Naphcon-a
Naphcon-a Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Naphcon-a is a brand name. Its generic name is Naphazoline + Pheniramine (Maleate).
Introduction
Naphazoline-Pheniramine Maleate is a medication containing two active ingredients: naphazoline hydrochloride and pheniramine maleate. It is an antihistamine and decongestant medicine used to treat symptoms associated with allergies such as sneezing, runny nose, itchy and watery eyes, and nasal congestion.Uses
Naphazoline-Pheniramine Maleate is typically used for the temporary relief of cold, hay fever, and other allergies. It is also used to relieve nasal congestion caused by flu and other respiratory tract infections.Mechanism of Action
Naphazoline-Pheniramine Maleate works by blocking the chemical histamine in the body, which reduces inflammation and nasal congestion. It also reduces swelling of nasal passages, making it easier to breathe.How Long Does It Take to Work?
Naphazoline-Pheniramine Maleate usually begins to work within 15 to 30 minutes after taking it. The full effect should be felt within 1-2 hours.Absorption
Naphazoline-Pheniramine is rapidly and almost completely absorbed following oral administration. Peak concentrations of the active ingredients are usually attained within 1-2 hours.Route of Elimination
Naphazoline-Pheniramine is primarily eliminated through metabolism in the liver and metabolites are mainly excreted in the urine.Dosage
Naphazoline-Pheniramine comes in generic forms of tablets/capsules, nasal spray, stamp/spot on, and eye drops/ointment. The typical dosage for oral forms is 1-2 tablets by mouth every 4-6 hours, not to exceed 8 tablets a day. The nasal spray is typically used 1-2 sprays per nostril every 4-6 hours not to exceed more than 4 sprays per day. The spot/stamp on form is usually used every 4-6 hours as needed. As for the eye drops or ointment, 1-2 drops by eye every 4-6 hours. It is important to always follow the instructions provided by a healthcare provider.Administration
Naphazoline-Pheniramine should be taken by mouth as either a tablet or capsule, nasally as a spray, or applied as either an eye drop or ointment. It can be taken with or without food.Side Effects
The most common side effects of Naphazoline-Pheniramine Maleate include: headache, drowsiness, blurred vision, nausea, dry mouth, and high blood pressure. Other side effects may include: dizziness, nervousness/restlessness, stomach pain, difficulty urinating, and ringing in the ears.Toxicity
Naphazoline-Pheniramine Maleate is generally well tolerated when taken in recommended dosages. In large doses, it can cause serious toxicity and death. If taken in excessive amounts or over a long period of time, it can increase the risk of liver and kidney damage.Precautions
Naphazoline-Pheniramine Maleate should not be taken by people who have been diagnosed with glaucoma, increased pressure on the brain, or urinary tract infections. It should not be taken during pregnancy unless the benefits outweigh the risks. It should also not be taken in combination with other medications, as this can increase the risk of side effects, or reduce the effectiveness of the medication.Interactions
Naphazoline-Pheniramine Maleate has the potential to interact with certain medications, such as monoamine oxidase inhibitors (MAOIs), tricyclic antidepressants, alcohol, and narcotics. It should not be taken while using any of these medications. It is also important to tell your doctor before taking Naphazoline-Pheniramine Maleate if you take any other medications including prescription, non-prescription, herbal medications, and dietary supplements.Disease Interactions
Naphazoline-Pheniramine Maleate can interact with certain conditions and diseases. It should not be taken if you have glaucoma or an overactive thyroid gland. It should also not be taken if you have phenylketonuria (PKU) or difficulty urinating.Drug Interactions
Naphazoline-Pheniramine Maleate has the potential to interact with other drugs, including monoamine oxidase inhibitors (MAOIs), tricyclic antidepressants, alcohol, and narcotics. It should not be taken while using any of these medications. It is important to tell your doctor before taking Naphazoline-Pheniramine Maleate if you are taking any other medications including prescription, non-prescription, herbal medicines, and dietary supplements.Food Interactions
Naphazoline-Pheniramine Maleate is generally not known to interact with any foods, but it is important to tell your doctor if you are taking any other medications or dietary supplements.Pregnancy Use
Naphazoline-Pheniramine Maleate should not be taken during pregnancy unless the benefits outweigh the risks. It should be used in the smallest possible dose and for the shortest possible duration of time.Lactation Use
Naphazoline-Pheniramine Maleate should not be taken while breast-feeding due to a lack of information regarding its safety during this period. It is important to consult your healthcare provider before taking this medication while breast-feeding.Acute Overdose
Symptoms of an acute overdose of Naphazoline-Pheniramine Maleate can include nausea, vomiting, headache, confusion, restlessness, agitation, rapid heart rate, sweating, dizziness, and dilated pupils. It is important to seek medical attention immediately if an overdose is suspected.Contraindication
Naphazoline-Pheniramine Maleate is contraindicated in patients with glaucoma, increased pressure on the brain, urinary tract obstruction or an overactive thyroid gland. Women who are pregnant or breastfeeding should not take this medication unless it is necessary and the risks of taking it are explained and understood.Use Direction
Naphazoline-Pheniramine Maleate should be taken as directed by your doctor or pharmacist. It should be taken orally as either a tablet or capsule, nasally as a spray, or applied as either an eye drop or ointment. It can be taken with or without food. The typical dosage for oral forms is 1-2 tablets by mouth every 4-6 hours, not to exceed 8 tablets a day. The nasal spray is usually used 1-2 sprays per nostril every 4-6 hours not to exceed more than 4 sprays per day. The spot/stamp on form is typically used every 4-6 hours as needed. As for the eye drops or ointment, 1-2 drops by eye every 4-6 hours.Storage Condition
Naphazoline-Pheniramine Maleate should be stored below 25 degrees Celsius (77F) and it should be kept in a tightly closed container. It should also be kept away from direct heat, light, and moisture.Volume of Distribution
The volume of distribution (Vd) of Naphazoline-Pheniramine Maleate is approximately 4 L/kg.Half Life
The elimination half-life of Naphazoline-Pheniramine Maleate is approximately 1.5-4 hours.Clearance
Naphazoline-Pheniramine Maleate has a hepatic clearance of approximately 5-15 mL/min/kg.Here you find in details version of Naphcon-a