Nimodipinum

Nimodipinum Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Nimodipinum is a brand name. Its generic name is Nimodipine.

Nimodipinum

Nimodipinum is a dihydropyridine calcium channel blocker used for the prevention and treatment of ischemic deficits that may result from a subarachnoid hemorrhage. It is used to reduce neurological deficits that can occur after a subarachnoid hemorrhage (SAH; an often-fatal form of stroke caused by bleeding in the brain), which involves a burst aneurysm. It is not used to treat primary strokes or SAH due to trauma or other causes.

Uses For Nimodipinum

Nimodipinum is used to reduce neurological deficits that may occur after a subarachnoid hemorrhage. It works by inhibiting the entry of calcium ions into vascular smooth muscle cells, inducing vasodilation and reducing vasospasm. By preventing the onset of vasospasm, it can reduce the risk of stroke and potentially life-threatening brain damage.

Mechanism of Action

Nimodipinum works by inhibiting the entry of calcium ions into vascular smooth muscle cells in the brain. Calcium ions are important for cell signaling and transport, but they can also cause spasms in the small arteries of the brain. By blocking calcium ions, nimodipine reduces the risk of spasms and helps to maintain normal blood flow in the brain.

How Long Does it Take to Work?

Nimodipinum typically begins to take effect within 1–2 hours after it is administered. It is generally recommended to keep taking the medication for at least three months to prevent recurrence of symptoms and maintain stable blood flow in the brain.

Absorption

Nimodipinum is rapidly absorbed after oral administration, reaching peak concentrations within 1–2 hours after dosing. The drug is highly bound (>90%) to plasma protein and is widely distributed in the body, with a volume of distribution of approximately 2 L/kg.

Route of Elimination

Nimodipinum is primarily eliminated via the kidneys. It has an elimination half-life of approximately 3 hours and is excreted unchanged in the urine.

Dosage

The recommended dose for adults is 60 mg orally administered every four hours for a total of 21 doses per day. For pediatric patients, the total daily dose should not exceed 3.6 mg/kg per day. Nimodipinum should not be administered intravenously. It is advised to take nimodipine with food to help reduce irritation of the stomach.

Administration

Nimodipinum is oral medication to be taken every four hours with food. It may be taken with or without food. For pediatric patients, nimodipine should not be administered intravenously.

Side Effects

Common side effects of nimodipine include dizziness, headache, nausea, weakness, rash, and flushing. Other rare side effects may include hypotension (low blood pressure), heart block, and bradycardia (slow heart rate). Long-term use of nimodipine may increase the risk of developing cancer.

Toxicity

The LD50 of nimodipine is 550 mg/kg in rats. In humans, the drug has a low toxicity, even at high doses. At doses above 300 mg/day, nimodipine may cause drowsiness, dizziness, and weakness.

Precaution

Nimodipinum should be used with caution in patients with renal impairment, as it is eliminated primarily via the kidneys. Nimodipinum should also be used with caution in patients with heart block due to the risk of severe bradycardia. Patients may be more prone to dizziness while taking nimodipine, and should be encouraged to remain seated or lie down when symptoms occur.

Interaction

Nimodipinum may interact with other medications, such as antihypertensives, anticonvulsants, and calcium channel blockers. It may also interact with herbs and supplements, such as St. John’s Wort, garlic, and ginseng. It is important to inform your doctor of any medications or supplements you are taking.

Disease Interactions

Nimodipinum should not be used in patients with hypotension or heart block due to the risk of further reduction in blood pressure or bradycardia. Other diseases that may be contraindicated in patients taking nimodipine include heart failure, hypertension, and liver or kidney disease.

Drug Interactions

Nimodipinum may interact with medications including antihypertensives, anticonvulsants, and calcium channel blockers. It is important to inform your doctor of any medications you are taking.

Food Interactions

Nimodipinum may interact with certain foods, including dairy, caffeine, and alcohol. It is important to inform your doctor of any dietary changes that may affect your treatment.

Pregnancy Use

Nimodipinum should be used with caution during pregnancy as it may cause adverse effects in the fetus. It is not recommended for women who are breastfeeding.

Lactation Use

Nimodipinum is not recommended for women who are breastfeeding due to the potential risks to the infant.

Acute Overdose

An acute overdose of nimodipine may result in symptoms such as dizziness, confusion, drowsiness, hypotension, tachycardia, arrhythmias, and respiratory depression. If an overdose is suspected, it is important to seek medical attention immediately.

