Imanib
Imanib Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Imanib is a brand name. Its generic name is Imatinib.
Introduction
Imanib, brand name Gleevec, is a type of targeted therapy drug used for the treatment of certain types of cancer, including leukaemia and certain forms of lymphoma and certain cancers of the stomach or digestive system. It is a tyrosine kinase inhibitor, which works by inhibiting the activity of certain proteins in cancer cells called tyrosine kinases. This prevents cancer cells from multiplying and helps to reduce the size of cancerous tumours.Uses
Imanib is used to treat certain types of leukaemia, including chronic myelogenous leukaemia and acute lymphoblastic leukaemia. It is also used to treat Philadelphia chromosome-positive chronic myelogenous leukaemia and to prevent the recurrence of certain types of gastrointestinal stromal tumours.Mechanism Of Action
Imanib works by inhibiting the activity of certain proteins in cancer cells called tyrosine kinases. Tyrosine kinases are enzymes that are involved in sending signals within cells that control their development and growth. By blocking the activity of these enzymes, imatinib disrupts the signal pathways that promote tumour growth.How Long Does It Take To Work?
The effects of imatinib can take 2 to 4 months to be seen. It may take longer in some patients. In order for the drug to be fully effective, it is important to keep taking it as prescribed by your doctor.Absorption
Imanib is rapidly absorbed in the gastrointestinal tract with peak concentrations of the drug being reached in 1 to 2 hours. The absorption of the drug is increased when taken with food.Route of Elimination
Imanib is mainly eliminated through the urine, with around 75% of the drug being excreted this way. The rest of the drug is excreted in the faeces.Dosage
The recommended dose of Imanib is 400mg once daily, to be taken orally.Administration
Imanib tablets are usually taken orally, with or without food. Tablets should be swallowed with a glass of water.Side Effects
Common side effects of Imanib include: nausea, vomiting, diarrhoea, abdominal pain, weight loss, rash, headache, joint pain, and fatigue. More serious side effects include liver damage, decreased blood cell counts, heart problems, bone marrow suppression, and allergic reactions.Toxicity
Toxic levels of Imanib can occur if high doses are taken for extended periods of time, or if the drug is taken in combination with other drugs that interact with it. Signs of toxicity include nausea, vomiting, diarrhoea, abdominal pain, weight loss, rash, headache, joint pain, fatigue, bleeding, and low blood cell counts.Precautions
Imanib should be used with caution in patients with pre-existing liver or kidney damage, and those with heart conditions. It should also be used with caution in pregnant or breastfeeding women, as it may cause harm to a developing baby.Interactions
Imanib may interact with other drugs, particularly those that are metabolised by the same enzyme. This includes drugs like Metformin, Warfarin, and Phenytoin. It may also interact with St John's Wort and certain supplements. It is important to tell your doctor about all medicines and supplements you are taking.Disease Interactions
Imanib may interact with certain diseases, such as urinary tract infections, liver disease, or lung disease. If you have any of these conditions, or any other medical conditions, it is important to tell your doctor before taking Imanib.Drug Interactions
Imanib may interact with other drugs, particularly those metabolised by the same enzyme. These include Metformin, Warfarin, and Phenytoin. It is important to tell your doctor about all medicines and supplements you are taking, as certain combinations may result in decreased effectiveness of Imanib or increased side effects.Food Interactions
Imanib should be taken with food for increased absorption. Grapefruit and grapefruit juice should be avoided, as they may increase the concentration of Imanib in the bloodstream.Pregnancy Use
Imanib is classified as a Pregnancy Category D drug, meaning it is not recommended for use in pregnant or breastfeeding women. Imanib may cause harm to a developing baby and should not be used unless the potential benefits outweigh the risks.Lactation Use
Imanib is classified as a Lactation Category C drug, meaning it is not recommended for use in breastfeeding women. Imanib may be present in breast milk and cause harm to a nursing baby.Acute Overdose
Symptoms of an acute overdose may include dizziness, headache, nausea, or vomiting. Treatment involves managing symptoms, and gastric lavage or activated charcoal may be used to remove any residual Imanib from the stomach.Contraindication
Imanib is contraindicated in patients with known hypersensitivity to the drug or any of its components. It is also contraindicated in pregnant or breastfeeding women.Use Direction
Imanib should be taken as directed by your doctor or pharmacist. It should be taken once daily with or without food. Do not stop taking Imanib unless your doctor tells you to.Storage Condition
Imanib should be stored in a cool, dry place at room temperature. Do not store in the bathroom, kitchen, or any other moist area. Keep the tablets in their original container with the lid tightly closed.Volume of Distribution
The volume of distribution of Imanib is 11.2 L/kg.Half Life
The half life of Imanib is 18 hours.Clearance
The clearance of Imanib is 5.41 L/h/kg.Here you find in details version of Imanib
Some Frequently Asked Questions About Imanib
What is Imanib?
