Sigtil

Sigtil Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Sigtil is a brand name. Its generic name is Sitagliptin.

Introduction

Sigtil is an oral antidiabetic medication used to treat type 2 diabetes. It is a member of the dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs and works by increasing levels of active incretins in the body, leading to an increase in insulin secretion.

Uses

Sigtil is used for the treatment of type 2 diabetes mellitus. It is used in combination with other diabetes medicines to improve glycemic control in adults when diet and exercise alone are not enough.

Mechanism of Action

Sigtil works by targeting an enzyme called DPP-4 (dipeptidyl peptidase-4). It blocks the activity of this enzyme, resulting in an increase of two hormones in the body called incretins, which stimulate the release of insulin.

How Long Does It Take To Work?

Sigtil generally begins to work in about 1 week and is usually taken once a day. After about 3-4 weeks its full effect should be noticed. However, the exact time it takes to work can vary from person to person.

Absorption

Sigtil is rapidly and extensively absorbed after oral administration with an average bioavailability of 87%. Maximum concentration (Cmax) is achieved in 1.5-2.5 hours.

Route of Elimination

Sigtil is rapidly and extensively metabolized in the liver and is primarily excreted by the kidneys with two metabolites being present in the urine. Less than 1% of the drug is eliminated unchanged in the urine.

Dosage

The recommended dose of Sigtil is 100 mg taken once daily. The maximum recommended dose is 100 mg per day. Your doctor may adjust your dose as needed. Your doctor may start you on a lower dose of Sigtil if needed.

Administration

Sigtil should be taken orally with or without food. It is important to take it once daily at the same time each day to get the most benefit from it.

Side Effects

The most common side effects of Sigtil are headache, upper respiratory tract infection, nausea, nasopharyngitis, and increased creatinine levels. Other less common side effects include diarrhea, dizziness, and rash.

Toxicity

High doses of Sigtil can lead to hypotension, hyperglycemia, and pancreatitis. The most severe adverse effects are anaphylaxis and angioedema.

Precautions

Sigtil should be used with caution in persons with renal impairment since renal elimination is a major route of elimination for this drug. It should also be used with caution in those with hepatic impairment.

Interactions

Sigtil may interact with other medications, including some diuretics, some antibiotics, some antidepressants, some nonsteroidal anti-inflammatory drugs (NSAIDs), some antifungals, and some medications used to treat HIV/AIDs.

Disease Interactions

Sigtil may interact with certain diseases, including kidney disease, liver disease, and congestive heart failure. It should be used with caution in these patients.

Drug Interactions

Sigtil may interact with other drugs, including certain diuretics, antibiotics, antidepressants, nonsteroidal anti-inflammatory drugs (NSAIDs), antifungals, and drugs used to treat HIV/AIDS. It is important to tell your doctor about all other medications you are taking before starting Sigtil.

Food Interactions

Sigtil may interact with certain foods and drinks, including high-fat foods and alcoholic beverages. It is important to avoid drinking alcohol while taking Sigtil, since this can increase the risk of side effects.

Pregnancy Use

Sigtil is not recommended for use during pregnancy since its safety in this population has not been established. The use of sitagliptin is not recommended in women who are pregnant or planning to become pregnant.

Lactation Use

Sigtil is not recommended for use during breastfeeding since its safety in this population has not been established. The use of sitagliptin is not recommended in women who are breastfeeding or planning to breastfeed.

Acute Overdose

Symptoms of acute overdose with sitagliptin include hypoglycemia, hypotension, and tachycardia. Patients should be monitored for these symptoms and treated accordingly.

Contraindication

Sigtil is contraindicated in patients with known hypersensitivity to any component of the product. It is also contraindicated in patients with type 1 diabetes or diabetic ketoacidosis.

Use Direction

Sigtil should be taken as directed by your doctor. It should be taken orally with or without food, once daily at the same time each day. Do not change your dose or stop taking it without talking to your doctor first.

Storage Condition

Sigtil should be stored at room temperature, in a light resistant container. Keep the container tightly closed and do not store it in moist, wet, or damp conditions.