Contraindication

Nimodipinum is contraindicated in patients with a known hypersensitivity to dihydropyridine calcium channel blockers. It should also not be used in patients with hypotension or heart block due to the risk of further reduction in blood pressure or bradycardia. Nimodipinum should also not be taken with alcohol or other CNS depressants.

Use Direction

Nimodipinum should be taken orally, typically every four hours. It may be taken with or without food. Patients should not exceed the recommended dose of 60 mg every four hours and should not take more than 21 doses in a 24 hour period.

Storage Conditions

Nimodipinum should be stored in a cool, dry place at room temperature. It should be kept in its original container and away from light, heat, and moisture.

Volume of Distribution

Nimodipinum has a volume of distribution of approximately 2L/kg.

Half Life

Nimodipinum has an elimination half-life of approximately 3 hours.

Clearance

Nimodipinum is largely eliminated from the body via the kidneys, though a small amount is excreted unchanged in the urine.

Here you find in details version of Nimodipinum

Some Frequently Asked Questions About Nimodipinum

What is Nimodipinum?

Nimodipinum is a calcium channel blocker medication used to treat high blood pressure and prevent headache associated with a subarachnoid hemorrhage.

How does Nimodipinum work?

Nimodipinum works by blocking calcium channels in the brain, which helps to reduce pressure inside the head and helps to prevent some of the neurologic complications that can result from a subarachnoid hemorrhage.

What is Nimodipinum used for?

Nimodipinum is used to prevent headaches and other neurological complications resulting from a subarachnoid hemorrhage, which is a type of stroke. It is also used to treat and prevent high blood pressure.

Who should not take Nimodipinum?

People who are allergic to nimodipine or any of its ingredients should not take this medication. People with certain medical conditions, including heart problems, should also consult their doctor before taking Nimodipinum.

How do I take Nimodipinum?

Nimodipinum is usually taken in the form of a capsule or tablet. Your doctor will tell you how much and how often to take your medication. You should take it with food, as directed by your doctor.

What are the side effects of Nimodipinum?

The most common side effects of Nimodipinum include dizziness, headache, fatigue, flushing of the skin, and low blood pressure. Less common but more serious side effects include heart problems, liver problems, and difficulty breathing.

What should I do if I experience any side effects while taking Nimodipinum?

If you experience any side effects while taking Nimodipinum, contact your doctor immediately. Do not stop taking the medication or alter your dose without speaking with your doctor first.

What should I avoid while taking Nimodipinum?

You should avoid alcohol while taking Nimodipinum because it may increase your risk of experiencing side effects. You should also avoid driving or operating machinery until you know how this medication will affect you.

How long does Nimodipinum stay in my system?

The half-life of nimodipine is approximately 5-8 hours, meaning that it will take around 5-7 half-lives (or 25-56 hours) for the medication to be completely cleared from your system.

Are there any interactions with other medications I should be aware of when taking Nimodipinum?

Yes, you should always tell your doctor about all medications that you are taking, including prescription and over-the-counter medications, vitamins, and supplements. Certain medications, such as blood pressure medications, can interact with Nimodipinum.

Does Nimodipinum cause weight gain?

Weight gain is not a common side effect of Nimodipinum. If you experience an unexplained change in your weight while taking Nimodipinum, contact your doctor.

What should I do if I miss a dose of Nimodipinum?

If you miss a dose of Nimodipinum, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and take your next dose at the regular time.

Are there any long-term side effects related to Nimodipinum?

There are no known long-term side effects related to Nimodipinum. However, it is important to talk to your doctor about any potential risks and benefits of taking this medication.

Should I take Nimodipinum with food?

Yes, it is recommended that you take Nimodipinum with food, as this may help reduce some of the common side effects such as dizziness.

Can I take Nimodipinum while pregnant or breastfeeding?

Pregnant and breastfeeding women should consult their doctor before taking Nimodipinum. Nimodipinum is not typically recommended for use during pregnancy.

Does Nimodipinum increase my risk of falls?

Yes, Nimodipinum may increase your risk of falls, which can lead to serious injuries. If you experience dizziness, tiredness, or light headedness while taking Nimodipinum, contact your doctor immediately.

What should I do if I accidentally take an overdose of Nimodipinum?

If you or someone you know has taken an overdose of Nimodipinum, seek emergency medical attention right away. Overdose symptoms can include muscle weakness, dizziness, fainting, and slower breathing.

Are generic forms of Nimodipinum available?

