Ebirintazide
Ebirintazide Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Ebirintazide is a brand name. Its generic name is Irbesartan + Diuretika.
Ebirintazide Introduction
Ebirintazide is a combination drug containing irbesartan (an angiotensin II receptor blocker) and diuretika (an aquaretic used to reduce fluid retention). It is used to treat high blood pressure, congestive heart failure, and kidney diseases. The combination was approved by the US Food and Drug Administration in 2015.
Uses For Ebirintazide
Ebirintazide is used to treat high blood pressure (hypertension), congestive heart failure, and kidney diseases of various sorts. It is also used to prevent cardiovascular complications caused by diabetes, such as heart attack, stroke, and renal complications.
Mechanism of Action
The two drugs in Ebirintazide work in different ways on different cells and systems in the body to achieve their desired effect. The irbesartan works to block the angiotensin II receptors, which are responsible for constricting the blood vessels, thereby reducing the blood pressure. The diuretika, on the other hand, works to reduce fluid retention by increasing the amount of water lost through urine production. By combining the two drugs, the aim is to reduce both excess fluid and blood pressure.
How Long Does It Take To Work?
The effects of Ebirintazide can be seen within 24 hours, but may take up to two weeks to reach their full effect. Your doctor may adjust the dose of the medication to find the right dose for you.
Absorption
Ebirintazide is quickly and completely absorbed by the body. The peak concentrations of both drugs are reached approximately 2-3 hours after ingestion. Approximately 95% of the drug is bound to plasma proteins, so it is available for systemic absorption.
Route of Elimination
The two drugs in Ebirintazide are primarily eliminated through the urine. Approximately 84% of the dose is excreted in the urine as unchanged irbesartan and 10-20% as metabolites, and the diuretika is eliminated mostly unchanged.
Dosage
The recommended starting dosage of Ebirintazide is one tablet containing 50 mg of irbesartan and 10 mg of diuretika once daily, taken with or without food. Your doctor may increase the dose if needed.
Administration
Ebirintazide is taken orally, with or without food. The tablet should not be crushed or chewed, and should be swallowed whole. If you miss a dose, take it as soon as you remember. Do not take a double dose.
Side Effect
Some of the most common side effects of Ebirintazide include dizziness, headache, nausea, vomiting, and diarrhea. Other side effects may include muscle cramps, dry mouth, weakness, and constipation.
Toxicity
Ebirintazide is generally well-tolerated, but dangerously high concentrations of the drugs can cause arrhythmias, low blood pressure, or cardiac arrest. Overdose should be treated as an emergency.
Precaution
Patients should inform their doctor if they have a history of kidneydisease, heart disease, allergies, or diabetes before taking Ebirintazide. This medication should be used with caution in pregnant and nursing women. Patients may need to be monitored for electrolyte abnormalities, especially during the first few weeks of beginning the medication.
Interaction
Irbesartan may interact with certain drugs, such as potassium-sparing diuretics, potassium supplements, or non-steroidal anti-inflammatory drugs (NSAIDs). You should tell your doctor if you are taking any of these medications before taking Ebirintazide.
Disease Interaction
Patients with diabetes may be at an increased risk of complications when taking Ebirintazide; close monitoring of blood sugar levels is advised. People with a history of kidney disease or congestive heart failure may need to be monitored more closely.
Drug Interaction
Drugs that interact with Ebirintazide include ACE inhibitors, potassium-sparing diuretics, and potassium supplements (e.g. Klor-Con). Additionally, non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen may affect the absorption of the medication, so it should be avoided when taking Ebirintazide.
Food Interactions
Ebirintazide can be taken with or without food. It is important to take it with the same meal each day to ensure that the drug is absorbed properly. Avoid drinking grapefruit juice while taking this drug, as it can increase the amount of the drug in the body and increase the risk of side effects.
Pregnancy Use
The safety of Ebirintazide during pregnancy has not been established. Therefore, it should not be used during pregnancy unless the clinical benefits outweigh the potential risks to the fetus.
Lactation Use
Ebirintazide has not been studied in lactating mothers, and its safety has not been established. Therefore, it should not be used while breastfeeding unless the clinical benefits outweigh the potential risks to the baby.
Acute Overdose
It is possible to overdose on Ebirintazide, which can cause electrolyte imbalance and low blood pressure. An overdose should be treated as an emergency, and medical attention should be sought immediately.
Contraindication
Ebirintazide should not be used in patients with an allergy to any of the ingredients, pregnant women, and those with chronic kidney or liver disease. Additionally, it should not be taken by patients who are already taking ACE inhibitors, potassium-sparing diuretics, or potassium-containing supplements.
Use Direction
Patients should follow their doctor's instructions when taking Ebirintazide. The tablet should be taken once a day, with or without food. It should not be crushed or chewed. If you miss a dose, take it as soon as you remember. Do not take a double dose.
Storage Condition
Ebirintazide should be stored at room temperature, away from moisture and heat. The tablets should not be opened, crushed, or cut.
Volume of Distribution
The volume of distribution of Ebirintazide is approximately 0.9 L/kg, indicating that the drug is distributed throughout the body.
Half Life
The half-life of Ebirintazide is approximately 8.5 hours, which is the amount of time required for the drug to be reduced by half in the body.
Clearance
Ebirintazide has a renal clearance of approximately 4.6 ml/min/kg, indicating that it is mainly eliminated from the body through the kidneys.
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