Nimodipino

Nimodipino Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Nimodipino is a brand name. Its generic name is Nimodipine.

Nimodipino

Nimodipino is a dihydropyridine calcium channel blocker used for the prevention and treatment of ischemic deficits that may result from a subarachnoid hemorrhage. It is used to reduce neurological deficits that can occur after a subarachnoid hemorrhage (SAH; an often-fatal form of stroke caused by bleeding in the brain), which involves a burst aneurysm. It is not used to treat primary strokes or SAH due to trauma or other causes.

Uses For Nimodipino

Nimodipino is used to reduce neurological deficits that may occur after a subarachnoid hemorrhage. It works by inhibiting the entry of calcium ions into vascular smooth muscle cells, inducing vasodilation and reducing vasospasm. By preventing the onset of vasospasm, it can reduce the risk of stroke and potentially life-threatening brain damage.

Mechanism of Action

Nimodipino works by inhibiting the entry of calcium ions into vascular smooth muscle cells in the brain. Calcium ions are important for cell signaling and transport, but they can also cause spasms in the small arteries of the brain. By blocking calcium ions, nimodipine reduces the risk of spasms and helps to maintain normal blood flow in the brain.

How Long Does it Take to Work?

Nimodipino typically begins to take effect within 1–2 hours after it is administered. It is generally recommended to keep taking the medication for at least three months to prevent recurrence of symptoms and maintain stable blood flow in the brain.

Absorption

Nimodipino is rapidly absorbed after oral administration, reaching peak concentrations within 1–2 hours after dosing. The drug is highly bound (>90%) to plasma protein and is widely distributed in the body, with a volume of distribution of approximately 2 L/kg.

Route of Elimination

Nimodipino is primarily eliminated via the kidneys. It has an elimination half-life of approximately 3 hours and is excreted unchanged in the urine.

Dosage

The recommended dose for adults is 60 mg orally administered every four hours for a total of 21 doses per day. For pediatric patients, the total daily dose should not exceed 3.6 mg/kg per day. Nimodipino should not be administered intravenously. It is advised to take nimodipine with food to help reduce irritation of the stomach.

Administration

Nimodipino is oral medication to be taken every four hours with food. It may be taken with or without food. For pediatric patients, nimodipine should not be administered intravenously.

Side Effects

Common side effects of nimodipine include dizziness, headache, nausea, weakness, rash, and flushing. Other rare side effects may include hypotension (low blood pressure), heart block, and bradycardia (slow heart rate). Long-term use of nimodipine may increase the risk of developing cancer.

Toxicity

The LD50 of nimodipine is 550 mg/kg in rats. In humans, the drug has a low toxicity, even at high doses. At doses above 300 mg/day, nimodipine may cause drowsiness, dizziness, and weakness.

Precaution

Nimodipino should be used with caution in patients with renal impairment, as it is eliminated primarily via the kidneys. Nimodipino should also be used with caution in patients with heart block due to the risk of severe bradycardia. Patients may be more prone to dizziness while taking nimodipine, and should be encouraged to remain seated or lie down when symptoms occur.

Interaction

Nimodipino may interact with other medications, such as antihypertensives, anticonvulsants, and calcium channel blockers. It may also interact with herbs and supplements, such as St. John’s Wort, garlic, and ginseng. It is important to inform your doctor of any medications or supplements you are taking.

Disease Interactions

Nimodipino should not be used in patients with hypotension or heart block due to the risk of further reduction in blood pressure or bradycardia. Other diseases that may be contraindicated in patients taking nimodipine include heart failure, hypertension, and liver or kidney disease.

Drug Interactions

Nimodipino may interact with medications including antihypertensives, anticonvulsants, and calcium channel blockers. It is important to inform your doctor of any medications you are taking.

Food Interactions

Nimodipino may interact with certain foods, including dairy, caffeine, and alcohol. It is important to inform your doctor of any dietary changes that may affect your treatment.

Pregnancy Use

Nimodipino should be used with caution during pregnancy as it may cause adverse effects in the fetus. It is not recommended for women who are breastfeeding.

Lactation Use

Nimodipino is not recommended for women who are breastfeeding due to the potential risks to the infant.

Acute Overdose

An acute overdose of nimodipine may result in symptoms such as dizziness, confusion, drowsiness, hypotension, tachycardia, arrhythmias, and respiratory depression. If an overdose is suspected, it is important to seek medical attention immediately.

