Mirolast
Mirolast Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Mirolast is a brand name. Its generic name is Pemirolast.
Mirolast Introduction
Mirolast is a medication used for the treatment of allergic symptoms such as hay fever or allergic rhinitis. Mirolast blocks the action of various chemicals that are responsible for the inflammation, congestion, itching, and other allergic reactions. Mirolast is available as a tablet, nasal spray, and eye drops.
Uses For Mirolast
Mirolast is used to treat allergic symptoms such as hay fever, watery eyes, runny nose, sneezing, itching eyes/nose, and hives. It can also be used to treat itching and inflammation caused by an allergic reaction and allergic conjunctivitis.
Mechanism of Action
Mirolast works by blocking the action of various chemicals that are released during an allergic reaction. These chemicals, including histamine, are responsible for the inflammation, congestion, itching, and other allergic reactions. By blocking these chemicals, pemirolast reduces inflammation, congestion, itching, sneezing, and other symptoms of allergies.
How Long Does it Take to Work?
The effects of pemirolast can be seen within minutes to hours, depending on the dose taken and the individual. In general, pemirolast can start to relieve symptoms within minutes and the maximum effect can be seen after 2 hours.
Absorption
Mirolast is rapidly absorbed into the bloodstream when taken orally. The nasal spray is also rapidly absorbed but has a lower bioavailability than the oral formulation.
Route of Elimination
Mirolast is rapidly metabolized and is largely excreted via the kidneys. It is not known to accumulate in the body.
Dosage
The recommended dosage of pemirolast is 25-50mg orally twice daily or two sprays in each nostril twice daily. The dosage may be increased depending on the severity of the symptoms. Patients should follow their doctorʼs advice when taking pemirolast.
Administration
Mirolast can be taken orally or as a nasal spray. Oral tablets should be taken with a glass of water. The nasal spray should be used as directed by the patientʼs healthcare provider.
Side Effects
Side effects of pemirolast may include headache, nausea, vomiting, diarrhea, drowsiness, dry mouth, and fatigue. Serious side effects include anaphylaxis, angioedema, Stevens-Johnson Syndrome, and other allergic reactions.
Toxicity
Mirolast is generally well tolerated. Overdose can cause dizziness, confusion, nausea, drowsiness, blurred vision, and tachycardia. If overdose is suspected, seek medical attention.
Precautions
Patients should talk to their doctor before taking pemirolast if they have a history of liver or kidney disease, glaucoma, heart disease, or high blood pressure. Patients should also inform their doctor if they are taking any other medications, including prescription, over-the-counter, and herbal supplements.
Interactions
Mirolast may interact with a number of medications. It is important to tell your doctor about all medications you are taking.
Disease Interactions
Mirolast may interact with certain conditions such as pregnancy, lactation, or certain diseases. Talk to your doctor about potential interactions.
Drug Interactions
Mirolast may interact with a number of medications, such as antibiotics, antifungals, antidepressants, blood pressure medications, heart medications, and sedatives. It is important to tell your doctor about all medications you are taking.
Food Interactions
Mirolast may interact with certain foods or beverages. Alcohol may decrease the effectiveness of pemirolast. It is important to speak with your doctor about potential food interactions.
Pregnancy Use
Mirolast should not be used during pregnancy, unless it is deemed necessary by a doctor. Patients should speak to their doctor about the risks and benefits of taking pemirolast during pregnancy.
Lactation Use
Mirolast should not be used during lactation unless it is deemed necessary by a doctor. Patients should speak to their doctor about the risks and benefits of taking pemirolast while breastfeeding.
Acute Overdose
An acute overdose of pemirolast can cause dizziness, confusion, nausea, drowsiness, blurred vision, and tachycardia. If overdose is suspected, seek medical attention.
Contraindications
Mirolast should not be used in patients with a known hypersensitivity to pemirolast, or any of its components. It should also not be used in patients taking certain medications, such as monoamine oxidase inhibitors or tricyclic antidepressants.
Use Direction
Mirolast should be taken exactly as prescribed by the doctor. It should be taken with a full glass of water. The oral tablets should not be crushed or chewed. The nasal spray should be used as directed.
Storage Condition
Mirolast should be stored at room temperature and kept away from moisture and heat. Keep it out of the reach of children and pets.
Volume of Distribution
Mirolast is rapidly distributed in the body with an apparent volume of distribution of 21L.
Half Life
The half-life of pemirolast is 3-4 hours.
Clearance
Mirolast is mainly cleared from the body through the kidneys with a total clearance of 2.3L/h.
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