Orlipastat

Orlipastat Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Orlipastat is a brand name. Its generic name is Orlistat.

Orlipastat Introduction

Orlipastat is a medicine used for weight management. It belongs to a group of medicines known as gastrointestinal lipase inhibitors, or GI lipase inhibitors, and it works by reduing the amount of fat that is absorbed by the body. Orlipastat is available both over-the-counter (OTC) and in prescription form, and is marketed under various brand names, such as Xendos and Alli.

Uses for Orlipastat

Orlipastat is used to help enhance weight loss in overweight adults who are taking part in a weight-loss program. It is also used in certain patients for obesity management. Orlipastat may be used in conjunction with other medications and a reduced-calorie diet to achieve greater weight-loss.

Mechanism Of Action

Orlipastat works by inhibiting the absorption of fat in your body. It does this by inhibiting an enzyme in the stomach and intestines called lipase. The lipase enzyme helps the body break down and absorb fat. When Orlipastat blocks the action of the lipase enzyme, less fat is absorbed from the diet, resulting in a smaller increase in blood fat levels.

In addition to its weight loss benefits, Orlipastat can also reduce triglyceride levels and improve blood cholesterol levels. This is important because both elevations in triglyceride levels and blood cholesterol levels are associated with an increased risk of cardiovascular disease.

How Long Does It Take To Work?

The effectiveness of Orlipastat depends on its adequate and consistent use. Most people will begin to see results within three months of regularly taking the dosage of Orlipastat prescribed by their doctor. However, it is important to follow the recommended instructions to maximize the effects of the medication.

Absorption

Orlipastat is mostly not absorbed in the body, it mainly works in the lower intestine and only a small amount is absorbed into the bloodstream. The medication is broken down by the gut bacteria in the lower intestine.

Route Of Elimination

The inactive metabolites are eliminated as feces, and the active form of the drug is eliminated in urine.

Dosage

The recommended dose of Orlipastat is one 120 mg capsule, taken orally with a full glass of liquid, three times a day. Orlipastat is generally taken during, or up to one hour after each main meal of the day. The missed doses should be skipped and the regular schedule should be resumed.

Administration

Orlipastat can be taken orally with a full glass of liquid either before, during or up to one hour after each meal. It should not be taken more than three times a day.

Side Effect

The most common side effects associated with Orlipastat include gas with discharge, loose stools, abdominal pain, fecal urgency, difficulty controlling bowel movements, increased bowel movements, diarrhea, nausea, and headache.

Toxicity

Orlipastat is relatively nontoxic and the most severe side effect can be gastrointestinal (GI) distress. If Orlipastat is taken with meals that are very high in fat, the side effects may be more pronounced. In such cases, Orlipastat should be discontinued until the symptoms resolve.

Precaution

Before taking Orlipastat, you should tell your doctor if you have ever had any type of liver or kidney problems. You should also tell your doctor if you have gallbladder problems or if you are pregnant or plan to become pregnant.

Interaction

Orlipastat should not be taken with certain medications such as warfarin, because it can reduce the effectiveness of the warfarin and increase the risk of bleeding. Orlipastat should also not be taken with some vitamins, as their absorption may be reduced.

Disease Interaction

Orlipastat may interact with certain disease states and alter their natural history. For example, Orlipastat has been linked to reduced risk of Crohn's disease, colorectal cancer, and type 2 diabetes. It is important to discuss any potential interactions with your doctor before taking Orlipastat.

Drug Interaction

Certain drugs may interact with Orlipastat. For example, if you take anticoagulants, such as warfarin, the effectiveness of the drug may be reduced by Orlipastat. In addition, some medications, such as thyroid hormones, can interact with Orlipastat.

Food Interactions

Orlipastat should be taken with meals that contain less than 30% fat in order for it to be most effective. Foods such as nuts, seeds, fried foods, creamy sauces, gravies, and high-fat dairy products should be avoided, as these foods tend to be high in fat.

Pregnancy Use

Orlipastat is not recommended for women who are pregnant, breastfeeding, or trying to become pregnant as it may interfere with the absorption of important nutrients. Women should also not take Orlipastat if they are nursing, as it may interfere with the production of breast milk.

Lactation Use

It is not recommended for breastfeeding women to take Orlipastat, as it may interfere with the production of breast milk.

Acute Overdose

In the event of an overdose, the patient should stop taking the medication and seek immediate medical attention. Signs and symptoms of an overdose may include abdominal cramps, nausea, and diarrhea.

Contraindication

Orlipastat is contraindicated in patients with chronic malabsorption syndromes, as well as those with known hypersensitivity to Orlipastat or any of its components.

