Amlos L
Amlos L Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Amlos L is a brand name. Its generic name is Lisinopril + Amlodipine.
Introduction
Lisinopril is an angiotensin-converting enzyme (ACE) inhibitor, prescribed for high blood pressure, certain types of heart failure, and preventing death due to certain types of heart attack & stroke. Amlodipine Besylate is a Calcium channel blocker, prescribed for high blood pressure and chest pain. The combination of lisinopril and amlodipine is used to treat high blood pressure (hypertension).
Uses
The combination of lisinopril and amlodipine is used to treat high blood pressure (hypertension). It is also used to reduce the risk of stroke and heart attack.
Mechanism of Action
Lisinopril blocks the action of angiotensin-converting enzyme, which is required for the body to produce the hormone called angiotensin II. Angiotensin II causes constriction of blood vessels, leading to elevated blood pressure. By blocking the formation of angiotensin II, lisinopril relaxes the blood vessels and lowers the blood pressure. Amlodipine works by preventing the action of calcium on the tissues and blood vessels. This ultimately results in the relaxation of the blood vessels and improves blood flow. By blocking calcium movement through the cells in the muscle of the heart and the blood vessels, amlodipine relaxes the blood vessels, and this leads to lowered blood pressure.
How long does it take to work?
Lisinopril and amlodipine combination tablets may start to work within 1 hour, but it may take several weeks before full blood pressure lowering effects are seen.
Absorption
Lisinopril is rapidly and completely absorbed after oral administration, with an absolute bioavailability of approximately 25%. Amlodipine is completely absorbed after oral administration, with bioavailability ranging from 64% to 80%.
Route of Elimination
Lisinopril is mainly eliminated in the form of metabolites in the urine (60%) and the remainder is eliminated in the feces (40%). Amlodipine is mainly eliminated in urine (71%) and feces (20%).
Dosage
The usual starting dose of lisinopril and amlodipine is 5/5 mg twice daily. Depending on factors like age, medical condition, etc the dose can be increased to 10/10 mg twice daily.
Administration
Lisinopril and amlodipine combination tablets should be taken with or without food. It should be taken at the same time each day, preferably in the morning and evening.
Side Effects
Common side effects of lisinopril and amlodipine combination tablets include dizziness, headache, fatigue, drowsiness, nausea, vomiting, lightheadedness, difficulty breathing, fast/irregular/pounding heartbeat, weakness, chest pain, nausea and dry mouth. Seek medical attention immediately if any of these side effects persist or worsen.
Toxicity
Lisinopril and amlodipine combination tablets are generally considered to be safe and well tolerated. In case of severe toxicity, the patient should seek immediate medical attention.
Precautions
It is important to monitor the blood pressure regularly while taking lisinopril and amlodipine combination tablets. You should also inform your doctor if you have any other medical condition or allergies that you may have. You should inform your doctor if you are pregnant, planning a pregnancy or breastfeeding.
Interaction
- Lisinopril and amlodipine may increase the risk of side effects when taken with certain other drugs.
- You should inform your doctor of all the drugs that you are taking, including any non-prescription drugs and herbal supplements, to avoid any potential drug-drug interactions.
Disease Interaction
Lisinopril and amlodipine combination tablets may interact with certain diseases and worsen them. Therefore, it is advisable that you inform your doctor of any underlying medical condition such as kidney disease or liver disease before taking this medication.
Drug Interaction
Lisinopril and amlodipine combination tablets may interact with certain drugs and worsen the side effects. You should inform your doctor of all the medications that you are taking, including non-prescription drugs. Your doctor will be able to identify any potential drug-drug interactions and advise you about taking the medications together.
Food Interactions
Lisinopril and amlodipine combination tablets should be taken on an empty stomach, preferably in the morning. You should avoid eating a high-fat meal before taking the medication, as it may increase the absorption of the drugs.
Pregnancy Use
Lisinopril and amlodipine combination tablets are not recommended for use in pregnant women unless absolutely necessary. Your doctor will weigh the potential benefits and risks before prescribing the medication. You should inform your doctor if you are breastfeeding, as this medication is not recommended for women who are breastfeeding.
Lactation Use
Lisinopril and amlodipine combination tablets are not recommended for use in breastfeeding women unless absolutely necessary. Your doctor will weigh the potential benefits and risks before prescribing the medication. If the medication is prescribed, the infant should be monitored closely for any adverse effects.
Acute Overdose
In case of an acute overdose, seek medical attention immediately. The symptoms of an overdose of lisinopril and amlodipine are dizziness, fainting, nausea, vomiting, hypotension, bradycardia and renal failure.
Contraindication
Lisinopril and amlodipine combination tablets are contraindicated in patients who are allergic to lisinopril or amlodipine, or any other ingredient present in the drug. It is also contraindicated in patients who are currently taking a calcium channel blocker or an ACE inhibitor.
