Incrit

Incrit Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Incrit is a brand name. Its generic name is Sitagliptin.

Introduction

Incrit is an oral antidiabetic medication used to treat type 2 diabetes. It is a member of the dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs and works by increasing levels of active incretins in the body, leading to an increase in insulin secretion.

Uses

Incrit is used for the treatment of type 2 diabetes mellitus. It is used in combination with other diabetes medicines to improve glycemic control in adults when diet and exercise alone are not enough.

Mechanism of Action

Incrit works by targeting an enzyme called DPP-4 (dipeptidyl peptidase-4). It blocks the activity of this enzyme, resulting in an increase of two hormones in the body called incretins, which stimulate the release of insulin.

How Long Does It Take To Work?

Incrit generally begins to work in about 1 week and is usually taken once a day. After about 3-4 weeks its full effect should be noticed. However, the exact time it takes to work can vary from person to person.

Absorption

Incrit is rapidly and extensively absorbed after oral administration with an average bioavailability of 87%. Maximum concentration (Cmax) is achieved in 1.5-2.5 hours.

Route of Elimination

Incrit is rapidly and extensively metabolized in the liver and is primarily excreted by the kidneys with two metabolites being present in the urine. Less than 1% of the drug is eliminated unchanged in the urine.

Dosage

The recommended dose of Incrit is 100 mg taken once daily. The maximum recommended dose is 100 mg per day. Your doctor may adjust your dose as needed. Your doctor may start you on a lower dose of Incrit if needed.

Administration

Incrit should be taken orally with or without food. It is important to take it once daily at the same time each day to get the most benefit from it.

Side Effects

The most common side effects of Incrit are headache, upper respiratory tract infection, nausea, nasopharyngitis, and increased creatinine levels. Other less common side effects include diarrhea, dizziness, and rash.

Toxicity

High doses of Incrit can lead to hypotension, hyperglycemia, and pancreatitis. The most severe adverse effects are anaphylaxis and angioedema.

Precautions

Incrit should be used with caution in persons with renal impairment since renal elimination is a major route of elimination for this drug. It should also be used with caution in those with hepatic impairment.

Interactions

Incrit may interact with other medications, including some diuretics, some antibiotics, some antidepressants, some nonsteroidal anti-inflammatory drugs (NSAIDs), some antifungals, and some medications used to treat HIV/AIDs.

Disease Interactions

Incrit may interact with certain diseases, including kidney disease, liver disease, and congestive heart failure. It should be used with caution in these patients.

Drug Interactions

Incrit may interact with other drugs, including certain diuretics, antibiotics, antidepressants, nonsteroidal anti-inflammatory drugs (NSAIDs), antifungals, and drugs used to treat HIV/AIDS. It is important to tell your doctor about all other medications you are taking before starting Incrit.

Food Interactions

Incrit may interact with certain foods and drinks, including high-fat foods and alcoholic beverages. It is important to avoid drinking alcohol while taking Incrit, since this can increase the risk of side effects.

Pregnancy Use

Incrit is not recommended for use during pregnancy since its safety in this population has not been established. The use of sitagliptin is not recommended in women who are pregnant or planning to become pregnant.

Lactation Use

Incrit is not recommended for use during breastfeeding since its safety in this population has not been established. The use of sitagliptin is not recommended in women who are breastfeeding or planning to breastfeed.

Acute Overdose

Symptoms of acute overdose with sitagliptin include hypoglycemia, hypotension, and tachycardia. Patients should be monitored for these symptoms and treated accordingly.

Contraindication

Incrit is contraindicated in patients with known hypersensitivity to any component of the product. It is also contraindicated in patients with type 1 diabetes or diabetic ketoacidosis.

Use Direction

Incrit should be taken as directed by your doctor. It should be taken orally with or without food, once daily at the same time each day. Do not change your dose or stop taking it without talking to your doctor first.

