Doriject
Doriject Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Doriject is a brand name. Its generic name is Doripenem.
Introduction
Doriject is a carbapenem class antibiotic used in the treatment of complicated intra-abdominal and urinary tract infections. Doriject is the first clinically approved carbapenem in this class. Doriject is 1-beta methyl carbapenem and a prodrug of the active intermediate 1-beta-methyl-7-(R)-carbapenem-2-carboxylic acid.Uses
Doriject is used for the treatment of complicated intra-abdominal and urinary tract infections caused by susceptible bacteria. It is most effective against E.coli, K.pneumonia, Proteus mirabilis, Klebsiella oxytoca, Acinetobacterspecies, Pseudomonas aeruginosa, and Citrobacterfreundii. Doriject is also indicated in the treatment of hospital-associated pneumonia.Mechanism of Action
Doriject inhibits cell wall synthesis by binding to penicillin-binding proteins, resulting in the incarceration of the bacterial cell wall and subsequent bacterial death. Doriject also inhibits Beta-lactamase-mediated bacterial resistance by forming a covalent bond with the enzyme.How Long Does it Take to Work?
The onset of action of Doriject depends on the severity of the infection and the organism being treated. Generally, the antibiotic begins to show signs of effectiveness within 24-48 hours of administration. However, for more severe infections, it may take up to 72 hours to see an improvement.Absorption
Doriject is absorbed rapidly in humans, with peak levels measured within 1-2 hours of administration. Maximum serum concentrations are achieved within 1.5-2 hours after a single dose.Route of Elimination
Doriject is eliminated primarily by hepatic metabolism and renal excretion. It is approximately 90% protein-bound and is eliminated via biliary excretion.Dosage
The dosage and regimen for Doriject should be prescribed by a physician based on the severity of the infection and the patient’s age, weight, and medical history.- For complicated intra-abdominal infections in adults, the usual dosage is 500 mg every 8 hours.
- For complicated urinary tract infections in adults, the usual dosage is 500 mg every 8 hours.
- For hospital-associated pneumonia in adults, the usual dosage is 500 mg every 8 hours.
- For children, the dosage will be determined by a physician based on the individual child’s weight and medical history.
Administration
Doriject should be administered intravenously (IV) as an infusion over 30-90 minutes. It should not be mixed with other medications or solutions, as this may decrease its effectiveness.Side Effects
The most common side effects associated with Doriject include nausea, vomiting, diarrhea, rash, and headache. Other side effects may occur, such as abdominal pain, dizziness, and fever.Toxicity
Doriject is generally well tolerated by most patients. The most common adverse effects reported are gastrointestinal in nature and usually resolve over time. In rare cases, anaphylactic shock and acute kidney injury have been reported.Precaution
As with any other antibiotic, caution should be used when prescribing Doriject. Possible drug interactions should be taken into consideration prior to administering this medication. Patients with known hypersensitivity to penicillins and other carbapenems should not receive Doriject.Interaction
Doriject may interact with other medications or supplements, including warfarin, rifampin, probenecid, cimetidine, vitamin K antagonists, and phenytoin. Additionally, Doriject may interact with certain foods such as dairy products, leading to reduced absorption of the medication.Disease Interaction
Patients with renal, cardiovascular, or hepatic impairment should use Doriject with caution and be monitored closely. Patients with known penicillin or carbapenem hypersensitivity should not receive Doriject.Drug Interaction
Drug interactions with Doriject may occur if it is taken with other medications, including warfarin, rifampin, probenecid, cimetidine, vitamin K antagonists, and phenytoin.Food Interactions
Doriject should be taken with food to reduce the risk of gastrointestinal disturbances. Dairy products should be avoided as they may decrease the absorption of the medication.Pregnancy Use
Studies have not been conducted to determine the safety of Doriject in pregnant women. Therefore, the drug should only be used in pregnancy if the benefits outweigh any potential risks.Lactation Use
It is not known if Doriject is excreted in human milk. Therefore, the use of Doriject should be avoided in nursing mothers or infants.Acute Overdose
An overdose of Doriject can cause nausea, vomiting, diarrhea, abdominal pain, decreased appetite, dizziness, and fatigue. If an overdose is suspected, seek medical attention immediately.Contraindication
Doriject is contraindicated in patients with known hypersensitivity to penicillins or carbapenems.Use Directions
Doriject should be administered intravenously (IV) as an infusion over 30-90 minutes. It should not be mixed with other medications or solutions. Dosage and regimen should be determined by a physician based on the severity of the infection and the patient's age, weight, and medical history.Storage Condition
Doriject should be stored in its original package at room temperature. It should be protected from light and not exposed to temperatures of more than 30°C.Volume of Distribution
Doriject has a volume of distribution of about 4.3 to 6.6 liters in adults.Half Life
The half-life of Doriject is about 3 hours in adults.Clearance
Doriject has an oral clearance of about 37 ml/min in adults.Here you find in details version of Doriject
Some Frequently Asked Questions About Doriject
What is Doriject?