Use Direction
Lisinopril and amlodipine combination tablets should be taken as directed by the doctor. The medication should be taken with or without food, preferably in the morning and evening. It is important to take the dosage exactly as prescribed by the doctor, and not to take more or less than what is directed.
Storage Condition
Lisinopril and amlodipine combination tablets should be stored in a cool, dry place. Keep away from direct heat and light. Do not keep the medication in the refrigerator or freezer.
Volume of Distribution
The volume of distribution for lisinopril is 0.3 L/kg and for amlodipine is 8.4 L/kg.
Half Life
The half life of lisinopril is 12 hours and the half life of amlodipine is 40-50 hours.
Clearance
The clearance of lisinopril is 0.09 L/h/kg, and the clearance of amlodipine is 0.7 L/h/kg.
Here you find in details version of Amlos L
Some Frequently Asked Questions About Amlos L
What is Lisinopril?
Lisinopril is an angiotensin-converting enzyme (ACE) inhibitor, which is a type of medication used to treat high blood pressure by relaxing blood vessels, allowing for improved blood flow.
Are there any side effects associated with Lisinopril?
Yes, there may be some common side effects associated with taking Lisinopril, including headache, dizziness, tiredness, coughing, nausea, diarrhea, and decreased appetite.
What is Amlodipine?
Amlodipine is a type of prescription medication that belongs to a class of drugs called calcium channel blockers. It is used to treat high blood pressure and chest pain (angina).
What are the side effects of Amlodipine?
Some common side effects with Amlodipine include headache, dizziness, nausea, diarrhea, constipation, stomach pain, back pain, tiredness, and increased urination.
Can Amlodipine and Lisinopril be taken together?
Yes, it is generally safe to take Amlodipine and Lisinopril together. However, since they are both medications used to lower blood pressure, it is important to talk to your doctor about the best dose for you.
Is it safe to take Lisinopril with other medicines?
Yes, it is usually safe to take Lisinopril with other medicines. However, certain medicines such as aspirin or other blood thinners, as well as potassium supplements, may interact with Lisinopril, so it is important to talk to your doctor before taking any other medications.
What happens if I miss a dose of Amlodipine?
If you miss a dose of Amlodipine, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the next dose at the usual time. Do not double the dose.
What should I do if I experience any side effects while taking Amlodipine?
If you experience any side effects while taking Amlodipine, such as headaches, dizziness, nausea, fatigue, or any other unusual symptoms, you should contact your doctor as soon as possible.
What is the typical dose of Lisinopril?
The typical dose of Lisinopril is 10mg to 40mg once daily. The exact dose will depend on factors such as the severity of your high blood pressure and other medical conditions, so it is important to talk to your doctor about the most appropriate dose for you.
Can I take Amlodipine and Lisinopril together if I am pregnant?
No, it is not recommended to take Amlodipine and Lisinopril together if you are pregnant. Both medications can be harmful to an unborn baby, and therefore should only be used under close supervision of your doctor.
How long does it take for Amlodipine to work?
It usually takes 2-4 weeks for Amlodipine to reach its full effect, although some people may start feeling the effects sooner. It is important to talk to your doctor about how quickly it is working for you, as your dose may need to be adjusted.
How long can I take Lisinopril for?
Lisinopril is a long-term medication and is usually taken for years in order to effectively control blood pressure. It is important to talk to your doctor about the best treatment plan for you.
Can I drive while taking Amlodipine?
Amlodipine may cause dizziness or blurred vision, so it is important to be aware of how you are feeling when taking this medication. If you experience these side effects while taking Amlodipine, it is recommended to refrain from driving or operating machinery.
Does Lisinopril lower blood pressure quickly?
Yes, Lisinopril begins working quickly to lower blood pressure. It can usually begin to reduce blood pressure within 1 week, although it may take several weeks for the full effect.
Is Lisinopril safe for elderly people?
Yes, Lisinopril is generally safe for elderly people. However, since elderly people are more prone to side effects, it is important to talk to your doctor about the best dose for your individual needs.
Can I drink alcohol while taking Amlodipine?
Yes, you can drink alcohol while taking Amlodipine as long as you do so in moderation and only after consulting with your doctor. Heavy alcohol consumption may increase the risk of side effects, such as dizziness or low blood pressure.
What are the symptoms of an allergic reaction to Amlodipine?
Allergic reactions to Amlodipine are rare, but if they do occur they may include hives, difficulty breathing, swelling of the face, lips, tongue, or throat, or severe dizziness.
Does Lisinopril interact with other medicines?