Imanib is an oral medication that is used to treat certain types of cancer, including chronic myeloid leukemia (CML) and certain types of gastrointestinal stromal tumors (GIST). It is sometimes referred to as a “targeted therapy” because it targets specific proteins, proteins found in certain cancer cells, to stop the growth of those cells.
How does Imanib work?
Imanib works by blocking certain proteins that are involved in the growth of cancer cells. This stops the cancer cells from growing, and eventually leads to their death.
What are the side effects of Imanib?
The most common side effects of Imanib are nausea, vomiting, diarrhea, headache, muscle cramps, rash, and fatigue. Less common side effects include low blood counts, fluid retention, joint pain, and abdominal pain.
How often should I take Imanib?
Your doctor will tell you how often you should take Imanib. Generally, it should be taken once daily, with or without food.
Can I take Imanib with other medications?
You should always check with your doctor before taking any other medications while taking Imanib. Certain medications may interact with Imanib and should not be taken together.
How long does it take for Imanib to start working?
It may take a few weeks for Imanib to start working. Some people may start to see results after a few weeks, while others may take longer. Your doctor will be able to monitor your progress and adjust your treatment if needed.
What if I miss a dose of Imanib?
If you miss a dose, you should take it as soon as you remember. However, if it is almost time for your next dose, you should skip the missed dose and continue with your regular dosing schedule. Do not take two doses at once.
Can I take Imanib while pregnant or breastfeeding?
Imanib is not recommended for use in pregnant women. If you are breastfeeding, talk to your doctor before taking Imanib.
What should I do if I experience any serious side effects while taking Imanib?
You should contact your doctor right away if you experience any serious side effects while taking Imanib. Serious side effects may include symptoms such as chest pain, shortness of breath, severe dizziness, or sudden changes in vision.
What tests do I need to have done before starting Imanib?
Your doctor will order certain tests before starting Imanib. These tests may include blood tests, chest x-rays, and other imaging tests to evaluate your condition. Your doctor may also order tests to monitor your response to Imanib and adjust your treatment plan if needed.
Can I drink alcohol while taking Imanib?
It is not recommended to drink alcohol while taking Imanib. Alcohol can increase the risk of side effects with this medication.
Can Imanib be used to treat other types of cancer?
Imanib is only approved to treat certain types of cancer, including chronic myeloid leukemia (CML) and certain types of gastrointestinal stromal tumors (GIST). It is not approved for the treatment of any other type of cancer.
What other medications should I avoid while taking Imanib?
You should always check with your doctor before taking any other medications while taking Imanib. Certain medications may interact with Imanib, including antifungals, antibiotics, blood thinners, and heart medications.
Can I still exercise while taking Imanib?
You should talk to your doctor before starting any new exercise program while taking Imanib, as it may affect your blood counts. If your doctor approves, it is usually safe to continue with the same level of regular physical activity while taking Imanib.
What is the most common Imanib dosage?
The most commonly prescribed dosage of Imanib is 400 mg taken once daily. Your doctor may prescribe a different dosage if needed, depending on the type of cancer and your individual response to Imanib.
Should I avoid certain foods while taking Imanib?
There are no foods that you need to avoid while taking Imanib. However, it is best to eat a healthy diet while taking any medication, as it can help to optimize your treatment results.
What if I am unable to swallow the Imanib tablets?
You should contact your doctor if you are having difficulty swallowing the Imanib tablets. Your doctor may be able to provide alternative forms of the medication that are easier to swallow.
Should I take Imanib with food or without food?
You can take Imanib with or without food. However, do not take it with anything dairy, grapefruit, or high-fat foods.
Is Imanib a chemotherapy drug?
No, Imanib is not a chemotherapy drug. It is an oral targeted therapy, meaning that it specifically targets certain proteins found in certain cancer cells in order to stop their growth and lead to their death.
What are the possible long-term side effects of Imanib?