Contraindication

Nimodipino is contraindicated in patients with a known hypersensitivity to dihydropyridine calcium channel blockers. It should also not be used in patients with hypotension or heart block due to the risk of further reduction in blood pressure or bradycardia. Nimodipino should also not be taken with alcohol or other CNS depressants.

Use Direction

Nimodipino should be taken orally, typically every four hours. It may be taken with or without food. Patients should not exceed the recommended dose of 60 mg every four hours and should not take more than 21 doses in a 24 hour period.

Storage Conditions

Nimodipino should be stored in a cool, dry place at room temperature. It should be kept in its original container and away from light, heat, and moisture.

Volume of Distribution

Nimodipino has a volume of distribution of approximately 2L/kg.

Half Life

Nimodipino has an elimination half-life of approximately 3 hours.

Clearance

Nimodipino is largely eliminated from the body via the kidneys, though a small amount is excreted unchanged in the urine.

Here you find in details version of Nimodipino

Some Frequently Asked Questions About Nimodipino

What is Nimodipino?

Nimodipino is a calcium channel blocker medication used to treat high blood pressure and prevent headache associated with a subarachnoid hemorrhage.

How does Nimodipino work?

Nimodipino works by blocking calcium channels in the brain, which helps to reduce pressure inside the head and helps to prevent some of the neurologic complications that can result from a subarachnoid hemorrhage.

What is Nimodipino used for?

Nimodipino is used to prevent headaches and other neurological complications resulting from a subarachnoid hemorrhage, which is a type of stroke. It is also used to treat and prevent high blood pressure.

Who should not take Nimodipino?

People who are allergic to nimodipine or any of its ingredients should not take this medication. People with certain medical conditions, including heart problems, should also consult their doctor before taking Nimodipino.

How do I take Nimodipino?

Nimodipino is usually taken in the form of a capsule or tablet. Your doctor will tell you how much and how often to take your medication. You should take it with food, as directed by your doctor.

What are the side effects of Nimodipino?

The most common side effects of Nimodipino include dizziness, headache, fatigue, flushing of the skin, and low blood pressure. Less common but more serious side effects include heart problems, liver problems, and difficulty breathing.

What should I do if I experience any side effects while taking Nimodipino?

If you experience any side effects while taking Nimodipino, contact your doctor immediately. Do not stop taking the medication or alter your dose without speaking with your doctor first.

What should I avoid while taking Nimodipino?

You should avoid alcohol while taking Nimodipino because it may increase your risk of experiencing side effects. You should also avoid driving or operating machinery until you know how this medication will affect you.

How long does Nimodipino stay in my system?

The half-life of nimodipine is approximately 5-8 hours, meaning that it will take around 5-7 half-lives (or 25-56 hours) for the medication to be completely cleared from your system.

Are there any interactions with other medications I should be aware of when taking Nimodipino?

Yes, you should always tell your doctor about all medications that you are taking, including prescription and over-the-counter medications, vitamins, and supplements. Certain medications, such as blood pressure medications, can interact with Nimodipino.

Does Nimodipino cause weight gain?

Weight gain is not a common side effect of Nimodipino. If you experience an unexplained change in your weight while taking Nimodipino, contact your doctor.

What should I do if I miss a dose of Nimodipino?

If you miss a dose of Nimodipino, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and take your next dose at the regular time.

Are there any long-term side effects related to Nimodipino?

There are no known long-term side effects related to Nimodipino. However, it is important to talk to your doctor about any potential risks and benefits of taking this medication.

Should I take Nimodipino with food?

Yes, it is recommended that you take Nimodipino with food, as this may help reduce some of the common side effects such as dizziness.

Can I take Nimodipino while pregnant or breastfeeding?

Pregnant and breastfeeding women should consult their doctor before taking Nimodipino. Nimodipino is not typically recommended for use during pregnancy.

Does Nimodipino increase my risk of falls?

Yes, Nimodipino may increase your risk of falls, which can lead to serious injuries. If you experience dizziness, tiredness, or light headedness while taking Nimodipino, contact your doctor immediately.

What should I do if I accidentally take an overdose of Nimodipino?

If you or someone you know has taken an overdose of Nimodipino, seek emergency medical attention right away. Overdose symptoms can include muscle weakness, dizziness, fainting, and slower breathing.

