Pruease

Pruease Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Pruease is a brand name. Its generic name is Prucalopride.

Pruease

Pruease belongs to a group of medications known as selective serotonin receptor agonists. It is used for the treatment of constipation in adults. Pruease works by increasing the movement of the colon and rectum, thereby making it easier for the patient to pass stools.

Uses for

Pruease is used for the treatment of constipation, particularly when other constipation medications do not provide relief. It is also useful in patients who have not responded well to other treatments such as laxatives.

Mechanism of Action

Pruease works by stimulating 5-hydroxytryptamine 4 (5-HT4) receptors in the intestine wall. 5-HT4 receptors are involved in regulating secretory and motor functions of the gut. Stimulation of 5-HT4 receptors leads to the secretion of water and electrolytes, as well as increasing the rate of muscle contractions in the intestine wall, leading to increased passage of stool.

How long does it take to work?

Pruease usually takes 1-2 days for patients to experience relief from constipation. The effects are expected to be felt within 7-10 days of taking this medication. Higher doses are needed to achieve a greater effect.

Absorption

Pruease is well absorbed (more than 90%) from the gut. The peak concentration of the medication is reached in 4 to 5 hours.

Route of Elimination

Pruease is eliminated through the kidneys.

Dosage

For adults the recommended dosage of prucalopride is 1 mg once a day. Dosage can be increased up to 4 mg a day if needed, depending on individual response to the medication. The dosage for children is not yet established.

Administration

Pruease is available as a tablet and should be taken orally with water. It should be taken with food or immediately after a meal to reduce the potential for GI side effects.

Side Effect

The most common side effects of prucalopride are gastrointestinal upset such as nausea, diarrhoea and abdominal discomfort. Other rarer side effects include headache, dizziness, stomach pain, bloating and flatulence. If any of these symptoms occur, please contact your doctor immediately.

Toxicity

No toxicity has been reported with prucalopride. However, overdose may lead to severe constipation, diarrhoea, dizziness, headache, nausea and vomiting.

Precaution

Pruease should not be taken by patients who are hypersensitive to it. It is also not suitable for use in pregnant or breastfeeding women, or in young children. People with liver and kidney related diseases should not take this medication. People taking other medications must consult their doctor before taking prucalopride.

Interactions

Pruease interacts with certain other medications, including antidepressant and opioid formulations, so they should not be taken together. Some vitamins and herbal supplements can also interact with this drug, so consult your doctor before starting them.

Disease Interaction

Pruease is not suitable for patients with renal impairment or those with severe liver disease. It is also not suitable for those with GI obstruction or perforation.

Drug Interaction

Pruease may interact with medications such as antidepressants, opioids and certain vitamins and herbal supplements. Patients on these medications must consult their doctor before taking prucalopride.

Food Interactions

Pruease does not interact with food and can be taken with or without food.

Pregnancy use

Pruease is not suitable for pregnant or breastfeeding women. Consult your doctor before taking it.

Lactationuse

Pruease is not suitable for breastfeeding women. Consult your doctor before taking it.

Acute Overdose

An overdose of prucalopride can lead to severe constipation, diarrhoea, dizziness, headache, nausea and vomiting. Seek medical attention immediately if any of these symptoms occur.

Contraindication

Pruease is not suitable for pregnant or breastfeeding women, people with hypersensitivity to the medication, liver or kidney related diseases, and those with GI obstruction or perforation.

Use Direction

Pruease should be taken orally with water and with food or immediately after meal. The recommended dosage for adults is 1 mg once a day, which may be increased up to 4 mg a day depending on individual response to the medication.

Storage Condition

Pruease should be stored at room temperature and protected from light and moisture.

Volume of Distribution

The volume of distribution of prucalopride is approximately 2.2 L/kg.

Half Life

The half life of prucalopride is 8 hours.

Clearance

The clearance of prucalopride is 66.6 mL/min/kg.

Here you find in details version of Pruease

Some Frequently Asked Questions About Pruease

What is Pruease?

Pruease is a medication used to treat chronic idiopathic constipation (CIC). It works by selectively stimulating certain receptors in the digestive tract, which increases the movement of the gut and speeds up digestion.

How does Pruease work?

Pruease selectively stimulates certain receptors in the digestive tract, which increases the movement of the gut and speeds up digestion. It also helps increase the absorption of water, which softens stool and makes it easier to pass.

How is Pruease taken?

Pruease is available in tablet and oral suspension forms. The recommended adult dosage is one 2 mg tablet each day taken on an empty stomach, one hour before or two hours after a meal.

What are the side effects of Pruease?

The most common side effects of Pruease include headache, nausea, abdominal pain, and diarrhea. Other side effects may include dizziness, sleeping difficulties, constipation, and flatulence.

What should I do if I experience side effects with Pruease?

If you experience side effects with Pruease, stop taking the medication and contact your doctor right away. It is important to tell your doctor about any side effects so that they can determine the best course of treatment.

Who should not take Pruease?

Pruease should not be taken by people who are allergic to it or any of its ingredients. It should also not be taken by pregnant or breastfeeding women, and it should be used with caution in people with kidney or liver diseases.

What should I tell my doctor before taking Pruease?

Before taking Pruease, it is important to tell your doctor about any other medications you may be taking, as well as any allergies you have. Your doctor will also need to know about any medical conditions you may have, such as kidney or liver disease.