Potential long-term side effects of Imanib may include heart problems, liver problems, vision problems, a reduction in white blood cells, and an increase in cholesterol levels. However, these side effects are rare and will be monitored by your doctor during your treatment.
Is Imanib suitable for everyone?
No, Imanib is not suitable for everyone. You should always talk to your doctor before starting any new medication. Imanib should not be taken by people with certain medical conditions or anyone who is pregnant or breastfeeding.
Is it possible to become resistant to Imanib?
Yes, it is possible to become resistant to Imanib over time. If this happens, your doctor may need to adjust your treatment plan or switch to a different type of medication.
Should I be tested for other diseases or conditions before taking Imanib?
You should always talk to your doctor before starting any new medication. Your doctor may recommend certain tests to evaluate your condition and check for any underlying or pre-existing conditions.
Can Imanib be used to treat other forms of cancer besides CML and GIST?
No, Imanib is only approved to treat chronic myeloid leukemia (CML) and certain types of gastrointestinal stromal tumors (GIST). It is not approved for the treatment of any other type of cancer.
What is the cost of Imanib?
The cost of Imanib will vary depending on the pharmacy or manufacturer you buy it from. Your insurance provider may also cover the cost of the medication. You should check with your provider and pharmacist for more information.
Should I take Imanib with other medications?
You should always consult with your doctor before taking any other medications while taking Imanib. Certain medications may interact with Imanib and should not be taken together.
Can Imanib cure cancer?
Imanib is an effective treatment for certain types of cancer, including chronic myeloid leukemia (CML) and certain types of gastrointestinal stromal tumors (GIST). However, it is not a cure-all. Other treatments may be needed to help manage symptoms or prevent the cancer from returning.
Can I donate blood while taking Imanib?
No, you should not donate blood while taking Imanib. You can donate blood once you have completed your treatment and your doctor has determined that it is safe for you to do so.
What if I forget to take my dose of Imanib?
If you forget to take a dose of Imanib, you should take it as soon as you remember. However, if it is almost time for your next dose, you should skip the missed dose and continue with your regular dosing schedule. Do not take two doses at once.
Is Imanib safe for children?
Imanib is not recommended for use in children. It has only been studied in adults and there is no reliable data to suggest it is safe or effective for use in children.
Are there any known drug interactions with Imanib?
Yes, certain medications may interact with Imanib, including antifungals, antibiotics, blood thinners, and heart medications. You should always check with your doctor before taking any other medications while taking Imanib.
What should I do if I experience any serious side effects while taking Imanib?
You should contact your doctor right away if you experience any serious side effects while taking Imanib. Serious side effects may include symptoms such as chest pain, shortness of breath, severe dizziness, or sudden changes in vision.
How long should I take Imanib for?
How long you take Imanib for will depend on your individual response to the medication. Your doctor will be able to monitor your progress and adjust your treatment if needed.
What happens if I stop taking Imanib?
If you stop taking Imanib, your cancer may come back or become more difficult to treat. It is important to follow your doctor's instructions for taking your medication and not to stop taking it without consulting your doctor first.
Should I talk to my doctor before starting Imanib?
Yes, it is important to talk to your doctor before starting Imanib. Your doctor will evaluate your condition and recommend the most appropriate treatment for your specific needs.
How long does it take for Imanib to start working?
It may take a few weeks for Imanib to start working. Some people may start to see results after a few weeks, while others may take longer. Your doctor will be able to monitor your progress and adjust your treatment if needed.
What if I am having difficulty swallowing the Imanib tablets?
You should contact your doctor if you are having difficulty swallowing the Imanib tablets. Your doctor may be able to provide alternative forms of the medication that are easier to swallow.
Are there any dietary or lifestyle changes I should make while taking Imanib?
It is important to eat a healthy diet, get regular exercise, and get plenty of rest while taking Imanib. Your doctor may also recommend avoiding foods or beverages that contain grapefruit juice.
Should I be following up with my doctor regularly while taking Imanib?
Yes, it is important to attend follow-up appointments with your doctor while taking Imanib. Your doctor will be able to monitor your progress and adjust your treatment if needed.
What are the benefits of taking Imanib?
The primary benefit of taking Imanib is that it is an effective treatment for certain types of cancer, including chronic myeloid leukemia (CML) and certain types of gastrointestinal stromal tumors (GIST). It is generally well tolerated and can lead to improved quality of life for those who take it.