Dexzole
Dexzole Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Dexzole is a brand name. Its generic name is Dexlansoprazole.
Introduction
Dexzole (DLP) is a proton pump inhibitor and is used to treat gastric and duodenal ulcers. It is a combination of lansoprazole and dexrabeprazole, two different proton pump inhibitors. DLP works by blocking the production of acid in the stomach.Uses
DLP is used to treat gastroesophageal reflux disease (GERD), peptic ulcers, erosive esophagitis, Zollinger-Ellison Syndrome, and other conditions caused by excessive acid production in the stomach. It is sometimes prescribed off-label to prevent recurring heartburn or to prevent duodenal ulcers caused by long-term use of NSAIDs.Mechanism of Action
DLP works by inhibiting H+/K+-ATPase (the acid pump in gastric parietal cells), thereby reducing gastric acid secretion. By reducing the amount of acid in the stomach, DLP helps to both treat and prevent the occurrence of gastric and duodenal ulcers.How Long Does it Take to Work?
The effects of DLP are usually seen within 1 hour after taking a dose, and the maximum effect is usually seen within 3-4 hours.Absorption
The lansoprazole component of DLP is rapidly absorbed, reaching peak serum concentrations within 1-2 hours. The dexrabeprazole component is delayed-release and is not absorbed until it reaches the small intestine. This substantially increases the bioavailability of dexrabeprazole and provides longer lasting effects.Route of Elimination
DLP is eliminated primarily in the urine, with up to 99% of a dose eliminated within 72 hours.Dosage
DLP is available as 15 mg, 30 mg, and 60 mg delayed-release capsules. The recommended dosage for adults with GERD is 30 mg once daily for 4-8 weeks. For erosive esophagitis, the recommended dosage is 30 mg once daily for up to 8 weeks. The minimum effective dosage is 15 mg once daily.Administration
DLP should be taken on an empty stomach at least 30 minutes before a meal. It should be swallowed whole with a glass of water. Chewing, crushing, or splitting the capsules can damage the delayed-release coating.Side Effect
The most common side effects of DLP include nausea, diarrhea, headaches, and abdominal pain. Less common side effects include gastrointestinal bleeding, rash, and dizziness.Toxicity
The maximum recommended daily dose of DLP is 60 mg per day. Doses greater than 60 mg/day have been associated with increased toxicity. An overdose of DLP can cause serious side effects, including rapid heart rate, confusion, seizures, and low blood pressure.Precautions
DLP should not be used in patients with active peptic ulcers, or any condition involving obstruction of the duodenum, as it can cause gastrointestinal obstruction. It should also not be used in patients with hypersensitivity to any of its components.Interaction
DLP may interact with other medications. It is important to take at least one hour before or two hours after other medications.Disease Interaction
DLP should be used with caution in patients with hepatic impairment or congestive heart failure due to its effects on electrolytes, especially magnesium. Patients with hepatic impairment should not take doses greater than 30 mg per day.Drug Interactions
DLP may interact with other medications such as antacids, benzodiazepines, digoxin, warfarin, iron supplements, and antidepressants, among others. It is important to tell your doctor about all medications you are taking before starting DLP.Food Interactions
DLP should be taken with food for optimal absorption. Taking DLP with food may reduce the risk of gastroesophageal reflux and increase the effectiveness of the medication.Pregnancy Use
DLP is not recommended for pregnant women, as the safety of the medication has not been established in pregnant women.Lactation Use
DLP is not recommended for use in breastfeeding mothers, as the drug is excreted in breastmilk.Acute Overdose
DLP overdose may cause serious side effects, including rapid heart rate, confusion, seizures, and low blood pressure. If an overdose occurs, contact your doctor or nearest poison control center immediately.Contraindication
DLP is contraindicated in patients with hepatic impairment, congestive heart failure, and any condition involving obstruction of the duodenum, as it can cause gastrointestinal obstruction.Use Direction
DLP should be taken 30 minutes before meals, on an empty stomach, with a full glass of water. The capsule should be swallowed whole and should not be chewed, crushed, or split.Storage Condition
DLP should be stored at room temperature, away from light and moisture. Keep out of reach of children.Volume of Distribution
The volume of distribution for DLP is 32–39 L.Half Life
The half-life of DLP is 1.3–2.5 hours.Clearance
The renal clearance of DLP is 0.8–1.0 L/h.Here you find in details version of Dexzole
Some Frequently Asked Questions About Dexzole
What is Dexzole?
Dexzole is a prescription medication that belongs to a class of drugs called proton pump inhibitors (PPIs). It works by blocking the production of stomach acid. It is used to treat gastroesophageal reflux disease (GERD), heartburn, and certain ulcers.
What is the difference between Dexzole and Lansoprazole?
Dexzole is the active ingredient in lansoprazole. Dexzole is an extended-release form that is absorbed more slowly in the intestines than lansoprazole, allowing for lower doses and fewer doses needed to be taken.
Is Dexzole used for ulcers?
Yes, Dexzole is used to treat duodenal and gastric ulcers.
What are the possible side effects of Dexzole?
Common side effects of Dexzole include nausea, headache, diarrhea, abdominal pain, constipation, and dry mouth. More serious side effects may include increased heart rate, chest pain, seizure, and vision changes. Tell your doctor if you experience any of these side effects.
Can I take Dexzole with food?
