Lacrima
Lacrima Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Lacrima is a brand name. Its generic name is Dextran + Hypromellose.
Introduction
Dextran and Hypromellose are two viscous polysaccharide derivatives, which are commonly used as gelling agents and lubricants in a range of pharmaceutical products, including ophthalmic solutions, suspensions, emulsions, and topical creams.Uses
Dextran and Hypromellose are used as a protective colloid for stabilizing emulsions, suspensions and dispersions and often prescribed for ophthalmic use, as well as for intestinal and urinary tract laxation.Mechanism of Action
Dextran and Hypromellose are both hydrophilic molecules that bind to water, allowing for the formation of suspensions and emulsions. This helps protect other drugs in the product from damage due to environmental factors like humidity and temperature. They also act as lubricants, creating a slippery coating on the skin or eye surface which prevents irritation and tearing.How Long Does it Take to Work?
The effects of Dextran and Hypromellose can be seen immediately after administration.Absorption
Due to their hydrophilic nature, Dextran and Hypromellose molecules are not easily absorbed into the body, so very little, if any, is taken up.Route of Elimination
Dextran and Hypromellose are eliminated via the feces and the urine.Dosage
Dosage information should be provided by a doctor.Administration
Dextran and Hypromellose may be administered orally, intravenously, or rectally depending on the specific product and patient requirement.Side Effects
Dextran and Hypromellose are generally considered to be safe, but some side effects may be experienced including itching, rash, stomach discomfort, bloating, diarrhea, or constipation.Toxicity
Dextran and Hypromellose are low-toxicity materials, and no adverse systemic effects have been noted with recommended doses.Precaution
Dextran and Hypromellose should be used with caution in individuals with a known hypersensitivity or allergy to either material.Interaction
Dextran and Hypromellose may interact with other drugs in the body. It is best to consult a doctor or pharmacist before taking any medications.Disease Interaction
Dextran and Hypromellose may interact with diseases such as diabetes and heart failure, and should be taken with caution in patients with these conditions.Drug Interaction
Dextran and Hypromellose may interact with some drugs, including anticoagulants, blood thinners, and laxatives. It is best to consult a doctor or pharmacist before taking any medications.Food Interactions
Dextran and Hypromellose may interact with certain foods, particularly those that are high in fiber or starch. It is best to consult a doctor or pharmacist before making any dietary changes.Pregnancy Use
Dextran and Hypromellose should be avoided during pregnancy.Lactation Use
Dextran and Hypromellose should be avoided during breastfeeding.Acute Overdose
An overdose of Dextran and Hypromellose may cause symptoms such as abdominal discomfort, diarrhea, or nausea and vomiting. In case of an overdose, it is recommended to consult a doctor or pharmacist immediately.Contraindication
Dextran and Hypromellose should not be used in individuals with known hypersensitivity to either of the materials.Use Direction
Dextran and Hypromellose should be used in accordance with the instructions provided by the doctor or pharmacist.Storage Condition
Dextran and Hypromellose should be stored at room temperature and away from light and moisture.Volume of Distribution
The volume of distribution of Dextran and Hypromellose is unknown.Half Life
The half-life of Dextran and Hypromellose in the body is unknown.Clearance
The clearance rate of Dextran and Hypromellose is also unknown.Here you find in details version of Lacrima
Some Frequently Asked Questions About Lacrima
What is Dextran?
Dextran is a polysaccharide produced by certain bacteria from glucose molecules. It is usually a linear chain of a few hundred to several thousand glucose molecules and is used as a stabilizer, thickener, and emulsifier for a number of consumer products and pharmaceuticals.
What is Hypromellose?
Hypromellose is a semisynthetic, inert, viscoelastic polymer used as an ophthalmic lubricant, as well as an excipient and controlled-release vehicle in oral and topical pharmaceutical formulations.
What is Lacrima?
Lacrima is a combination product of polysaccharide Polydextran and semisynthetic semi-inert hypromellose polymer. It is used as an ophthalmic lubricant, as an excipient and controlled-release vehicle in oral and topical pharmaceutical formulations.
What are the benefits of using Lacrima?
The combined product provides better functionality than either polysaccharide or hypromellose alone. It improves stability, thickening properties, and adhesion to the surface of the ocular tissue. Furthermore, Lacrima facilitates better drug release and absorption, and improves the overall performance of drug formulations compared to Dextran and Hypromellose individually.
How is Lacrima administered?
Lacrima is typically administered topically, drop by drop, applied directly to the affected area.
Is Lacrima safe for use?
Yes, Lacrima is considered safe for use and has been approved by the US FDA for ophthalmic lubrication and other purposes.
What are the possible side effects of Lacrima?
The possible side effects are mild and include irritation, inflammation, oedema, and blurred vision. Other rare but possible side effects include anaphylactic reactions.
How long does Lacrima take to work?