Yes, Lisinopril can interact with certain medicines, such as nonsteroidal anti-inflammatory drugs (NSAIDs), potassium supplements, and other blood pressure medications. It is important to talk to your doctor before taking any other medicines, especially while taking Lisinopril.
Can I take Amlodipine if I have high cholesterol?
Yes, it is safe to take Amlodipine if you have high cholesterol. However, cholesterol-lowering medications, such as statins, may be more effective in treating high cholesterol levels.
How soon can I expect to see the effects of Lisinopril?
You may begin to feel the effects of Lisinopril within 1 week of starting treatment. However, it may take several weeks for the full effects to be seen, depending on your individual needs.
Is it safe to take Amlodipine if I have kidney disease?
Yes, it is usually safe to take Amlodipine if you have kidney disease. However, it is important to talk to your doctor about the most appropriate dose for you.
Can Lisinopril cause a dry cough?
Yes, Lisinopril can cause a dry cough in some people. If you experience this side effect, it is important to talk to your doctor about the best way to manage it.
Can Lisinopril and Amlodipine be taken with food?
Yes, both Lisinopril and Amlodipine can be taken with food. However, it is important to take them at the same time every day and to follow your doctor's instructions for taking them.
Can I take Amlodipine if I have diabetes?
Yes, it is generally safe to take Amlodipine if you have diabetes. However, it is important to make sure your blood sugar is being monitored and to talk to your doctor about any other medications you are taking.
Can I take Lisinopril if I have liver disease?
Yes, it is generally safe to take Lisinopril if you have liver disease. However, since this medication affects the liver, it is important to talk to your doctor about the most appropriate dose for your individual needs.
What should I do if I experience chest pain while taking Amlodipine?
If you experience chest pain while taking Amlodipine, stop taking the medication and contact your doctor immediately. Chest pain is an uncommon side effect of Amlodipine, so it is important to be aware of any chest pain you may experience while taking the medication.
Does Lisinopril cause weight gain?
No, Lisinopril does not cause weight gain. However, certain side effects, such as fatigue or decreased appetite, may lead to weight changes.
How should Amlodipine be stored?
Amlodipine should be stored at room temperature between 59-86 degrees F (15-30 degrees C). It should be kept away from light, heat, and moisture and should not be stored in the bathroom.
How often should I take Lisinopril?
Lisinopril is typically taken once daily. However, the exact dosage and frequency will depend on factors such as the severity of your condition and other medical conditions, so it is important to talk to your doctor about the best dose for you.
Can I take Amlodipine if I am breastfeeding?
No, it is not recommended to take Amlodipine while breastfeeding. Amlodipine can pass into breast milk and may harm an unborn baby, so it is important to speak to your doctor before taking Amlodipine while breastfeeding.
Can Lisinopril cause a rash?
Yes, a rash is a possible side effect of Lisinopril. If you experience any unexplained rash while taking Lisinopril, it is important to contact your doctor immediately as it may be a sign of an allergic reaction.
How long does it take for Lisinopril to start working?
Lisinopril usually begins to work within 1 week of starting treatment, although it may take several weeks for the full effects to be seen. It is important to talk to your doctor about any changes you are feeling while taking the medication.
Can I take Lisinopril and Amlodipine together if I have kidney disease?
Yes, you can take Lisinopril and Amlodipine together if you have kidney disease. However, since these medications can affect kidney function, it is important to talk to your doctor about the most appropriate dose for you.
Can I take Lisinopril if I am pregnant?
No, it is not recommended to take Lisinopril if you are pregnant. Lisinopril can pass into the placenta and may harm an unborn baby, so it is important to speak to your doctor before taking this medication while pregnant.
Is it safe to take Amlodipine if I have a heart condition?
Yes, it is usually safe to take Amlodipine if you have a heart condition. However, it is important to talk to your doctor about the most appropriate dose for you.
Should I take Lisinopril in the morning or at night?
It is typically recommended to take Lisinopril once daily in the morning. However, your doctor may advise you to take it at a different time of day, so it is important to talk to your doctor about the best time for you.
Can I take Amlodipine if I am breastfeeding?
No, it is not recommended to take Amlodipine while breastfeeding. Amlodipine can pass into breast milk and may harm an unborn baby, so it is important to speak to your doctor before taking Amlodipine while breastfeeding.
Does Amlodipine cause dizziness?
Yes, dizziness is a possible side effect of Amlodipine. If you experience dizziness while taking Amlodipine, you should contact your doctor as soon as possible.
Can I take Lisinopril if I am pregnant?
No, it is not recommended to take Lisinopril if you are pregnant. Lisinopril can pass into the placenta and may harm an unborn baby, so it is important to speak to your doctor before taking this medication while pregnant.
What should I do if I miss a dose of Lisinopril?
If you miss a dose of Lisinopril, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the next dose at the usual time. Do not double the dose.