Brigatinib
Brigatinib Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Brigatinib is a brand name. Its generic name is Brigatinib.
Introduction
Brigatinib is an ALK inhibitor approved by the FDA in 2017 for the treatment of unresectable or metastatic ALK-positive non-small cell lung cancer (NSCLC). It is a kinase inhibitor that works by blocking the action of a certain enzyme (anaplastic lymphoma kinase, or ALK) which helps cancer cells to grow and spread.Uses For
Brigatinib is used for the treatment of advanced non-small cell lung cancer (NSCLC) in adults that has progressed after treatment with crizotinib, a different type of ALK inhibitor.Mechanism of Action
Brigatinib works by blocking the activity of certain enzymes (anaplastic lymphoma kinase, or ALK) which help cancer cells to grow and spread. By blocking ALK, Brigatinib may help to stop the growth and spread of the cancer cells.How Long Does it Take to Work?
It is difficult to predict exactly how long it will take for Brigatinib to work in each person. However, in clinical trials, people taking Brigatinib have seen improvements in their disease within 3 months.Absorption
Brigatinib has been shown to be rapidly and well-absorbed following oral administration. Peak plasma levels are achieved within two to three hours after ingestion.Route of Elimination
Brigatinib is eliminated mainly through metabolism and urinary excretion.Dosage
Brigatinib is available in 180 mg or 90 mg tablets. The usual recommended dose is 180 mg taken orally once daily with or without food. The dose can be lowered depending on individual patients’ tolerability and side effects.Administration
Brigatinib is taken by mouth, usually once a day with or without food. Swallow the tablets whole and do not chew or crush them.Side Effect
The most common side effects of Brigatinib include nausea, vomiting, diarrhea, constipation, fatigue, headache, cough, decreased appetite, muscle/bone pain, fever, swelling in the limbs, rash, decreased taste, dry mouth, and changes in sense of smell.Toxicity
Brigatinib is generally well-tolerated, but the drug may become toxic in some patients if the dose is too high or if the patient is not taking the drug properly. Symptoms of toxicity may include nausea, vomiting, diarrhea, dehydration, headache, fatigue, and increase in appetite.Precaution
Patients should notify their doctor if they have any signs and symptoms of toxicity, as well as any questions or concerns about Brigatinib.Interactions
Brigatinib may interact with certain other medications, including HIV protease inhibitors, anti-seizure medications, certain antibiotics, antifungal medications, and other ALK inhibitors.Disease Interactions
Brigatinib may increase the risk of certain diseases, including hypertension, interstitial lung disease, and tumor lysis syndrome. Patients should notify their doctor if they have any history of these conditions.Drug Interactions
Brigatinib may interact with certain drugs such as medications for HIV, antidepressants, certain oral contraceptives, and some antibiotics. Patients should inform their doctor of all medications they are taking prior to starting Brigatinib.Food Interactions
Brigatinib may interact with certain foods such as grapefruit and grapefruit juice, as well as certain dietary antioxidants. Patients should inform their doctor of any dietary supplements or herbal medicines they may be taking prior to starting Brigatinib.Pregnancy Use
It is not known if Brigatinib can harm an unborn baby. Patients should tell their doctor if they are pregnant, or intend to become pregnant while taking Brigatinib.Lactation Use
It is not known if Brigatinib is safe for use in breastfeeding women. Patients should tell their doctor if they are breastfeeding prior to starting Brigatinib.Acute Overdose
An acute overdose of Brigatinib can lead to serious adverse effects such as severe nausea, vomiting, and diarrhea, as well as difficulty breathing and an irregular heartbeat. Patients should seek immediate medical attention if they suspect an overdose.Contraindications
Brigatinib is contraindicated in patients with known hypersensitivity to other ALK inhibitors.Use Directions
Patients should take Brigatinib exactly as prescribed by their doctor. Do not change the dose or stop taking Brigatinib without consulting the doctor.Storage Conditions
Store Brigatinib at room temperature, away from light and moisture. Store the tablets in their original container and keep the container tightly closed.Volume of Distribution
The volume of distribution of Brigatinib is approximately 1235.6 liters.Half Life
The half-life of Brigatinib is 68 hours.Clearance
The clearance of Brigatinib is approximately 34.7 mL/min.Here you find in details version of Brigatinib
Some Frequently Asked Questions About Brigatinib
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