Brivaracetam
Brivaracetam Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Brivaracetam is a brand name. Its generic name is Brivaracetam.
Introduction
Brivaracetam (brand name Briviact) is an antiepileptic medication that belongs to the racetam group of drugs. It is used in the treatment of partial-onset seizures in adults and adolescents aged 16 years or older who have epilepsy.Uses
Brivaracetam is used to treat and prevent partial-onset seizures in adults and adolescents aged 16 years or older who have epilepsy.Mechanism of Action
Brivaracetam binds to SV2A in the brain and works by protecting neurons from over-excitation. It is thought to work by normalizing electrical signals in the brain and preventing seizure activity.How Long Does it Take to Work?
The effects of Brivaracetam can begin within hours after the first dose, and may reach its full effect after a few weeks.Absorption
Brivaracetam is quickly and almost completely absorbed after oral administration and has an absolute bioavailability of 94%. It is also rapidly and nearly completely converted to its active metabolite R-brivaracetam.Route of Elimination
Brivaracetam and its metabolites are predominantly eliminated via the urine.Dosage
Brivaracetam is available in tablets of 10 mg, 20 mg, 50 mg, and 100 mg, and as a solution of 10 mg per 5 mL. The dosage should be increased gradually as per directions of a physician. The maximum daily dose of Brivaracetam should not exceed 100 mg.Administration
Brivaracetam can be taken with or without food. It is usually administered twice daily as evenly spaced doses.Side Effects
The most common side effects of Brivaracetam include: headaches, dizziness, fatigue, nausea, sleepiness, irritability, and vomiting.Toxicity
The minimum lethal dose of Brivaracetam in rats is greater than 2000 mg/kg, indicating low acute toxicity.Precautions
Brivaracetam should be used with caution in patients with renal impairment as it is eliminated primarily by the kidneys.Interactions
Brivaracetam may interact with other medications such as birth control pills, antibiotics, antifungal medicines, cholesterol-lowering medicines, HIV/AIDS medicines, seizure medicines, and antacids.Disease Interactions
Brivaracetam should be used with caution in patients with severe hepatic or renal impairment, or those taking enzyme-inducing antiepileptic medications.Drug Interactions
Brivaracetam may interact with other drugs such as hormonal contraceptives, cimetidine, oral antibiotics, antifungal medications, cholesterol-lowering medications, HIV/AIDS medications, seizure medications, and antacids.Food Interactions
Brivaracetam may interact with grapefruit or grapefruit juice. Consult your physician or pharmacist before taking any medication or consuming grapefruit or grapefruit juice.Pregnancy Use
Brivaracetam is not recommended for pregnant women due to lack of data on safety in pregnancy.Lactation Use
Brivaracetam is contraindicated in breastfeeding women due to the potential for serious adverse effects on the newborn.Acute Overdose
Symptoms of acute overdose include drowsiness, confusion, nausea, vomiting, and diarrhea. In cases of overdose, supportive and symptomatic treatment is recommended.Contraindication
Brivaracetam is contraindicated in patients with a known hypersensitivity to any of the components of the drug.Use Direction
Brivaracetam should be used as directed under the supervision of a healthcare professional.Storage Condition
Brivaracetam should be stored at room temperature, 15-30° C (59-86° F) and protected from heat and direct sunlight.Volume of Distribution
The volume of distribution of Brivaracetam is 0.72±0.3 L/kg.Half-Life
The half-life of Brivaracetam is approximately 6 hours.Clearance
The clearance of Brivaracetam is approximately 0.19 L/hr/kg.Here you find in details version of Brivaracetam
Some Frequently Asked Questions About Brivaracetam
What is Brivaracetam?
Brivaracetam is an anticonvulsant medication used to treat certain types of seizures in patients with epilepsy. It works by regulating abnormal electrical activity in the brain, helping to reduce seizure frequency and severity.
How is Brivaracetam taken?
Brivaracetam is typically taken orally in tablet or capsule form. It can also be given through injection. Follow your doctor's instructions for taking this medication and use it exactly as prescribed for best results.
What are the possible side effects of Brivaracetam?
Common side effects of Brivaracetam include dizziness, drowsiness, fatigue, nausea, and vomiting. Other potential side effects include blurred vision, dry mouth, headache, and weight gain. Consult your doctor if you experience any of these side effects.
