Bacnox
Bacnox Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Bacnox is a brand name. Its generic name is Ozenoxacin.
Bacnox
Bacnox is a novel topical antibiotic that belongs to the oxazolidinone class of antimicrobials. It was developed as an effective, long-acting treatment option for skin and skin-structure infections caused by gram-positive bacteria, including both Staphylococcus aureus (including methicillin-resistant S. aureus) and Streptococcus pyogenes. It is a topical cream formulation intended to be applied once a day for five consecutive days.
Uses For
Bacnox is used for the treatment of mild impetigo and other skin infections caused by certain bacteria.
Mechanism of Action
Bacnox acts by inhibiting the synthesis of bacterial proteins necessary for survival. It works by binding to the ribosomal 50S subunit of susceptible strains of bacteria and thereby halting the production of new proteins that are needed for the bacteria to grow and reproduce.
How Long Does it Take to Work?
For most patients, the medication will begin to take effect within 48 to 72 hours after the initial dose is taken.
Absorption
Bacnox is a topical drug that is not expected to be absorbed systemically. Thus, it can be used for the treatment of localized skin and skin-structure infections without significant systemic absorption.
Route of Elimination
Any Bacnox that is not absorbed and metabolized is excreted as metabolites in the urine, primarily as conjugated glucuronides.
Dosage
The recommended dosage of Bacnox is 1% cream applied topically, once a day for five consecutive days to the affected skin area. A thin layer of Bacnox cream (about a ½ inch in length) should be applied to the affected area. The area should be covered with a gauze pad and elastic bandage for 12 hours after each application.
Administration
Bacnox cream should be applied once daily, preferably at bedtime, for five consecutive days to the affected skin area. It should be applied in a thin layer and then covered with a gauze pad and elastic bandage for 12 hours, and then be removed and discarded.
Side Effects
The most common side effects of Bacnox include burning, stinging, itching, redness, and dryness at the application site. Other side effects may include rash, hives, swollen lips or tongue, joint pain, sore throat, and fever.
Toxicity
Bacnox has an extremely low potential for systemic toxicity due to its topical application and low systemic absorption. However, in rare cases it may cause systemic toxicity if ingested or if large amounts are applied over a wide area.
Precaution
Patients should use Bacnox exactly as prescribed. Bacnox should not be used more than five consecutive days nor should it be applied to the eyes or inside the nose or mouth. Patients should contact their doctor if they experience side effects such as rash, hives, sore throat, fever, or other severe reactions.
Interaction
No known drug interactions have been reported with the use of Bacnox. As with any medication, however, it is important to tell your physician about any other medications you are taking before using this product.
Disease Interaction
Patients with moderate to severe eczema or skin disease should not use Bacnox. Patients with a known hypersensitivity to lincomycin or clindamycin should also not use Bacnox.
Drug Interaction
No known drug interactions have been reported with the use of Bacnox. However, close clinical monitoring is necessary as interactions with other medications cannot be excluded.
Food Interaction
No known food interactions have been reported with the use of Bacnox.
Pregnancy Use
Bacnox is not recommended for use in pregnancy. In general, the potential benefit of this medication should be weighed against its potential risks.
Lactation Use
It is not known if Bacnox can be passed in breast milk. Therefore, it is not recommended for use in lactating women.
Acute Overdose
No clinical data is available on acute overdosing of Bacnox. Therefore, supportive therapy should be provided as warranted.
Contraindications
Bacnox is contraindicated in patients with known hypersensitivity to lincomycin or clindamycin, as well as in patients with moderate to severe eczema or skin disease.
Use Direction
Bacnox cream should be applied once a day for five consecutive days to the affected area of skin, preferably at bedtime. It should be applied in a thin layer, and then covered with a gauze pad and elastic bandage for 12 hours, and then discarded.
Storage Condition
Bacnox should be stored at room temperature, away from direct light and moisture.
Volume of Distribution
No data is available on the volume of distribution of Bacnox.
Half Life
No data is available on the half-life of Bacnox.
Clearance
No data is available on the clearance of Bacnox.
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