Enalaprilmaleaat/Hydrochloorthiazide
Enalaprilmaleaat/Hydrochloorthiazide Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Enalaprilmaleaat/Hydrochloorthiazide is a brand name. Its generic name is Enalapril + Diuretika.
Enalaprilmaleaat/Hydrochloorthiazide
Enalaprilmaleaat/Hydrochloorthiazide is a combination of two drugs – enalapril and a diuretic. Enalapril belongs to a class of medication called angiotensin-converting enzyme (ACE) inhibitors. It works by relaxing blood vessels and helping the body to maintain normal blood pressure levels. Diuretics are medications used to increase the production of urine and reduce fluid retention. It can be used to treat high blood pressure, congestive heart failure, and swelling of the legs or ankles.
Uses
Enalaprilmaleaat/Hydrochloorthiazide is used to treat high blood pressure (hypertension), congestive heart failure, and swelling associated with certain medical conditions. It is also used to reduce the risk of death and hospitalization in people with congestive heart failure.
Mechanism of Action
Enalapril works by blocking an enzyme called angiotensin-converting enzyme (ACE). This enzyme helps to constrict blood vessels, resulting in elevating blood pressure. By inhibiting the action of ACE, the drug relaxes blood vessels and hence lowers blood pressure. The diuretic component of the combo increases the amount of urine excreted by the body, thereby reducing the amount of fluid in the body, thereby reducing swelling.
How long does it take to work?
The effects of enalapril + diuretika can be felt within 1-2 weeks of initial use. It is important to keep taking the medication as prescribed, even if effects are not seen immediately.
Absorption, Route of Elimination, Dosage, Administration
Enalpril is rapidly absorbed in the small intestine and well distributed into tissues and organs, including the liver and kidneys. It is metabolized in the liver and eliminated by the kidneys. The recommended dosage of enalapril + diuretika varies depending on the age, weight, and medical condition of the patient. The drug should be taken orally, usually once or twice a day with or without food.
Side Effect
The most common side effects of enalapril + diuretika include headache, dizziness, nausea, fatigue, and low blood pressure. Other less common side effects include, edema, hypotension, dyspnea, chest pain, dry mouth, diarrhea, increased urination, urinary tract infections, decreased kidney function, hyperkalemia, and swelling of the face, lips, and tongue.
Toxicity, Precaution, & Interaction
Enalapril + diuretika may interact with other medications causing adverse reactions or changes in the effectiveness of this compound. Little data is available regarding the acute toxicity of this combination, however, it is important that the drug is taken in the prescribed dosage only. Care should be taken when using this medication in elderly patients as they are more prone to side effects.
Disease Interaction, Drug Interaction, Food Interactions, Pregnancy Use, Lactation Use, Acute Overdose, Contraindication, Use Direction
Enalapril + diuretika should not be used in combination with other medications that lower blood pressure levels. The drug can pass into breast milk and can cause harm to the infant. Therefore, it should not be used during breastfeeding. Enalapril + diuretika should be avoided in pregnant women and those who are allergic to any of the components. It should not be taken if the patient is on dialysis. Also, it should not be used with certain drugs such as diuretics and potassium supplements. The drug can interact with certain foods, so it is important to inform your doctor about any dietary supplements or food items the patient is consuming. Overdose of the drug can lead to serious medical conditions including excessive drowsiness, slow heartbeat, and fainting.
Storage Conditions, Volume of Distribution, Half Life, Clearance
Enalapril + diuretika should be stored in a cool and dry place and should be kept out of the reach of children. The volume of distribution of this combination is about 3.2-6.2 liters/kg. The half-life of enalapril is 2-4 hours and the clearance of the drug is 0.08-0.13 ml/min/kg.
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