When should Brivaracetam not be taken?
Brivaracetam should not be taken if you have a known allergy to the drug or any of its ingredients. It should also not be used if you are pregnant or breastfeeding, or if you are taking certain medications, as drug interactions could occur. Be sure to discuss any other medications, vitamins, or supplements you are taking with your doctor before beginning a regimen of Brivaracetam.
Is Brivaracetam safe for long-term use?
Long-term safety and effectiveness of Brivaracetam have not been established in patients with epilepsy. Talk to your doctor about your particular needs before starting or continuing a regimen of Brivaracetam.
What should I do if I miss a dose of Brivaracetam?
If you miss a dose of Brivaracetam take it as soon as you remember, unless it is close to the time of your next dose. In that case, skip the missed dose and take the next one as scheduled. Do not double up on doses to make up for missing them.
Can children take Brivaracetam?
Brivaracetam is approved for use in children ages 4 years and older for the treatment of seizures related to a specific type of epilepsy. It should be used only with a doctor's supervision and should not be used in children younger than 4 years.
Can pregnant women take Brivaracetam?
Brivaracetam should not be taken by pregnant women unless absolutely necessary. If it is prescribed for the treatment of seizures, your doctor will weigh the potential risks and benefits and carefully monitor your health while you are taking the drug. Talk to your doctor about the risks and benefits of taking Brivaracetam while pregnant.
Is Brivaracetam likely to cause addiction?
Brivaracetam is not believed to be habit-forming or to be prone to dependency or addiction. However, some people may misuse or abuse the drug, so it is important to take it as prescribed and not exceed the recommended dosage.
Can Brivaracetam be taken with other medications?
It depends on the other medications. Before taking Brivaracetam with other drugs (prescription or over-the-counter), discuss potential interactions and side effects with your doctor, as some drugs may interact with Brivaracetam and increase the risk of certain side effects.
Can Brivaracetam be used to treat other conditions?
Brivaracetam is only approved for the treatment of seizures related to a specific type of epilepsy but it may be used off-label to treat other conditions. Off-label use should only be carried out under the supervision of a qualified medical professional.
What should I do if I have an allergic reaction to Brivaracetam?
If you have a known allergy to Brivaracetam or any of its ingredients, do not take the medication. If you experience a severe allergic reaction while taking the medication, such as difficulty breathing, swelling of the face, lips, throat, or tongue, stop taking the medication and seek medical attention immediately.
What is the most common side effect of Brivaracetam?
The most common side effect of Brivaracetam is dizziness. Other common side effects include drowsiness, fatigue, nausea, and vomiting. Talk to your doctor if you experience any of these side effects.
Can I drink alcohol while taking Brivaracetam?
It is not recommended that you drink alcohol while taking Brivaracetam, as alcohol can increase the risk of certain side effects. Talk to your doctor for more information and for advice on drinking alcohol while taking this medication.
Are there any long-term effects associated with Brivaracetam?
The long-term effects of Brivaracetam have not been established. Talk to your doctor about the potential risks and benefits of taking this medication for long periods of time.
Does Brivaracetam cause weight gain?
Weight gain has been reported as a rare side effect of Brivaracetam. If you experience an increase in weight while taking this medication, talk to your doctor.
Can Brivaracetam be crushed or split in half?
Brivaracetam tablets and capsules should not be crushed or split in half. Follow your doctor's instructions for taking this medication and only take it as prescribed.
Are there any alternatives to Brivaracetam?
Depending on the type of epilepsy you have there may be other medications that are more appropriate. Talk to your doctor about what other medications may work better for you.
What is the recommended dosage of Brivaracetam?
The recommended dosage of Brivaracetam will vary depending on your age, weight, medical history, and other factors. Talk to your doctor before taking Brivaracetam, and only use it as prescribed.
Is Brivaracetam available as a generic?
No. Brivaracetam is not currently available in generic form.
What should I do if I overdose on Brivaracetam?
If you or someone else has taken an overdose of Brivaracetam, contact your local poison control center or seek emergency medical attention right away. Overdoses can lead to serious complications and should be avoided.
What if I forget to take my dose of Brivaracetam?
If you forget to take your dose of Brivaracetam, take it as soon as you remember unless it is close to the time of your next dose. In that case, skip the missed dose and take the next one as scheduled. Do not double up on doses to make up for missing them.
