Ivabradine
Ivabradine Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Ivabradine is a brand name. Its generic name is Ivabradine.
Ivabradine Introduction and Uses
Ivabradine is an antiarrhythmic drug used in the treatment of symptomatic stable angina, specifically in those patients having hypertension and a resting heart rate of 75 beats per minute or greater. It is a selective if inhibitor – acting on the If current in the sinoatrial node of the heart. Its primary effect is to reduce heart rate, and in doing so, reduce the oxygen demand on the myocardium by up to 10–15%.
Mechanism of Action
Ivabradine acts by selectively inhibiting the If current within the sinoatrial node, a specialized group of cells in the heart responsible for setting the pace of the heartbeat. The If current determines the slow-inward diastolic depolarization of the cells, meaning it determines how often the cells depolarize. By inhibiting the If current, the heart rate is decreased which reduces the oxygen demand of the myocardium.
How Long Does It Take to Work?
The effects of ivabradine can be seen within two hours of ingestion and its effect on heart rate is usually seen within two days. It is recommended to take the medication on an empty stomach to achieve the fullest effect.
Absorption
Ivabradine is rapidly absorbed from the gut but its rate of absorption is not affected by food intake. After maximal absorption, the concentration of ivabradine in the circulation increases slowly and reaches its peak concentration after four to six hours.
Route of Elimination
Ivabradine is primarily eliminated through biliary excretion. Following a single dose of ivabradine, approximately 68% of the dose was eliminated in the bile. The remainder of the dose is excreted in the urine and feces.
Dosage
Ivabradine is available as oral tablets with doses ranging from 2.5 mg to 15 mg. The usual recommended dose for the treatment of stable angina is 7.5 mg once daily taken on an empty stomach. The dose can be titrated up to a maximum of 15 mg once daily if necessary.
Administration
Ivabradine should be taken with a full glass of water and should be taken on an empty stomach, i.e. at least two hours after eating or two hours before eating, for maximum effect. To reduce the risk of dizziness, it is important to take this medication exactly as prescribed.
Side Effects
The most common side effects of ivabradine include dizziness, headache, nausea, bradycardia, fatigue, diarrhea, abdominal pain and dyspepsia. Patients should seek medical attention if these side effects persist or become worse. Rarely, serious side effects such as swelling, breathing difficulty and palpitations may occur.
Toxicity
The toxicity of ivabradine has not been established. There have been no reported cases of overdose with this drug. In the event of an overdose, symptomatic treatment is recommended.
Precautions
Patients with certain medical conditions should not take ivabradine, including those with severe bradycardia, severe hypotension, moderate to severe renal impairment, or heart failure of NYHA class III or IV. In addition, patients taking certain medications such as calcium channel blockers, vasodilators, beta-blockers, and certain antibiotics should not take ivabradine.
Interaction
Ivabradine can interact with certain drugs, including calcium channel blockers, vasodilators such as nitroglycerin, certain antibiotics, beta-blockers, and digoxin. The combination of these drugs could cause an excessive bradycardia and hypotension. Close medical monitoring is recommended for patients taking these medications.
Disease Interaction
Patients with certain diseases should not take ivabradine, including those with severe bradycardia, severe hypotension, moderate to severe renal impairment, or heart failure of NYHA class III or IV. Certain medications, such as calcium channel blockers, vasodilators, beta-blockers, and certain antibiotics, can also interact with ivabradine and should be avoided in these patients.
Drug Interaction
Certain drugs, including calcium channel blockers, vasodilators, beta-blockers, and certain antibiotics, can interact with ivabradine and should be avoided. Ivabradine should not be used concomitantly with other If current inhibitors due to the risk of additive bradycardic effect.
Food Interactions
The rate of absorption of ivabradine is not affected by food intake, but it is recommended to take on an empty stomach for maximum effect.
Pregnancy Use
Ivabradine has not been studied in pregnant women and its use is not recommended. Animal studies have shown some evidence of fetotoxicity but a risk to humans has not been established.
Lactation Use
Ivabradine has not been studied in women who are breastfeeding and its use is not recommended.
Acute Overdose
There are no known reports of an overdose of ivabradine and its toxicity has not been established. Symptomatic treatment should be initiated if an overdose is suspected.
Contraindication
Ivabradine is contraindicated in patients with severe bradycardia, severe hypotension, moderate to severe renal impairment, or heart failure of NYHA class III or IV, as well as in patients taking certain medications such as calcium channel blockers, vasodilators, beta-blockers, and certain antibiotics.
Use Direction
Ivabradine should be taken with a full glass of water and should be taken on an empty stomach, i.e. at least two hours after eating or two hours before eating, for maximum effect. The dose should be reduced in patients with renal impairment. The dose should be gradually reduced and/or discontinued in patients with a reduction in heart rate or increase in blood pressure.