Is Pruease safe for long-term use?

Pruease is generally considered safe for long-term use. However, it is important to speak to your doctor before continuing to use it for an extended period of time.

What should I do if I miss a dose of Pruease?

If you miss a dose of Pruease, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your normal dosing schedule.

Can I take Pruease with other medications?

Pruease can interact with some medications, so it is important to tell your doctor about any other medications you are taking. It is also important to speak to your doctor before taking any new medications while taking Pruease.

What are the precautions associated with taking Pruease?

Common precautions associated with taking Pruease include avoiding alcohol and other drugs that cause drowsiness, talking to your doctor about any other medications you may be taking, monitoring your weight, and informing your doctor of any side effects you may be experiencing.

Is there a generic version of Pruease?

No, there is currently no generic version of Pruease available. Brand-name versions of the medication are available in most countries.

Can children take Pruease?

No, Pruease is not recommended for use in children under the age of 18.

What is the usual dose of Pruease?

The recommended adult dosage is one 2 mg tablet each day taken on an empty stomach, one hour before or two hours after a meal.

Can I take Pruease while pregnant?

No, Pruease should not be taken by pregnant women.

Can I take Pruease with other digestive medications?

It is important to talk to your doctor before taking Pruease with other digestive medications. Certain drugs can interact with each other and cause dangerous side effects.

Can I take Pruease while breastfeeding?

No, Pruease should not be taken by breastfeeding women.

What foods should I avoid while taking Pruease?

It is important to avoid foods that can cause constipation such as processed convenience foods, cheese, white flour products, and high-fat foods.

Are there any drug interactions with Pruease?

Yes, certain drugs such as anticholinergics, opioid drugs, and certain antacids can interact with Pruease. It is important to tell your doctor about any medications you may be taking before starting Pruease.

Does Pruease cause weight gain?

No, Pruease does not typically cause weight gain.

Does Pruease work immediately?

No, it may take several weeks for Pruease to take effect. Some people may experience relief of symptoms within 1-2 weeks, while others may take longer.

What are the potential drug interactions with Pruease?

Pruease can interact with certain drugs such as anticholinergics, opioid drugs, and certain antacids. It is important to tell your doctor about any other medications you may be taking before starting Pruease.

Can I take Pruease while taking other medications?

Yes, you can take Pruease with other medications, but it is important to talk to your doctor before taking Pruease with other drugs. Certain drugs can interact with each other and cause dangerous side effects.

Should I stop taking Pruease if my symptoms get worse?

Yes, if your symptoms get worse after starting Pruease, stop taking the medication and contact your doctor right away.

What other medications should I avoid while taking Pruease?

Certain drugs such as anticholinergics, opioid drugs, and certain antacids can interact with Pruease. To avoid potential drug interactions, it is important to tell your doctor about any other medications you may be taking before starting Pruease.

Can I drink alcohol while taking Pruease?

No, it is recommended to avoid alcohol while taking Pruease. Alcohol can interact with certain medications and can increase the risk of some side effects.

Can Pruease be used to treat irritable bowel syndrome?

No, Pruease is not indicated for the treatment of irritable bowel syndrome.

What other conditions is Pruease used to treat?

Pruease is indicated for the treatment of chronic idiopathic constipation (CIC).

How quickly will I see results with Pruease?

Some people may experience relief of symptoms within 1-2 weeks, while others may take longer to see results. If you do not see improvement within 2-4 weeks, speak to your doctor.

Are there any potential risks associated with taking Pruease?

The most common risks associated with taking Pruease include headache, nausea, abdominal pain, and diarrhea. Less common side effects may include dizziness, sleeping difficulties, constipation, and flatulence. If you experience any of these side effects, stop taking the medication and contact your doctor right away.

Should elderly people use Pruease?

Yes, although elderly people should take caution when using Pruease. It is important to speak to your doctor before taking any medication while elderly.

What precautions should I take while taking Pruease?

Common precautions associated with taking Pruease include avoiding alcohol and other drugs that cause drowsiness, talking to your doctor about any other medications you may be taking, monitoring your weight, and informing your doctor of any side effects you may be experiencing.

Is Pruease banned in any countries?

No, Pruease is not banned in any countries. Brand-name versions of the medication are available in most countries.

How long does Pruease stay in the body?

The half-life of Pruease is approximately 16 hours, meaning it takes approximately 16 hours for half of the dose of the medication to be eliminated from the body.

What is the difference between Pruease and other medications for constipation?

Pruease works by selectively stimulating certain receptors in the digestive tract, which increases the movement of the gut and speeds up digestion. Other medications for constipation, such as laxatives, work by either increasing the movement of the gut or softening stool.

Is there a generic version of Pruease available?

No, there is currently no generic version of Pruease available. Brand-name versions of the medication are available in most countries.

Can Pruease be used to treat conditions other than constipation?

No, Pruease is not indicated for the treatment of any conditions other than chronic idiopathic constipation (CIC).

Can I become addicted to Pruease?

No, it is very unlikely that one can become addicted to Pruease. However, it is important to take the medication as directed by your doctor.

Are there any special instructions for storage of Pruease?

Pruease should be stored at room temperature, away from light and moisture. Keep the medication out of the reach of children and pets.