Should I avoid certain activities while taking Brivaracetam?
It is recommended to avoid activities that require alertness such as driving, operating hazardous machinery, or engaging in potentially hazardous activities while taking Brivaracetam as the medication may cause drowsiness. Be sure to talk to your doctor if you have any questions or concerns.
Can I take Brivaracetam with other medications?
It depends on the other medications. Before taking Brivaracetam with other drugs (prescription or over-the-counter), discuss potential interactions and side effects with your doctor, as some drugs may interact with Brivaracetam and increase the risk of certain side effects.
What should I tell my doctor before taking Brivaracetam?
You should tell your doctor about any allergies you have, any other medications you are taking, and if you are pregnant or breastfeeding before taking Brivaracetam. This will help your doctor ensure that Brivaracetam is the best treatment option for you.
What is the safest way to take Brivaracetam?
The safest way to take Brivaracetam is to follow your doctor's instructions for taking the medication. Do not take more or less than the recommended dosage and do not take the medication for longer than prescribed. Be sure to talk to your doctor if you have any questions or concerns.
Does Brivaracetam cause withdrawal symptoms?
Generally, no. Brivaracetam usually does not cause withdrawal symptoms if it is stopped abruptly. However, it is important to talk to your doctor before stopping the medication to make sure it is safe for you to do so.
Can I take other medications while taking Brivaracetam?
It depends on the other medications. Before taking Brivaracetam with other drugs (prescription or over-the-counter), discuss potential interactions and side effects with your doctor, as some drugs may interact with Brivaracetam and increase the risk of certain side effects.
What should I do if I experience side effects while taking Brivaracetam?
If you experience side effects while taking Brivaracetam, such as dizziness, drowsiness, fatigue, nausea, vomiting, or blurred vision, talk to your doctor. Your doctor may be able to adjust the dosage of the medication or change to an alternative treatment.
What is the risk of taking too much Brivaracetam?
Taking too much Brivaracetam may result in an increased risk of seizures and other serious side effects. If you suspect you have taken too much Brivaracetam, seek medical attention right away.
Can I take Brivaracetam with food?
Yes, you can take Brivaracetam with or without food. Talk to your doctor for specific instructions on the best way to take this medication.
What if I forget a dose of Brivaracetam?
If you forget a dose of Brivaracetam, take it as soon as you remember unless it is close to the time of your next dose. In that case, skip the missed dose and take the next one as scheduled. Do not double up on doses to make up for missing them.
Are there any other precautions I should take when taking Brivaracetam?
Be sure to avoid activities that require alertness such as driving, operating hazardous machinery, or engaging in potentially hazardous activities while taking Brivaracetam as the medication may cause drowsiness. Be sure to talk to your doctor if you have any questions or concerns.
Does Brivaracetam interact with other medications?
Yes, Brivaracetam may interact with other medications. Talk to your doctor about any other medications, vitamins, or supplements you are taking, as drug interactions could occur. Be sure to share this information with your doctor before starting a regimen of Brivaracetam.
Can I drink alcohol while taking Brivaracetam?
It is not recommended that you drink alcohol while taking Brivaracetam, as alcohol can increase the risk of certain side effects. Talk to your doctor for more information and for advice on drinking alcohol while taking this medication.
What are the possible side effects of Brivaracetam?
Common side effects of Brivaracetam include dizziness, drowsiness, fatigue, nausea, and vomiting. Other potential side effects include blurred vision, dry mouth, headache, and weight gain. Consult your doctor if you experience any of these side effects.
Does Brivaracetam cause weight gain?
Weight gain has been reported as a rare side effect of Brivaracetam. If you experience an increase in weight while taking this medication, talk to your doctor.
Does Brivaracetam help prevent seizures?
Yes, Brivaracetam works to reduce the frequency and severity of seizures related to a specific type of epilepsy. It works by regulating abnormal electrical activity in the brain. Talk to your doctor for more information.
Does Brivaracetam have any beneficial effects on cognitive functioning?
It is uncertain if Brivaracetam has any effects on cognitive functioning, as research is limited. Talk to your doctor about the potential risks and benefits of taking this medication.
Is Brivaracetam safe for long-term use?
Long-term safety and effectiveness of Brivaracetam have not been established in patients with epilepsy. Talk to your doctor about your particular needs before starting or continuing a regimen of Brivaracetam.