Storage Condition

Incrit should be stored at room temperature, in a light resistant container. Keep the container tightly closed and do not store it in moist, wet, or damp conditions.

Volume of Distribution

The volume of distribution for sitagliptin is approximately 16 L. There is a large range in the volume of distribution, with some estimates as high as 26 L.

Half Life

The average half-life of sitagliptin is estimated to be around 12-14 hours. This means that the drug is metabolized and eliminated from the body within this time frame.

Clearance

The estimated clearance of sitagliptin is 8.3 L/h. This indicates that the drug is eliminated from the body at a moderate rate.

Here you find in details version of Incrit

Some Frequently Asked Questions About Incrit

What is Incrit?

Incrit is an oral antidiabetic medication used to treat type 2 diabetes. It belongs to a class of drugs called DPP-4 inhibitors, or dipeptidyl peptidase-4 inhibitors, which work to regulate the body's production of insulin.

How does Incrit work?

Incrit works by inhibiting dipeptidyl peptidase-4 (DPP-4), an enzyme involved in controlling the amount of insulin your body produces. By blocking the action of this enzyme, Incrit helps to stimulate the production of insulin in response to high glucose levels, helping to keep blood glucose levels in the normal range.

Is Incrit a generic drug?

No, Incrit is a brand name medication. Its generic name is Januvia.

What are the side effects of Incrit?

Possible side effects of Incrit include headache, runny nose, dizziness, diarrhea, constipation, and abdominal pain. If you experience serious side effects, such as chest pain, shortness of breath, swelling of the limbs, nausea, vomiting, or rapid weight gain, contact your doctor immediately.

How much does Incrit cost?

The cost of Incrit will vary depending on the pharmacy where you fill your prescription. To find the lowest price, you can use an online drug price comparison tool.

Does Incrit help with weight loss?

No, Incrit is not intended for weight loss. Although it may lead to some modest weight loss in some patients, this is not the main purpose of taking Incrit.

Can I drink alcohol while taking Incrit?

No, it is not recommended to drink alcohol while taking Incrit. Alcohol can increase the risk of low blood sugar, so it is best to avoid alcohol while on this medication.

What other medications can I take with Incrit?

You should check with your doctor before taking any other medications while taking Incrit. Some medications, such as insulin and some diuretics, should not be taken with Incrit.

How long does it take for Incrit to start working?

Incrit is a relatively fast-acting medication, typically taking effect within one to two weeks. However, it may take up to two months to reach its maximum effect.

Should I take Incrit in the morning or evening?

It is generally recommended to take Incrit once daily in the morning, unless otherwise directed by your doctor.

What should I do if I miss a dose of Incrit?

If you miss a dose of Incrit, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and take your next dose at the regular time. Do not take two doses of Incrit at the same time.

What if I take too much Incrit?

If you take too much Incrit, contact your doctor or seek emergency medical attention right away. Overdose symptoms may include severe nausea, vomiting, and low blood sugar.

Does Incrit lower my cholesterol?

Yes, Incrit has been shown to reduce levels of triglycerides (a type of fat in the blood) and LDL-cholesterol (the “bad” cholesterol). Studies have also shown that Incrit may reduce levels of HDL-cholesterol (the “good” cholesterol) in some cases.

Does Incrit cause weight gain?

No, Incrit has not been shown to cause weight gain. In fact, some patients may experience modest weight loss while taking this medication.

Can I take Incrit if I’m pregnant?

No, Incrit is not recommended for use during pregnancy. Talk with your doctor before taking this medication if you are pregnant or may become pregnant during treatment.

Can children take Incrit?

No, Incrit is not approved for use in children. Talk with your child’s doctor before taking this medication if your child is under 18 years of age.

Does Incrit cause hypoglycemia?

Yes, Incrit may cause hypoglycemia, or low blood sugar. If you experience signs of low blood sugar, such as sweating, dizziness, nausea, or confusion, contact your doctor right away.

Can I take Incrit with insulin?

