Doripenam
Doripenam Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Doripenam is a brand name. Its generic name is Doripenem.
Introduction
Doripenam is a carbapenem class antibiotic used in the treatment of complicated intra-abdominal and urinary tract infections. Doripenam is the first clinically approved carbapenem in this class. Doripenam is 1-beta methyl carbapenem and a prodrug of the active intermediate 1-beta-methyl-7-(R)-carbapenem-2-carboxylic acid.Uses
Doripenam is used for the treatment of complicated intra-abdominal and urinary tract infections caused by susceptible bacteria. It is most effective against E.coli, K.pneumonia, Proteus mirabilis, Klebsiella oxytoca, Acinetobacterspecies, Pseudomonas aeruginosa, and Citrobacterfreundii. Doripenam is also indicated in the treatment of hospital-associated pneumonia.Mechanism of Action
Doripenam inhibits cell wall synthesis by binding to penicillin-binding proteins, resulting in the incarceration of the bacterial cell wall and subsequent bacterial death. Doripenam also inhibits Beta-lactamase-mediated bacterial resistance by forming a covalent bond with the enzyme.How Long Does it Take to Work?
The onset of action of Doripenam depends on the severity of the infection and the organism being treated. Generally, the antibiotic begins to show signs of effectiveness within 24-48 hours of administration. However, for more severe infections, it may take up to 72 hours to see an improvement.Absorption
Doripenam is absorbed rapidly in humans, with peak levels measured within 1-2 hours of administration. Maximum serum concentrations are achieved within 1.5-2 hours after a single dose.Route of Elimination
Doripenam is eliminated primarily by hepatic metabolism and renal excretion. It is approximately 90% protein-bound and is eliminated via biliary excretion.Dosage
The dosage and regimen for Doripenam should be prescribed by a physician based on the severity of the infection and the patient’s age, weight, and medical history.- For complicated intra-abdominal infections in adults, the usual dosage is 500 mg every 8 hours.
- For complicated urinary tract infections in adults, the usual dosage is 500 mg every 8 hours.
- For hospital-associated pneumonia in adults, the usual dosage is 500 mg every 8 hours.
- For children, the dosage will be determined by a physician based on the individual child’s weight and medical history.
Administration
Doripenam should be administered intravenously (IV) as an infusion over 30-90 minutes. It should not be mixed with other medications or solutions, as this may decrease its effectiveness.Side Effects
The most common side effects associated with Doripenam include nausea, vomiting, diarrhea, rash, and headache. Other side effects may occur, such as abdominal pain, dizziness, and fever.Toxicity
Doripenam is generally well tolerated by most patients. The most common adverse effects reported are gastrointestinal in nature and usually resolve over time. In rare cases, anaphylactic shock and acute kidney injury have been reported.Precaution
As with any other antibiotic, caution should be used when prescribing Doripenam. Possible drug interactions should be taken into consideration prior to administering this medication. Patients with known hypersensitivity to penicillins and other carbapenems should not receive Doripenam.Interaction
Doripenam may interact with other medications or supplements, including warfarin, rifampin, probenecid, cimetidine, vitamin K antagonists, and phenytoin. Additionally, Doripenam may interact with certain foods such as dairy products, leading to reduced absorption of the medication.Disease Interaction
Patients with renal, cardiovascular, or hepatic impairment should use Doripenam with caution and be monitored closely. Patients with known penicillin or carbapenem hypersensitivity should not receive Doripenam.Drug Interaction
Drug interactions with Doripenam may occur if it is taken with other medications, including warfarin, rifampin, probenecid, cimetidine, vitamin K antagonists, and phenytoin.Food Interactions
Doripenam should be taken with food to reduce the risk of gastrointestinal disturbances. Dairy products should be avoided as they may decrease the absorption of the medication.Pregnancy Use
Studies have not been conducted to determine the safety of Doripenam in pregnant women. Therefore, the drug should only be used in pregnancy if the benefits outweigh any potential risks.Lactation Use
It is not known if Doripenam is excreted in human milk. Therefore, the use of Doripenam should be avoided in nursing mothers or infants.Acute Overdose
An overdose of Doripenam can cause nausea, vomiting, diarrhea, abdominal pain, decreased appetite, dizziness, and fatigue. If an overdose is suspected, seek medical attention immediately.Contraindication
Doripenam is contraindicated in patients with known hypersensitivity to penicillins or carbapenems.Use Directions
Doripenam should be administered intravenously (IV) as an infusion over 30-90 minutes. It should not be mixed with other medications or solutions. Dosage and regimen should be determined by a physician based on the severity of the infection and the patient's age, weight, and medical history.Storage Condition
Doripenam should be stored in its original package at room temperature. It should be protected from light and not exposed to temperatures of more than 30°C.Volume of Distribution
Doripenam has a volume of distribution of about 4.3 to 6.6 liters in adults.Half Life
The half-life of Doripenam is about 3 hours in adults.Clearance
Doripenam has an oral clearance of about 37 ml/min in adults.Here you find in details version of Doripenam
Some Frequently Asked Questions About Doripenam
What is Doripenam?
