several weeks of treatment before the benefits of pentoxifylline can be felt. The patient should discuss with their doctor if they do not experience any improvement after a few weeks of treatment.

Absorption, Route of Elimination, Dosage, Administration

Oxifyl CR is absorbed from the gastrointestinal tract and primarily metabolized and eliminated in the urine. It is usually taken orally, in the form of tablets or capsules, three times per day. The adult dosage of pentoxifylline is 400mg to 600mg per day. Pediatric dosage of pentoxifylline is 20mg to 50mg per kilogram of body weight per day, depending on the condition being treated.

Side Effects

The most common side effects of pentoxifylline are headache, nausea, vomiting, diarrhea, increased heart rate, and dizziness. Patients should contact their doctor if they experience any severe side effects such as chest pain, difficulty breathing, confusion, irregular heartbeat, and swollen ankles or feet.

Toxicity

Oxifyl CR can be toxic if taken in high doses. The risk of toxicity increases with higher doses. It is important for patients to follow the dosing instructions of their doctor to avoid potential toxicity.

Precautions and Interactions

Patients should discuss their medical history with their doctor before taking pentoxifylline. Patients should also be aware of potential drug interactions when taking this medication. Oxifyl CR can interact with other drugs, including anticoagulants, hormonal medications, drugs for diabetes, and other xanthines. Additionally, pentoxifylline should not be used by patients with kidney or liver disease, a history of gastrointestinal bleeding, or certain blood disorders.

Disease Interactions

Oxifyl CR can interact with certain diseases, such as anemia, diabetes, kidney or liver disease, or cardiovascular diseases. Patients should discuss these conditions with their doctor before taking pentoxifylline.

Drug Interactions

Oxifyl CR can interact with other drugs, including anticoagulants, drugs for diabetes, and other xanthines. Patients should discuss all drug interactions with their doctor and should not take other medications without first consulting their doctor.

Food Interactions

Oxifyl CR can interact with certain foods, such as grapefruit, which can increase the risk of toxicity. Patients should discuss any food interactions with their doctor and be sure to read any labels before consuming any food or beverage.

Pregnancy Use

Oxifyl CR has not been studied in pregnant women, so there is a potential risk associated with taking this medication during pregnancy. Patients should only take pentoxifylline if the potential benefits outweigh the risks. Patients should discuss their individual risk with their doctor.

Lactation Use

Oxifyl CR has been found to be excreted in breastmilk. Therefore, it is not recommended for use while breastfeeding. Patients should discuss their individual risk with their doctor.

Acute Overdose

A single overdose of pentoxifylline can cause serious side effects and even death. Patients who have taken an overdose should seek medical attention immediately.

Contraindication

Oxifyl CR is contraindicated in patients with known hypersensitivity to the drug. It is also contraindicated in patients with kidney or liver disease, a history of gastrointestinal bleeding, or certain blood disorders.

Use Directions

Patients should take pentoxifylline exactly as prescribed by their doctor. Patients should not exceed the recommended dose or take the medication for longer than recommended. The tablets should be swallowed whole with a full glass of water.

Storage Condition

Oxifyl CR should be stored at room temperature, away from light and moisture. It should be kept in a safe place, out of reach of children and pets.

Volume of Distribution

The volume of distribution of pentoxifylline is approximately 3.5-5 L/kg.

Half Life

The half-life of pentoxifylline is approximately 20-30 minutes.

Clearance

The clearance of pentoxifylline is approximately 7-9 mL/min/kg.

Here you find in details version of Oxifyl CR

Some Frequently Asked Questions About Oxifyl CR

What is Oxifyl CR?

Oxifyl CR is an anti-inflammatory drug that is used to treat a variety of conditions such as severe skin conditions, blood flow disorders, loss of vision, and inflammation of the arteries.

How does Oxifyl CR work?

Oxifyl CR works by blocking certain receptors in the body which reduce inflammation and improve blood flow. It increases the flexibility of vessel walls, which in turn reduces the stiffness of the artery walls.

What are the side effects of Oxifyl CR?

Common side effects of pentoxifylline include nausea, vomiting, stomach pain, headache, dizziness, and rash. Less common side effects include chest pain, muscle pain, and swelling in the legs or feet. More serious side effects include fever, difficulty breathing, and seizures.

What is the usual dosage of Oxifyl CR?

The usual dosage of pentoxifylline is 400-600mg taken three times a day. The dosage may be adjusted depending on the individual's response to the medication.

Who should not take Oxifyl CR?

Oxifyl CR should not be taken by people with kidney or liver disease, diabetes, or bleeding disorders without consulting a doctor. It should also not be taken by pregnant or breastfeeding women.

Is Oxifyl CR effective in treating peripheral neuropathy?

Oxifyl CR has been found to be effective in some cases of peripheral neuropathy, particularly in patients with lower limb diabetic neuropathy.

Is Oxifyl CR a steroid?

No, pentoxifylline is not a steroid. It is an anti-inflammatory drug.

Is Oxifyl CR safe to take?

Oxifyl CR is generally safe to take as long as it is used as prescribed and any potential side effects are monitored by a doctor.

How long does it take for Oxifyl CR to work?

The effects of pentoxifylline may start to be felt within a few weeks of starting treatment, but it may take several months before the full benefits are seen.

Does Oxifyl CR have any interactions with other medications?

Yes, pentoxifylline can interact with some medications, including blood thinners, anticoagulants, anti-seizure medications, and certain antibiotics. It is important to speak to a doctor or pharmacist before taking pentoxifylline with any other medications.

Can Oxifyl CR be taken with alcohol?

No, pentoxifylline should not be taken with alcohol. Alcohol can increase the risk of side effects or reduce the effectiveness of the medication.