Volume of Distribution

The volume of distribution for sitagliptin is approximately 16 L. There is a large range in the volume of distribution, with some estimates as high as 26 L.

Half Life

The average half-life of sitagliptin is estimated to be around 12-14 hours. This means that the drug is metabolized and eliminated from the body within this time frame.

Clearance

The estimated clearance of sitagliptin is 8.3 L/h. This indicates that the drug is eliminated from the body at a moderate rate.

Here you find in details version of Sigtil

Some Frequently Asked Questions About Sigtil

What is Sigtil?

Sigtil is an oral antidiabetic medication used to treat type 2 diabetes. It belongs to a class of drugs called DPP-4 inhibitors, or dipeptidyl peptidase-4 inhibitors, which work to regulate the body's production of insulin.

How does Sigtil work?

Sigtil works by inhibiting dipeptidyl peptidase-4 (DPP-4), an enzyme involved in controlling the amount of insulin your body produces. By blocking the action of this enzyme, Sigtil helps to stimulate the production of insulin in response to high glucose levels, helping to keep blood glucose levels in the normal range.

Is Sigtil a generic drug?

No, Sigtil is a brand name medication. Its generic name is Januvia.

What are the side effects of Sigtil?

Possible side effects of Sigtil include headache, runny nose, dizziness, diarrhea, constipation, and abdominal pain. If you experience serious side effects, such as chest pain, shortness of breath, swelling of the limbs, nausea, vomiting, or rapid weight gain, contact your doctor immediately.

How much does Sigtil cost?

The cost of Sigtil will vary depending on the pharmacy where you fill your prescription. To find the lowest price, you can use an online drug price comparison tool.

Does Sigtil help with weight loss?

No, Sigtil is not intended for weight loss. Although it may lead to some modest weight loss in some patients, this is not the main purpose of taking Sigtil.

Can I drink alcohol while taking Sigtil?

No, it is not recommended to drink alcohol while taking Sigtil. Alcohol can increase the risk of low blood sugar, so it is best to avoid alcohol while on this medication.

What other medications can I take with Sigtil?

You should check with your doctor before taking any other medications while taking Sigtil. Some medications, such as insulin and some diuretics, should not be taken with Sigtil.

How long does it take for Sigtil to start working?

Sigtil is a relatively fast-acting medication, typically taking effect within one to two weeks. However, it may take up to two months to reach its maximum effect.

Should I take Sigtil in the morning or evening?

It is generally recommended to take Sigtil once daily in the morning, unless otherwise directed by your doctor.

What should I do if I miss a dose of Sigtil?

If you miss a dose of Sigtil, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and take your next dose at the regular time. Do not take two doses of Sigtil at the same time.

What if I take too much Sigtil?

If you take too much Sigtil, contact your doctor or seek emergency medical attention right away. Overdose symptoms may include severe nausea, vomiting, and low blood sugar.

Does Sigtil lower my cholesterol?

Yes, Sigtil has been shown to reduce levels of triglycerides (a type of fat in the blood) and LDL-cholesterol (the “bad” cholesterol). Studies have also shown that Sigtil may reduce levels of HDL-cholesterol (the “good” cholesterol) in some cases.

Does Sigtil cause weight gain?

No, Sigtil has not been shown to cause weight gain. In fact, some patients may experience modest weight loss while taking this medication.

Can I take Sigtil if I’m pregnant?

No, Sigtil is not recommended for use during pregnancy. Talk with your doctor before taking this medication if you are pregnant or may become pregnant during treatment.

Can children take Sigtil?

No, Sigtil is not approved for use in children. Talk with your child’s doctor before taking this medication if your child is under 18 years of age.

Does Sigtil cause hypoglycemia?

Yes, Sigtil may cause hypoglycemia, or low blood sugar. If you experience signs of low blood sugar, such as sweating, dizziness, nausea, or confusion, contact your doctor right away.

Can I take Sigtil with insulin?