It typically takes about 15 to 20 minutes for Lacrima to take effect.
What are the contraindications for using Lacrima?
Lacrima is contraindicated in patients with known hypersensitivity to any component of the formulation.
What is the recommended dosage of Lacrima?
The dose of Lacrima should be determined by the physician based on the patient’s condition and response to treatment.
Can Lacrima be used in combination with other medication?
Yes, Lacrima can be used in combination with other medications, but any such combination should be discussed with the healthcare provider.
How long does a bottle of Lacrima last?
The shelf life of Lacrima is up to two years and it should be stored at room temperature.
Can Lacrima be stored in the refrigerator?
No, Lacrima should not be stored in the refrigerator and should be stored at room temperature.
What is the shelf life of Lacrima?
The shelf life of Lacrima is up to two years.
What are the storage requirements for Lacrima?
Lacrima should be stored at room temperature, away from direct sunlight and in an airtight container.
What are the inactive ingredients in Lacrima?
The inactive ingredients in Lacrima include polysorbate 80, sodium chloride, potassium chloride, glycerin, sodium bicarbonate and preservatives.
Can Lacrima be used during pregnancy?
Yes, Lacrima can be used during pregnancy but only if a physician recommends it.
Can Lacrima be used on children?
Yes, Lacrima can be used in children over 2 years of age, but it should be used with caution and only if recommended by a physician.
Should Lacrima be used in the presence of an allergic reaction?
No, Lacrima should not be used in the presence of an allergic reaction.
Can Lacrima cause an allergic reaction?
Yes, Lacrima can cause an allergic reaction, and it should be used with caution and only if recommended by a physician.
Can Lacrima be used for the treatment of dry eyes?
Yes, Lacrima can be used for the treatment of dry eyes, but only if recommended by a physician.
What is the onset time of Lacrima?
The onset time of Lacrima is typically 15 to 20 minutes.
What is the difference between Lacrima and other ophthalmic lubricants?
Lacrima is a combination product whereas other ophthalmic lubricants are typically either Polydextran or Hypromellose alone. The combined product offers better lubrication properties than either polysaccharide or hypromellose alone.
How long can Lacrima be used before needing a new prescription?
The duration of use of Lacrima can vary depending on the severity of the condition and the patient’s response to treatment, and it should be discussed with the healthcare provider.
Does Lacrima expire?
Yes, Lacrima has an expiration date printed on the packaging and should not be used beyond this date.
Does Lacrima come in different strengths?
No, Lacrima comes in one strength.
What are the most common adverse reactions associated with Lacrima?
The most common adverse reactions associated with Lacrima are irritation, inflammation, oedema, and blurred vision. These side effects are typically mild in nature.
Can Lacrima be used with contact lenses?
Yes, Lacrima can be used with contact lenses but it should be used as directed by the physician.
Is Lacrima safe for use in patients with diabetes?
Yes, Lacrima is safe for use in patients with diabetes, but any changes in blood sugar levels should be monitored carefully.
Does Lacrima have any drug interactions?
Yes, Lacrima may interact with other medications, and any such interactions should be discussed with the healthcare provider.
Can Lacrima cause blurred vision?
Yes, Lacrima may cause blurred vision, but this is usually mild in nature and should improve with continued use of the product.
Can Lacrima cause a rash?
Yes, Lacrima may cause a mild rash, but this is usually mild in nature and should improve with continued use of the product.
Is Lacrima available over the counter?
No, Lacrima is a prescription-only medication and it should be used only if recommended by a healthcare provider.
How much does Lacrima cost?
The cost of Lacrima varies depending on the pharmacy and the strength of the product.
Can Lacrima be used while breastfeeding?
Yes, Lacrima can be used while breastfeeding but only if recommended by a physician.
Can Lacrima be used with other medications?
Yes, Lacrima can be used with other medications, but any such combination should be discussed with the healthcare provider.
Are there any age restrictions for using Lacrima?
Yes, Lacrima should not be used in children under the age of 2 years and should be used with caution in children under 12 years of age.
Are there any drug interactions associated with Lacrima?
Yes, Lacrima may interact with other medications, and any such interactions should be discussed with the healthcare provider.
What are the benefits of using Lacrima?
The benefits of Lacrima include improved stability, thickening properties, and adhesion to the surface of the ocular tissue. Furthermore, it facilitates better drug release and absorption, and improves the overall performance of drug formulations compared to using Dextran and Hypromellose individually.
Can Lacrima be used for long term treatment?
Yes, Lacrima can be used for long term treatment but any such use should only be done under the supervision of a healthcare provider.
Does Lacrima need to be taken on an empty stomach?
No, Lacrima does not need to be taken on an empty stomach.
Does Lacrima require special handling?
No, Lacrima does not require special handling and can be stored at room temperature.
What type of packaging is available for Lacrima?
Lacrima is available in single-use vials, eye dropper bottles, and plastic dispensers.