Yes, you can take Dexzole with food, but it may be best to take it on an empty stomach as it is more effective. Ask your doctor for the best way to take the medication.
What are the common dosages of Dexzole?
The common dosage for adults is 30 mg, taken once a day. Your doctor may adjust your dosage based on your condition and other medical factors.
How long does it take for Dexzole to work?
It takes at least a few days for Dexzole to reach maximum effectiveness. It is important to remain consistent with taking the medication and to keep follow up appointments with your doctor.
What should I avoid while taking Dexzole?
Grapefruit and grapefruit juice should be avoided while taking Dexzole as it may increase the amount of the drug in the body, resulting in side effects. Certain medications may also interact negatively with Dexzole, so it is important to tell your doctor about all medications and supplements you are taking.
What should I do if I miss a dose of Dexzole?
If you miss a dose of Dexzole, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take your next dose as scheduled.
What if I overdose on Dexzole?
If you think you have overdosed on Dexzole, seek emergency medical attention right away. Overdoses may cause serious side effects such as confusion, restlessness, wheezing, or nausea.
Does Dexzole interact with other medications?
Yes, Dexzole can interact with other medications. Tell your doctor about any medications and supplements you are taking, so they can adjust your dosage and help prevent interactions. Some common medications that interact with Dexzole are warfarin, diazepam, and citalopram.
Is Dexzole safe to take during pregnancy?
Dexzole is generally safe to take during pregnancy. However, it is important to speak to your doctor about all the risks and benefits of taking the medication while pregnant.
Does Dexzole cause weight gain?
No, Dexzole does not typically cause weight gain, but can cause other minor side effects.
Is Dexzole available over the counter?
No, Dexzole is only available by prescription.
Does Dexzole treat complications from GERD?
Yes, Dexzole can be used to treat complications from gastroesophageal reflux disease (GERD).
Can Dexzole be used to treat a sore throat caused by acid reflux?
Yes, Dexzole can be used to treat a sore throat caused by acid reflux. It works by reducing the amount of acid in the stomach, which can help relieve the pain associated with a sore throat caused by acid reflux.
What is the maximum dose of Dexzole?
The maximum dose of Dexzole is 60 mg per day. It is important to follow your doctor's instructions when taking the medication.
Can I take Dexzole with ibuprofen?
It is generally safe to take Dexzole with ibuprofen, but it is important to speak to your doctor about all the medications and supplements you are taking, as some can interact with the medicine.
Can I take antacids while taking Dexzole?
It is not recommended to take antacids while taking Dexzole, as antacids can reduce the effectiveness of Dexzole.
What forms of Dexzole are available?
Dexzole is available as an oral capsule, an oral disintegrating tablet (ODT), and an oral suspension (liquid).
Does Dexzole cause fatigue?
Fatigue is not a common side effect of Dexzole, but it is possible. If you experience extreme fatigue, check with your doctor.
Can Dexzole cause headaches?
Yes, headaches can be a common side effect of Dexzole. Talk to your doctor if you experience any side effects from taking the medication.
Can Dexzole be used to treat an ulcer caused by NSAIDs?
Yes, Dexzole can be used to treat an ulcer caused by nonsteroidal anti-inflammatory drugs (NSAIDs). It works by reducing the amount of acid in the stomach, which can help heal the ulcer.
What should I do if I experience abdominal pain while taking Dexzole?
If you experience abdominal pain while taking Dexzole, contact your doctor right away. Abdominal pain may indicate an allergic reaction, so it is important to seek medical attention right away.
Can Dexzole be used to treat gastroesophageal reflux in infants?
Yes, Dexzole can be used to treat gastroesophageal reflux in infants. The medication can help reduce the amount of acid produced in the stomach, which can help ease discomfort.
Can Dexzole be taken with other medications treating stomach issues?
Yes, Dexzole can be taken with other medications treating stomach issues. However, it is important to let your doctor know of any other medications and supplements you are taking, as certain combinations may not be safe.
Should Dexzole be taken on an empty stomach?
It may be best to take Dexzole on an empty stomach as it is more effective. However, talk to your doctor about the best way to take the medication.
Can Dexzole cause depression?
Depression is not a common side effect of Dexzole but it is possible. Talk to your doctor if you experience any emotional changes while taking the medication.
Can I take Dexzole with vitamins?
Yes, it is generally safe to take Dexzole with vitamins, although certain combinations may not be safe. Talk to your doctor about all the medications and supplements you are taking.
Is it okay to take Dexzole long-term?
Yes, it is generally safe to take Dexzole long-term, though it is important to speak to your doctor about any risks associated with taking the medication for an extended period of time.
What should I do if I experience adverse reactions while taking Dexzole?
If you experience any adverse reactions while taking Dexzole, contact your doctor right away. Adverse reactions may include difficulty breathing, chest pain, or changes in vision. It is important to seek medical attention immediately if any of these side effects occur.
Can I stop taking Dexzole without consulting my doctor?
No, it is important to speak to your doctor before stopping or changing your dosage of Dexzole. Stopping the medication suddenly or abruptly may cause more stomach acid to be produced too quickly, leading to increased symptoms.
Is Dexzole habit-forming?
No, Dexzole is not habit-forming. However, it is important to only take the amount of Dexzole prescribed by your doctor, as taking too much of the medication may cause side effects.