Storage Condition
Ivabradine should be stored between 4 C and 25 C. It should be kept away from direct moisture, humidity, and light.
Volume of Distribution
The volume of distribution of ivabradine is 11 liters.
Half Life
The elimination half-life of ivabradine is 6 hours.
Clearance
The clearance of ivabradine is 5.9 liters/hour.
Here you find in details version of Ivabradine
Some Frequently Asked Questions About Ivabradine
What is Ivabradine?
Ivabradine is a prescription medication used to treat chronic stable angina (chest pain) associated with chronic coronary artery disease. It works by reducing the heart rate to improve blood flow to the heart and reduce symptoms of angina.
What is Ivabradine used for?
Ivabradine is used to treat chronic stable angina (chest pain) associated with chronic coronary artery disease. It works by reducing the heart rate to improve blood flow to the heart and reduce symptoms of angina.
Who is Ivabradine for?
Ivabradine is for adults with chronic stable angina pectoris (chest pain) associated with chronic coronary artery disease. It may not be appropriate for those with certain medical conditions, so it’s important to talk to your doctor before taking it.
How does Ivabradine work?
Ivabradine works by reducing the heart rate. It blocks some of the nerve signals that tell your heart to beat faster and harder, reducing the amount of work your heart has to do. This helps to reduce symptoms of angina and improve blood flow to the heart.
What are the side effects of Ivabradine?
The most common side effects of Ivabradine include headache, nausea, dizziness, tiredness, and diarrhea. Other possible side effects include flushing, rash, and palpitations. If any of these side effects become persistent or bothersome, speak to your doctor.
Is Ivabradine safe?
Yes, Ivabradine is generally safe when taken as prescribed. However, like all medications, it may not be right for everyone. It’s important to talk to your doctor before taking Ivabradine to make sure it is safe for you.
What is the dosage of Ivabradine?
The recommended starting dose for Ivabradine is 5 mg twice daily, taken with or without food. Your dose should be adjusted to a maximum of 7.5 mg twice daily depending on how you respond to the medication and any side effects you may experience.
Can I take other medications with Ivabradine?
Yes, you can take other medications with Ivabradine, but it’s important to talk to your doctor before combining it with any other medications. Certain medications may interfere with the way Ivabradine works or increase your risk of side effects.
What should I do if I miss a dose of Ivabradine?
If you miss a dose of Ivabradine, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the next dose at the regular time. Do not take a double dose of Ivabradine to make up for a missed dose.
Is Ivabradine available over the counter?
No, Ivabradine is not available over the counter. It is a prescription medication that must be prescribed by a doctor.
Should I take Ivabradine with food?
Ivabradine can be taken with or without food. However, it may be best to take it with food to reduce the risk of nausea.
What are the warnings and precautions associated with Ivabradine?
Ivabradine should not be used if you are pregnant or breastfeeding. It is also important to tell your doctor if you have any other medical conditions or allergies, and if you are taking any other medications, supplements, or herbal remedies.
Can I drink alcohol with Ivabradine?
It is not recommended to drink alcohol while taking Ivabradine as it can increase the risk of certain side effects. If you choose to drink alcohol while taking Ivabradine, it is important to do so in moderation.
Can I drive or operate machinery while taking Ivabradine?
Ivabradine can cause drowsiness and dizziness. It is best to avoid driving or operating machinery until you know how Ivabradine affects you.
How long does Ivabradine take to work?
It may take several weeks for Ivabradine to have its full effect. Talk to your doctor if you do not notice any improvements in your symptoms after taking the medication for a few weeks.
What are the storage requirements for Ivabradine
Ivabradine should be stored at room temperature between 59 to 86 degrees Fahrenheit (15 to 30 degrees Celsius). Keep it in a closed, airtight container, away from heat, moisture, and direct sunlight.
Can Ivabradine be crushed or split?
Do not crush or split the Ivabradine tablets. Swallow them whole with a glass of water. Talk to your doctor or pharmacist if you have any difficulty swallowing the medication.
What is the cost of Ivabradine?
The cost of Ivabradine varies depending on where it is purchased. It may be covered by your insurance or may require a co-pay. Talk to your doctor or pharmacist about any questions you may have about the cost of Ivabradine.
How should Ivabradine be stored?
Ivabradine should be stored at room temperature between 59 to 86 degrees Fahrenheit (15 to 30 degrees Celsius). Keep it in a closed, airtight container, away from heat, moisture, and direct sunlight.
Are there any interactions with Ivabradine and other medications?