Yes, generic forms of Nimodipinum are available. These medications may be less expensive but are just as effective as brand-name Nimodipinum.

What medications can I take with Nimodipinum?

You should always tell your doctor about all the medications that you are taking. Certain medications may interact with Nimodipinum, so it is important to check with your doctor before taking any new medications.

Is it safe to take aspirin while taking Nimodipinum?

It is generally safe to take aspirin while taking Nimodipinum, however, it is important to talk to your doctor before taking any medications, including aspirin.

Does Nimodipinum cause dry mouth?

Dry mouth is not a common side effect of Nimodipinum, but some people may experience this side effect while taking this medication.

Can I take antacids while taking Nimodipinum?

Yes, it is generally safe to take antacids while taking Nimodipinum, however, it is important to talk to your doctor about any medications you are taking, including antacids.

Can I take over-the-counter medications while taking Nimodipinum?

You should always tell your doctor about any medications that you are taking, including over-the-counter medications. Some over-the-counter medications can interact with Nimodipinum, so it is important to check with your doctor before taking any new medications.

Can I take other medications to treat headaches while taking Nimodipinum?

You should talk to your doctor before taking any additional medications to treat headaches while taking Nimodipinum. Some medications, including over-the-counter pain relievers, may interact with Nimodipinum and should be avoided.

Can I drive while taking Nimodipinum?

You should not drive or operate machinery while taking Nimodipinum until you know how this medication affects you. Effects such as dizziness, lightheadedness, and drowsiness may impair your ability to safely operate a motor vehicle.

Can I drink alcohol while taking Nimodipinum?

No, you should avoid alcohol while taking Nimodipinum as this may increase your risk of experiencing side effects or could interfere with the effectiveness of the medication.

Can I share my Nimodipinum with someone else?

No, you should not share your medication with anyone else as Nimodipinum is prescribed to you based on your specific medical needs and should not be used by anyone else.

What if I don't take my Nimodipinum as prescribed?

You should always take Nimodipinum as prescribed. If you miss doses or do not take the medication as directed by your doctor, your condition may not improve or may worsen. Make sure to follow your doctor's instructions carefully.

What if I don't feel any effects after taking Nimodipinum?

It is important to take Nimodipinum as prescribed and regularly to experience the full effects of this medication. If you do not feel any effects after taking this medication, contact your doctor.

What should I do if I experience chest pain while taking Nimodipinum?

If you experience chest pain while taking Nimodipinum, you should seek emergency medical attention immediately. Chest pain may be a symptom of a serious medical condition, such as a heart attack.

Are there any alternatives to Nimodipinum?

There are several alternatives to Nimodipinum including other calcium channel blockers and blood pressure medications. Speak with your doctor about any potential alternatives.

What should I do if I experience any difficulty breathing while taking Nimodipinum?

If you experience any difficulty breathing while taking Nimodipinum, seek medical attention immediately. Difficulty breathing is a serious and potentially life-threatening side effect of this medication.

Is it safe to take Nimodipinum if I have diabetes?

Yes, it is generally safe to take Nimodipinum if you have diabetes. However, you should talk to your doctor about any medications you are taking and be sure to monitor your blood glucose levels.

What should I do if I experience any anxiety or trembling while taking Nimodipinum?

If you experience any anxiety or trembling while taking Nimodipinum, contact your doctor immediately. These may be side effects of this medication and should be discussed with your doctor.

Can I take sleeping pills while taking Nimodipinum?

You should talk to your doctor before taking any sleeping pills while taking Nimodipinum. Some medications may interact with Nimodipinum and should be avoided.

Is it safe to take other medications while taking Nimodipinum?

You should always talk to your doctor before taking any new medications while taking Nimodipinum. Certain medications may interact with Nimodipinum and should be discussed with your doctor.

What should I do if I experience nausea or vomiting while taking Nimodipinum?

If you experience nausea or vomiting while taking Nimodipinum, contact your doctor. These may be side effects of this medication and should be discussed with your doctor.

Are there any restrictions on what I can eat or drink while taking Nimodipinum?

You should always talk to your doctor before making any changes to your diet. Certain foods and drinks, such as alcohol, can interact with Nimodipinum and should be avoided.

Are there any other medical conditions I should discuss with my doctor before taking Nimodipinum?

Yes, you should always discuss any pre-existing or new medical conditions with your doctor before taking Nimodipinum. Certain medical conditions, such as heart problems, can interact with this medication.