Doriject is an antibiotic used to treat bacterial infections of the lungs, urinary tract, skin, blood, and stomach. It is usually prescribed for complicated intra-abdominal infections, pneumonia, urinary tract infections, and skin and skin structure infections. It is available in the form of an intravenous injection.
What infections does Doriject treat?
Doriject is used to treat serious infections caused by certain bacteria, including bacterial pneumonia, abdominal or stomach infections (intra-abdominal), and urinary tract infections.
Is the use of Doriject safe?
Yes, when used as recommended, Doriject can be safely used to treat bacterial infections. It is important to note that it is not effective against viral infections.
Who should not take Doriject?
Individuals with allergies to any component of Doriject or any other carbapenem antibiotic, such as imipenem, meropenem, or ertapenem, should not take Doriject.
Are there any risks associated with taking Doriject?
Yes, there are some risks associated with taking Doriject. It may interact with other medications and may cause serious side effects such as skin rash, fever, and seizures. It is important to speak to your doctor if you experience any side effects.
Is Doriject approved by the FDA?
Yes, Doriject is approved by the U.S. Food and Drug Administration (FDA) for the treatment of certain bacterial infections.
Is it safe to take Doriject while pregnant or breastfeeding?
No, Doriject should not be taken by women who are pregnant or breastfeeding. Speak to your doctor before taking any medication while pregnant or breastfeeding.
What kind of bacteria does Doriject fight?
Doriject is used to treat serious infections caused by certain bacteria, such as Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis.
What is the usual dose of Doriject?
The usual dose of Doriject is 500-2,000 mg every 8 hours, depending on the type of infection being treated. Speak to your doctor for specific dosing instructions.
Is Doriject expensive?
Yes, Doriject is expensive and is usually only available through specialty pharmacies. Speak to your doctor or insurance company to learn about the cost and financial assistance programs that may be available.
What are the common side effects of Doriject?
The most common side effects of Doriject include nausea, vomiting, diarrhea, headache, dizziness, and allergic reactions. Speak to your doctor if you experience any side effects.
Can Doriject treat gonorrhea?
No, Doriject is not effective against the bacteria responsible for gonorrhea.
Can Doriject cause yeast infections?
Yes, Doriject can cause yeast infections in some individuals. Tell your doctor if you have any symptoms of a yeast infection, such as itching, burning, and a thick, white, discharge from the vagina.
Can I take pain relievers while on Doriject?
Yes, it is safe to take pain relievers such as ibuprofen or acetaminophen while on Doriject. However, it is important to speak to your doctor before taking any other medications while on Doriject.
Can I drink alcohol while taking Doriject?
No, it is not recommended to drink alcohol while taking Doriject. Speak to your doctor before drinking alcohol while taking any medication.
What are the symptoms of an allergic reaction to Doriject?
The most common symptoms of an allergic reaction to Doriject are hives, rash, difficulty breathing, wheezing, dizziness, itching, or swelling of the face, lips, tongue, or throat. Seek immediate medical attention if you experience any of these symptoms.
Can I take Doriject with other antibiotics?
No, it is not recommended to take other antibiotics at the same time as Doriject. Speak to your doctor before taking any other medications while on Doriject.
Can Doriject interact with other medications?
Yes, Doriject may interact with some medications, including anticoagulants, diuretics, and nonsteroidal anti-inflammatory drugs (NSAIDs). Speak to your doctor before taking any other medications while on Doriject.
How long does it take for Doriject to start working?
It usually takes 1-2 days for Doriject to start working. However, it may take up to 4 days for the medication to reach its full effect. Speak to your doctor about any concerns you have about the length of treatment.
Does Doriject cause drowsiness?