Yes, you can take Incrit with insulin. However, make sure to tell your doctor about all the medications you are taking, as high doses of insulin may increase your risk of hypoglycemia.

Can I take Incrit with metformin?

Yes, Incrit can be taken with metformin. However, your doctor may recommend a lower dose of metformin when taken with Incrit.

How long does Incrit stay in your system?

Incrit can stay in your system for up to 24 hours. It can take up to five days to completely clear from your body.

Can I take other diabetes meds while taking Incrit?

Yes, you can take other medications for diabetes while taking Incrit. However, make sure to talk to your doctor first to make sure these medications can be safely taken together.

Will Incrit help to reduce HbA1c?

Yes, Incrit has been shown to reduce Hemoglobin A1c (HbA1c) levels, which is a marker for long-term blood glucose levels. In clinical trials, patients taking Incrit had an average decrease in HbA1c of 0.6% to 1.5%.

Is Incrit a blood thinner?

No, Incrit is not a blood thinner. In fact, it is not known to affect the clotting of the blood.

Does Incrit cause fatigue?

Yes, fatigue is a possible side effect of Incrit. If you experience fatigue or other symptoms while taking Incrit, contact your doctor.

Can I take Incrit if I have kidney disease?

Yes, Incrit can be taken by patients with kidney disease. In these patients, it is recommended to start with a lower dose of Incrit and to monitor blood glucose levels closely.

Can I take Incrit if I have liver disease?

Yes, Incrit can be taken by patients with liver disease. However, it is recommended to start with a lower dose of Incrit and to monitor liver function tests closely.

How long can I safely take Incrit?

You can safely take Incrit for as long as your doctor recommends. However, if you experience any side effects, contact your doctor right away.

Do I need to have regular blood tests while taking Incrit?

Yes, it is important to have regular blood tests while taking Incrit. These tests help your doctor to monitor your response to treatment and check for any side effects.

Can I donate blood while taking Incrit?

No, you should not donate blood while taking Incrit. Tell your doctor if you are on this medication before donating blood.

Can Incrit cause dehydration?

Yes, Incrit may cause dehydration, especially in people who drink alcohol or caffeinated drinks. Make sure to drink plenty of water while taking Incrit.

Can I take Incrit if I’m breastfeeding?

No, Incrit is not recommended for use while breastfeeding. Talk to your doctor before taking this medication if you are breastfeeding or plan to breastfeed.

Can I take other diabetes medications with Incrit?

Yes, you can take other diabetes medications with Incrit. However, make sure to tell your doctor about all the medications you are taking, as some of them may interact with Incrit.

Can I take vitamin supplements with Incrit?

Yes, it is safe to take vitamin supplements with Incrit. However, make sure to tell your doctor about all the supplements you are taking, as some of them may interact with this medication.

Does Incrit cause mood swings?

Yes, mood swings are a possible side effect of Incrit. If you experience mood swings while taking this medication, contact your doctor.

Does taking Incrit cause erectile dysfunction?

No, Incrit has not been shown to cause erectile dysfunction. However, it is possible that it may worsen existing erectile dysfunction.

Can Incrit cause kidney damage?

No, Incrit has not been shown to cause kidney damage in clinical studies. However, patients with kidney disease should talk with their doctor before taking this medication.

Does Incrit raise blood pressure?

No, Incrit has not been shown to raise blood pressure in clinical studies. However, high blood pressure is a possible side effect of this medication.

Can I take Incrit if I have heart disease?

Yes, Incrit can be taken by patients with heart disease. However, make sure to tell your doctor if you have any history of heart problems before taking this medication.

Can I take Incrit if I’m on dialysis?

Yes, Incrit can be taken by patients who are on dialysis. However, make sure to tell your doctor if you are on dialysis before taking this medication.

Can Incrit make skin rash worse?

Yes, Incrit may make a skin rash worse. If you experience a rash or other skin reaction while taking this medication, contact your doctor.