Does Oxifyl CR require a prescription?

Yes, Oxifyl CR requires a prescription from a doctor in order to be dispensed.

What form does Oxifyl CR come in?

Oxifyl CR typically comes in tablet form, but may also come in an oral solution or injection.

What is the cost of Oxifyl CR?

The cost of Oxifyl CR depends on the pharmacy and dosage. Before taking Oxifyl CR, it is a good idea to ask your pharmacist for an estimate of the cost.

Is Oxifyl CR available over the counter?

No, Oxifyl CR is not available over the counter. It requires a prescription from a doctor.

When should Oxifyl CR be taken?

Oxifyl CR should be taken as prescribed by your doctor. It is usually taken three times a day, with or without food.

Can Oxifyl CR be taken with food?

Yes, Oxifyl CR can be taken with food to reduce the risk of gastric irritation or other side effects.

Can Oxifyl CR be used for long-term treatment?

Yes, Oxifyl CR can be used for long-term treatment, although it is important to speak to a doctor to discuss the risks and benefits of long-term treatment before starting treatment.

Does Oxifyl CR cause weight gain?

No, Oxifyl CR does not typically cause weight gain. However, if it is taken in high doses, there is a possibility of weight gain as a side effect.

Does Oxifyl CR have any effect on blood pressure?

Yes, Oxifyl CR has been found to have a slight effect on blood pressure. It has been found to slightly reduce blood pressure, although the effects are usually minor.

Does Oxifyl CR cause fatigue?

Yes, fatigue is one of the common side effects of pentoxifylline. If this occurs, it is advisable to speak to a doctor about reducing the dose or switching to a different medication.

Does Oxifyl CR interact with warfarin?

Yes, pentoxifylline can interact with warfarin, which can affect its effectiveness in thinning the blood. It is important to speak to your doctor before taking pentoxifylline with warfarin.

What are the long-term effects of taking Oxifyl CR?

The long-term effects of taking pentoxifylline may vary depending on the condition being treated. Possible long-term effects may include an increased risk of bleeding, liver damage, or kidney damage.

Can Oxifyl CR be taken with other anti-inflammatory medications?

No, pentoxifylline should not be taken with other anti-inflammatory medications such as ibuprofen or aspirin without consulting a doctor. Taking these medications at the same time can cause serious side effects.

Can Oxifyl CR cause diarrhoea?

Yes, diarrhoea is one of the possible side effects of pentoxifylline, though it is not common. If diarrhoea occurs, it is important to speak to a doctor.

Is Oxifyl CR used to treat arthritis?

No, pentoxifylline is not used to treat arthritis. It is usually used to treat blood flow disorders, severe skin conditions, loss of vision, and inflammation of the arteries.

Can Oxifyl CR cause dizziness?

Yes, dizziness is one of the possible side effects of pentoxifylline. It is important to speak to a doctor if you experience dizziness while taking pentoxifylline.

Can Oxifyl CR be used to treat high blood pressure?

No, pentoxifylline is not typically used to treat high blood pressure. There are other medications that are more effective in treating high blood pressure.

Can Oxifyl CR be taken during pregnancy?

No, pentoxifylline should not be taken during pregnancy. The risks of taking the medication during pregnancy outweigh the potential benefits.

Is Oxifyl CR habit-forming?

No, pentoxifylline is not habit-forming. It can be stopped without any significant withdrawal symptoms.

Can Oxifyl CR cause kidney damage?

Yes, in rare cases, pentoxifylline can cause kidney damage. It is important to monitor for signs of kidney damage such as increased thirst, confusion, fatigue, or swelling while taking pentoxifylline.

Can Oxifyl CR cause liver damage?

Yes, in rare cases, pentoxifylline can cause liver damage. It is important to monitor for signs of liver damage such as jaundice, nausea, vomiting, and abdominal pain while taking pentoxifylline.

Which drugs interact with Oxifyl CR?

Oxifyl CR can interact with some medications, including blood thinners, anticoagulants, anti-seizure medications, and certain antibiotics. It is important to speak to a doctor or pharmacist before taking pentoxifylline with any other medications.

Is Oxifyl CR used to treat heart conditions?

Yes, pentoxifylline can be used to treat certain heart conditions such as claudication, or poor circulation in the legs. It can also be used to treat high cholesterol and cholesterol buildup in the arteries.

Can Oxifyl CR be used to treat pulmonary hypertension?

Yes, pentoxifylline can be used to treat pulmonary hypertension, or abnormally high blood pressure in the arteries of the lungs.

Can Oxifyl CR be used to treat Raynaud's phenomenon?

Yes, pentoxifylline can be used to treat Raynaud's phenomenon, or a condition in which the body has difficulty regulating blood circulation to the fingers and toes.

Can Oxifyl CR be taken on an empty stomach?

Yes, Oxifyl CR can be taken on an empty stomach, but it is generally recommended to take it with food to reduce the risk of gastric irritation or other side effects.

Is Oxifyl CR safe for children to take?

Oxifyl CR is not usually recommended for children under the age of 12, but it can be given to children over 12 after consulting a doctor.

Can Oxifyl CR cause blurred vision?

Yes, blurred vision is one of the possible side effects of pentoxifylline. If this occurs, it is important to speak to a doctor about reducing the dose or switching to a different medication.

Can Oxifyl CR be used to treat ulcerative colitis?

Yes, pentoxifylline has been found to be effective in treating ulcerative colitis in some cases.

Does Oxifyl CR cause constipation?

Yes, constipation is one of the possible side effects of pentoxifylline. If this occurs, it is important to speak to a doctor about reducing the dose or switching to a different medication.

Is Oxifyl CR approved by the FDA?

Yes, Oxifyl CR has been approved by the FDA for use in the treatment of certain conditions.