Yes. Ivabradine may interact with certain medications, including beta-blockers, calcium channel blockers, and digoxin. It is important to talk to your doctor before taking any new medications while taking Ivabradine.
What are the signs of an allergic reaction to Ivabradine?
Signs of an allergic reaction to Ivabradine may include hives, difficulty breathing, rash, itching, swelling of the face, throat, tongue, or lips, or wheezing. If you experience any of these symptoms, stop taking Ivabradine and seek medical attention immediately.
Does Ivabradine lower blood pressure?
No, Ivabradine does not lower blood pressure. It is used to treat chronic stable angina (chest pain) associated with chronic coronary artery disease by reducing the heart rate.
Is Ivabradine safe for long-term use?
Ivabradine is generally safe for long-term use when taken as prescribed. However, it is important to talk to your doctor if you plan to take the medication for a long period of time.
Does Ivabradine cause weight gain?
No, Ivabradine does not cause weight gain. However, some people may gain weight while taking Ivabradine due to other side effects, such as fatigue and dizziness, which can lead to overeating.
Does Ivabradine cause erectile dysfunction?
No, there is no evidence that suggests Ivabradine causes erectile dysfunction. However, some men may experience decreased sexual desire or difficulty getting an erection while taking Ivabradine. If this occurs, talk to your doctor.
Does Ivabradine affect blood sugar levels?
No, Ivabradine does not affect blood sugar levels. However, some people with diabetes may experience changes in blood sugar levels while taking Ivabradine. It’s important to monitor your blood sugar levels closely while taking Ivabradine.
Can I take Ivabradine while breastfeeding?
No, Ivabradine should not be taken while breastfeeding. If you are breastfeeding, talk to your doctor before taking Ivabradine to discuss whether it is safe for you.
Is Ivabradine effective in treating angina?
Yes, Ivabradine is effective in treating angina (chest pain) associated with chronic coronary artery disease. It works by reducing the heart rate to improve blood flow to the heart and reduce symptoms of angina.
Can I take a pain reliever while taking Ivabradine?
Yes, it is generally safe to take a pain reliever such as ibuprofen or acetaminophen while taking Ivabradine. However, it’s important to talk to your doctor before taking any new medications while taking Ivabradine.
Does Ivabradine cause insomnia?
No, there is no evidence that Ivabradine causes insomnia. However, some people may experience insomnia or other sleep disturbances while taking Ivabradine. If this occurs, talk to your doctor.
Does Ivabradine cause constipation?
No, there is no evidence that Ivabradine causes constipation. However, some people may experience constipation or other gastrointestinal side effects while taking Ivabradine. If this occurs, talk to your doctor.
Does Ivabradine interact with alcohol?
Yes, it is not recommended to drink alcohol while taking Ivabradine as it can increase the risk of certain side effects. If you choose to drink alcohol while taking Ivabradine, it is important to do so in moderation.
What should I do if I experience side effects from taking Ivabradine?
If you experience any bothersome or persistent side effects while taking Ivabradine, talk to your doctor. Your doctor may adjust your dose or offer other treatments to help reduce your symptoms.
Can I take Ivabradine during pregnancy?
No, Ivabradine should not be used during pregnancy as it may cause harm to the fetus. Talk to your doctor if you are pregnant or planning to become pregnant before taking Ivabradine.
Does Ivabradine have any long-term effects?
No serious long-term effects have been reported with the use of Ivabradine. However, it is important to talk to your doctor before taking the medication for a long period of time.
How often should I take Ivabradine?
Ivabradine should be taken twice daily, with or without food. Your doctor will determine the right dosage for you based on your individual needs.
Is Ivabradine a blood thinner?
No, Ivabradine is not a blood thinner. It is used to treat chronic stable angina (chest pain) associated with chronic coronary artery disease by reducing the heart rate.
Does Ivabradine cause fatigue?
Yes, fatigue is a common side effect of Ivabradine. If you experience fatigue while taking Ivabradine, talk to your doctor as your dose may need to be adjusted.
Does Ivabradine cause hair loss?
No, there is no evidence that Ivabradine causes hair loss. If you experience any unusual hair loss, talk to your doctor.
Does Ivabradine cause dizziness?
Yes, dizziness is a common side effect of Ivabradine. If you experience dizziness while taking Ivabradine, talk to your doctor as your dose may need to be adjusted.
Can Ivabradine be taken with other heart medications?
Yes, Ivabradine can be taken with other heart medications, such as beta-blockers, calcium channel blockers, and digoxin. It is important to talk to your doctor before combining any medications.
Does Ivabradine cause headaches?
Yes, headache is a common side effect of Ivabradine. If you experience headaches while taking Ivabradine, talk to your doctor as your dose may need to be adjusted.