Are generic forms of Nimodipino available?

Yes, generic forms of Nimodipino are available. These medications may be less expensive but are just as effective as brand-name Nimodipino.

What medications can I take with Nimodipino?

You should always tell your doctor about all the medications that you are taking. Certain medications may interact with Nimodipino, so it is important to check with your doctor before taking any new medications.

Is it safe to take aspirin while taking Nimodipino?

It is generally safe to take aspirin while taking Nimodipino, however, it is important to talk to your doctor before taking any medications, including aspirin.

Does Nimodipino cause dry mouth?

Dry mouth is not a common side effect of Nimodipino, but some people may experience this side effect while taking this medication.

Can I take antacids while taking Nimodipino?

Yes, it is generally safe to take antacids while taking Nimodipino, however, it is important to talk to your doctor about any medications you are taking, including antacids.

Can I take over-the-counter medications while taking Nimodipino?

You should always tell your doctor about any medications that you are taking, including over-the-counter medications. Some over-the-counter medications can interact with Nimodipino, so it is important to check with your doctor before taking any new medications.

Can I take other medications to treat headaches while taking Nimodipino?

You should talk to your doctor before taking any additional medications to treat headaches while taking Nimodipino. Some medications, including over-the-counter pain relievers, may interact with Nimodipino and should be avoided.

Can I drive while taking Nimodipino?

You should not drive or operate machinery while taking Nimodipino until you know how this medication affects you. Effects such as dizziness, lightheadedness, and drowsiness may impair your ability to safely operate a motor vehicle.

Can I drink alcohol while taking Nimodipino?

No, you should avoid alcohol while taking Nimodipino as this may increase your risk of experiencing side effects or could interfere with the effectiveness of the medication.

Can I share my Nimodipino with someone else?

No, you should not share your medication with anyone else as Nimodipino is prescribed to you based on your specific medical needs and should not be used by anyone else.

What if I don't take my Nimodipino as prescribed?

You should always take Nimodipino as prescribed. If you miss doses or do not take the medication as directed by your doctor, your condition may not improve or may worsen. Make sure to follow your doctor's instructions carefully.

What if I don't feel any effects after taking Nimodipino?

It is important to take Nimodipino as prescribed and regularly to experience the full effects of this medication. If you do not feel any effects after taking this medication, contact your doctor.

What should I do if I experience chest pain while taking Nimodipino?

If you experience chest pain while taking Nimodipino, you should seek emergency medical attention immediately. Chest pain may be a symptom of a serious medical condition, such as a heart attack.

Are there any alternatives to Nimodipino?

There are several alternatives to Nimodipino including other calcium channel blockers and blood pressure medications. Speak with your doctor about any potential alternatives.

What should I do if I experience any difficulty breathing while taking Nimodipino?

If you experience any difficulty breathing while taking Nimodipino, seek medical attention immediately. Difficulty breathing is a serious and potentially life-threatening side effect of this medication.

Is it safe to take Nimodipino if I have diabetes?

Yes, it is generally safe to take Nimodipino if you have diabetes. However, you should talk to your doctor about any medications you are taking and be sure to monitor your blood glucose levels.

What should I do if I experience any anxiety or trembling while taking Nimodipino?

If you experience any anxiety or trembling while taking Nimodipino, contact your doctor immediately. These may be side effects of this medication and should be discussed with your doctor.

Can I take sleeping pills while taking Nimodipino?

You should talk to your doctor before taking any sleeping pills while taking Nimodipino. Some medications may interact with Nimodipino and should be avoided.

Is it safe to take other medications while taking Nimodipino?

You should always talk to your doctor before taking any new medications while taking Nimodipino. Certain medications may interact with Nimodipino and should be discussed with your doctor.

What should I do if I experience nausea or vomiting while taking Nimodipino?

If you experience nausea or vomiting while taking Nimodipino, contact your doctor. These may be side effects of this medication and should be discussed with your doctor.

Are there any restrictions on what I can eat or drink while taking Nimodipino?

You should always talk to your doctor before making any changes to your diet. Certain foods and drinks, such as alcohol, can interact with Nimodipino and should be avoided.

Are there any other medical conditions I should discuss with my doctor before taking Nimodipino?

Yes, you should always discuss any pre-existing or new medical conditions with your doctor before taking Nimodipino. Certain medical conditions, such as heart problems, can interact with this medication.