Doripenam is an antibiotic used to treat bacterial infections of the lungs, urinary tract, skin, blood, and stomach. It is usually prescribed for complicated intra-abdominal infections, pneumonia, urinary tract infections, and skin and skin structure infections. It is available in the form of an intravenous injection.
What infections does Doripenam treat?
Doripenam is used to treat serious infections caused by certain bacteria, including bacterial pneumonia, abdominal or stomach infections (intra-abdominal), and urinary tract infections.
Is the use of Doripenam safe?
Yes, when used as recommended, Doripenam can be safely used to treat bacterial infections. It is important to note that it is not effective against viral infections.
Who should not take Doripenam?
Individuals with allergies to any component of Doripenam or any other carbapenem antibiotic, such as imipenem, meropenem, or ertapenem, should not take Doripenam.
Are there any risks associated with taking Doripenam?
Yes, there are some risks associated with taking Doripenam. It may interact with other medications and may cause serious side effects such as skin rash, fever, and seizures. It is important to speak to your doctor if you experience any side effects.
Is Doripenam approved by the FDA?
Yes, Doripenam is approved by the U.S. Food and Drug Administration (FDA) for the treatment of certain bacterial infections.
Is it safe to take Doripenam while pregnant or breastfeeding?
No, Doripenam should not be taken by women who are pregnant or breastfeeding. Speak to your doctor before taking any medication while pregnant or breastfeeding.
What kind of bacteria does Doripenam fight?
Doripenam is used to treat serious infections caused by certain bacteria, such as Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis.
What is the usual dose of Doripenam?
The usual dose of Doripenam is 500-2,000 mg every 8 hours, depending on the type of infection being treated. Speak to your doctor for specific dosing instructions.
Is Doripenam expensive?
Yes, Doripenam is expensive and is usually only available through specialty pharmacies. Speak to your doctor or insurance company to learn about the cost and financial assistance programs that may be available.
What are the common side effects of Doripenam?
The most common side effects of Doripenam include nausea, vomiting, diarrhea, headache, dizziness, and allergic reactions. Speak to your doctor if you experience any side effects.
Can Doripenam treat gonorrhea?
No, Doripenam is not effective against the bacteria responsible for gonorrhea.
Can Doripenam cause yeast infections?
Yes, Doripenam can cause yeast infections in some individuals. Tell your doctor if you have any symptoms of a yeast infection, such as itching, burning, and a thick, white, discharge from the vagina.
Can I take pain relievers while on Doripenam?
Yes, it is safe to take pain relievers such as ibuprofen or acetaminophen while on Doripenam. However, it is important to speak to your doctor before taking any other medications while on Doripenam.
Can I drink alcohol while taking Doripenam?
No, it is not recommended to drink alcohol while taking Doripenam. Speak to your doctor before drinking alcohol while taking any medication.
What are the symptoms of an allergic reaction to Doripenam?
The most common symptoms of an allergic reaction to Doripenam are hives, rash, difficulty breathing, wheezing, dizziness, itching, or swelling of the face, lips, tongue, or throat. Seek immediate medical attention if you experience any of these symptoms.
Can I take Doripenam with other antibiotics?
No, it is not recommended to take other antibiotics at the same time as Doripenam. Speak to your doctor before taking any other medications while on Doripenam.
Can Doripenam interact with other medications?
Yes, Doripenam may interact with some medications, including anticoagulants, diuretics, and nonsteroidal anti-inflammatory drugs (NSAIDs). Speak to your doctor before taking any other medications while on Doripenam.
How long does it take for Doripenam to start working?
It usually takes 1-2 days for Doripenam to start working. However, it may take up to 4 days for the medication to reach its full effect. Speak to your doctor about any concerns you have about the length of treatment.
Does Doripenam cause drowsiness?
No, Doripenam does not typically cause drowsiness. However, some individuals may experience dizziness or tiredness. Speak to your doctor if you experience any of these side effects.