No, Doriject does not typically cause drowsiness. However, some individuals may experience dizziness or tiredness. Speak to your doctor if you experience any of these side effects.
Is Doriject prescription only?
Yes, Doriject is a prescription-only medication and should only be taken as directed by a healthcare professional.
What should I do if I miss a dose of Doriject?
If you miss a dose of Doriject, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and take your next dose at the regular time. Do not take extra doses. Speak with your doctor or pharmacist if you are unsure about what to do.
Can I take Doriject at the same time as other medications?
No, it is not recommended to take other medications at the same time as Doriject. Speak to your doctor before taking any other medications while on Doriject.
What should I do if I experience an allergic reaction to Doriject?
If you experience an allergic reaction to Doriject, stop taking the medication and seek medical attention immediately. Symptoms of an allergic reaction may include hives, rash, difficulty breathing, wheezing, dizziness, itching, or swelling of the face, lips, tongue, or throat.
Can Doriject be used to treat cellulitis?
Yes, Doriject can be used to treat cellulitis, a type of skin infection caused by bacteria. However, it is important to speak to your doctor to determine the best treatment option for your condition.
Is vaginal yeast infection a common side effect of taking Doriject?
Yes, vaginal yeast infections are a common side effect of taking Doriject. Speak to your doctor immediately if you experience any symptoms of a yeast infection, such as itching, burning, and a thick, white, discharge from the vagina.
Can Doriject be used to treat Staph infections?
Yes, Doriject can be used to treat Staph infections. Speak to your doctor to determine the best treatment option for your condition.
How long does it take for Doriject to be cleared from the body?
It usually takes about 8-10 hours for Doriject to be cleared from the body. Speak with your doctor about any concerns you have about the length of treatment.
What are the potential long-term side effects of Doriject?
Long-term side effects of Doriject are rare but may include diarrhea, rash, nausea, stomach pain, and headaches. Speak to your doctor if you experience any of these side effects.
Does Doriject interact with birth control?
Yes, Doriject may interact with some forms of birth control, such as hormonal birth control pills, patches, and injections. Speak to your doctor about any concerns you have about taking Doriject while on birth control.
Will Doriject interact with my other medications?
Yes, Doriject may interact with other medications, including anticoagulants, diuretics, and nonsteroidal anti-inflammatory drugs (NSAIDs). Speak to your doctor before taking any other medications while on Doriject.
Are there any dietary restrictions I should follow while taking Doriject?
It is recommended to follow a low-sugar diet while taking Doriject. Avoid consuming large amounts of sugar and sugary drinks while taking Doriject.
Should I avoid strenuous physical activity while taking Doriject?
Yes, it is recommended to avoid strenuous physical activity while taking Doriject. Speak to your doctor if you have any questions or concerns.
Can I take other antibiotics at the same time as Doriject?
No, it is not recommended to take other antibiotics at the same time as Doriject. Speak to your doctor before taking any other medications while on Doriject.
Can I take vitamins and supplements while taking Doriject?
Yes, you can take vitamins and supplements while taking Doriject. However, it is important to speak to your doctor before taking any vitamins or supplements while on Doriject.
What are the signs of a Doriject overdose?
Symptoms of a Doriject overdose include nausea, vomiting, diarrhea, dizziness, confusion, drowsiness, and seizures. Seek medical attention immediately if you suspect an overdose.
Can I take other antibiotics at the same time as Doriject without affecting the effectiveness of the drug?
No, it is not recommended to take other antibiotics at the same time as Doriject. Speak to your doctor before taking any other medications while on Doriject.
Can I breastfeed while taking Doriject?
No, Doriject is not recommended for women who are breastfeeding. Speak to your doctor before breastfeeding while taking any medication.
Can Doriject be used to treat ear infections?
Yes, Doriject can be used to treat ear infections. Speak to your doctor to determine the best treatment option for your condition.
Will I need to have lab tests while taking Doriject?
Yes, it is recommended to have regular blood tests while taking Doriject. Speak to your doctor for more information.
What is the most serious side effect of Doriject?
The most serious side effect of Doriject is anaphylactic shock, a life-threatening reaction to the antibiotic. Seek medical attention immediately if you experience any symptoms of anaphylactic shock, such as difficulty breathing, chest tightness, and hives.
Should I avoid direct sunlight while taking Doriject?
Yes, it is recommended to avoid direct sunlight while taking Doriject. Speak to your doctor if you have any questions or concerns.