Use Directions

Orlipastat should be taken as directed by your physician. Generally, the recommended dose is one 120mg capsule taken with a full glass of liquid up to three times a day with meals. Orlipastat should not be taken with meals that contain more than 30% fat. It is important to follow the instructions provided by your physician in order to maximize the effectiveness of the medication.

Storage Conditions

Orlipastat should be stored at room temperature away from moisture and light. It should be kept out of the reach of children and pets.

Volume Of Distribution

Orlipastat has a volume of distribution of 11.7 L and is not significantly bound to plasma proteins.

Half Life

The half life of Orlipastat is approximately 1 to 2 hours.

Clearance

The clearance of Orlipastat is approximately 20 L/h.

Here you find in details version of Orlipastat

Some Frequently Asked Questions About Orlipastat

What is Orlipastat?

Orlipastat is a prescription weight loss medication which is used to aid in weight loss, or to help reduce the risk of regaining weight already lost.

What does Orlipastat do?

Orlipastat works by blocking some of the fat that you consume from being absorbed by your body. This helps you to reduce the amount of fat absorbed from your diet, helping you to lose weight and reduce the risk of regaining weight.

How long does Orlipastat take to start working?

Orlipastat should begin to take effect within a few days of starting treatment. However, the effects of Orlipastat will be most noticeable after you have been using it for a few weeks.

What is a typical dose of Orlipastat?

The recommended dose of Orlipastat is one capsule three times a day, taken during or up to one hour after each main meal. Do not take more than the recommended dose.

How long can I take Orlipastat for?

Orlipastat should only be taken for a maximum of six months. After six months, it is recommended that you have a break of one month before starting the treatment again. That said, if you are still losing weight after six months, consider changing to a different form of weight loss treatment.

Can I buy Orlipastat over the counter?

No, Orlipastat is only available with a valid prescription from your doctor or another healthcare professional.

Does Orlipastat have any side effects?

Like all medications, Orlipastat can cause side effects. Common side effects of Orlipastat include changes in bowel habits, oily spotting, passing gas, and an increased number of bowel movements. Speak to your doctor if you experience any side effects while taking Orlipastat.

Is Orlipastat suitable for everyone?

No, Orlipastat is not suitable for everyone. If you have any underlying health condition, such as liver or kidney disease, Orlipastat is not suitable for you. Speak to your doctor or pharmacist before taking Orlipastat.

Does Orlipastat interact with other medications?

Yes, Orlipastat may interact with other medications. Therefore, it is important to tell your doctor or pharmacist about all medications you are taking, before starting Orlipastat, to ensure that all interactions are avoided.

Does Orlipastat cause weight loss without dieting?

No, Orlipastat does not cause weight loss without dieting. Orlipastat is used to aid weight loss, or to help reduce the risk of regaining weight already lost. It is important to stick to a reduced calorie, low-fat diet whilst taking Orlipastat in order to achieve the best results.

Is Orlipastat suitable for people with diabetes?

Yes, Orlipastat may be suitable for people with diabetes. However, it is important to discuss this with your doctor, in case any additional dietary advice is needed. Additionally, if you are taking any diabetes medications, it is important to tell your doctor before starting Orlipastat.

What should I do if I forget to take Orlipastat?

If you forget to take a dose of Orlipastat, simply take it as soon as you remember. Do not take a double dose to make up for the dose that you have missed.

Does Orlipastat have any long-term effects?

No, Orlipastat does not have any long-term effects. Once you stop taking Orlipastat, any unwanted effects should stop within a few days.

Does Orlipastat interact with any herbal remedies?

Yes, you should not take any herbal remedies whilst taking Orlipastat, as they may interact and cause unwanted side effects. Always tell your doctor or pharmacist about any herbal remedies you are taking before starting Orlipastat.

Does Orlipastat cause weight gain?

No, Orlipastat does not cause weight gain. In fact, it is used to aid weight loss or to help reduce the risk of regaining weight already lost.

Is Orlipastat suitable for children?

No, Orlipastat is not suitable for children. Orlipastat is a weight loss medication for adults over the age of 18 only.

Does Orlipastat work without exercise?

No, Orlipastat should only be taken in conjunction with a calorie-controlled diet and regular exercise. Taking Orlipastat without dieting or exercise is unlikely to be effective.

Is Orlipastat safe to use while breastfeeding?

It is not recommended to take Orlipastat when breastfeeding. Speak to your doctor for further advice on how to safely lose weight while breastfeeding.

Is Orlipastat available on the NHS?

Yes, Orlipastat is available on the NHS for people with a BMI over 30, and those with a BMI over 28 who have other health risks associated with being overweight or obese.

Is Orlipastat safe to take while pregnant?