Yes, you can take Sigtil with insulin. However, make sure to tell your doctor about all the medications you are taking, as high doses of insulin may increase your risk of hypoglycemia.

Can I take Sigtil with metformin?

Yes, Sigtil can be taken with metformin. However, your doctor may recommend a lower dose of metformin when taken with Sigtil.

How long does Sigtil stay in your system?

Sigtil can stay in your system for up to 24 hours. It can take up to five days to completely clear from your body.

Can I take other diabetes meds while taking Sigtil?

Yes, you can take other medications for diabetes while taking Sigtil. However, make sure to talk to your doctor first to make sure these medications can be safely taken together.

Will Sigtil help to reduce HbA1c?

Yes, Sigtil has been shown to reduce Hemoglobin A1c (HbA1c) levels, which is a marker for long-term blood glucose levels. In clinical trials, patients taking Sigtil had an average decrease in HbA1c of 0.6% to 1.5%.

Is Sigtil a blood thinner?

No, Sigtil is not a blood thinner. In fact, it is not known to affect the clotting of the blood.

Does Sigtil cause fatigue?

Yes, fatigue is a possible side effect of Sigtil. If you experience fatigue or other symptoms while taking Sigtil, contact your doctor.

Can I take Sigtil if I have kidney disease?

Yes, Sigtil can be taken by patients with kidney disease. In these patients, it is recommended to start with a lower dose of Sigtil and to monitor blood glucose levels closely.

Can I take Sigtil if I have liver disease?

Yes, Sigtil can be taken by patients with liver disease. However, it is recommended to start with a lower dose of Sigtil and to monitor liver function tests closely.

How long can I safely take Sigtil?

You can safely take Sigtil for as long as your doctor recommends. However, if you experience any side effects, contact your doctor right away.

Do I need to have regular blood tests while taking Sigtil?

Yes, it is important to have regular blood tests while taking Sigtil. These tests help your doctor to monitor your response to treatment and check for any side effects.

Can I donate blood while taking Sigtil?

No, you should not donate blood while taking Sigtil. Tell your doctor if you are on this medication before donating blood.

Can Sigtil cause dehydration?

Yes, Sigtil may cause dehydration, especially in people who drink alcohol or caffeinated drinks. Make sure to drink plenty of water while taking Sigtil.

Can I take Sigtil if I’m breastfeeding?

No, Sigtil is not recommended for use while breastfeeding. Talk to your doctor before taking this medication if you are breastfeeding or plan to breastfeed.

Can I take other diabetes medications with Sigtil?

Yes, you can take other diabetes medications with Sigtil. However, make sure to tell your doctor about all the medications you are taking, as some of them may interact with Sigtil.

Can I take vitamin supplements with Sigtil?

Yes, it is safe to take vitamin supplements with Sigtil. However, make sure to tell your doctor about all the supplements you are taking, as some of them may interact with this medication.

Does Sigtil cause mood swings?

Yes, mood swings are a possible side effect of Sigtil. If you experience mood swings while taking this medication, contact your doctor.

Does taking Sigtil cause erectile dysfunction?

No, Sigtil has not been shown to cause erectile dysfunction. However, it is possible that it may worsen existing erectile dysfunction.

Can Sigtil cause kidney damage?

No, Sigtil has not been shown to cause kidney damage in clinical studies. However, patients with kidney disease should talk with their doctor before taking this medication.

Does Sigtil raise blood pressure?

No, Sigtil has not been shown to raise blood pressure in clinical studies. However, high blood pressure is a possible side effect of this medication.

Can I take Sigtil if I have heart disease?

Yes, Sigtil can be taken by patients with heart disease. However, make sure to tell your doctor if you have any history of heart problems before taking this medication.

Can I take Sigtil if I’m on dialysis?

Yes, Sigtil can be taken by patients who are on dialysis. However, make sure to tell your doctor if you are on dialysis before taking this medication.

Can Sigtil make skin rash worse?

Yes, Sigtil may make a skin rash worse. If you experience a rash or other skin reaction while taking this medication, contact your doctor.