Is Doripenam prescription only?
Yes, Doripenam is a prescription-only medication and should only be taken as directed by a healthcare professional.
What should I do if I miss a dose of Doripenam?
If you miss a dose of Doripenam, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and take your next dose at the regular time. Do not take extra doses. Speak with your doctor or pharmacist if you are unsure about what to do.
Can I take Doripenam at the same time as other medications?
No, it is not recommended to take other medications at the same time as Doripenam. Speak to your doctor before taking any other medications while on Doripenam.
What should I do if I experience an allergic reaction to Doripenam?
If you experience an allergic reaction to Doripenam, stop taking the medication and seek medical attention immediately. Symptoms of an allergic reaction may include hives, rash, difficulty breathing, wheezing, dizziness, itching, or swelling of the face, lips, tongue, or throat.
Can Doripenam be used to treat cellulitis?
Yes, Doripenam can be used to treat cellulitis, a type of skin infection caused by bacteria. However, it is important to speak to your doctor to determine the best treatment option for your condition.
Is vaginal yeast infection a common side effect of taking Doripenam?
Yes, vaginal yeast infections are a common side effect of taking Doripenam. Speak to your doctor immediately if you experience any symptoms of a yeast infection, such as itching, burning, and a thick, white, discharge from the vagina.
Can Doripenam be used to treat Staph infections?
Yes, Doripenam can be used to treat Staph infections. Speak to your doctor to determine the best treatment option for your condition.
How long does it take for Doripenam to be cleared from the body?
It usually takes about 8-10 hours for Doripenam to be cleared from the body. Speak with your doctor about any concerns you have about the length of treatment.
What are the potential long-term side effects of Doripenam?
Long-term side effects of Doripenam are rare but may include diarrhea, rash, nausea, stomach pain, and headaches. Speak to your doctor if you experience any of these side effects.
Does Doripenam interact with birth control?
Yes, Doripenam may interact with some forms of birth control, such as hormonal birth control pills, patches, and injections. Speak to your doctor about any concerns you have about taking Doripenam while on birth control.
Will Doripenam interact with my other medications?
Yes, Doripenam may interact with other medications, including anticoagulants, diuretics, and nonsteroidal anti-inflammatory drugs (NSAIDs). Speak to your doctor before taking any other medications while on Doripenam.
Are there any dietary restrictions I should follow while taking Doripenam?
It is recommended to follow a low-sugar diet while taking Doripenam. Avoid consuming large amounts of sugar and sugary drinks while taking Doripenam.
Should I avoid strenuous physical activity while taking Doripenam?
Yes, it is recommended to avoid strenuous physical activity while taking Doripenam. Speak to your doctor if you have any questions or concerns.
Can I take other antibiotics at the same time as Doripenam?
No, it is not recommended to take other antibiotics at the same time as Doripenam. Speak to your doctor before taking any other medications while on Doripenam.
Can I take vitamins and supplements while taking Doripenam?
Yes, you can take vitamins and supplements while taking Doripenam. However, it is important to speak to your doctor before taking any vitamins or supplements while on Doripenam.
What are the signs of a Doripenam overdose?
Symptoms of a Doripenam overdose include nausea, vomiting, diarrhea, dizziness, confusion, drowsiness, and seizures. Seek medical attention immediately if you suspect an overdose.
Can I take other antibiotics at the same time as Doripenam without affecting the effectiveness of the drug?
No, it is not recommended to take other antibiotics at the same time as Doripenam. Speak to your doctor before taking any other medications while on Doripenam.
Can I breastfeed while taking Doripenam?
No, Doripenam is not recommended for women who are breastfeeding. Speak to your doctor before breastfeeding while taking any medication.
Can Doripenam be used to treat ear infections?
Yes, Doripenam can be used to treat ear infections. Speak to your doctor to determine the best treatment option for your condition.
Will I need to have lab tests while taking Doripenam?
Yes, it is recommended to have regular blood tests while taking Doripenam. Speak to your doctor for more information.
What is the most serious side effect of Doripenam?
The most serious side effect of Doripenam is anaphylactic shock, a life-threatening reaction to the antibiotic. Seek medical attention immediately if you experience any symptoms of anaphylactic shock, such as difficulty breathing, chest tightness, and hives.
Should I avoid direct sunlight while taking Doripenam?
Yes, it is recommended to avoid direct sunlight while taking Doripenam. Speak to your doctor if you have any questions or concerns.