No, Orlipastat is not safe to take while pregnant. Speak to your doctor or midwife for advice on safe weight loss while pregnant.

Does Orlipastat cause constipation?

Orlipastat may cause changes to your bowel habits. If you experience constipation while taking Orlipastat, speak to your doctor or pharmacist for advice on how to prevent or relieve it.

How quickly will I lose weight when taking Orlipastat?

Weight loss with Orlipastat will vary from person to person. However, you should aim to lose at least 5% of your starting weight during the first three months of treatment.

What foods should I avoid while taking Orlipastat?

It is important to stick to a reduced-calorie, low-fat diet while taking Orlipastat. Foods that are high in saturated fat, such as full-fat dairy products, processed foods, and fried foods should be avoided.

Is Orlipastat related to fat burning?

No, Orlipastat is not related to fat burning. Orlipastat works by blocking some of the fat that you consume from being absorbed by your body. This helps you to reduce the amount of fat absorbed from your diet, helping you to lose weight and reduce the risk of regaining weight.

How often should I take Orlipastat?

The recommended dose of Orlipastat is one capsule three times a day, taken during or up to one hour after each main meal. Do not take more than the recommended dose.

How should Orlipastat be stored?

Orlipastat should be stored at room temperature, away from moisture and heat. Ensure the capsule is tightly closed when not in use. Keep all medications out of the reach of children.

Can Orlipastat be used for weight loss in people with type 2 diabetes?

Yes, Orlipastat may be used to aid weight loss in people with type 2 diabetes. However, it is important to speak to your doctor first, as any additional dietary advice may be needed.

Does Orlipastat cause fatigue?

Fatigue is not a common side effect of Orlipastat. If you experience any unwanted side effects while taking Orlipastat, such as fatigue, speak to your doctor or pharmacist for advice.

Is Orlipastat suitable for vegetarians?

Yes, Orlipastat is suitable for vegetarians as the capsules are made from ingredients derived from plant sources.

Does Orlipastat cause nausea?

Nausea is not a common side effect of Orlipastat. However, speak to your doctor or pharmacist if you experience any unwanted side effects while taking Orlipastat.

Is diet and exercise essential for taking Orlipastat?

Yes, a calorie-controlled diet and regular exercise are essential for achieving the best results when taking Orlipastat. Try to exercise at least five times a week, for at least 30 minutes per day. Additionally, it is important to stick to a healthy, balanced diet to ensure your body is getting the nutrients that it needs.

What is the best way to take Orlipastat?

The best way to take Orlipastat is to take the capsule during or up to one hour after each main meal. Do not take more than the recommended dose and stick to a calorie-controlled diet and regular exercise for best results.

Can Orlipastat be taken long-term?

No, Orlipastat should not be taken long-term. Orlipastat should only be taken for a maximum of six months. After six months, it is recommended that you have a break of one month before starting the treatment again. That said, if you are still losing weight after six months, consider changing to a different form of weight loss treatment.

Is Orlipastat safe to take for a long period of time?

No, Orlipastat should not be taken for a long period of time. Orlipastat should only be taken for a maximum of six months. After six months, it is recommended that you have a break of one month before starting the treatment again. That said, if you are still losing weight after six months, consider changing to a different form of weight loss treatment.

How long after taking Orlipastat can I drink alcohol?

Alcohol should be avoided while taking Orlipastat. Alcohol may further reduce the absorption of fat from the body, leading to fluctuations in blood sugar levels. It is recommended to avoid alcohol until after you have finished your course of Orlipastat.

How quickly will I notice results when taking Orlipastat?

Weight loss with Orlipastat will vary from person to person. However, you should aim to lose at least 5% of your starting weight during the first three months of treatment. Results should begin to be noticeable within a few days of starting Orlipastat, but the effects will be more noticeable after you have been using it for a few weeks.

Can I take Orlipastat if I am taking other medications?

Yes, it is possible to take Orlipastat if you are taking other medications. However, it is important to tell your doctor or pharmacist about any other medications you are taking, before starting Orlipastat, to ensure that all interactions are avoided.

Can I take Orlipastat while on other forms of weight loss treatments, such as weight watchers?

Yes, you can take Orlipastat while on other forms of weight loss treatments, such as weight watchers. However, speak to your doctor or pharmacist if you are considering combining Orlipastat with any other weight loss treatments, as drug interactions may occur.

Does Orlipastat cause any permanent changes to my body?

No, Orlipastat does not cause any permanent changes to your body. Any unwanted effects should stop within a few days of stopping treatment.

Can Orlipastat be used to treat obesity?

Yes, Orlipastat can be used to aid weight loss for people with obesity. However, it is important to stick to a reduced-calorie, low-fat diet and regular exercise for best results.