Diclonina
Diclonina Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Diclonina is a brand name. Its generic name is Dyclonine.
Diclonina
Diclonina is an oral medication that is used to treat sore throat and its associated symptoms. Diclonina hydrochloride is a synthetic non-narcotic analgesic-antitussive used in the treatment of sore throat, hoarseness, and cough.
Uses
Diclonina is mainly used for treating sore throats and associated symptoms. It is used for treating pain associated with minor surgical procedures and other conditions such as colds and flu.
Mechanism of Action
Diclonina acts by blocking the action of sensory nerve impulses in the mucous membrane of the throat. It inhibits the sensation of pain by preventing the signals from reaching the brain. It also has antitussive properties which help in subduing coughing.
How Long Does it Take to Work?
Diclonina usually takes 15-30 minutes to start working after ingestion. Its effects can last from four to six hours.
Absorption
Diclonina is absorbed rapidly from the gastrointestinal tract. It is quickly metabolized in the liver and has a bioavailability of 90 percent.
Route of Elimination
Diclonina is eliminated mainly through the kidneys by a combination of glomerular filtration and tubular secretion.
Dosage
Diclonina is available in 0.5 and 1mg oral tablets. For adults, the recommended dosage is one tablet every four to six hours as needed for pain relief. It is not recommended for children under six years old.
Administration
Diclonina should be taken orally, with a full glass of water. It can be taken with or without food.
Side Effects
Side effects of Diclonina include dizziness, lightheadedness, headache, nausea, and upset stomach. Other side effects are rare and may include allergic reactions, confusion, drowsiness, and blurred vision.
Toxicity
There is no known toxicity associated with Diclonina. However, overdoses are possible and symptoms may include dizziness, confusion, vomiting, blurred vision, and tremor. In case of an overdose, medical help should be sought.
Precautions
Diclonina should be used with caution in people who have a history of gastric or intestinal disease, epilepsy, cardiovascular disease, and renal impairment. It should also not be used by people who are pregnant or lactating.
Interactions
Diclonina may interact with other medications, including anticholinergics, narcotics, sedatives, and antihistamines. It should be used with caution in people taking these medications as it may lead to adverse reactions.
Disease Interactions
Diclonina may interact with certain medical conditions, such as increased intraocular pressure, glaucoma, hyperthyroidism, and asthma. People with these conditions should use Diclonina with caution.
Drug Interactions
Diclonina may interact with other medications, including anticholinergics, narcotics, sedatives, and antihistamines. Therefore, care should be taken when prescribing these medications to people taking Diclonina.
Food Interactions
Diclonina should not be taken with milk, alcohol, or grapefruit juice, as these may interact with the medication and cause adverse reactions.
Pregnancy Use
Diclonina should be avoided during pregnancy, as its safety has not been established in pregnant women. The potential risks to the mother and fetus should be weighed against the potential benefits.
Lactation Use
Diclonina is excreted in breast milk and should be avoided during lactation. It is recommended that breastfeeding mothers stop taking Diclonina and seek alternative treatment.
Acute Overdose
Symptoms of an acute overdose of Diclonina may include confusion, dizziness, nausea, vomiting, blurred vision, and tremor. In case of an overdose, medical help should be sought immediately.
Contraindications
Diclonina should not be used by people who are pregnant, lactating, or have a history of hypersensitivity to Diclonina. It should also be avoided in patients with increased intraocular pressure, glaucoma, hyperthyroidism, and asthma.
Use Direction
Diclonina tablets should be swallowed whole, with a full glass of water. The tablets should not be crushed, chewed, or dissolved in water as this may cause adverse effects. The dosage should be determined based on the severity of symptoms and the response to treatment.
Storage Condition
Diclonina should be stored at room temperature away from direct sunlight and heat. It should be kept out of reach of children and pets.
Volume of Distribution
The volume of distribution of Diclonina in adults is estimated to be 2.4 L/kg.
Half Life
The half life of Diclonina in adults is estimated to be 2.5-4 hours.
Clearance
The clearance of Diclonina is estimated to be 1.2-1.6 L/h/kg in adults.
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